Maternal alcohol use, adverse neonatal outcomes and pregnancy complications in British Columbia, Canada: a population-based study

Abstract Background The current study aimed to estimate the prevalence of alcohol use identified as a risk factor during pregnancies by the antenatal care providers, resulting in live births in British Columbia (BC) and to examine associations between alcohol use, adverse neonatal outcomes, and pregnancy complications. Methods This population-based cross-sectional study utilized linked obstetrical and neonatal records within the BC Perinatal Data Registry (BCPDR), for deliveries that were discharged between January 1, 2015 and March 31, 2018. The main outcome measures were alcohol use identified as a risk factor during pregnancy, associated maternal characteristics, pregnancy complications, and adverse neonatal outcomes. Estimates for the period and fiscal year prevalence were calculated. Chi-square tests were used to compare adverse neonatal outcomes and pregnancy complications by alcohol use during pregnancy identified as a risk factor. Logistic regression was used to examine the association between alcohol use identified as a risk factor during pregnancy and adverse neonatal outcomes and pregnancy complications, after adjusting for identified risk factors. Results A total of 144,779 linked records within the BCPDR were examined. The period prevalence of alcohol use during pregnancy identified as a risk factor was estimated to be 1.1% and yearly prevalence was 1.1, 1.1, 1.3 and 0.9% from the 2014/2015 to 2017/2018 fiscal years, respectively. Alcohol use identified as a risk factor was associated with younger maternal age, fewer antenatal visits, being primiparous, a history of mental illness, substance use and smoking. Neonates with alcohol use during pregnancy identified as a risk factor had greater odds of being diagnosed with: “low birth weight (1000-2499g)” (ICD-10: P07.1; aOR = 1.25; 95% CI: 1.01, 1.53), “other respiration distress of newborn” (ICD-10: P22.8; aOR = 2.57; 95% CI: 1.52, 4.07), “neonatal difficulty in breastfeeding” (ICD-10: P92.5; aOR = 1.97; 95% CI: 1.27, 2.92) and “feeding problems, unspecified” (ICD-10: P92.9; aOR = 2.06; 95% CI: 1.31, 3.09). Conclusions The prevalence of alcohol use during pregnancy identified as a risk factor was comparable to previous estimates within the BCPDR. Identified prenatal alcohol exposure was associated with notable differences in maternal and neonatal characteristics and adverse neonatal outcomes. More consistent, thorough screening and prevention efforts targeting alcohol use in pregnancy are urgently needed in Canada.

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Maternal Alcohol Use, Adverse Neonatal Outcomes and Pregnancy Complications in British Columbia, Canada: A Population-based Study

10.21203/rs.3.rs-97764/v1 ◽

2020 ◽

Author(s):

Svetlana Popova ◽

Danijela Dozet ◽

Graham O'Hanlon ◽

Valerie Temple ◽

Jurgen Rehm

Keyword(s):

British Columbia ◽

Risk Factor ◽

Alcohol Use ◽

Pregnancy Complications ◽

Alcohol Exposure ◽

Population Based ◽

Neonatal Outcomes ◽

Fiscal Year ◽

Care Providers ◽

Adverse Neonatal Outcomes

Abstract BackgroundThe current study aimed to estimate the prevalence of alcohol use identified as a risk factor during pregnancies by the antenatal care providers, resulting in live births in British Columbia (BC) and to examine associations between alcohol use, adverse neonatal outcomes, and pregnancy complications.MethodsThis population-based cross-sectional study utilized linked obstetrical and neonatal records within the BC Perinatal Data Registry (BCDPR), for deliveries that were discharged between January 1, 2015 and March 31, 2018. The main outcome measures were alcohol use identified as a risk factor during pregnancy, associated maternal characteristics, pregnancy complications, and adverse neonatal outcomes. Estimates for the period and fiscal year prevalence were calculated. Chi-square tests were used to compare adverse neonatal outcomes and pregnancy complications by alcohol use during pregnancy. Logistic regression was used to examine the association between alcohol use during pregnancy and adverse neonatal outcomes and pregnancy complications, after adjusting for identified risk factors.ResultsA total of 144,779 linked records within the BCDPR were examined. The period prevalence of alcohol use during pregnancy identified as a risk factor was estimated to be 1.1% and yearly prevalence was 1.1%, 1.1%, 1.3% and 0.9% from the 2014/2015 fiscal year to 2017/2018, respectively. Indicated alcohol use was associated with younger maternal age, fewer antenatal visits, being nulliparous, a history of mental illness, substance use and smoking. Alcohol-exposed neonates had greater odds of being diagnosed with low birth weight (aOR = 1.25; 95% CI: 1.01, 1.53), other respiration distress of newborn (aOR = 2.57; 95% CI: 1.52, 4.07), neonatal difficulty in breastfeeding (aOR = 1.97; 95% CI: 1.27, 2.92) and unspecified feeding problems (aOR = 2.06; 95% CI: 1.31, 3.09)ConclusionsThe prevalence of alcohol use during pregnancy identified as a risk factor, estimated in this study, was comparable to the previous estimates within BCDPR. Prenatal alcohol exposure was associated with notable differences in maternal and neonatal characteristics and adverse neonatal outcomes. More consistent and thorough screening and prevention efforts targeting alcohol use in pregnancy are urgently needed in Canada.

