scholarly journals Higher fatty liver index is associated with increased risk of new onset heart failure in healthy adults: a nationwide population-based study in Korea

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Jae-Hyung Roh ◽  
Jae-Hyeong Park ◽  
Hanbyul Lee ◽  
Yong-Hoon Yoon ◽  
Minsu Kim ◽  
...  
Keyword(s):  
Heart Failure ◽  
Fatty Liver ◽  
Population Based ◽  
Healthy Adults ◽  
Population Based Study ◽  
Liver Index ◽  
Fatty Liver Index ◽  
Increased Risk ◽  
New Onset

scholarly journals Higher fatty liver index is associated with increased risk of new onset heart failure in healthy adults: A nationwide population-based study in Korea

2020 ◽  
Author(s):  
Jae-Hyung Roh ◽  
Jae-Hyeong Park ◽  
Hanbyul Lee ◽  
Yong-Hoon Yoon ◽  
Minsu Kim ◽  
...  
Keyword(s):  
Heart Failure ◽  
Liver Disease ◽  
Fatty Liver ◽  
Large Scale ◽  
Surrogate Marker ◽  
Cox Proportional Hazards ◽  
Liver Index ◽  
Fatty Liver Index ◽  
Increased Risk ◽  
New Onset

Abstract Background Heart failure (HF) is relatively common cardiovascular disease with high mortality and morbidity. Although it is associated with many cardiovascular risk factors, the association between nonalcoholic fatty liver disease (NAFLD), the most common chronic liver disease, and HF has not been evaluated in a large-scale cohort study. Thus, we evaluated the ability of the fatty liver Index (FLI), a surrogate marker of NAFLD, to predict the development of HF in healthy individuals. Methods We analyzed the association between the FLI and new-onset HF with multivariate Cox proportional-hazards models in 308,578 healthy persons without comorbidities who underwent the National Health check-ups in the republic of Korea from 2009 to 2014. Results A total of 2,532 subjects (0.8%) were newly diagnosed with HF during the study period (a median of 5.4 years). We categorized our subjects into quartile groups according to FLI (Q1, 0-4.9; Q2, 5.0-12.5; Q3, 12.6-31.0; and Q4, >31.0). The cumulative incidence of HF was significantly higher in the highest FLI group than in the lowest FLI group (Q1, 307 [0.4%] and Q4, 890 [1.2%]; P<0.001). Adjusted hazard ratio (HRs) indicated that the highest FLI group was independently associated with an increased risk for HF (HR between Q4 and Q1, 2.709; 95% confidence interval=2.380-3.085; P<0.001). FLI was significantly associated with an increased risk of new-onset HF regardless of their baseline characteristics.Conclusions Higher FLI was independently associated with increased risk of HF in a healthy Korean population.

scholarly journals Higher fatty liver index is associated with increased risk of new onset heart failure in healthy adults: A nationwide population-based study in Korea

2020 ◽  
Author(s):  
Jae-Hyung Roh ◽  
Jae-Hyeong Park ◽  
Hanbyul Lee ◽  
Yong-Hoon Yoon ◽  
Minsu Kim ◽  
...  
Keyword(s):  
Heart Failure ◽  
Liver Disease ◽  
Fatty Liver ◽  
Large Scale ◽  
Surrogate Marker ◽  
Cox Proportional Hazards ◽  
Liver Index ◽  
Fatty Liver Index ◽  
Increased Risk ◽  
New Onset

Abstract Background Heart failure (HF) is relatively common cardiovascular disease with high mortality and morbidity. Although it is associated with many cardiovascular risk factors, the association between nonalcoholic fatty liver disease (NAFLD), the most common chronic liver disease, and HF has not been evaluated in a large-scale cohort study. Thus, we evaluated the ability of the fatty liver Index (FLI), a surrogate marker of NAFLD, to predict the development of HF in healthy individuals. Methods We evaluated 308,578 healthy persons without comorbidities who underwent the National Health check-ups in the republic of Korea from 2009 to 2014. The association between the FLI and HF was analyzed using multivariate Cox proportional-hazards models. Results During a median of 5.4 years’ follow-up, 2,532 subjects (0.8%) were newly diagnosed with HF. Subjects were categorized into quartile groups according to FLI (Q1, 0-4.9; Q2, 5.0-12.5; Q3, 12.6-31.0; and Q4, >31.0). The cumulative incidence of HF was significantly higher in subjects with the highest FLI than in those with the lowest FLI (Q1, 307 [0.4%] and Q4, 890 [1.2%]; P<0.001). Adjusted hazard ratios (HRs) indicated that the highest FLI was independently associated with an increased risk for HF (HR between Q4 and Q1, 2.709; 95% confidence interval=2.380-3.085; P<0.001). FLI was significantly associated with increased risk of new-onset HF regardless of their baseline characteristics. Conclusions Higher FLI was independently associated with increased risk of HF in healthy Korean population.

