scholarly journals Native T1 mapping in children and young adults with hypertrophic cardiomyopathy

2016 ◽  
Vol 18 (S1) ◽  
Author(s):  
Keyur Parekh ◽  
Michael Markl ◽  
Jie Deng ◽  
Roger A de Freitas ◽  
Cynthia K Rigsby
Keyword(s):  
Young Adults ◽  
Hypertrophic Cardiomyopathy ◽  
T1 Mapping ◽  
Native T1 ◽  
Children And Young Adults

scholarly journals T1 mapping in children and young adults with hypertrophic cardiomyopathy

2016 ◽  
Vol 33 (1) ◽  
pp. 109-117 ◽  
Author(s):  
Keyur Parekh ◽  
Michael Markl ◽  
Jie Deng ◽  
Roger A. de Freitas ◽  
Cynthia K. Rigsby
Keyword(s):  
Young Adults ◽  
Hypertrophic Cardiomyopathy ◽  
T1 Mapping ◽  
Children And Young Adults

scholarly journals Native T1 mapping for differential diagnosis of left ventricular hypertrophy

2021 ◽  
Vol 22 (Supplement_2) ◽  
Author(s):  
D Lavall ◽  
NH Vosshage ◽  
S Stoebe ◽  
T Denecke ◽  
A Hagendorff ◽  
...  
Keyword(s):  
Differential Diagnosis ◽  
Heart Disease ◽  
Hypertrophic Cardiomyopathy ◽  
Cardiac Amyloidosis ◽  
T1 Mapping ◽  
Hypertensive Heart Disease ◽  
Left Ventricular ◽  
Characteristic Analysis ◽  
Native T1 ◽  
Healthy Control

Abstract Funding Acknowledgements Type of funding sources: None. Purpose The aim of this study was to investigate native T1 mapping cardiac magnetic resonance (CMR) tomography for the differential diagnosis of left ventricular (LV) hypertrophy. Background Mapping techniques are useful to characterize myocardial tissue abnormalities, particularly cardiac amyloidosis. However, specific cut-off values to differentiate LV hypertrophic phenotypes on 3.0 tesla CMR scanners have not been established, yet. Methods We retrospectively identified patients in the CMR database of Leipzig university hospital with increased LV wall thickness (≥12mm diameter at end-diastole) who were referred for the evaluation of LV hypertrophy or ischemia between 2017 and 2020 on a 3T scanner (Philips Achieva). Patients with suspected or confirmed myocarditis were excluded. Diagnosis of cardiac amyloidosis was made by either biopsy or non-invasively by bone scintigraphy and screening for monoclonal gammopathy. T1 mapping was measured as global mean value from 3 short axis slices of the LV. Results 128 consecutive patients were included in the study. 31 subjects without evidence of structural heart disease served as healthy control. The final diagnosis was cardiac amyloidosis in 24 patients (5 patients with light-chain, 18 with transthyretin amyloidosis, 1 undetermined), hypertrophic cardiomyopathy in 24, and hypertensive heart disease in 80 patients. Mean age of patients was 65 ± 13years, 84% were male. LV mass was increased in patients with LV hypertrophy compared to healthy control (p < 0.001). Native T1 values of the LV myocardium were higher in patients with cardiac amyloidosis (1409 ± 59ms, p < 0.0001 vs. all other groups) compared to healthy control (1225 ± 21ms), patients with hypertrophic cardiomyopathy (HCM; 1263 ± 43ms) and hypertensive heart disease (HHD; 1257 ± 41ms) (Figure). Patients with hypertrophic cardiomyopathy and hypertensive heart disease did not differ in their native T1 values, but both groups were increased compared to healthy control (p < 0.01). Receiver operating characteristic analysis of native T1 values demonstrated an area under the curve for the detection of cardiac amyloidosis of 0.9954 (p < 0.0001) vs. hypertrophic cardiomyopathy, hypertensive heart disease and healthy control. The optimal cut-off value was 1341ms, with a sensitivity of 100% and a specificity of 97%. Conclusion Native T1 mapping has high diagnostic accuracy for the diagnosis of cardiac amyloidosis among patients with LV hypertrophy. These data need confirmation in a prospective clinical trial. Study ID DRKS00022048

scholarly journals Quantitative non-contrast T1 mapping of left ventricle in children and young adults

