scholarly journals ERalpha-status of disseminated tumour cells in bone marrow of primary breast cancer patients

2008 ◽  
Vol 10 (5) ◽  
Author(s):  
Tanja Fehm ◽  
Natalia Krawczyk ◽  
Erich-Franz Solomayer ◽  
Graziella Becker-Pergola ◽  
Silke Dürr-Störzer ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Bone Marrow ◽  
Cancer Patients ◽  
Primary Breast Cancer ◽  
Tumour Cells ◽  
Breast Cancer Patients ◽  
Disseminated Tumour Cells

scholarly journals Comparison of bone marrow, disseminated tumour cells and blood-circulating tumour cells in breast cancer patients after primary treatment

2008 ◽  
Vol 100 (1) ◽  
pp. 160-166 ◽  
Author(s):  
M J Slade ◽  
R Payne ◽  
S Riethdorf ◽  
B Ward ◽  
S A A Zaidi ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Bone Marrow ◽  
Cancer Patients ◽  
Primary Treatment ◽  
Tumour Cells ◽  
Circulating Tumour Cells ◽  
Breast Cancer Patients ◽  
Disseminated Tumour Cells

Prognostic relevance of disseminated tumour cells from the bone marrow of early stage breast cancer patients – Results from a large single-centre analysis

2014 ◽  
Vol 50 (15) ◽  
pp. 2550-2559 ◽  
Author(s):  
Andreas D. Hartkopf ◽  
Florin-Andrei Taran ◽  
Markus Wallwiener ◽  
Markus Hahn ◽  
Sven Becker ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Bone Marrow ◽  
Cancer Patients ◽  
Early Stage ◽  
Tumour Cells ◽  
Early Stage Breast Cancer ◽  
Breast Cancer Patients ◽  
Single Centre ◽  
Prognostic Relevance ◽  
Disseminated Tumour Cells

Disseminated tumour cells from the bone marrow of early breast cancer patients: Results from an international pooled analysis

2021 ◽  
Vol 154 ◽  
pp. 128-137
Author(s):  
Andreas D. Hartkopf ◽  
Sara Y. Brucker ◽  
Florin-Andrei Taran ◽  
Nadia Harbeck ◽  
Alexandra von Au ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Bone Marrow ◽  
Cancer Patients ◽  
Early Breast Cancer ◽  
Pooled Analysis ◽  
Tumour Cells ◽  
Breast Cancer Patients ◽  
Disseminated Tumour Cells

The incidence of bone marrow circulating tumour cells in breast cancer patients is directly related to the size of the primary tumour

2003 ◽  
Vol 114 (2) ◽  
pp. 293
Author(s):  
M.A. Kelly ◽  
N. Relihan ◽  
K.C. Redmond ◽  
N.J. Aherne ◽  
J.H. Wang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Bone Marrow ◽  
Cancer Patients ◽  
Primary Tumour ◽  
Tumour Cells ◽  
Circulating Tumour Cells ◽  
Breast Cancer Patients

Estrogen receptor (ER) status of disseminated tumor cells in the bone marrow of breast cancer patients

2007 ◽  
Vol 25 (18_suppl) ◽  
pp. 21013-21013
Author(s):  
F. N. Tanja ◽  
N. Krawczyk ◽  
D. Wallwiener ◽  
S. Becker ◽  
E. Solomayer
Keyword(s):  
Breast Cancer ◽  
Bone Marrow ◽  
Cancer Patients ◽  
Tumor Cells ◽  
Primary Tumor ◽  
Hormone Receptor ◽  
Primary Breast Cancer ◽  
Disseminated Tumor Cells ◽  
Breast Cancer Patients ◽  
Primary Tumors

21013 Background: The presence of disseminated tumor cells (DTC) in bone marrow (BM) of primary breast cancer patients is associated with poor prognosis. These patients may benefit from adjuvant endocrine therapy since cytotoxic agents are not able to completely eliminate DTCs as previously shown. Only patients with hormone receptor positive breast cancer are eligible for hormonal treatment. The ERa status is routinely defined in primary tumor tissue. However, the ERa status of DTC may differ compared to the primary tumor. Therefore, the aims of this study were (1) to determine the ERa status of DTC in BM of breast cancer patients, (2) and to compare the ERa status of DTC and corresponding primary tumors. Methods: BM aspirates from 251 primary breast cancer patients were included into the study. A double immunofluorescence staining procedure was established for the identification of cytokeratin-positive (CK)/ERa positive cells. ERa status of the primary tumor was immunohistochemically assessed using the same antibody against ERa. Results: In 105 of 251 (42%) breast cancer patients CK-positive cells could be detected in BM. The number of detected cells ranged between 1 and 13 / cells per 2*106 mononuclear cells. Disseminated tumor cells demonstrated ERa positivity in 13 (12%) of these 105 patients. The ERa expression on DTC was heterogeneous in 10 of 13 (79%) patients. Concordance rate of ERa status between primary tumor and DTC was 27%. Only 11 of 83 patients with ER a positive tumors had also ERa positives DTC. Conclusions: (1)The hormone receptor status between primary tumor and corresponding DTC is disconcordant. (2)This discrepancy may explain the rate of non-responders to adjuvant endocrine therapy despite ER-positive primary tumors. (3)These patients may benefit from adjuvant therapy regimens based on antibody strategies or bisphosphonates. No significant financial relationships to disclose.

Trastuzumab clears HER2/neu-positive isolated tumor cells from bone marrow in primary breast cancer patients

2011 ◽  
Vol 285 (2) ◽  
pp. 485-492 ◽  
Author(s):  
Brigitte Rack ◽  
Julia Jückstock ◽  
Maria Günthner-Biller ◽  
Ulrich Andergassen ◽  
Julia Neugebauer ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Bone Marrow ◽  
Cancer Patients ◽  
Tumor Cells ◽  
Primary Breast Cancer ◽  
Breast Cancer Patients ◽  
Isolated Tumor Cells

Immunocytochemical detection of epithelial cells in the bone marrow of primary breast cancer patients: a meta-analysis

2004 ◽  
Vol 87 (3) ◽  
pp. 215-224 ◽  
Author(s):  
Patr�cia Weinschenker ◽  
Heloisa Prado Soares ◽  
Otavio Clark ◽  
Auro Del Giglio
Keyword(s):  
Breast Cancer ◽  
Bone Marrow ◽  
Epithelial Cells ◽  
Cancer Patients ◽  
Primary Breast Cancer ◽  
Meta Analysis ◽  
Breast Cancer Patients ◽  
Immunocytochemical Detection

Simultaneous quantitative assessment of tumor cells in blood and bone marrow in primary breast cancer patients.

2009 ◽  
Author(s):  
AP Moore ◽  
MM Magbanua ◽  
J Scott ◽  
D Moore ◽  
MD Alvarado ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Bone Marrow ◽  
Cancer Patients ◽  
Tumor Cells ◽  
Primary Breast Cancer ◽  
Quantitative Assessment ◽  
Breast Cancer Patients
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