scholarly journals Clinical tolerability of artesunate-amodiaquine versus comparator treatments for uncomplicated falciparum malaria: an individual-patient analysis of eight randomized controlled trials in sub-Saharan Africa

2012 ◽  
Vol 11 (1) ◽  
pp. 260 ◽  
Author(s):  
Julien Zwang ◽  
Grant Dorsey ◽  
Abdoulaye Djimdé ◽  
Corine Karema ◽  
Andreas Mårtensson ◽  
...  
PLoS ONE ◽  
2011 ◽  
Vol 6 (7) ◽  
pp. e22601 ◽  
Author(s):  
Helen A. Weiss ◽  
Gabriela Paz Bailey ◽  
Sam Phiri ◽  
Gerard Gresenguet ◽  
Jerome LeGoff ◽  
...  

2018 ◽  
Vol 21 (4) ◽  
pp. 643-659 ◽  
Author(s):  
Cliodhna Cork ◽  
Ross White ◽  
Pia Noel ◽  
Niamh Bergin

Background: Intimate partner violence (IPV) perpetrated by males is the most prevalent form of violence against women across the globe. A systematic review was carried out to identify published randomized controlled trials of interventions aiming to prevent or reduce IPV in Sub-Saharan Africa. Details were sought on the interventions, outcomes, and risk of bias in evaluations. Methods: Articles were identified by searching MEDLINE, Embase, Web of Science, and PsycInfo. The search included terms pertaining to IPV, the research design, and the target geographical region. To be included, studies needed to have assessed the impact of an intervention on reported incidence, prevalence of IPV, or measures of related attitudes and behaviors. Fifteen papers were included in the final review. Risk of bias was evaluated using the Cochrane Library “Risk of Bias” tool. Results: Findings suggest that interventions have the potential to reduce IPV-related behaviors and attitudes. Certain types of IPV were more amenable to change than others. Higher levels of efficacy were identified in interventions that had longer follow-up, addressed IPV as a main aim, and occurred at the community level or multiple levels of the social ecology. Conclusions: Findings should be interpreted in light of varying risks of bias. Suggestions are made for future research and practice.


2017 ◽  
Vol 17 (1) ◽  
Author(s):  
Julien Zwang ◽  
Umberto D’Alessandro ◽  
Jean-Louis Ndiaye ◽  
Abdoulaye A Djimdé ◽  
Grant Dorsey ◽  
...  

2009 ◽  
Vol 8 (1) ◽  
Author(s):  
Julien Zwang ◽  
Piero Olliaro ◽  
Hubert Barennes ◽  
Maryline Bonnet ◽  
Philippe Brasseur ◽  
...  

Trials ◽  
2019 ◽  
Vol 20 (1) ◽  
Author(s):  
Ali Sié ◽  
◽  
Mamadou Ouattara ◽  
Mamadou Bountogo ◽  
Cheik Bagagnan ◽  
...  

Abstract Background Biannual, mass azithromycin distribution has previously been shown to reduce all-cause child mortality in sub-Saharan Africa. Subgroup analysis suggested that the strongest effects were in the youngest children, leading to the hypothesis that targeting younger age groups might be an effective strategy to prevent mortality. We present the methods of two randomized controlled trials designed to evaluate mass and targeted azithromycin distribution for the prevention of child mortality in Burkina Faso, West Africa. Methods/design The Child Health with Azithromycin Treatment (CHAT) study consists of two nested, randomized controlled trials. In the first, communities are randomized in a 1:1 fashion to biannual, mass azithromycin distribution or placebo. The primary outcome is under-5 all-cause mortality measured at the community level. In the second, children attending primary healthcare facilities during the first 5–12 weeks of life for a healthy child visit (e.g., for vaccination) are randomized in a 1:1 fashion to a single orally administered dose of azithromycin or placebo. The primary outcome is all-cause mortality measured at 6 months of age. The trial commenced enrollment in August 2019. Discussion This study is expected to provide evidence on two health systems delivery approaches (mass and targeted treatment) for azithromycin to prevent all-cause child mortality. The results will inform global and national policies related to azithromycin for the prevention of child mortality. Trial registration ClinicalTrials.gov, ID: NCT03676764. Registered on 19 September 2018; prospectively registered pre results.


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