An Altered Peptide Ligand derived from heat-shock protein 60 induces regulatory T cells in JIA patients and suppresses adjuvant-induced arthritis

Dolores Cantera; Noraylis Lorenzo; Ariana Barberá; Amarys Alonso; Yamile Heredia; Elsy Chall; Lourdes Franco; Ramón G Padrón; Maria C Domínguez

doi:10.1186/1546-0096-9-s1-p182

An Altered Peptide Ligand derived from heat-shock protein 60 induces regulatory T cells in JIA patients and suppresses adjuvant-induced arthritis

Pediatric Rheumatology ◽

10.1186/1546-0096-9-s1-p182 ◽

2011 ◽

Vol 9 (S1) ◽

Author(s):

Dolores Cantera ◽

Noraylis Lorenzo ◽

Ariana Barberá ◽

Amarys Alonso ◽

Yamile Heredia ◽

...

Keyword(s):

T Cells ◽

Heat Shock ◽

Regulatory T Cells ◽

Heat Shock Protein ◽

Peptide Ligand ◽

Altered Peptide Ligand ◽

Heat Shock Protein 60 ◽

Adjuvant Induced Arthritis

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An altered peptide ligand corresponding to a novel epitope from heat-shock protein 60 induces regulatory T cells and suppresses pathogenic response in an animal model of adjuvant-induced arthritis

Autoimmunity ◽

10.3109/08916934.2010.550590 ◽

2011 ◽

Vol 44 (6) ◽

pp. 471-482 ◽

Cited By ~ 26

Author(s):

Maria del Carmen Dominguez ◽

Noraylis Lorenzo ◽

Ariana Barbera ◽

Guillaume Darrasse-Jeze ◽

Maria Victoria Hernández ◽

...

Keyword(s):

Animal Model ◽

T Cells ◽

Heat Shock ◽

Regulatory T Cells ◽

Heat Shock Protein ◽

Peptide Ligand ◽

Altered Peptide Ligand ◽

Heat Shock Protein 60 ◽

Adjuvant Induced Arthritis

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APL1, an altered peptide ligand derived from human heat-shock protein 60, increases the frequency of Tregs and its suppressive capacity against antigen responding effector CD4 + T cells from rheumatoid arthritis patients

Cell Stress and Chaperones ◽

10.1007/s12192-016-0698-0 ◽

2016 ◽

Vol 21 (4) ◽

pp. 735-744 ◽

Cited By ~ 6

Author(s):

Ariana Barberá ◽

Noraylis Lorenzo ◽

Peter van Kooten ◽

Joel van Roon ◽

Wilco de Jager ◽

...

Keyword(s):

Rheumatoid Arthritis ◽

T Cells ◽

Heat Shock ◽

Heat Shock Protein ◽

Cd4 T Cells ◽

Peptide Ligand ◽

Altered Peptide Ligand ◽

Heat Shock Protein 60 ◽

Suppressive Capacity ◽

Human Heat Shock Protein

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APL-1, an altered peptide ligand derived from human heat-shock protein 60, selectively induces apoptosis in activated CD4+ CD25+ T cells from peripheral blood of rheumatoid arthritis patients

International Immunopharmacology ◽

10.1016/j.intimp.2013.10.010 ◽

2013 ◽

Vol 17 (4) ◽

pp. 1075-1083 ◽

Cited By ~ 10

Author(s):

Ariana Barberá ◽

Noraylis Lorenzo ◽

Greta Garrido ◽

Yuliet Mazola ◽

Viviana Falcón ◽

...

Keyword(s):

Rheumatoid Arthritis ◽

T Cells ◽

Heat Shock ◽

Heat Shock Protein ◽

Peripheral Blood ◽

Peptide Ligand ◽

Altered Peptide Ligand ◽

Heat Shock Protein 60 ◽

Human Heat Shock Protein

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OR.42. Human Heat Shock Protein 60 Induces Differentiation of Cd4+Cd3//Q T-Cells Into Foxp3+Cd4+Cd25//0 Regulatory T-Cells

Clinical Immunology ◽

10.1016/j.clim.2006.04.198 ◽

2006 ◽

Vol 119 ◽

pp. S19-S20

Author(s):

Yvonne Vercoulen ◽

Isme De Kleer ◽

Sylvia Kamphuis ◽

Huib de Jong ◽

Mark Klein ◽

...

