scholarly journals Necrotizing soft tissue infection: clinical characteristics and outcomes at a reconstructive center in Jilin Province

2017 ◽  
Vol 17 (1) ◽  
Author(s):  
Jing-Chun Zhao ◽  
Bo-Ru Zhang ◽  
Kai Shi ◽  
Xi Zhang ◽  
Chun-Hui Xie ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Soft Tissue Infection ◽  
Clinical Characteristics ◽  
Tissue Infection ◽  
Jilin Province ◽  
Necrotizing Soft Tissue Infection

scholarly journals Necrotizing soft tissue infection: clinical characteristics, diagnosis, and management of 32 cases in Beijing

2021 ◽  
Vol 49 (5) ◽  
pp. 030006052110184
Author(s):  
Zhen Cui ◽  
Shuai Lu ◽  
Ying Bai ◽  
Xu Sun ◽  
Peng Tian ◽  
...  
Keyword(s):  
Intensive Care Unit ◽  
Intensive Care ◽  
Soft Tissue ◽  
Blood Urea Nitrogen ◽  
Soft Tissue Infection ◽  
Clinical Characteristics ◽  
Tissue Infection ◽  
Gram Positive ◽  
Urea Nitrogen ◽  
Necrotizing Soft Tissue Infection

Objective Necrotizing soft tissue infection (NSTI) is a rare but life-threatening bacterial infection. This study was performed to analyze the clinical characteristics of patients with NSTI admitted to the intensive care unit of a trauma and burn center in Beijing and to summarize the treatment experience. Methods This retrospective study involved patients with NSTI admitted to the intensive care unit from January 2010 to January 2020. The clinical manifestations, pathogens, laboratory test results, and prognosis were compared between survivors and nonsurvivors. Results Thirty-two patients were enrolled (28 men, 4 women), including 25 (78.1%) survivors and 7 (21.9%) nonsurvivors. The patients’ median age was 41.5 years (range, 30.0–52.5 years). Mortality was significantly higher in patients with a blood urea nitrogen concentration of ≥11.5 mg/dL, creatinine concentration of <3.4 mg/dL, prothrombin time of ≥15.9 s, and international normalized ratio of ≥1.3. Streptococcus pyogenes and Clostridium perfringens infections were associated with higher mortality. Conclusions More attention should be given to elderly patients and those with hyponatremia, coagulation disorder, and higher blood urea nitrogen or creatinine concentrations. The finding of large gram-positive rods or large numbers of gram-positive cocci in wound secretion smears is a helpful early warning sign of highly lethal NSTI.

Nekrotisierende Weichteilphlegmone (Necrotizing Soft-Tissue-Infection/NSTI) der Brust als Mastitis non puerperalis getarnt – Ein Fallbeispiel

2016 ◽  
Vol 76 (10) ◽  
Author(s):  
C Willenberg ◽  
S Steer ◽  
WL Müller ◽  
C Thomssen ◽  
R Große
Keyword(s):  
Soft Tissue ◽  
Soft Tissue Infection ◽  
Tissue Infection ◽  
Necrotizing Soft Tissue Infection

Group G Streptococcal Necrotizing Soft Tissue Infection

2016 ◽  
Vol 78 (6) ◽  
pp. 644-649
Author(s):  
Eriko MAEHARA ◽  
Gaku TSUJI ◽  
Yukihiro MIZOTE ◽  
Naohide TAKEUCHI ◽  
Masutaka FURUE
Keyword(s):  
Soft Tissue ◽  
Soft Tissue Infection ◽  
Tissue Infection ◽  
Necrotizing Soft Tissue Infection

Can Paronychia Cause a Remote Necrotizing Soft Tissue Infection?

2011 ◽  
Vol 40 (1) ◽  
pp. e11-e13 ◽  
Author(s):  
Julian E. Losanoff ◽  
Anne E. Missavage ◽  
Paul Linneman ◽  
Boyd E. Terry
Keyword(s):  
Soft Tissue ◽  
Soft Tissue Infection ◽  
Tissue Infection ◽  
Necrotizing Soft Tissue Infection

scholarly journals Hyperbaric oxygen treatment impacts oxidative stress markers in patients with necrotizing soft-tissue infection

2021 ◽  
pp. jim-2021-001837
Author(s):  
Morten Hedetoft ◽  
Peter Østrup Jensen ◽  
Claus Moser ◽  
Julie Vinkel ◽  
Ole Hyldegaard
Keyword(s):  
Oxidative Stress ◽  
Septic Shock ◽  
Soft Tissue ◽  
Hyperbaric Oxygen ◽  
Soft Tissue Infection ◽  
Tissue Infection ◽  
Heme Oxygenase 1 ◽  
Necrotizing Soft Tissue Infection ◽  
Before And After ◽  
Nitrite Nitrate

Necrotizing soft-tissue infection (NSTI) is a rare, severe, and fast-progressing bacterial infection associated with a high risk of developing sepsis or septic shock. Increasing evidence indicates that oxidative stress is crucial in the development and progression of sepsis, but its role in NSTI specifically has not been investigated. Some patients with NSTI receive hyperbaric oxygen (HBO2) treatment as the restoration of oxidative stress balance is considered an important mechanism of action, which HBO2 facilitates. However, a gap in knowledge exists regarding the effect of HBO2 treatment on oxidative stress in patients with NSTI. In the present observational study, we aimed to investigate HBO2 treatment effects on known markers of oxidative stress in patients with NSTI. We measured plasma myeloperoxidase (MPO), superoxide dismutase (SOD), heme oxygenase-1 (HO-1) and nitrite+nitrate in 80 patients with NSTI immediately before and after their first HBO2 treatment, and on the following day. We found that HBO2 treatment was associated with a significant increase in MPO and SOD by a median of 3.4 and 8.8 ng/mL, respectively. Moreover, we observed an HBO2 treatment-associated increase in HO-1 in patients presenting with septic shock (n=39) by a median of 301.3 pg/mL. All markers were significantly higher in patients presenting with septic shock compared to patients without shock, and all markers correlated with disease severity. High baseline SOD was associated with 90-day mortality. In conclusion, HBO2 treatment was associated with an increase in MPO and SOD in patients with NSTI, and oxidative stress was more pronounced in patients with septic shock.

scholarly journals A case of Apophysomyces trapeziformis necrotizing soft tissue infection

2013 ◽  
Vol 17 (12) ◽  
pp. e1240-e1242 ◽  
Author(s):  
Jose F. Echaiz ◽  
Carey-Ann D. Burnham ◽  
Thomas C. Bailey
Keyword(s):  
Soft Tissue ◽  
Soft Tissue Infection ◽  
Tissue Infection ◽  
Necrotizing Soft Tissue Infection

Necrotizing Soft Tissue Infection of the Thorax Due to Methicillin-Sensitive Staphylococcus aureus Empyem

CHEST Journal ◽  
2011 ◽  
Vol 140 (4) ◽  
pp. 125A
Author(s):  
Krishna Aparanji ◽  
Ariel Shiloh ◽  
Adam Keene
Keyword(s):  
Staphylococcus Aureus ◽  
Soft Tissue ◽  
Soft Tissue Infection ◽  
Tissue Infection ◽  
Necrotizing Soft Tissue Infection
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