scholarly journals Higher fatty liver index is associated with increased risk of new onset heart failure in healthy adults: A nationwide population-based study in Korea

2020 ◽  
Author(s):  
Jae-Hyung Roh ◽  
Jae-Hyeong Park ◽  
Hanbyul Lee ◽  
Yong-Hoon Yoon ◽  
Minsu Kim ◽  
...  
Keyword(s):  
Heart Failure ◽  
Liver Disease ◽  
Fatty Liver ◽  
Large Scale ◽  
Surrogate Marker ◽  
Cox Proportional Hazards ◽  
Liver Index ◽  
Fatty Liver Index ◽  
Increased Risk ◽  
New Onset

Abstract Background Heart failure (HF) is relatively common cardiovascular disease with high mortality and morbidity. Although it is associated with many cardiovascular risk factors, the association between nonalcoholic fatty liver disease (NAFLD), the most common chronic liver disease, and HF has not been evaluated in a large-scale cohort study. Thus, we evaluated the ability of the fatty liver Index (FLI), a surrogate marker of NAFLD, to predict the development of HF in healthy individuals. Methods We evaluated 308,578 healthy persons without comorbidities who underwent the National Health check-ups in the republic of Korea from 2009 to 2014. The association between the FLI and HF was analyzed using multivariate Cox proportional-hazards models. Results During a median of 5.4 years’ follow-up, 2,532 subjects (0.8%) were newly diagnosed with HF. Subjects were categorized into quartile groups according to FLI (Q1, 0-4.9; Q2, 5.0-12.5; Q3, 12.6-31.0; and Q4, >31.0). The cumulative incidence of HF was significantly higher in subjects with the highest FLI than in those with the lowest FLI (Q1, 307 [0.4%] and Q4, 890 [1.2%]; P<0.001). Adjusted hazard ratios (HRs) indicated that the highest FLI was independently associated with an increased risk for HF (HR between Q4 and Q1, 2.709; 95% confidence interval=2.380-3.085; P<0.001). FLI was significantly associated with increased risk of new-onset HF regardless of their baseline characteristics. Conclusions Higher FLI was independently associated with increased risk of HF in healthy Korean population.

scholarly journals Higher fatty liver index is associated with increased risk of new onset heart failure in healthy adults: A nationwide population-based study in Korea

2020 ◽  
Author(s):  
Jae-Hyung Roh ◽  
Jae-Hyeong Park ◽  
Hanbyul Lee ◽  
Yong-Hoon Yoon ◽  
Minsu Kim ◽  
...  
Keyword(s):  
Heart Failure ◽  
Liver Disease ◽  
Fatty Liver ◽  
Large Scale ◽  
Surrogate Marker ◽  
Cox Proportional Hazards ◽  
Liver Index ◽  
Fatty Liver Index ◽  
Increased Risk ◽  
New Onset

Abstract Background Heart failure (HF) is relatively common cardiovascular disease with high mortality and morbidity. Although it is associated with many cardiovascular risk factors, the association between nonalcoholic fatty liver disease (NAFLD), the most common chronic liver disease, and HF has not been evaluated in a large-scale cohort study. Thus, we evaluated the ability of the fatty liver Index (FLI), a surrogate marker of NAFLD, to predict the development of HF in healthy individuals. Methods We evaluated 308,578 healthy persons without comorbidities who underwent the National Health check-ups in the republic of Korea from 2009 to 2014. The association between the FLI and HF was analyzed using multivariate Cox proportional-hazards models. Results During a median of 5.4 years’ follow-up, 2,532 subjects (0.8%) were newly diagnosed with HF. Subjects were categorized into quartile groups according to FLI (Q1, 0-4.9; Q2, 5.0-12.5; Q3, 12.6-31.0; and Q4, >31.0). The cumulative incidence of HF was significantly higher in subjects with the highest FLI than in those with the lowest FLI (Q1, 307 [0.4%] and Q4, 890 [1.2%]; P<0.001). Adjusted hazard ratios (HRs) indicated that the highest FLI was independently associated with an increased risk for HF (HR between Q4 and Q1, 2.709; 95% confidence interval=2.380-3.085; P<0.001). FLI was significantly associated with increased risk of new-onset HF regardless of their baseline characteristics. Conclusions Higher FLI was independently associated with increased risk of HF in healthy Korean population.

scholarly journals Higher fatty liver index is associated with increased risk of new onset heart failure in healthy adults: A nationwide population-based study in Korea

2019 ◽  
Author(s):  
Jae-Hyung Roh ◽  
Jae-Hyeong Park ◽  
Hanbyul Lee ◽  
Yong-Hoon Yoon ◽  
Minsu Kim ◽  
...  
Keyword(s):  
Heart Failure ◽  
Liver Disease ◽  
Fatty Liver ◽  
Large Scale ◽  
Surrogate Marker ◽  
Cox Proportional Hazards ◽  
Liver Index ◽  
Fatty Liver Index ◽  
Increased Risk ◽  
New Onset