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Country of first birth and neonatal outcomes in migrant and Norwegian-born parous women in Norway: a population-based study

10.21203/rs.2.19047/v1 ◽

2019 ◽

Author(s):

Eline Skirnisdottir Vik ◽

Roy Miodini Nilsen ◽

Vigdis Aasheim ◽

Rhonda Small ◽

Dag Moster ◽

...

Keyword(s):

Preterm Birth ◽

Population Based ◽

Neonatal Outcomes ◽

Migrant Women ◽

First Birth ◽

Population Based Study ◽

Very Preterm ◽

Very Preterm Birth ◽

Adverse Neonatal Outcomes ◽

Moderately Preterm

Abstract Background: This study compares subsequent birth outcomes in migrant women who had already had a child before arriving in Norway with those in migrant women whose first birth occurred in Norway. The aim of this study was to investigate the associations between country of first birth and adverse neonatal outcomes (very preterm birth, moderately preterm birth, post-term birth, small for gestational age, large for gestational age, low Apgar score, stillbirth and neonatal death) in parous migrant and Norwegian-born women. Methods: National population-based study including second and subsequent singleton births in Norway from 1990-2016. Data were retrieved from the Medical Birth Registry of Norway and Statistics Norway. Neonatal outcomes were compared between births to: 1) migrant women with a first birth before immigration to Norway (n=30,062) versus those with a first birth after immigration (n=66,006), and 2) Norwegian-born women with a first birth outside Norway (n=6,205) versus those with a first birth in Norway (n=514,799). Associations were estimated as crude and adjusted odds ratios (aORs) with 95% confidence intervals (CIs) using multiple logistic regression. Results: Migrant women with a first birth before immigrating to Norway had increased odds of adverse outcomes in subsequent births relative to those with a first birth after immigration: very preterm birth (22-31 gestational weeks (gwks); aOR=1.27; CI 1.09-1.48), moderately preterm birth (32-36 gwks; aOR=1.10; CI 1.02-1.18), post-term birth (≥42 gwks; aOR=1.19; CI 1.11-1.27), low Apgar score (<7 at 5 minutes; aOR=1.27; CI 1.16-1.39) and stillbirth (aOR=1.29; CI 1.05-1.58). Similar results were found in the sample of births to Norwegian-born women. Conclusions: The increased odds of adverse neonatal outcomes for migrant and Norwegian-born women who had their first births outside Norway should serve as a reminder of the importance of taking a careful obstetric history in these parous women to ensure appropriate care for their subsequent pregnancies and births in Norway. Keywords: immigration, parous women, neonatal outcomes, obstetric history, predictor

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Commentary on the paper “Is alexithymia a risk factor for major depression, personality disorder, or alcohol use disorders? A prospective population-based study”

Journal of Psychosomatic Research ◽

10.1016/j.jpsychores.2009.07.016 ◽

2010 ◽

Vol 68 (3) ◽

pp. 275-277 ◽

Cited By ~ 9

Author(s):

Olivier Luminet

Keyword(s):

Risk Factor ◽

Major Depression ◽

Personality Disorder ◽

Alcohol Use ◽

Alcohol Use Disorders ◽

Population Based ◽

Population Based Study

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Depression during pregnancy: a risk factor for adverse neonatal outcomes? A critical review of the literature

The Journal of Maternal-Fetal & Neonatal Medicine ◽

10.3109/14767058.2013.845157 ◽

2013 ◽

Vol 27 (9) ◽

pp. 960-967 ◽

Cited By ~ 66

Author(s):

