Soybean allergy in a population with a low prevalence of betulacae pollen allergy and a high soybean consumption

SummaryHaemophilia is the most frequent hereditary haemorrhagic illness and it is due to the deficiency of coagulation factors VIII (haemophilia A, HA) or IX (haemophilia B, HB).The prevalence of this disease varies according to the country, those having better survival rates having also higher prevalences. Specifically in Costa Rica, there are around 130 HA and 30 HB families. This study reports the prevalence and a spatial distribution analysis of both types of the disease in this country. The prevalence of haemophilia in this country is 7 cases per 100 000 men, for HA it is 6 cases per 100 000 and for HB it is 1 case per 100 000 male inhabitants. The prevalence of this disease is low when compared with other populations. This low prevalence could be due to the many patients that have died because of infection with human immunodeficiency virus during the 1980s. The prevalence of haemophilia in Costa Rica is almost one half of that present in developed countries. Nevertheless, the ratio between HA and HB follows world tendency: 5 : 1. In this study, nationwide geographical distribution maps were drawn in order to visualize the origin of severe cases and how this influences the pattern of distribution for both types of haemophilia. By means of these maps, it was possible to state that there is no association between the sites of maximum prevalence of mutated alleles and ethnicity. With this study, haemophilia prevalence distribution maps can be used to improve efforts for the establishment of hemophilia clinics or specialized health centers in those areas which hold the highest prevalences in this country. Also, this knowledge can be applied to improve treatment skills and offer the possibility of developing focused genetic counseling for these populations.

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Prevalence of Factor V Leiden Mutation in Non-European Populations

Thrombosis and Haemostasis ◽

10.1055/s-0038-1655963 ◽

1997 ◽

Vol 77 (02) ◽

pp. 329-331 ◽

Cited By ~ 55

Author(s):

Guglielmina Pepe ◽

Olga Rickards ◽

Olga Camacho Vanegas ◽

Tamara Brunelli ◽

Anna Maria Gori ◽

...

Keyword(s):

Factor V Leiden ◽

Indirect Evidence ◽

Factor V ◽

Factor V Leiden Mutation ◽

The World ◽

Fv Leiden ◽

Sub Saharan ◽

Low Prevalence ◽

European Populations ◽

Apparently Healthy

SummaryA difference in the prevalence of venous thromboembolism (TE) in major human groups has been described and an uneven distribution of FV Leiden mutation over the world has recently been reported.We investigated FV Leiden mutation in 584 apparently healthy sub#jects mostly from populations different from those previously investi#gated: 170 Europeans (Spanish, Italians), 101 sub-saharan Africans (Fon, Bariba, Berba, Dendi), 115 Asians (Indonesians, Chinese, Tharus), 57 Amerindians (Cayapa), 84 Afroamericans (Rio Cayapa, Viche), and 57 Ethiopians (Amhara, Oromo).The mutation was detected in only 1/115 Asian (Tharu) and in 5/170 Europeans (4 Italians, 1 Spanish).These data confirm that in non-Europeans the prevalence of FV mutation is at least 7 times lower than in Europeans and provide indirect evidence of a low prevalence not only of the FV Leiden gene but also of other genes leading to more severe thrombophilia. Finally, findings from the literature together with those pertaining to this study clearly show a marked heterogeneity among Europeans.

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A case of Japanese cedar pollen allergy with throat itching and dyspnea by eating tomatoes during sublingual immunotherapy for Japanese cedar pollinosis

Nihon Shoni Arerugi Gakkaishi The Japanese Journal of Pediatric Allergy and Clinical Immunology ◽

10.3388/jspaci.34.334 ◽

2020 ◽

Vol 34 (3) ◽

pp. 334-338

Author(s):

Taisuke Hashimoto ◽

Saki Kasuga ◽

Sakura Ando ◽

Naho Yamamoto ◽

Shiori Fujikawa ◽

...

Keyword(s):

Sublingual Immunotherapy ◽

Pollen Allergy ◽

Japanese Cedar ◽

Japanese Cedar Pollen ◽

Japanese Cedar Pollinosis ◽

Cedar Pollen

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199-LB: Low Prevalence of Small-for-Gestational-Age in Women with Type 1 Diabetes and Chronic Hypertension

Diabetes ◽

10.2337/db19-199-lb ◽

2019 ◽

Vol 68 (Supplement 1) ◽

pp. 199-LB

Author(s):

SARIT HELMAN ◽

TAMARRA JAMES-TODD ◽

FLORENCE M. BROWN

Keyword(s):

Type 1 Diabetes ◽

Gestational Age ◽

Small For Gestational Age ◽

Chronic Hypertension ◽

Low Prevalence

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Staphylococcus aureus Nasal Carriage in Medical Students of Universiti Teknologi MARA

Journal of Clinical and Health Sciences ◽

10.24191/jchs.v2i1.5875 ◽

2017 ◽

Vol 2 (1) ◽

pp. 29 ◽

Cited By ~ 1

Author(s):

Zaini Mohd Zain ◽

Muhammad Fikri Johari ◽

Nurul Shahirah Mohd Husin ◽

Nurul Syamimi Rozman ◽

Athirah Ab Rashid ◽

...

