scholarly journals Comparative analysis of apoptotic changes in peripheral immune organs and lungs following experimental infection of piglets with highly pathogenic and classical porcine reproductive and respiratory syndrome virus

2014 ◽  
Vol 11 (1) ◽  
pp. 2 ◽  
Author(s):  
Gang Wang ◽  
Yuli He ◽  
Yabin Tu ◽  
Yonggang Liu ◽  
En-Min Zhou ◽  
...  
Keyword(s):  
Comparative Analysis ◽  
Experimental Infection ◽  
Respiratory Syndrome Virus ◽  
Highly Pathogenic ◽  
Immune Organs

scholarly journals Comparative analysis of immune responses following experimental infection of pigs with European porcine reproductive and respiratory syndrome virus strains of differing virulence

2013 ◽  
Vol 163 (1-2) ◽  
pp. 1-12 ◽  
Author(s):  
Eefke Weesendorp ◽  
Sophie Morgan ◽  
Norbert Stockhofe-Zurwieden ◽  
Ditta J. Popma-De Graaf ◽  
Simon P. Graham ◽  
...  
Keyword(s):  
Comparative Analysis ◽  
Immune Responses ◽  
Experimental Infection ◽  
Respiratory Syndrome Virus ◽  
Virus Strains

scholarly journals Experimental infection of United States swine with a Chinese highly pathogenic strain of porcine reproductive and respiratory syndrome virus

Virology ◽  
2013 ◽  
Vol 435 (2) ◽  
pp. 372-384 ◽  
Author(s):  
Baoqing Guo ◽  
Kelly M. Lager ◽  
Jamie N. Henningson ◽  
Laura C. Miller ◽  
Sarah N. Schlink ◽  
...  
Keyword(s):  
United States ◽  
Experimental Infection ◽  
Pathogenic Strain ◽  
Respiratory Syndrome Virus ◽  
Highly Pathogenic

scholarly journals The Genomic and Pathogenic Characteristics of the Highly Pathogenic Porcine Reproductive and Respiratory Syndrome Virus Isolate WUH2

ISRN Virology ◽  
2014 ◽  
Vol 2014 ◽  
pp. 1-15 ◽  
Author(s):  
Bin Li ◽  
Liurong Fang ◽  
Suyan Liu ◽  
Yunbo Jiang ◽  
Huanchun Chen ◽  
...  
Keyword(s):  
Genetic Diversity ◽  
Experimental Infection ◽  
Virus Isolate ◽  
Genomic Sequence ◽  
Point Mutations ◽  
Genomic Diversity ◽  
Respiratory Syndrome Virus ◽  
Highly Pathogenic ◽  
Insight Into ◽  
Highly Pathogenic Prrsv

To fully understand the extent of genetic diversity and pathogenesis of the highly pathogenic PRRSV found in China, we determined the genomic sequence of PRRSV WUH2; the pathogenicity of WUH2 was compared to the classical PRRSV isolate CH-1a. Our results showed that the WUH2 genome had a discontinuous deletion of 30 aa in Nsp2, a 1 nucleotide deletion located in both the 5′ and 3′ UTRs, and point mutations within GP5. Experimental infection demonstrated that PRRSV WUH2 reproduced the phenotype and symptoms of porcine high fever syndrome. Importantly, we found that there were differences in viral burden in the serum and tissues when comparing infections of the pathogenic isolate WUH2 to those of the classical isolate CH-1a. These data provide insight into the genomic diversity and altered pathogenicity of Chinese PRRSV isolates and help elucidate the evolution and potential pathogenic mechanisms of PRRSV.

scholarly journals Highly Pathogenic Porcine Reproductive and Respiratory Syndrome Virus Infection Induced Apoptosis and Autophagy in Thymi of Infected Piglets

PLoS ONE ◽  
2015 ◽  
Vol 10 (6) ◽  
pp. e0128292 ◽  
Author(s):  
Gang Wang ◽  
Ying Yu ◽  
Yabin Tu ◽  
Jie Tong ◽  
Yonggang Liu ◽  
...  
Keyword(s):  
Virus Infection ◽  
Respiratory Syndrome Virus ◽  
Highly Pathogenic ◽  
Induced Apoptosis
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