scholarly journals Simultaneous gastric cancer and breast cancer metastases to the stomach with lymph node collision tumor: a case report

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Takeshi Okamoto ◽  
Hidekazu Suzuki ◽  
Katsuyuki Fukuda
Keyword(s):  
Breast Cancer ◽  
Gastric Cancer ◽  
Lymph Node ◽  
Gastric Adenocarcinoma ◽  
Submucosal Tumor ◽  
Collision Tumor ◽  
Resected Specimen ◽  
Breast Cancer Metastases ◽  
Cancer Metastases ◽  
Gastric Metastases

Abstract Background While double primary cancers are common in breast cancer patients, co-existence of primary gastric cancer and gastric metastases of breast cancer is exceedingly rare. Case presentation A 51-year-old woman receiving chemotherapy for breast cancer presented with melena and presyncope. A circumferential thickening of the pylorus and small submucosal tumor-like lesions in the gastric fundus and corpus were confirmed on endoscopy. Immunohistochemistry of biopsies revealed that the former was composed of poorly differentiated gastric cancer cells, while the latter were breast cancer metastases. Distal gastrectomy was performed. Pathological evaluation of the resected specimen revealed gastric adenocarcinoma in the pyloric lesion and breast countless cancer metastases throughout the remainder of the stomach, with positive margins. One lymph node had evidence of both stomach cancer and breast cancer metastases, forming a collision tumor. Despite a successful surgery, the patient died 6 months later due to progression of breast cancer. Conclusion We report a case of synchronous primary gastric adenocarcinoma and gastric metastases of breast cancer. Inter-disciplinary collaboration is crucial in determining the optimal treatment in double cancers.

scholarly journals Reliability of Whole Sentinel Lymph Node Analysis by One-Step Nucleic Acid Amplification for Intraoperative Diagnosis of Breast Cancer Metastases

2012 ◽  
Vol 255 (2) ◽  
pp. 334-342 ◽  
Author(s):  
Isabella Castellano ◽  
Luigia Macrì ◽  
Cristina Deambrogio ◽  
Davide Balmativola ◽  
Riccardo Bussone ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Lymph Node ◽  
Nucleic Acid ◽  
Sentinel Lymph Node ◽  
Nucleic Acid Amplification ◽  
Intraoperative Diagnosis ◽  
Breast Cancer Metastases ◽  
Cancer Metastases ◽  
One Step

Patterns of DNA copy number changes in sentinel lymph node breast cancer metastases

2008 ◽  
Vol 122 (1) ◽  
pp. 16-21 ◽  
Author(s):  
S.C.L. Santos ◽  
I.J. Cavalli ◽  
E.M. Ribeiro ◽  
C.A. Urban ◽  
R.S. Lima ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Lymph Node ◽  
Sentinel Lymph Node ◽  
Copy Number ◽  
Dna Copy Number ◽  
Breast Cancer Metastases ◽  
Cancer Metastases ◽  
Copy Number Changes

Axillary lymph node core biopsy for breast cancer metastases — How many needle passes are enough?

2012 ◽  
Vol 67 (5) ◽  
pp. 417-419 ◽  
Author(s):  
E.J. Macaskill ◽  
C.A. Purdie ◽  
L.B. Jordan ◽  
D. Mclean ◽  
P. Whelehan ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Lymph Node ◽  
Axillary Lymph Node ◽  
Core Biopsy ◽  
Axillary Lymph ◽  
Breast Cancer Metastases ◽  
Cancer Metastases

Demonstration of Mucinous-Like Carcinoma-Associated Antigen in Bone Marrow and Lymph Node Biopsies from Patients with Breast Carcinoma

1991 ◽  
Vol 6 (3) ◽  
pp. 167-172 ◽  
Author(s):  
G. Saccani Jotti ◽  
C. Grassi ◽  
M. Fontanesi ◽  
G. Becchi ◽  
A. Tardini
Keyword(s):  
Breast Cancer ◽  
Bone Marrow ◽  
Lymph Node ◽  
Unknown Primary ◽  
Positive Staining ◽  
Bone Marrow Biopsies ◽  
Lung Cancers ◽  
Breast Cancer Metastases ◽  
Colon Cancers ◽  
Cancer Metastases

Two hundred and fifty bone marrow and 140 lymph nodal biopsies were analyzed immunocytochemically, using a mouse monoclonal antibody b-12 (MAb b-12), which reacts with MCA (mucinous-like carcinoma-associated antigen). The presence of MCA in bone marrow specimens was demonstrated in 102 out of 105 (97.1%) breast cancer metastases, 5 out of 8 (62.5%) gastric cancers, 5 out of 6 (83.3%) colon cancers, 3 out of 5 (60%) prostate cancers, 11 out of 26 (42.3%) lung cancers and 25 out of 30 (83.3%) unknown primary cancers, while no positivity to anti-MCA antibody was found in 30 cases of normal bone marrow biopsies, 5 cases of non epithelial malignancies and 30 cases of hemolymphoproliferative disease. Normal lymph nodes and non-epithelial lymph node metastases did not show any reaction to MAb b-12; on the contrary MCA positive staining was observed in 75 out of 75 (100%) lymph nodal metastases in breast cancer. These results suggest that application of MAb b-12 in immunohistochemistry is valid for the detection of bone marrow and lymph nodal micrometastases of epithelial origin.

Liver Surgery for Breast Cancer Metastases

2009 ◽  
Vol 69 (05) ◽  
Author(s):  
EC Schest ◽  
H Cerwenka ◽  
A El-Shabrawi ◽  
H Bacher ◽  
HJ Mischinger
Keyword(s):  
Breast Cancer ◽  
Liver Surgery ◽  
Breast Cancer Metastases ◽  
Cancer Metastases

Deprivation of the vitamin D receptor (VDR) fuels breast cancer metastases to bone

2019 ◽  
Author(s):  
K Horas ◽  
M Abraham ◽  
F Jakob ◽  
R Ebert ◽  
G Maier ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Vitamin D ◽  
Vitamin D Receptor ◽  
Breast Cancer Metastases ◽  
Cancer Metastases

Olfactomedin-like 2A, 2B and 3 are differentially expressed in breast cancer metastases.

2019 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Breast Cancer ◽  
Genetically Engineered ◽  
Differentially Expressed ◽  
Genetically Engineered Mouse Models ◽  
Breast Cancer Metastases ◽  
Multiple Datasets ◽  
Cancer Metastases ◽  
Distant Organ ◽  
Metastatic Process ◽  
Differential Gene

Differential gene expression analysis of multiple datasets, in mice and in men revealed that transcripts of the olfactomedin-like family are differentially expressed in metastases, both in patients with breast cancer and in genetically engineered mouse models of breast cancer. The expression of olfactomedin-like genes was perturbed in metastases to the bone, brain and the lung, suggesting that these molecules function in the metastatic process rather than having tissue-specific associations with the site of dissemination. The olfactomedin-like family may play a role in the progression of breast cancer from frank tumor to colonization of distant organ sites.

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