Keyword(s):

Staphylococcus Aureus ◽

Medical Students ◽

Methicillin Resistant Staphylococcus Aureus ◽

Nasal Carriage ◽

Tissue Necrosis ◽

Mannitol Salt Agar ◽

Microbiological Techniques ◽

Polymerase Chain ◽

Low Prevalence ◽

Panton Valentine Leukocidin

Introduction: To determine the prevalence of methicillin-resistant Staphylococcus aureus (MRSA) nasal carriage and detection of S. aureus leukotoxins among medical students of Universiti Teknologi MARA. Methods: Both sides of the anterior nares of 136 volunteers, comprising 68 preclinical and 68 clinical medical students, were swabbed and immediately cultured onto mannitol salt agar for growth of S. aureus. Standard microbiological techniques were conducted to identify and confirm the S. aureus colonies and susceptibility test against oxacillin were conducted by using Kirby-Bauer method to determine their resistance to methicillin. Polymerase chain reaction was performed for detection of leukotoxins, i.e., Panton-Valentine Leukocidin (PVL) and -haemolysin genes. Results: Nineteen students (14%) consisting of 10 preclinical (14.7%) and 9 clinical (13.2%) were nasal carriers of S. aureus. However, none of the S. aureus isolates were MRSA. No PVL gene was detected but eight of them were positive for -haemolysin gene. Conclusion: There were no MRSA nasal carriers among the medical students, but a low prevalence of S. aureus nasal carriers was detected. These carriers do not pose as high risk because none of the strains of S. aureus possess both the -haemolysin toxin and the PVL toxin that are associated with tissue necrosis.

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Serum immunoglobulin E reactivity to cross-reacting panallergen components in north-eastern Poland patients pollen sensitized

Allergy and Asthma Proceedings ◽

10.2500/aap.2020.41.200002 ◽

2020 ◽

Vol 41 (3) ◽

pp. 183-191

Author(s):

Krzysztof Kowal ◽

Agnieszka Pampuch ◽

Ewa Sacharzewska ◽

Ewa Swiebocka ◽

Zenon Siergiejko ◽

...

Keyword(s):

Allergic Rhinitis ◽

Allergen Immunotherapy ◽

Immunoglobulin E ◽

Pollen Allergy ◽

Serum Ige ◽

Ige Reactivity ◽

Allergen Components ◽

North Eastern ◽

Allergen Sources ◽

Seasonal Pollen

Background: The presence of immunoglobulin E (IgE), which cross-reacts with allergen components, such as profilins, polcalcins, and cross-reacting carbohydrate determinants (CCD), creates a problem when selecting patients for allergen immunotherapy by using conventional methods. The aim of this study was to evaluate the prevalence of sensitization to profilins, polcalcins, and CCDs in patients with seasonal pollen allergic rhinitis. Methods: The study was performed on a group of 112 patients with seasonal pollen allergic rhinitis, ages 14 to 55 years, with sensitization to at least one seasonal allergen (IgE > 0.7 kUA/L). The presence of IgE sensitization to recombinant (r) Bet v 2, rPhl p 12, rBet v 4, rPhl p 7, and CCDs, in addition to rBet v 1, rPhl p 1, rPhl p 5, was evaluated by using a multiparameter immunoblot. Results: Among the studied patients, 64.3, 80.4, and 41.1% were sensitized to birch, timothy grass, and mugwort pollen, respectively. Sensitization to profilins rBet v 2/Phl p 12 was demonstrated in 28.6%, to polcalcins Bet v 4/Phl p 7 in 8.9%, and to CCDs in 25%. In 29.3%, serum IgE reactivity to any of the cross-reactive components could be demonstrated. Serum IgE reactivity to rBet v 2 was always accompanied by IgE reactivity to rPhl p 12, and IgE reactivity to rBet v 4 was always accompanied by IgE reactivity to rPhl p 7. Among the patients with pollinosis co-sensitized to at least two allergen sources according to extract-based diagnosis, possible false-positive results due to sensitization to cross-reactive components were detected in 17.9%. Conclusion: Evaluation of sensitization to cross-reacting components may be useful in evaluation of patients with pollen allergy who are being assessed for allergen immunotherapy to optimize the constitution of their immunotherapy vaccines.

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