scholarly journals Early life blood lead levels and asthma diagnosis at age 4–6 years

2021 ◽  
Vol 26 (1) ◽  
Author(s):  
Marina Oktapodas Feiler ◽  
Carly J. Pavia ◽  
Sean M. Frey ◽  
Patrick J. Parsons ◽  
Kelly Thevenet-Morrison ◽  
...  

AbstractThe USA has a high burden of childhood asthma. Previous studies have observed associations between higher blood lead levels and greater hypersensitivity in children. The objective of the present study was to estimate the association between blood lead concentrations during early childhood and an asthma diagnosis between 48 and 72 months of age amongst a cohort with well-characterized blood lead concentrations. Blood lead concentrations were measured at 6, 12, 18, 24, 36, and 48 months of age in 222 children. The presence of an asthma diagnosis between 48 and 72 months was assessed using a questionnaire which asked parents or guardians whether they had been told by a physician, in the past 12 months, that their child had asthma. Crude and adjusted risk ratios (RR) of an asthma diagnosis were estimated for several parameterizations of blood lead exposure including lifetime average (6 to 48 months) and infancy average (6 to 24 months) concentrations. After adjustment for child sex, birthweight, daycare attendance, maternal race, education, parity, breastfeeding, income, and household smoking, age-specific or composite measures of blood lead were not associated with asthma diagnosis by 72 months of age in this cohort.

1993 ◽  
Vol 27 (7-8) ◽  
pp. 253-262 ◽  
Author(s):  
H. A. Foner

The lead content of petrol used in Israel has been steadily decreasing over the past few years from 0.42 g/litre to 0.15 g/litre. Unleaded petrol has also been introduced. Blood lead levels measured in Israel suggest that some children may be above the 10 µg/dl threshold now considered to be hazardous. The lead contents of soils, food crops, water, and air in Israel are generally low compared with those in other developed countries, but measurements indicate that lead is still being added to surface soils. Further work in areas with heavy traffic shows that the reduced Pb level in petrol has so far not resulted in lower soil lead contents.


2015 ◽  
Vol 52 (4) ◽  
pp. 303-306 ◽  
Author(s):  
Ahmed Abdullah Mohammed ◽  
Faisal Yosef Mohamed ◽  
El-Sayed El-Okda ◽  
Adel Besheer Ahmed

1988 ◽  
Vol 29 (6) ◽  
pp. 745-746 ◽  
Author(s):  
H. H. T. Madsen ◽  
T. Skjødt ◽  
P. J. Jørgensen ◽  
P. Grandjean

Author(s):  
Nam Soo Kim ◽  
Sung Woo Choi ◽  
Jin Ho Kim ◽  
Jung O Ham ◽  
Hae Yoon Park ◽  
...  

2021 ◽  
Vol 33 (1) ◽  
Author(s):  
Sahar Mahmoud Shawky ◽  
Reeham Abdel Aziz Abdel Hamid ◽  
Lina Essam Khedr

Abstract Background Pruritus is a common and often distressing symptom in patients with chronic kidney disease. Though the pathogenesis of uremic pruritus remains poorly understood, systemic inflammation has presented itself as one of the possible explanations. High blood lead levels (BLLs) have been noted to be associated with inflammation and poor nutritional status in hemodialysis patients. Our aim is to study the relation between blood lead levels and uremic pruritus. This is a cross-sectional study that enrolled 50 patients; all were on regular hemodialysis 3 times per week for at least 6 months. Patients were divided into 2 groups, group 1 (n =10) with no pruritus and group 2 (n=40) with varying degrees of pruritus. Group 2 was further divided according to intensity of pruritus by visual analog score (VAS) into mild (n=10), moderate (n=20), and severe pruritus (n=10). Results There was a significant difference in serum lead levels and ferritin levels between groups 1 and 2 (p value < 0.01 and < 0.05, respectively). There was a statistically significant difference in serum lead levels in the groups with varying intensity of pruritus, having higher serum lead levels in patients who exhibited severe pruritus (p value < 0.005) Moreover, a statistically significant relation between elevated blood lead levels and the duration of dialysis was observed in this study. Conclusion Uremic pruritus is a multi-factorial phenomenon, and our study showed that blood lead levels in hemodialysis patients might be associated with increased intensity of pruritus.


1981 ◽  
Vol 1 (2) ◽  
pp. 87-88
Author(s):  
V. P. Garnys ◽  
R. Freeman ◽  
L. E. Smythe

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