Safety and performance of trehalose hyaluronic acid versus standard infiltrative therapy based on medium weight sodium hyaluronate in knee joint osteoarthritis treatment

2021 ◽  
Author(s):  
Macarena Morales
Keyword(s):  
Hyaluronic Acid ◽  
Knee Joint ◽  
Sodium Hyaluronate ◽  
Acid Versus ◽  
Osteoarthritis Treatment ◽  
And Performance ◽  
Medium Weight

Self-Assembled Hyaluronic Acid Nanoparticles for Osteoarthritis Treatment

Biomaterials ◽  
2021 ◽  
pp. 120967
Author(s):  
Li-Jung Kang ◽  
Juhwan Yoon ◽  
Jun Gi Rho ◽  
Hwa Seung Han ◽  
Seulbi Lee ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Osteoarthritis Treatment ◽  
Self Assembled

scholarly journals Intravesical Instillation of Sodium Hyaluronate (Cystistat®) for the Treatment of Patients with Radiation Cystitis-Randomized Clinical Trial

2020 ◽  
Vol 13 (11) ◽  
Author(s):  
Farzad Allameh ◽  
Abbas Basiri ◽  
Saleh Ghiasy ◽  
Atefeh Javadi ◽  
Seyyed Ali Hojjati ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Clinical Trial ◽  
Hyaluronic Acid ◽  
Sodium Hyaluronate ◽  
Intravesical Instillation ◽  
Control Group ◽  
Radiation Cystitis ◽  
Vas Score ◽  
The Mean

Background: Radiotherapy (RT) is a choice to manage pelvic organ malignancies that can affect bladder; therefore, it causes radiation cystitis with some bothering urinary symptoms and decreasing the patient’s quality of life. Intravesical hyaluronic acid (HA) is an agent with promising results in some studies for cystitis, and Cystistat is a derivative of hyaluronic acid. Objectives: This clinical trial aimed at evaluating the effects of intravesical instillation of Cystistat on symptoms of radiation cystitis and quality of life (QOL). Methods: A total of 58 patients with radiation cystitis were randomized in 2 groups (case: 30, control: 28). One group received intravesical Cystistat, the other received normal saline weekly for up to 4 weeks and then monthly for up to 2 months. Hematuria, Visual Analog scale (VAS) and QOL based on King’s Health questionnaire were compared before and 3, 6 and 9 months after intravesical instillation. Results: The mean age of the patients was 63.93 ± 10.89 years old. The mean of each sub-category of QOL and total score of QOL, as well as, VAS score were significantly improved in comparison to the control group at each time of follow-ups (P < 0.05). Hematuria was significantly different in the 3rd, 6th and 9th month of follow-ups (P < 0.05). Conclusions: Findings showed that patients with radiation cystitis could significantly benefit from intravesical instillation of HA, their hematuria would be successfully resolved rather than control group in addition to lowering the VAS score, so their QOL would be improved.

scholarly journals Hope, Hype, Hurdles & Future Perspective for PRP, PRP versus Hyaluronic Acid Injection in Osteoarthritis of Knee: A Review Article.

2020 ◽  
Vol 2 (1) ◽  
pp. e1-e12
Author(s):  
Ashok Kumar ◽  
Anikait Ghosh Kadamb ◽  
Krish Ghosh Kadamb
Keyword(s):  
Hyaluronic Acid ◽  
Knee Joint ◽  
Platelet Rich Plasma ◽  
Future Perspective ◽  
Osteoarthritis Of The Knee ◽  
Stiff Knee ◽  
Injection Interval ◽  
One Year

BackgroundComparative studies of platelet-rich plasma (PRP) and hyaluronic acid show variable results. PurposeA review was conducted to understand the current role of PRP and its efficacy versus hyaluronic acid in osteoarthritis (OA) of the knee joint. MethodsOut of 170 identified studies, 14 studies involving 1575 patients with 637 males and 938 females were selected based on PRISMA flow chart guidelines and were analyzed for the study. ResultsA standard PRP regimen consisting of 2–3 intra-articular injections (IA) of 4–6 mL of leucocyte poor PRP at 1–2 weekly intervals provides a better result than HA during the first 3–6 months, and which may continue up to one year. PRP and HA may have synergistic effect; pain and swelling are the two most com-mon complications with PRP, the incidence is more with leucocyte rich PRP (LP-PRP) and intra-osseous PRP treatment.ConclusionPRP provides hope and is more effective than hyaluronic acid in pain relief and improving the quality of life in mild to moderate osteoarthritis of the knee joint. However, hype, that is effective in all, irrespective of grades of OA, mal-aligned or stiff knee, ligamentous laxity, and can avoid joint replacement is a big hindrance in establishing it as a preferred treatment in OA knee. The author follows the above-mentioned PRP regimen; and recommends to combine leucocyte poor PRP with HA for IA injections & with LP-PRP injections along with the two most common painful points (medial collateral ligament, pesanisernius) in a highly painful OA knee. PRP may not address extra-articular causes of knee pain (mal-alignment, muscle wasting, tendinosis), should be corrected for optimum outcome. Contact sports, running, exercises putting pressure on knee and NSAID should be avoided during PRP treatment. Also, more randomized controlled trials are required to further standardize the PRP preparation, administration, injection interval & proper documentation of efficacy and complications in the regenerative registry.

