scholarly journals Notch polymorphisms associated with sensitivity of noise induced hearing loss among Chinese textile factory workers

2018 ◽  
Vol 19 (1) ◽  
Author(s):  
Enmin Ding ◽  
Jing Liu ◽  
Huanxi Shen ◽  
Wei Gong ◽  
Hengdong Zhang ◽  
...  
2018 ◽  
Vol 11 (1) ◽  
Author(s):  
Teklehaymanot Huluf Abraha ◽  
Asmelash Tekie Demoz ◽  
Haimanot Gebrehiwot Moges ◽  
Ansha Nega Ahmmed

2017 ◽  
Vol 76 (1) ◽  
Author(s):  
Ving F. Chan ◽  
Jyoti Naidoo ◽  
Farai S. Chinanayi ◽  
Kovin S. Naidoo

Background: Uncorrected near vision impairment affects the performance of near vision tasks and activities for an estimated 410 million people worldwide. Once normal vision becomes blurred or impaired, the ordinary and simple daily routines of individuals become difficult; often resulting in frustration and irritation, which is consequently reflected in their quality of life.Aim: We investigated the change of vision-related quality of life (VRQoL) following near correction among textile factory workers in South Africa.Methods: Presbyopic subjects who were 40 years and older with no other eye conditions were provided near spectacle correction. We interviewed subjects to ascertain their VRQoL scores using the National Eye Institute Visual Function Questionnaire, pre-treatment and 6 months after the provision of near corrections.Setting: The study was conducted among the textile factory workers in KwaZulu-Natal, South Africa.Results: A total of 423 textile factory workers were followed up from seven textile factories in Durban. The overall increase in VRQoL scores of 21.9 (95% CI 16.7–27) was significant (p < 0.01). This translates to a 36.5% (95% CI 30.6–42.4) change in VRQoL. The increase was highest among participants of African origin 25.1 (95% CI 21.14–29.1), males 18.8 (95% CI 12.6–27.2), among those who had completed primary school 35.8 (95% CI 21.7–49.9) and among participants with other responsibilities (ironing and quality assurance) 21.9 (95% CI 16.7–27).Conclusion: Correcting near vision impairment improved the VRQoL scores of textile factory workers. The results showed that VRQoL scores increased significantly across levels of education and categories of responsibility


1989 ◽  
Vol 79 (4) ◽  
pp. 347-349 ◽  
Author(s):  
J. M. Abarbanel ◽  
Y. O. Herishanu ◽  
A. Osimani ◽  
S. Frisher

2020 ◽  
Vol 25 (4) ◽  
pp. 200-208
Author(s):  
Haoyang Yin ◽  
Jiadi Guo ◽  
Enmin Ding ◽  
Hengdong Zhang ◽  
Lei Han ◽  
...  

Introduction: Noise-induced hearing loss (NIHL) is a common occupational disease that represents an irreversible hearing damage to the auditory system. It has been identified as a complicated disease involving both environmental and genetic factors. More efforts need to be made to explore the genes associated with susceptibility to NIHL. The main aim of this research is to detect the associations between SIK3 polymorphisms and NIHL susceptibility in Han people in China. Methods: A case-control study was performed in 586 cases and 639 controls in a textile factory matched for sex, age, smoking, drinking, work time with noise, and intensity of noise exposure. Three single nucleotide polymorphisms (SNPs) (rs493134, rs6589574, and rs7121898) of SIK3 were genotyped in the participants. Then, the main influences of the SNPs on and their interactions with NIHL were assessed. Results: Under the allelic model, distributions of rs493134 T, rs6589574 G, and rs7121898 A in the NIHL group are statistically different from those of the normal group (p = 0.001, p < 0.001, and p = 0.019, respectively). The following haplotype analysis shows that TAA (rs493134-rs6589574-rs7121898) may have a protective effect, while TGA (rs493134-rs6589574-rs7121898) (OR = 1.49, 95% CI = 1.25–1.79) may be a risk factor for NIHL. Multifactor dimensionality reduction analysis shows that the interaction of the 3 selected SNPs is associated with NIHL susceptibility (OR = 1.88, 95% CI = 1.50–2.36). Conclusion: The results suggest that 3 SNPs (rs493134, rs6589574, and rs7121898) of SIK3 may be an important part of NIHL susceptibility and can be applied in the prevention, early diagnosis, and treatment of NIHL in noise-exposed Chinese workers.


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