Abstract Background Heart failure (HF) is relatively common cardiovascular disease with high mortality and morbidity. Although it is associated with many cardiovascular risk factors, the association between nonalcoholic fatty liver disease (NAFLD), the most common chronic liver disease, and HF has not been evaluated in a large-scale cohort study. Thus, we evaluated the ability of the fatty liver Index (FLI), a surrogate marker of NAFLD, to predict the development of HF in healthy individuals.Methods We evaluated 308,578 healthy persons without comorbidities who underwent the National Health check-ups in the republic of Korea from 2009 to 2014. The association between the FLI and HF was analyzed using multivariate Cox proportional-hazards models.Results During a median of 5.4 years’ follow-up, 2,532 subjects (0.8%) were newly diagnosed with HF. Subjects were categorized into quartile groups according to FLI (Q1, 0-4.9; Q2, 5.0-12.5; Q3, 12.6-31.0; and Q4, >31.0). The cumulative incidence of HF was significantly higher in subjects with the highest FLI than in those with the lowest FLI (Q1, 307 [0.4%] and Q4, 890 [1.2%]; P<0.001). Adjusted hazard ratios (HRs) indicated that the highest FLI was independently associated with an increased risk for HF (HR between Q4 and Q1, 2.709; 95% confidence interval=2.380-3.085; P<0.001). FLI was significantly associated with increased risk of new-onset HF regardless of their baseline characteristics. Conclusions Higher FLI was independently associated with increased risk of HF in healthy Korean population.

Fatty liver index (FLI) and prediction of new cases of non-alcoholic fatty liver disease: A population-based study of northern Iran

2020 ◽  
Vol 39 (2) ◽  
pp. 468-474 ◽  
Author(s):  
Nima Motamed ◽  
Amir Hossein Faraji ◽  
Mahmood Reza Khonsari ◽  
Mansooreh Maadi ◽  
Fahimeh Safarnezhad Tameshkel ◽  
...  
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Fatty Liver Disease ◽  
Population Based ◽  
Northern Iran ◽  
Population Based Study ◽  
Alcoholic Fatty Liver ◽  
Liver Index ◽  
Fatty Liver Index ◽  
Alcoholic Fatty Liver Disease

Association Between Fatty Liver Index and Risk of Breast Cancer: A Nationwide Population-Based Study

2020 ◽  
Vol 20 (4) ◽  
pp. e450-e457
Author(s):  
Jin Hyun Park ◽  
In Sil Choi ◽  
Kyung-Do Han ◽  
Hyunkyung Park ◽  
Ki Hwan Kim ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Fatty Liver ◽  
Population Based ◽  
Population Based Study ◽  
Liver Index ◽  
Fatty Liver Index

scholarly journals Fatty liver index and development of cardiovascular disease in Koreans without pre-existing cardiovascular disease: a large population-based study

2020 ◽  
Author(s):  
Jun Hyung Kim ◽  
Jin Sil Moon ◽  
Seok Joon Byun ◽  
Jun Hyeok Lee ◽  
Dae Ryong Kang ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Ischemic Stroke ◽  
Fatty Liver ◽  
Primary Endpoint ◽  
Large Population ◽  
Cardiovascular Death ◽  
Population Based ◽  
Population Based Study ◽  
Liver Index ◽  
Fatty Liver Index

Abstract Background Despite the known association between non-alcoholic fatty liver disease (NAFLD) and cardiovascular disease (CVD), it remains uncertain whether NAFLD predicts future CVD events, especially CVD mortality. We evaluated the relationship between fatty liver index (FLI), a validated marker of NAFLD, and risk of major adverse cardiac events (MACE) in a large population-based study. Methods We identified 3,011,588 subjects without a history of CVD who underwent health examinations from 2009 to 2011 in the Korean National Health Insurance System cohort. The primary endpoint was a composite of cardiovascular deaths, non-fatal myocardial infarction (MI), and ischemic stroke. Cox proportional hazards regression analysis was performed to assess the independent association between FLI and the primary endpoint. Results During the median follow-up of 6 years, there were 46,010 cases of MACE (7,148 cases of cardiovascular death, 16,574 non-fatal MI, and 22,228 ischemic stroke). There was a linear association between higher FLI values and higher incidence of the primary endpoint. In the multivariable models adjusted for factors including body weight and cholesterol levels, the hazard ratio (95% CIs) for the primary endpoint comparing the highest vs. lowest quartiles of FLI was 1.99 (1.91–2.07). The corresponding odds ratios (95% CIs) for cardiovascular death, non-fetal MI, and ischemic stroke were 1.98 (1.9-2.06), 2.16 (2.01-2.31), and 2.01 (1.90-2.13), respectively. The results were similar when we stratified analysis by age, sex, dyslipidemia medication, obesity, diabetes, and hypertension. Conclusions Our findings indicate that FLI, a surrogate marker of NAFLD, has prognostic value for detecting individuals at higher risk of cardiovascular events.

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