Kathleen Szegda ◽

Glenn Markenson ◽

Elizabeth R. Bertone-Johnson ◽

Lisa Chasan-Taber

Keyword(s):

Risk Factor ◽

Critical Review ◽

Neonatal Outcomes ◽

Review Of The Literature ◽

Adverse Neonatal Outcomes

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Cholestasis after very preterm birth was associated with adverse neonatal outcomes but no significant long‐term liver disease: A population‐based study

Acta Paediatrica ◽

10.1111/apa.15408 ◽

2020 ◽

Vol 110 (1) ◽

pp. 141-148

Author(s):

Jonas Teng ◽

Kajsa Bohlin ◽

Antal Nemeth ◽

Björn Fischler

Keyword(s):

Liver Disease ◽

Preterm Birth ◽

Population Based ◽

Neonatal Outcomes ◽

Population Based Study ◽

Very Preterm ◽

Very Preterm Birth ◽

Adverse Neonatal Outcomes

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286: Is discordance in appropriately grown twin gestations a risk factor for adverse neonatal outcomes?

American Journal of Obstetrics and Gynecology ◽

10.1016/j.ajog.2015.10.325 ◽

2016 ◽

Vol 214 (1) ◽

pp. S165

Author(s):

Anna Palatnik ◽

Michelle A. Kominiarek

Keyword(s):

Risk Factor ◽

Neonatal Outcomes ◽

Adverse Neonatal Outcomes

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127 Hypertension at an early stage of prenatal is a major risk factor for adverse neonatal outcomes

Pregnancy Hypertension ◽

10.1016/j.preghy.2016.08.209 ◽

2016 ◽

Vol 6 (3) ◽

pp. 242-243

Author(s):

Júlio Augusto Gurgel Alves ◽

Nilce Ariane Spencer Santos ◽

Francisco Edson de Lucena Feitosa

Keyword(s):

Risk Factor ◽

Early Stage ◽

Neonatal Outcomes ◽

Major Risk Factor ◽

Adverse Neonatal Outcomes

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Systemic Sclerosis and Associated Interstitial Lung Disease in Ontario, Canada: An Examination of Prevalence and Survival Over 10 Years

The Journal of Rheumatology ◽

10.3899/jrheum.201049 ◽

2021 ◽

pp. jrheum.201049

Author(s):

Janet E. Pope ◽

Kobina Quansah ◽

Shazia Hassan ◽

Soo Jin Seung ◽

Jason Flavin ◽

...

Keyword(s):

Systemic Sclerosis ◽

Survival Rates ◽

Population Based ◽

Pulmonary Complications ◽

Administrative Databases ◽

Fiscal Year ◽

Discharge Abstract Database ◽

Kaplan Meier ◽

Prevalence Estimates ◽

Icd 10

Objective Systemic sclerosis (SSc) is a rare autoimmune disease. Pulmonary complications of SSc are one of the leading causes of morbidity and mortality. The objective of this study was to determine prevalence and survival estimates of SSc and SSc-ILD in a Canadian province (Ontario) using administrative data over 10 years. Methods Using ICD-10-CA codes, adult patients diagnosed with SSc and SSc-ILD between April 1, 2008 and March 31, 2018 were identified from the National Ambulatory Care Reporting System (NACRS) and Discharge Abstract Database (DAD) administrative databases. SSc was identified first and ILD if present occurred after the SSc diagnosis. Prevalence estimates were determined for both SSc and SSc-ILD. For survival, Kaplan Meier survival curves were generated. Results At the start of fiscal year 2017/18 (final year of the cohort), there were 2,114 prevalent SSc cases for a cumulative prevalence of 19.1 per 100,000 persons and 257 prevalent cases of SSc-ILD, generating a prevalence of 2.32 cases per 100,000 persons. Mean age was 57 and 58 years with 84% and 80% females for SSc and SSc- ILD patients, respectively. One, 5 and 10 year survival rates respectively for the SSc group were 85.0%, 64.5% and 44.9%, and 77.1%, 44.4% and 22.0% for the SSc-ILD. Conclusion This study provides the first population-based estimates of SSc and SSc- ILD in Canada for prevalence and survival. Results confirm that the prevalence estimates of SSc-ILD falls within the Canadian threshold of rare disease. It also demonstrates the poor survival in SSc especially when ILD is also present.

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