2014 ◽  
Vol 16 (S1) ◽  
Author(s):  
Keyur Parekh ◽  
Cynthia K Rigsby ◽  
Roger A deFreitas ◽  
Bruce S Spottiswoode ◽  
Michael Markl
Keyword(s):  
Young Adults ◽  
Left Ventricle ◽  
T1 Mapping ◽  
Children And Young Adults

scholarly journals Surgery for biventricular obstruction in hypertrophic cardiomyopathy in children and young adults: technique and outcomes†

2014 ◽  
Vol 47 (6) ◽  
pp. 1006-1012 ◽  
Author(s):  
Eduard Quintana ◽  
Jonathan N. Johnson ◽  
Anna Sabate Rotes ◽  
Frank Cetta ◽  
Steve R. Ommen ◽  
...  
Keyword(s):  
Young Adults ◽  
Hypertrophic Cardiomyopathy ◽  
Children And Young Adults

Outcome of Septal Myectomy for Obstructive Hypertrophic Cardiomyopathy in Children and Young Adults

2013 ◽  
Vol 95 (2) ◽  
pp. 663-669 ◽  
Author(s):  
Salah E. Altarabsheh ◽  
Joseph A. Dearani ◽  
Harold M. Burkhart ◽  
Hartzell V. Schaff ◽  
Salil V. Deo ◽  
...  
Keyword(s):  
Young Adults ◽  
Hypertrophic Cardiomyopathy ◽  
Septal Myectomy ◽  
Obstructive Hypertrophic Cardiomyopathy ◽  
Children And Young Adults

scholarly journals Incremental Values of T1 Mapping in the Prediction of Sudden Cardiac Death Risk in Hypertrophic Cardiomyopathy: A Comparison With Two Guidelines

2021 ◽  
Vol 8 ◽  
Author(s):  
Le Qin ◽  
Jiehua Min ◽  
Chihua Chen ◽  
Lan Zhu ◽  
Shengjia Gu ◽  
...  
Keyword(s):  
Regression Analysis ◽  
Hypertrophic Cardiomyopathy ◽  
Sudden Cardiac Death ◽  
Cardiac Death ◽  
T1 Mapping ◽  
Cox Regression ◽  
Volume Fraction ◽  
Healthy Individuals ◽  
Cox Regression Analysis ◽  
Native T1

Background: MRI native T1 mapping and extracellular volume fraction (ECV) are quantitative values that could reflect various myocardial tissue characterization. The role of these parameters in predicting the risk of sudden cardiac death (SCD) in hypertrophic cardiomyopathy (HCM) is still poorly understood.Aim: This study aims to investigate the ability of native T1 mapping and ECV values to predict major adverse cardiovascular events (MACE) in HCM, and its incremental values over the 2014 European Society of Cardiology (ESC) and enhanced American College of Cardiology/American Heart Association (ACC/AHA) guidelines.Methods: Between July 2016 and October 2020, HCM patients and healthy individuals with sex and age matched who underwent cardiac MRI were prospectively enrolled. The native T1 and ECV parameters were measured. The SCD risk was evaluated by the 2014 ESC guidelines and enhanced ACC/AHA guidelines. MACE included cardiac death, transplantation, heart failure admission, and implantable cardioverter-defibrillator implantation.Results: A total of 203 HCM patients (54.2 ± 14.9 years) and 101 healthy individuals (53.2 ± 14.7 years) were evaluated. During a median follow-up of 15 months, 25 patients (12.3%) had MACE. In multivariate Cox regression analysis, global native T1 mapping (hazard ratio (HR): 1.446; 95% confidence interval (CI): 1.195–1.749; P < 0.001) and non-sustained ventricular tachycardia (NSVT) (HR: 4.949; 95% CI, 2.033–12.047; P < 0.001) were independently associated with MACE. Ten of 86 patients (11.6%) with low SCD risk assessed by the two guidelines had MACE. In this subgroup of patients, multivariate Cox regression analysis showed that global native T1 mapping was independently associated with MACE (HR: 1.532; 95% CI: 1.221–1.922; P < 0.001). In 85 patients with conflicting results assessed by the two guidelines, end-stage systolic dysfunction was independently associated with MACE (HR: 7.942, 95% CI: 1.322–47.707, P = 0.023). In 32 patients with high SCD risk assessed by the two guidelines, NSVT was independently associated with MACE (HR: 9.779, 95% CI: 1.953–48.964, P = 0.006).Conclusion: The global native T1 mapping could provide incremental values and serve as potential supplements to the current guidelines in the prediction of MACE.

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