Safety and tolerability of the combination of veltuzumab and epratzumab with intensive chemotherapy in patients with relapsed B-cell acute lymphoblastic leukaemia (ALL)

2012 ◽  
Author(s):  
Joanne Meerabux
Keyword(s):  
Acute Lymphoblastic Leukaemia ◽  
B Cell ◽  
Lymphoblastic Leukaemia ◽  
Intensive Chemotherapy

scholarly journals DUX Hunting—Clinical Features and Diagnostic Challenges Associated with DUX4-Rearranged Leukaemia

Cancers ◽  
2020 ◽  
Vol 12 (10) ◽  
pp. 2815
Author(s):  
Jacqueline A. Rehn ◽  
Matthew J. O'Connor ◽  
Deborah L. White ◽  
David T. Yeung
Keyword(s):  
Next Generation Sequencing ◽  
Acute Lymphoblastic Leukaemia ◽  
B Cell ◽  
Clinical Features ◽  
Lymphoblastic Leukaemia ◽  
Diagnostic Techniques ◽  
Diagnostic Methods ◽  
Intensive Chemotherapy ◽  
Chromosome 4 ◽  
Generation Sequencing

DUX4-rearrangement (DUX4r) is a recently discovered recurrent genomic lesion reported in 4–7% of childhood B cell acute lymphoblastic leukaemia (B-ALL) cases. This subtype has favourable outcomes, especially in children and adolescents treated with intensive chemotherapy. The fusion most commonly links the hypervariable IGH gene to DUX4 a gene located within the D4Z4 macrosatellite repeat on chromosome 4, with a homologous polymorphic repeat on chromosome 10. DUX4r is cryptic to most standard diagnostic techniques, and difficult to identify even with next generation sequencing assays. This review summarises the clinical features and molecular genetics of DUX4r B-ALL and proposes prospective new diagnostic methods.

CKLF and IL1B transcript levels at diagnosis are predictive of relapse in children with pre‐B‐cell acute lymphoblastic leukaemia

2021 ◽  
Vol 193 (1) ◽  
pp. 171-175
Author(s):  
Stephen Fitter ◽  
Alanah L. Bradey ◽  
Chung Hoow Kok ◽  
Jacqueline E. Noll ◽  
Vicki J. Wilczek ◽  
...  
Keyword(s):  
Acute Lymphoblastic Leukaemia ◽  
B Cell ◽  
Lymphoblastic Leukaemia ◽  
Transcript Levels

Detection of dicentric chromosome (9;20) in paediatric B-cell acute lymphoblastic leukaemia: prognostic significance

2014 ◽  
Vol 94 (2) ◽  
pp. 187-193 ◽  
Author(s):  
Mathilde Letouzey ◽  
Dominique Penther ◽  
Catherine Roche-Lestienne ◽  
Brigitte Nelken ◽  
Catherine Devoldère ◽  
...  
Keyword(s):  
Acute Lymphoblastic Leukaemia ◽  
B Cell ◽  
Lymphoblastic Leukaemia ◽  
Prognostic Significance ◽  
Dicentric Chromosome

Intensive chemotherapy for Philadelphia-chromosome-positive acute lymphoblastic leukaemia

The Lancet ◽  
1994 ◽  
Vol 343 (8893) ◽  
pp. 331-332 ◽  
Author(s):  
W.M. Roberts ◽  
G.K. Rivera ◽  
S.C. Raimondi ◽  
V.M. Santana ◽  
J.T. Sandlund ◽  
...  
Keyword(s):  
Acute Lymphoblastic Leukaemia ◽  
Lymphoblastic Leukaemia ◽  
Philadelphia Chromosome ◽  
Intensive Chemotherapy ◽  
Philadelphia Chromosome Positive
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