scholarly journals Extending the sufficient component cause model to describe the Stable Unit Treatment Value Assumption (SUTVA)

2012 ◽  
Vol 9 (1) ◽  
pp. 3 ◽  
Author(s):  
Sharon Schwartz ◽  
Nicolle M Gatto ◽  
Ulka B Campbell
Keyword(s):  
Author(s):  
R.A. Milligan ◽  
P.N.T. Unwin

A detailed understanding of the mechanism of protein synthesis will ultimately depend on knowledge of the native structure of the ribosome. Towards this end we have investigated the low resolution structure of the eukaryotic ribosome embedded in frozen buffer, making use of a system in which the ribosomes crystallize naturally.The ribosomes in the cells of early chicken embryos form crystalline arrays when the embryos are cooled at 4°C. We have developed methods to isolate the stable unit of these arrays, the ribosome tetramer, and have determined conditions for the growth of two-dimensional crystals in vitro, Analysis of the proteins in the crystals by 2-D gel electrophoresis demonstrates the presence of all ribosomal proteins normally found in polysomes. There are in addition, four proteins which may facilitate crystallization. The crystals are built from two oppositely facing P4 layers and the predominant crystal form, accounting for >80% of the crystals, has the tetragonal space group P4212, X-ray diffraction of crystal pellets demonstrates that crystalline order extends to ~ 60Å.


Finisterra ◽  
2012 ◽  
Vol 38 (75) ◽  
Author(s):  
Nelson Mileu

AUTOMATIC STATISTICAL AREA DEFINITION IN ALGÉS PARISH. Portugal, along with many other countries, conducts a population census every 10 years. This way of counting the population offers a detailed photography of the country where many socio-economic variables are captured. In this study, it is assumed that census will be the way of population data collection and therefore the discussion deals with the issue of geographical aggregation of individuals and households enumerated. In this context, a methodological proposal for an automatic census area creation in the parish of Algés is described. The minimum geographic unit for completing the aggregations is the building since it was the smallest and stable unit for this purpose. The building layer was obtained in the municipal GIS of Oeiras and is based on large scale cartography (1:1000). Mainly, because the building layer is not contiguous, the study starts with the construction of a Thiessen polygon layer. This layer is drawn with the buildings layer centroids and having the master plan classes as barriers. The Thiessen polygon layer associated with the building attributes assumed a key role in this process and considering the range of possible data aggregation alternatives the zone boundaries are drawn concerning with some principles of consistence and homogeneity. To achieve a measurement of homogeneity for the statistical areas the variables used were the number of households, floors and type of building (residential, commercial, both). The automatic statistical area definition deals with the aggregation of the basic geographic units (Thiessen polygon layer), seeking for new optimized areas, considering the characteristics of the building and having a reference number of households around 100. To demonstrate the methodology used for the automatic statistical area definition, three simulation results are presented in this article.


1978 ◽  
Vol 21 (4) ◽  
pp. 303-316 ◽  
Author(s):  
Jan Trost

In this article it is shown that cohabitation (not legally married but living under marriage-like conditions) is an old Nordic tradition still remaining to some extent in Iceland and frequently occurring in Sweden and Denmark. Evidence proves that the ancient tradition of cohabitation is returning. It is assumed that the phenomenon of a post-industrialized society is instrumental in causing the societal change into this renewed social institution of cohabitation. It is also shown that the dyad as a stable unit is still popular, and thus that the nuclear family system is still preferred and prevalent.


1990 ◽  
Vol 109 (1) ◽  
pp. 97 ◽  
Author(s):  
Antonio Suarez Granero
Keyword(s):  

Author(s):  
Laura Tach

Families play a central role in the study of social mobility—they are units of analysis for measuring social class as well as settings that shape the intergenerational transmission of resources. The American family has undergone important changes since the mid-twentieth century. Divorce, nonmarital childbearing, and cohabitation increased dramatically. The rise in divorce and cohabitation made the family a less stable unit of socialization and led to a proliferation of step and blended family arrangements with complex configurations of residential and biological ties. As a result of these changes, less than half of children spend their entire childhood in an intact, two-biological parent household, and families are no longer defined solely by shared residence or biology. The instability and complexity of family life requires stratification scholars to rethink how they measure origin and destination class and to consider how parents in nontraditional families transmit class-specific resources to the next generation.


Author(s):  
Michael E. Pontecorvo ◽  
Silvestro Barbarino ◽  
Farhan Gandhi ◽  
Scott M. Bland ◽  
Robert J. Snyder ◽  
...  

1982 ◽  
Vol 152 (1) ◽  
pp. 63-71
Author(s):  
S Austin ◽  
F Hart ◽  
A Abeles ◽  
N Sternberg

The prophage form of bacteriophage P1 is a unit-copy plasmid which is maintained with great fidelity in its Escherichia coli host. The plasmid maintenance functions of P1 are clustered in one region of the genome. An 11.5-kilobase fragment from this region has been cloned into a lambda delta att vector and promotes stable unit-copy plasmid maintenance. The properties of the lambda vector facilitated the isolation of deletion mutants affecting the P1 DNA. Twenty-eight deletion mutants were isolated, and their lesions were mapped by physical techniques. The genetic properties of the mutants with respect to plasmid replication, stability of plasmid maintenance, and ability to exert incompatibility effects against P1 and P7 plasmids were determined. These properties, along with those of several subfragments of the P1 insert cloned into high-copy-number plasmid vectors, allow the construction of an unambiguous genetic and physical map of the maintenance functions. A region of less than 3 kilobases, the rep region, is essential for plasmid replication and contains the incA incompatibility determinant within an 800-base-pair segment. Immediately adjacent to rep is a second region of approximately 3 kilobases which is required for stable plasmid maintenance, but not replication. This region, par, contains a second incompatibility element incB which is approximately 1 kilobase in size. The par region appears to specify equipartition of plasmid copies to daughter cells during cell division.


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