scholarly journals The association between serum ferritin levels and malignant intraductal papillary mucinous neoplasms

BMC Cancer ◽  
2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Xiaoling Zhuge ◽  
Hao Zhou ◽  
Liming Chen ◽  
Hui Chen ◽  
Xiao Chen ◽  
...  
Keyword(s):  
Serum Ferritin ◽  
Invasive Carcinoma ◽  
Elevated Serum ◽  
Area Under The Curve ◽  
Carbohydrate Antigen ◽  
High Serum ◽  
Tumor Biomarker ◽  
Intraductal Papillary Mucinous Neoplasms ◽  
Lesion Location ◽  
Mucinous Neoplasms

Abstract Background Serum ferritin levels are elevated in many malignancies. In this study, we showed the performance of serum ferritin in identifying malignant intraductal papillary mucinous neoplasms (IPMNs). Methods A total of 151 patients with pathologically confirmed IPMNs were enrolled. Serum tumor biomarker (carbohydrate antigen 19–9 (CA19–9) and carcinoembryonic antigen (CEA)) levels and serum ferritin levels were recorded. Lesion location, tumor size, diameter of the main pancreatic duct (MPD), mural nodule, and IPMN type, were collected from imaging examinations. IPMNs with high grade dysplasia and associated invasive carcinoma were considered malignant IPMNs. Results Serum ferritin levels in patients with malignant IPMNs were higher than those in patients with nonmalignant IPMNs (p <  0.05). Serum ferritin was an independent factor for the occurrence of malignant IPMNs (odds ratio (OR) = 1.18, 95% confidence interval (CI):1.01–1.39). A similar trend was found between high serum ferritin (> 149 ng/ml) and malignant IPMNs (OR = 5.64, 95% CI:1.78–17.92). The area under the curve (AUC) of serum ferritin was higher than that of CEA and CA19–9 in identifying malignant IPMNs (AUC = 0.67 vs. AUC = 0.58, 0.65). The combination of serum ferritin with IPMN type showed a similar performance to MPD diameter and the combination of serum CA19–9 with IPMN types in identifying malignant IPMNs (AUC = 0.78 vs. AUC = 0.79, 0.77) and invasive carcinoma (AUC = 0.77 vs. AUC = 0.79, 0.79). Conclusions Elevated serum ferritin is a factor associated with malignant IPMNs. Serum ferritin may be a useful marker for identifying malignancy in IPMNs.

scholarly journals Malignant Potential of Intraductal Papillary Mucinous Neoplasms of the Pancreas, Especially Minimally Invasive Carcinoma

2015 ◽  
Vol 48 (8) ◽  
pp. 661-668
Author(s):  
Kazuhiro Koikawa ◽  
Kazuyoshi Nishihara ◽  
Yasuki Akiyama ◽  
Yohei Nakashima ◽  
Hiroaki Matsunaga ◽  
...  
Keyword(s):  
Minimally Invasive ◽  
Invasive Carcinoma ◽  
Malignant Potential ◽  
Intraductal Papillary Mucinous Neoplasms ◽  
Mucinous Neoplasms

Predicting Dysplasia and Invasive Carcinoma in Intraductal Papillary Mucinous Neoplasms of the Pancreas: Development of a Preoperative Nomogram

2013 ◽  
Vol 20 (13) ◽  
pp. 4348-4355 ◽  
Author(s):  
Camilo Correa-Gallego ◽  
Richard Do ◽  
Jennifer LaFemina ◽  
Mithat Gonen ◽  
Michael I. D’Angelica ◽  
...  
Keyword(s):  
Invasive Carcinoma ◽  
Pancreas Development ◽  
Intraductal Papillary Mucinous Neoplasms ◽  
Mucinous Neoplasms

scholarly journals High Grade Dysplasia And Invasive Carcinoma Among Sendai Negative Intraductal Papillary Mucinous Neoplasms

