scholarly journals When a vesicular placenta meets a live fetus: case report of twin pregnancy with a partial hydatidiform mole

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Minhuan Lin ◽  
Jinzhu Chen ◽  
Bing Liao ◽  
Zhiming He ◽  
Shaobin Lin ◽  
...  
Keyword(s):  
Twin Pregnancy ◽  
Hydatidiform Mole ◽  
First Trimester ◽  
Molar Pregnancy ◽  
Amniotic Cavity ◽  
Individualized Care ◽  
Partial Mole ◽  
Live Fetus ◽  
Hydatidiform Moles

Abstract Background Hydatidiform moles exhibit a distinctive gross appearance of multiple vesicles in the placenta. The advances in cytogenetic technologies have helped uncover novel entities of hydatidiform moles and enabled elaborate diagnoses. However, management of a vesicular placenta with a coexistent live fetus poses a bigger challenge beyond hydatidiform moles. Case presentation A 33-year-old woman was referred to our department for suspected hydatidiform mole coexistent with a live fetus at 24 weeks’ gestation. The patient had conceived through double embryo transplantation, and first-trimester ultrasonography displayed a single sac. Mid-trimester imaging findings of normal placenta parenchyma admixed with multiple vesicles and a single amniotic cavity with a fetus led to suspicion of a singleton partial molar pregnancy. After confirmation of a normal diploid by amniocentesis and close surveillance, the patient delivered a healthy neonate. Preliminary microscopic examination of the placenta failed to clarify the diagnosis until fluorescence in situ hybridization showed a majority of XXY sex chromosomes. The patient developed suspected choriocarcinoma and achieved remission for 5 months after chemotherapy, but relapsed with suspected intermediate trophoblastic tumor. Conclusion We report a rare case of twin pregnancy comprising a partial mole and a normal fetus that resembled a singleton partial molar pregnancy. Individualized care is important in conditions where a vesicular placenta coexists with a fetus. We strongly recommend ancillary examinations in addition to traditional morphologic assessment in such cases.

scholarly journals Partial molar pregnancy with live fetus in first trimester: what should we do next

2020 ◽  
Vol 20 (2) ◽  
Author(s):  
Eric Edwin ◽  
Uki Retno Budihastuti ◽  
Cut Sheira Elnita
Keyword(s):  
Hydatidiform Mole ◽  
First Trimester ◽  
Postnatal Period ◽  
Molar Pregnancy ◽  
Antenatal Consultation ◽  
Partial Mole ◽  
Close Observation ◽  
Live Fetus ◽  
Multiple Cysts

Abstract. The incidence of a normal live fetus with a partial mole is extremely rare, and it varies between 5 per 100000 and 1 per 10000 of the pregnancies. A partial molar pregnancy is a variation of a molar pregnancy in which an embryo either develops incompletely or with multiple structural anomalies.A 27-year-old Primigravide at 13 weeks of gestation got admitted with spotting per vaginam, excessive nausea and vomiting, and her ultrasound revealed a hydropic placenta with multiple cysts with a live fetus. Regarding these findings, the patient continued her pregnancy under close observation, and advanced sonographic evaluations were done to rule out other differentials. Ultrasonography found mosaicism in the partial mole (mostly diploid, a small part is triploid). In this condition, the prognosis condition for the fetus to be born safely is still probable. Ethics committee meetings are held with the consideration of the fetus's condition, whether monitoring is carried out regularly, and terminating the pregnancy in case of fetal emergency.The optimal management of hydatidiform mole with the coexistent live fetus is currently uncertain. Antenatal consultation should include a detailed discussion of maternal and fetal risks. It is also necessary to have close follow-up and evaluation of the patient's condition during the antenatal and postnatal period. Keywords: first trimester, live fetus , management, partial molar pregnancy

scholarly journals Management of twin pregnancy with a hydatidiform mole and surviving healthy co-existent fetus

2017 ◽  
Vol 6 (12) ◽  
pp. 5636
Author(s):  
Hale Goksever Celik ◽  
Gözde Meriç Demirezen ◽  
Baki Erdem ◽  
Alev Atış Aydın ◽  
Volkan Ülker
Keyword(s):  
Maternal Morbidity ◽  
Twin Pregnancy ◽  
Hydatidiform Mole ◽  
Uterine Cavity ◽  
First Trimester ◽  
Molar Pregnancy ◽  
Complete Mole ◽  
Live Fetus ◽  
Twin Pregnancies ◽  
Normal Placenta

