Abstract: India is a lower-middle-income country with improved industrial output and expansion of innovative technologies (information, biopharmaceutical) with some notable health benefits in controlling very few infectious diseases due to an inadequate health system. It mainly focuses on providing medical care for urban population and lacks a common health framework that plays a critical role in illness prevention. However, these diseases are caused not only by a lack of sanitation and population density but also by environmental and behavioural changes. This study reviewed the literature on infectious diseases that cause deaths in India, such as tuberculosis, lower respiratory infections, and Transfusion Transmitted Infections (TTIs), diagnostic procedures for treatment and disease burden. Keywords: lower-middle-income country, Infectious diseases, Transfusion Transmitted Infections (TTIs), disease burden.