Background: Therapy with corticosteroids often results in bone loss and
corticosteroid-induced osteoporosis. In previous studies, bone mineral density (BMD)
has been examined after administration of relatively high oral doses of corticosteroids.
However, practitioners use comparatively lower doses of corticosteroids for epidural
steroid injections (ESI). The interactions and relationships between BMD and ESI remain
to be determined.
Objective: The aim of this study was to explore the relationship between BMD and
ESI in postmenopausal women treated for lower back pain.
Study design: This study was a retrospective evaluation.
Methods: We reviewed the medical records of postmenopausal women with lower
back pain who were treated with or without ESI. BMD was measured before treatment
and one year after treatment in the lumbar spine, femoral neck, and total femur. A
total of 90 postmenopausal women were divided into 2 groups. Group 1 patients
received medications without ESI; Group 2 patients received ESI more than 4 times,
with a cumulative administered triamcinolone dose of > 120 mg.
Results: Decreased BMD was observed in patients treated with ESI. However, no
significant difference was observed between or within the groups in terms of mean
percentage change from baseline BMD.
Limitations: First, this study is limited by the fact that it was retrospective. Second,
our study did not consider the use of ESI with high-dose corticosteroids. Third, our
study did not include any long-term assessments of the effects of ESI on BMD.
Conclusions: These data suggest that ESI using triamcinolone (over 200 mg) for
a period of one year will have a negative effect on BMD in postmenopausal women
treated for lower back pain. However, ESI therapy using a maximum cumulative
triamcinolone dose of 200 mg in one year would be a safe treatment method with no
significant impact on BMD.
Key words: bone mineral density, corticosteroid, epidural steroid injection, lower
back pain, postmenopausal women, triamcinolone.