Twin pregnancies with complete mole and a coexisting live fetus are rare obstetric conditions seen in 1 case of 22000 to 100000 pregnancies. In our case, a twin molar pregnancy was diagnosed in the first trimester by ultrasound. In a 27-year-old patient with the first pregnancy, a 12-week live fetus with a normal placenta and a twin molar pregnancy appearance were observed on a routine ultrasonographic examination of the uterine cavity. Twin molar pregnancies are reported to be terminated by live birth in the literature, but termination of pregnancy is an important option to prevent maternal morbidity since molar pregnancy may lead to complications ranging from theca lutein cysts to gestational trophoblastic neoplasia.

scholarly journals Partial hydatidiform mole and coexistent live fetus: a case report and review of the literature

Open Medicine ◽  
2019 ◽  
Vol 14 (1) ◽  
pp. 843-846
Author(s):  
Chengying Zeng ◽  
Yanbi Chen ◽  
Lijuan Zhao ◽  
Bo Wan
Keyword(s):  
Case Report ◽  
Pregnant Woman ◽  
Peripheral Blood ◽  
Twin Pregnancy ◽  
Hydatidiform Mole ◽  
Molar Pregnancy ◽  
Review Of The Literature ◽  
Partial Hydatidiform Mole ◽  
Normal Fetus ◽  
Live Fetus

AbstractTwin pregnancy of a hydatidiform mole with a coexistent live fetus is very rare, and complete molar pregnancy is involved in most cases. A partial molar pregnancy almost always ends in miscarriage due to a triploid fetus. Here, we report a case of a 32-year-old Chinese woman with ultrasound diagnosis of a partial molar pregnancy. Amniocentesis suggested mosaicism, but the fetus was morphologically normal. The woman chose to continue the pregnancy after fully understanding the risk. The infant was delivered prematurely, and the presence of a large single placenta with molar changes. The baby’s peripheral blood chromosomes were diploid, and the pregnant woman had no serious complications. The diagnosis, management, and monitoring of this condition will remain challenging because of its rarity. Partial hydatidiform mole combined with pregnancy can result in delivering of a normal fetus and live birth under proper management.

Twin pregnancy with a complete hydatidiform mole and co-existent live fetus: two case reports and review of the literature

2008 ◽  
Vol 279 (3) ◽  
pp. 431-436 ◽  
Author(s):  
Kenan Dolapcioglu ◽  
Arif Gungoren ◽  
Sibel Hakverdi ◽  
Ali Ulvi Hakverdi ◽  
Ertugrul Egilmez
Keyword(s):  
Twin Pregnancy ◽  
Case Reports ◽  
Hydatidiform Mole ◽  
Review Of The Literature ◽  
Complete Hydatidiform Mole ◽  
Live Fetus

scholarly journals Successful Primary Treatment of a Hydatidiform Mole with Methotrexate and EMA/CO

2009 ◽  
Vol 2009 ◽  
pp. 1-3 ◽  
Author(s):  
M. De Vos ◽  
M. Leunen ◽  
C. Fontaine ◽  
Ph. De Sutter
Keyword(s):  
Surgical Treatment ◽  
Complete Remission ◽  
Treatment Option ◽  
Hydatidiform Mole ◽  
Uterine Fibroids ◽  
Treatment Method ◽  
Primary Treatment ◽  
Molar Pregnancy ◽  
Complete Hydatidiform Mole ◽  
Hydatidiform Moles

Background. The preferred treatment method of most hydatidiform moles is suction aspiration. In rare circumstances uterine abnormalities may preclude surgical treatment.Case. We report a case of complete molar pregnancy successfully treated with methotrexate followed by EMA/CO. A 38-year-old woman with a complete hydatidiform mole and multiple uterine fibroids underwent a failed attempt at suction aspiration. Following treatment with methotrexate, a nonmetastatic persistent trophoblastic tumour developed. Six cycles of EMA/CO led to complete remission.Conclusion. We propose that primary treatment of molar pregnancies with chemotherapy is a useful treatment option in cases where uterine abnormalities interfere with suction aspiration.