Keyword(s):

T Cells ◽

Heat Shock ◽

Regulatory T Cells ◽

Heat Shock Protein ◽

Heat Shock Protein 60 ◽

Human Heat Shock Protein

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Intranasal immunization with heat shock protein 60 induces CD4+CD25+GARP+and type 1 regulatory T cells and inhibits early atherosclerosis

Clinical & Experimental Immunology ◽

10.1111/cei.12726 ◽

2015 ◽

Vol 183 (3) ◽

pp. 452-468 ◽

Cited By ~ 24

Author(s):

Y. Zhong ◽

H. Tang ◽

X. Wang ◽

Q. Zeng ◽

Y. Liu ◽

...

Keyword(s):

T Cells ◽

Heat Shock ◽

Regulatory T Cells ◽

Heat Shock Protein ◽

Heat Shock Protein 60 ◽

Intranasal Immunization ◽

Early Atherosclerosis

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Phase I Clinical Trial with a Novel Altered Peptide Ligand Derived from Human Heat-Shock Protein 60 for Treatment of Rheumatoid Arthritis: Safety, Pharmacokinetics and Preliminary Therapeutic Effects

Journal of Clinical Trials ◽

10.4172/2167-0870.1000339 ◽

2018 ◽

Vol 08 (01) ◽

Cited By ~ 2

Author(s):

Dinorah Prada ◽

Jorge Gomez ◽

Norailys Lorenzo ◽

Oreste Corrales ◽

Ana Lopez ◽

...

Keyword(s):

Rheumatoid Arthritis ◽

Clinical Trial ◽

Heat Shock ◽

Heat Shock Protein ◽

Phase I ◽

Peptide Ligand ◽

Altered Peptide Ligand ◽

Therapeutic Effects ◽

Heat Shock Protein 60 ◽

Human Heat Shock Protein

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Heat-shock protein 60 as a tool for novel therapeutic strategies that target the induction of regulatory T cells in human arthritis

Expert Opinion on Biological Therapy ◽

10.1517/14712598.6.6.579 ◽

2006 ◽

Vol 6 (6) ◽

pp. 579-589 ◽

Cited By ~ 15

Author(s):

Berent J Prakken ◽

Sylvia Kamphuis ◽

Salvatore Albani

Keyword(s):

T Cells ◽

Heat Shock ◽

Regulatory T Cells ◽

Heat Shock Protein ◽

Therapeutic Strategies ◽

Heat Shock Protein 60 ◽

Novel Therapeutic Strategies ◽

Novel Therapeutic

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Establishment of nasal tolerance to heat shock protein-60 alleviates atherosclerosis by inducing TGF-β-dependent regulatory T cells

Journal of Huazhong University of Science and Technology [Medical Sciences] ◽

10.1007/s11596-012-0004-z ◽

2012 ◽

Vol 32 (1) ◽

pp. 24-30 ◽

Cited By ~ 15

Author(s):

Haiyu Li ◽

Yanping Ding ◽

Guiwen Yi ◽

Qiutang Zeng ◽

Wenkai Yang

Keyword(s):

T Cells ◽

Heat Shock ◽

Regulatory T Cells ◽

Heat Shock Protein ◽

Heat Shock Protein 60 ◽

Nasal Tolerance

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Therapeutic effect of an altered peptide ligand derived from heat-shock protein 60 by suppressing of inflammatory cytokines secretion in two animal models of rheumatoid arthritis

Autoimmunity ◽

10.3109/08916934.2012.697592 ◽

2012 ◽

Vol 45 (6) ◽

pp. 449-459 ◽

Cited By ~ 18

Author(s):

N. Lorenzo ◽

A. Barberá ◽

M. C. Domínguez ◽

A. M. Torres ◽

M. V. Hernandez ◽

...

Keyword(s):

Rheumatoid Arthritis ◽

Heat Shock ◽

Animal Models ◽

Heat Shock Protein ◽

Therapeutic Effect ◽

Inflammatory Cytokines ◽

Peptide Ligand ◽

Altered Peptide Ligand ◽

Heat Shock Protein 60 ◽

Cytokines Secretion

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Helicobacter pylori -derived heat shock protein 60 increases the induction of regulatory T-cells associated with persistent infection

Microbial Pathogenesis ◽

10.1016/j.micpath.2018.04.016 ◽

2018 ◽

Vol 119 ◽

pp. 152-161 ◽

Cited By ~ 4

Author(s):

Wei-Tung Hsu ◽

Shu-Yi Ho ◽

Ting-Yan Jian ◽

Han-Ning Huang ◽

Yu-Ling Lin ◽

...

Keyword(s):

T Cells ◽

Helicobacter Pylori ◽

Heat Shock ◽

Regulatory T Cells ◽

Heat Shock Protein ◽

Persistent Infection ◽

Heat Shock Protein 60

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