scholarly journals Regional lung aeration and ventilation during pressure support and biphasic positive airway pressure ventilation in experimental lung injury

Critical Care ◽  
2010 ◽  
Vol 14 (2) ◽  
pp. R34 ◽  
Author(s):  
Marcelo Gama de Abreu ◽  
Maximiliano Cuevas ◽  
Peter M Spieth ◽  
Alysson R Carvalho ◽  
Volker Hietschold ◽  
...  
Keyword(s):  
Lung Injury ◽  
Airway Pressure ◽  
Pressure Support ◽  
Positive Airway Pressure ◽  
Lung Aeration ◽  
Biphasic Positive Airway Pressure ◽  
Regional Lung ◽  
Positive Airway Pressure Ventilation

Comparison of oxygen cost of breathing with pressure-support ventilation and biphasic intermittent positive airway pressure ventilation

1998 ◽  
Vol 26 (9) ◽  
pp. 1518-1522 ◽  
Author(s):  
Thomas Staudinger ◽  
Hana Kordova ◽  
Martin Roggla ◽  
Pavel Tesinsky ◽  
Gottfried J. Locker ◽  
...  
Keyword(s):  
Pressure Support Ventilation ◽  
Airway Pressure ◽  
Pressure Support ◽  
Positive Airway Pressure ◽  
Oxygen Cost ◽  
Support Ventilation ◽  
Positive Airway Pressure Ventilation

scholarly journals Pressure Support Ventilation and Biphasic Positive Airway Pressure Improve Oxygenation by Redistribution of Pulmonary Blood Flow

2009 ◽  
Vol 109 (3) ◽  
pp. 856-865 ◽  
Author(s):  
Alysson R. Carvalho ◽  
Peter M. Spieth ◽  
Paolo Pelosi ◽  
Alessandro Beda ◽  
Agnaldo J. Lopes ◽  
...  
Keyword(s):  
Blood Flow ◽  
Pressure Support Ventilation ◽  
Airway Pressure ◽  
Pulmonary Blood Flow ◽  
Pressure Support ◽  
Positive Airway Pressure ◽  
Support Ventilation ◽  
Biphasic Positive Airway Pressure

scholarly journals Impact of different frequencies of controlled breath and pressure-support levels during biphasic positive airway pressure ventilation on the lung and diaphragm in experimental mild acute respiratory distress syndrome

PLoS ONE ◽  
2021 ◽  
Vol 16 (8) ◽  
pp. e0256021
Author(s):  
Alessandra F. Thompson ◽  
Lillian Moraes ◽  
Nazareth N. Rocha ◽  
Marcos V. S. Fernandes ◽  
Mariana A. Antunes ◽  
...  
Keyword(s):  
Acute Respiratory Distress Syndrome ◽  
Respiratory Distress Syndrome ◽  
Respiratory Distress ◽  
Airway Pressure ◽  
Pressure Support ◽  
Distress Syndrome ◽  
Positive Airway Pressure ◽  
Reference Value ◽  
Inspiratory Effort ◽  
Biphasic Positive Airway Pressure

Background We hypothesized that a decrease in frequency of controlled breaths during biphasic positive airway pressure (BIVENT), associated with an increase in spontaneous breaths, whether pressure support (PSV)-assisted or not, would mitigate lung and diaphragm damage in mild experimental acute respiratory distress syndrome (ARDS). Materials and methods Wistar rats received Escherichia coli lipopolysaccharide intratracheally. After 24 hours, animals were randomly assigned to: 1) BIVENT-100+PSV0%: airway pressure (Phigh) adjusted to VT = 6 mL/kg and frequency of controlled breaths (f) = 100 bpm; 2) BIVENT-50+PSV0%: Phigh adjusted to VT = 6 mL/kg and f = 50 bpm; 3) BIVENT-50+PSV50% (PSV set to half the Phigh reference value, i.e., PSV50%); or 4) BIVENT-50+PSV100% (PSV equal to Phigh reference value, i.e., PSV100%). Positive end-expiratory pressure (Plow) was equal to 5 cmH2O. Nonventilated animals were used for lung and diaphragm histology and molecular biology analysis. Results BIVENT-50+PSV0%, compared to BIVENT-100+PSV0%, reduced the diffuse alveolar damage (DAD) score, the expression of amphiregulin (marker of alveolar stretch) and muscle atrophy F-box (marker of diaphragm atrophy). In BIVENT-50 groups, the increase in PSV (BIVENT-50+PSV50% versus BIVENT-50+PSV100%) yielded better lung mechanics and less alveolar collapse, interstitial edema, cumulative DAD score, as well as gene expressions associated with lung inflammation, epithelial and endothelial cell damage in lung tissue, and muscle ring finger protein 1 (marker of muscle proteolysis) in diaphragm. Transpulmonary peak pressure (Ppeak,L) and pressure–time product per minute (PTPmin) at Phigh were associated with lung damage, while increased spontaneous breathing at Plow did not promote lung injury. Conclusion In the ARDS model used herein, during BIVENT, the level of PSV and the phase of the respiratory cycle in which the inspiratory effort occurs affected lung and diaphragm damage. Partitioning of inspiratory effort and transpulmonary pressure in spontaneous breaths at Plow and Phigh is required to minimize VILI.

Continuous Positive Airway Pressure Effects on Regional Lung Aeration in Patients With COPD

CHEST Journal ◽  
2010 ◽  
Vol 138 (2) ◽  
pp. 305-314 ◽  
Author(s):  
Marcelo A. Holanda ◽  
Simone C.B. Fortaleza ◽  
Mirizana Alves-de-Almeida ◽  
Georgia F.P. Winkeler ◽  
Ricardo C. Reis ◽  
...  
Keyword(s):  
Continuous Positive Airway Pressure ◽  
Airway Pressure ◽  
Positive Airway Pressure ◽  
Pressure Effects ◽  
Lung Aeration ◽  
Regional Lung
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