Underexpression of 4 Placenta-Associated MicroRNAs in Complete Hydatidiform Moles

2012 ◽  
Vol 22 (6) ◽  
pp. 1075-1080 ◽  
Author(s):  
Quan Na ◽  
Dan Wang ◽  
Weiwei Song
Keyword(s):  
In Situ Hybridization ◽  
Hydatidiform Mole ◽  
Polymerase Chain Reaction Analysis ◽  
Normal Pregnancy ◽  
Differentially Expressed ◽  
Control Group ◽  
Differentially Expressed Mirnas ◽  
Hydatidiform Moles

ObjectiveSeveral placental microRNAs (miRNAs) have been identified as placenta-associated miRNAs with the potential of estimating the condition of the placenta. However, our understanding of these miRNAs is limited. The aim of this study was to determine the expression of 8 placenta-associated miRNAs (miR-512-3p, miR-517a, miR-517b, miR-518b, miR-519a, miR-1185, miR-1283, and miR-1323) in complete hydatidiform mole (CHM).MethodsSamples were obtained from patients with CHM (CHM group, n = 12) and elective terminations of normal pregnancy (control group, n = 20). We detected differentially expressed placenta-associated miRNAs in placenta by quantitative real-time reverse transcriptase–polymerase chain reaction analysis. Subsequently, we assessed the expression location of differentially expressed miRNAs by in situ hybridization analysis.ResultsFour placenta-associated miRNAs (miR-517a, miR-517b, miR-518b, and miR-519a) were underexpressed in the CHM group, compared with the control group (P < 0.01). When further investigating these 4 miRNAs with regard to in vivo localization by in situ hybridization, we found that 2 miRNAs (miR-517b and miR-518b) were detected exclusively in the trophoblast layer, with little signal (if any) observed in villous stroma cells.ConclusionsThe results show that 4 miRNAs (miR-517a, miR-517b, miR-518b, and miR-519a) are deregulated in CHM, which suggests the involvement of these miRNAs in the functions of CHM placenta.

scholarly journals A Twin Pregnancy With Complete Hydatidiform Mole and Coexisting Live Fetus Complicated by Severe Preeclampsia

2021 ◽  
Vol 2 (2) ◽  
pp. 38-41
Author(s):  
Huri Güvey ◽  
Canan Soyer Caliskan ◽  
Samettin Celik ◽  
Safak Hatirnaz ◽  
Mehmet Kefeli ◽  
...  
Keyword(s):  
Twin Pregnancy ◽  
Hydatidiform Mole ◽  
Severe Preeclampsia ◽  
Complete Hydatidiform Mole ◽  
Live Fetus

scholarly journals KEHAMILAN KEMBAR DISERTAI MOLA HIDATIDOSA

2019 ◽  
Vol 8 (2) ◽  
pp. 75-83
Author(s):  
Harya Narottama ◽  
◽  
Erry Gumilar ◽  
Brahmana Askandar ◽  
◽  
...  
Keyword(s):  
Vaginal Bleeding ◽  
Rare Case ◽  
Twin Pregnancy ◽  
Ultrasound Examination ◽  
Hydatidiform Mole ◽  
Molar Pregnancy ◽  
Premature Labor ◽  
Triplet Pregnancy ◽  
Diagnostic Approaches

Twin pregnancy with Hydatidiform Mole is a rare case, only about 1 in 22.000 to 100.000 pregnancies. Molar pregnancy with triplet pregnancy is even rarer, which is only 6 cases reported and mostly occurred in women who received therapy for infertility. Management in cases of twin pregnancy with hydatidiform mole is dilemmatic both for the patient and physician. We present a case of 29 years old woman with her first pregnancy of twin fetuses complicated with hydatidiform mole. Diagnostic approaches were made mainly by ultrasound examination, continued with laboratory and radiology examinations which some did not performed due to worsened vaginal bleeding. This case ended with premature labor with the result of delivery of two babies and placenta with vesicles which is a characteristic of hydatidiform mole.

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