scholarly journals Folic acid supplementation normalizes the endothelial progenitor cell transcriptome of patients with type 1 diabetes: a case-control pilot study

2009 ◽  
Vol 8 (1) ◽  
pp. 47 ◽  
Author(s):  
Olivia van Oostrom ◽  
Dominique PV de Kleijn ◽  
Joost O Fledderus ◽  
Mario Pescatori ◽  
Andrew Stubbs ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Folic Acid ◽  
Pilot Study ◽  
Endothelial Progenitor Cell ◽  
Progenitor Cell ◽  
Folic Acid Supplementation ◽  
Case Control ◽  
Acid Supplementation ◽  
Cell Transcriptome

scholarly journals Identification of the Key Genes Involved in the Effect of Folic Acid on Endothelial Progenitor Cell Transcriptome of Patients with Type 1 Diabetes

2020 ◽  
Vol 2020 ◽  
pp. 1-7
Author(s):  
Yi Lu ◽  
Qianhong Yang ◽  
Wei Hu ◽  
Jian Dong
Keyword(s):  
Type 1 Diabetes ◽  
Folic Acid ◽  
Endothelial Progenitor Cell ◽  
Cellular Response ◽  
Progenitor Cell ◽  
Endothelial Progenitor ◽  
Ppi Networks ◽  
Cell Transcriptome ◽  
Upregulated Genes

Type 1 diabetes (T1D) is one of the most common autoimmune diseases in children. Previous studies have suggested that endothelial progenitor cells (EPCs) might be engaged in the regulating of the biological processes in T1D and folic acid (FA) might be engaged in regulating EPC function. The present study has identified 716 downregulated genes and 617 upregulated genes in T1D EPC cases after treated with FA. Bioinformatics analysis has shown that these DEGs were engaged in regulating metabolic processes, cell proliferation-related processes, bone marrow development, cell adhesion, platelet degranulation, and cellular response to growth factor stimulus. Furthermore, we have conducted and identified hub PPI networks. Importantly, we have identified 6 upregulated genes (POLR2A, BDNF, CDC27, LTN1, RAB1A, and CUL2) and 8 downregulated genes (SHC1, GRIN2B, TTN, GNAL, GNB2, PTK2, TF, and TLR9) as key regulators involved in the effect of FA on endothelial progenitor cell transcriptome of patients with T1D. We think that this study could provide novel information to understand the roles of FA in regulating EPCs of T1D patients.

A pilot study of d-chiro-inositol plus folic acid in overweight patients with type 1 diabetes

2016 ◽  
Vol 54 (4) ◽  
pp. 361-365 ◽  
Author(s):  
Anna Rita Maurizi ◽  
Marika Menduni ◽  
Rossella Del Toro ◽  
Shadi Kyanvash ◽  
Daria Maggi ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Folic Acid ◽  
Pilot Study

scholarly journals Maternal Periconceptional Folic Acid Supplementation and the Risk of Non-Syndromic Oral Clefts in Offspring: A Population-Based Case-Control Study in Chengdu, China

2021 ◽  
Author(s):  
Wenli Xu ◽  
Ling Yi ◽  
Changfei Deng ◽  
Ziling Zhao ◽  
Tianjin Zhou ◽  
...  
Keyword(s):  
Folic Acid ◽  
Cleft Palate ◽  
Statistical Power ◽  
Case Control Study ◽  
Population Based ◽  
Folic Acid Supplementation ◽  
Case Control ◽  
Oral Clefts ◽  
Acid Supplementation ◽  
Control Study

Abstract Maternal periconceptional folic acid supplementation (FAS) has been documented to be associated with decreased risk of nonsyndromic oral clefts (NsOC). However, the results remain inconclusive. In this population-based case-control study of 807 singletons affected by NsOC and 8070 healthy neonates who were born between October 2010 and September 2015 in Chengdu, China, we examined the association of maternal FAS with the risk of nonsyndromic cleft lip with or without cleft palate (NsCL/P), and cleft palate (NsCP). Unconditional logistic regression analysis was used to estimate the crude and adjusted odds ratios (ORs) and 95% confidential intervals (CI). Significant associations were found between maternal periconceptional FAS and decreased risk of NsCL/P (aOR = 0.41, 95% CI: 0.33–0.51). This protective effect was also detected for NsCL (aOR = 0.42, 95% CI: 0.30–0.58) and NsCLP (aOR = 0.41, 95% CI: 0.31–0.54). Both maternal FAS started before and after the last menstrual period (LMP) were negatively associated with NsCL/P (before LMP, aOR = 0.43, 95% CI: 0.33–0.56; after LMP, aOR = 0.41, 95% CI: 0.33–0.51). The association between NsCP and maternal FAS initiating before LMP was significant (aOR = 0.52, 95% CI: 0.30–0.90), but the statistical power seemed weak due to limited number of NsCP cases. The findings suggest that maternal periconceptional FAS can reduce the risk of each subtype of NsCL/P in offspring, while the potential effect on NsCP needs further investigations.

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