Nonsurgical Redefinition of the Chin and Jawline of Younger Adults With a Hyaluronic Acid Filler: Results Evaluated With a Grid System Approach

2020 ◽  
Author(s):  
Dario Bertossi ◽  
Massimo Robiony ◽  
Andrea Lazzarotto ◽  
Giorgio Giampaoli ◽  
Riccardo Nocini ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Grid System ◽  
Level Of Evidence ◽  
Younger Adults ◽  
Lower Face ◽  
Age Related ◽  
Tissue Edema ◽  
The Face ◽  
The Mean ◽  
And Performance

Abstract Background Aesthetic treatment of the lower face is increasingly in demand, particularly owing to age-related changes in appearance. VYC-25L is a novel hyaluronic acid filler with high G′ and high cohesivity, specifically designed for sculpting and contouring of the chin and jaw. Objectives The aim of this study was to assess the use of a grid traced onto the chin and jaw for guiding treatment with VYC-25L. Methods This was a retrospective, single-center analysis of data from adult patients undergoing treatment of the lower third of the face with VYC-25L. A grid system of horizontal and vertical lines was used to systematize the process of treatment planning and performance. Results Thirty subjects were enrolled (53.3% female; mean [standard deviation] age, 34.4 [2.8] years). The mean quantity of VYC-25L used was 4.0 [0.8] mL. Based on the 5-point Global Aesthetic Improvement Scale, 29 patients (96.7%) rated their appearance at 20 days posttreatment as “much improved” or “very much improved.” The only complications recorded were early transient soft-tissue edema (n = 14; 46.7%) and bruising (n = 6; 20.0%). There were no cases of infection, paresthesia, asymmetry, hematoma, necrosis, or skin discoloration. Conclusions Treatment of the chin and jawline with VYC-25L, with injection locations determined by a standardized grid-based approach, appears to be effective and safe with high rates of patient satisfaction. Injection of this filler offers a potentially high-impact approach for patients across a variety of biological and economic circumstances. Level of Evidence: 4

Intra-articular Corticosteroids and Hyaluronic Acid in the Knee Joint

2016 ◽  
pp. 23-28
Author(s):  
Carlos Kalbakdij-Sánchez ◽  
Enrique Gómez-Barrena
Keyword(s):  
Hyaluronic Acid ◽  
Knee Joint

Design, Development and Characterization of a Wrap Spring Clutch/Brake Mechanism As a Knee Joint for an Assistive Exoskeleton

2020 ◽  
Author(s):  
Vishnu Aishwaryan Subra Mani ◽  
Nathaniel Goldfarb ◽  
Gregory S. Fischer
Keyword(s):  
Knee Joint ◽  
Ground Level ◽  
Design Approach ◽  
Stress Tests ◽  
Design Development ◽  
Research Activities ◽  
Wide Range ◽  
And Performance ◽  
Spring Clutch ◽  
The Right

Abstract Over the past decade, wearable robotics and exoskeletons have been gaining recognition in the field of medical, assistive and augmentative robotics and have led to numerous new innovative mechanisms and designs. Due to fast-paced research activities, the critical importance and performance of established mechanisms such as wrap spring clutch/brake, Wafer Disc Brakes have been overlooked or used ineffectively. This paper describes a practical design approach that will enable the designer to choose a mechanism based on the application of the device, which will promote overall growth in current technology. The Legged Anthropomorphic Robotic Rehabilitation Exoskeleton (LARRE) project used this approach to design, manufacture, and test the knee joint for ground-level walking. This paper provides the reasoning behind the selection of wrap spring clutch, its evaluation, and testing standards as the knee joint. A thorough literature review was conducted to understand the current state of the art. This project collected a rich set of biomechanical data to ensure that the mechanism will produce the right moments and range of motions during walking. To ensure that our mechanism meets the requirements, the mechanism was put through a wide range of stress tests. The paper establishes a methodology to choose a mechanism for an exoskeleton’s joint based on the desired requirements. The outcome of this paper is an analytical based design approach that can be used by other researchers to impart additional traits and weights, which will aid in the development of exoskeleton design.

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