scholarly journals Underexpression of mitochondrial-DNA encoded ATP synthesis-related genes and DNA repair genes in systemic lupus erythematosus

2011 ◽  
Vol 13 (2) ◽  
pp. R63 ◽  
Author(s):  
Hooi-Ming Lee ◽  
Hidehiko Sugino ◽  
Chieko Aoki ◽  
Norihiro Nishimoto
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Dna Repair ◽  
Mitochondrial Dna ◽  
Lupus Erythematosus ◽  
Atp Synthesis ◽  
Dna Repair Genes ◽  
Systemic Lupus ◽  
Repair Genes

Efficiency of the DNA repair and polymorphisms of the XRCC1, XRCC3 and XRCC4 DNA repair genes in systemic lupus erythematosus

Lupus ◽  
2008 ◽  
Vol 17 (11) ◽  
pp. 988-995 ◽  
Author(s):  
CL Bassi ◽  
DJ Xavier ◽  
GM Palomino ◽  
P Nicolucci ◽  
CP Soares ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Dna Repair ◽  
Lupus Erythematosus ◽  
Dna Repair Genes ◽  
Systemic Lupus ◽  
Repair Genes

DNA REPAIR GENES POLYMORPHISMS: INFLUENCE UPON SYSTEMIC LUPUS ERYTHEMATOSUS AND ITS CLINICAL MANIFESTATIONS

2021 ◽  
pp. 47-57
Author(s):  
Suelen Cristina de Lima ◽  
Jaqueline de Azevêdo Silva ◽  
Nadja Maria Jorge Asano ◽  
Gisele Vagjel Fernandes ◽  
Lucila Maria Valente ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Dna Repair ◽  
Lupus Erythematosus ◽  
Clinical Manifestations ◽  
Dna Repair Genes ◽  
Systemic Lupus ◽  
Repair Genes

scholarly journals Association of Polymorphisms in the DNA Repair Genes XRCC1 and XRCC3 with Systemic Lupus Erythematosus

2019 ◽  
Vol 13 (1) ◽  
pp. 15-21 ◽  
Author(s):  
Cristhiane A. Leite Da Silva ◽  
Marcial F. Galera ◽  
Regiane R. Festi ◽  
Mariano M. Espinosa ◽  
Vander Fernandes ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Dna Repair ◽  
Lupus Erythematosus ◽  
Protective Role ◽  
Control Group ◽  
Dna Repair Genes ◽  
Systemic Lupus ◽  
Genotype Frequencies ◽  
Healthy Control ◽  
Repair Genes

Background: Evidence suggests that DNA damage is implicated in the development of Systemic Lupus Erythematosus (SLE). Objective: Investigate the possible association of polymorphisms in the DNA repair genes XRCC1 and XRCC3 with SLE and its clinical and laboratory features. Methods: This is a case-control study comparing the polymorphisms in the DNA repair genes XRCC1 and XRCC3 in SLE patients and control individuals. Genotyping for DNA repair genes was performed by polymerase chain reaction-restriction fragment length polymorphism in 76 patients and 82 healthy control individuals. Results: Our data indicated that the genotype frequencies in patients with the XRCC1 Arg399Gln and XRCC3 Thr241Met polymorphisms were similar to those observed in the control group (p > 0.05). However, the frequencies of the 399Gln allele (p = 0.023, OR = 0.58, 95% CI = 0.36–0.93) and 241Met allele (p = 0.0039, OR = 0.59, 95% CI = 0.36–0.98) were significantly lower in the patients than those in the control subjects. Conclusion: We demonstrated that 399Gln and 241Met alleles may play a protective role in SLE susceptibility.

LIG4 and RAD52 DNA repair genes polymorphisms and systemic lupus erythematosus

2014 ◽  
Vol 41 (4) ◽  
pp. 2249-2256 ◽  
Author(s):  
Jaqueline De Azevêdo Silva ◽  
João Alexandre Trés Pancotto ◽  
Eduardo Antônio Donadi ◽  
Sergio Crovella ◽  
Paula Sandrin-Garcia
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Dna Repair ◽  
Lupus Erythematosus ◽  
Dna Repair Genes ◽  
Systemic Lupus ◽  
Repair Genes

scholarly journals Mitochondrial DNA damage is associated with damage accrual and disease duration in patients with Systemic Lupus Erythematosus

Lupus ◽  
2014 ◽  
Vol 23 (11) ◽  
pp. 1133-1141 ◽  
Author(s):  
L López-López ◽  
M Nieves-Plaza ◽  
M del R Castro ◽  
YM Font ◽  
CA Torres-Ramos ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Dna Damage ◽  
Mitochondrial Dna ◽  
Lupus Erythematosus ◽  
Disease Duration ◽  
Systemic Lupus ◽  
Mitochondrial Dna Damage ◽  
Damage Accrual

scholarly journals DNA repair and systemic lupus erythematosus

DNA Repair ◽  
2017 ◽  
Vol 56 ◽  
pp. 174-182 ◽  
Author(s):  
Rithy Meas ◽  
Matthew J. Burak ◽  
Joann B. Sweasy
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Dna Repair ◽  
Lupus Erythematosus ◽  
Systemic Lupus

scholarly journals Leukocyte Mitochondrial DNA Alteration in Systemic Lupus Erythematosus and Its Relevance to the Susceptibility to Lupus Nephritis

2012 ◽  
Vol 13 (7) ◽  
pp. 8853-8868 ◽  
Author(s):  
Hui-Ting Lee ◽  
Chen-Sung Lin ◽  
Wei-Sheng Chen ◽  
Hsien-Tzung Liao ◽  
Chang-Youh Tsai ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Mitochondrial Dna ◽  
Lupus Nephritis ◽  
Lupus Erythematosus ◽  
Systemic Lupus

scholarly journals Association of common mitochondrial DNA variants with multiple sclerosis and systemic lupus erythematosus

2008 ◽  
Vol 129 (1) ◽  
pp. 31-35 ◽  
Author(s):  
Tamara Vyshkina ◽  
Andrew Sylvester ◽  
Saud Sadiq ◽  
Eduardo Bonilla ◽  
Jeff A. Canter ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Systemic Lupus Erythematosus ◽  
Mitochondrial Dna ◽  
Lupus Erythematosus ◽  
Systemic Lupus ◽  
Dna Variants ◽  
Mitochondrial Dna Variants

scholarly journals Novel Autoantibodies Related to Cell Death and DNA Repair Pathways in Systemic Lupus Erythematosus

2019 ◽  
Vol 17 (3) ◽  
pp. 248-259 ◽  
Author(s):  
Hui Luo ◽  
Ling Wang ◽  
Ding Bao ◽  
Li Wang ◽  
Hongjun Zhao ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Cell Death ◽  
Dna Repair ◽  
Lupus Erythematosus ◽  
Systemic Lupus ◽  
Repair Pathways
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