HPB ◽  
2020 ◽  
Vol 22 ◽  
pp. S15-S16
Author(s):  
C.L. Wolfgang ◽  
N. Amini ◽  
N. Rezaee ◽  
G.A. Margonis ◽  
J.L. Cameron ◽  
...  
Keyword(s):  
Invasive Carcinoma ◽  
High Grade Dysplasia ◽  
High Grade ◽  
Intraductal Papillary Mucinous Neoplasms ◽  
Mucinous Neoplasms

scholarly journals Smoking Is Not Associated with Severe Dysplasia or Invasive Carcinoma in Resected Intraductal Papillary Mucinous Neoplasms

2014 ◽  
Vol 19 (4) ◽  
pp. 656-665 ◽  
Author(s):  
Neda Rezaee ◽  
Saami Khalifian ◽  
John L. Cameron ◽  
Timothy M. Pawlik ◽  
Ralph H. Hruban ◽  
...  
Keyword(s):  
Invasive Carcinoma ◽  
Severe Dysplasia ◽  
Intraductal Papillary Mucinous Neoplasms ◽  
Mucinous Neoplasms

scholarly journals Neutrophil-to-Lymphocyte Ratio as a Predictor of Invasive Carcinoma in Patients With Intraductal Papillary Mucinous Neoplasms of the Pancreas

Pancreas ◽  
2019 ◽  
Vol 48 (6) ◽  
pp. 832-836 ◽  
Author(s):  
Caitlin A. McIntyre ◽  
Alessandra Pulvirenti ◽  
Sharon A. Lawrence ◽  
Kenneth Seier ◽  
Mithat Gonen ◽  
...  
Keyword(s):  
Invasive Carcinoma ◽  
Neutrophil To Lymphocyte Ratio ◽  
Intraductal Papillary Mucinous Neoplasms ◽  
Lymphocyte Ratio ◽  
Mucinous Neoplasms

Predictive Value of Serum Carbohydrate Antigen 19-9 in Malignant Intraductal Papillary Mucinous Neoplasms

2011 ◽  
Vol 35 (5) ◽  
pp. 1103-1109 ◽  
Author(s):  
Bin Xu ◽  
Wen-Yan Zheng ◽  
Da-Yong Jin ◽  
Wei-xing Ding ◽  
Wen-Hui Lou ◽  
...  
Keyword(s):  
Predictive Value ◽  
Carbohydrate Antigen ◽  
Intraductal Papillary Mucinous Neoplasms ◽  
Mucinous Neoplasms ◽  
Serum Carbohydrate Antigen

scholarly journals Ductal Dilatation of ≥5 mm in Intraductal Papillary Mucinous Neoplasm Should Trigger the Consideration for Pancreatectomy: A Meta-Analysis and Systematic Review of Resected Cases

Cancers ◽  
2021 ◽  
Vol 13 (9) ◽  
pp. 2031
Author(s):  
Y.H. Andrew Wu ◽  
Atsushi Oba ◽  
Laurel Beaty ◽  
Kathryn L. Colborn ◽  
Salvador Rodriguez Franco ◽  
...  
Keyword(s):  
Retrospective Studies ◽  
Invasive Carcinoma ◽  
Meta Analysis ◽  
Diagnostic Value ◽  
Published Data ◽  
Intraductal Papillary Mucinous Neoplasms ◽  
Mucinous Neoplasm ◽  
Mucinous Neoplasms ◽  
Sensitivity Specificity

Intraductal papillary mucinous neoplasms (IPMN) are common but difficult to manage since accurate tools for diagnosing malignancy are unavailable. This study tests the diagnostic value of the main pancreatic duct (MPD) diameter for detecting IPMN malignancy using a meta-analysis of published data of resected IPMNs. Collected from a comprehensive literature search, the articles included in this analysis must report malignancy cases (high-grade dysplasia (HGD) and invasive carcinoma (IC)) and MPD diameter so that two MPD cut-offs could be created. The sensitivity, specificity, and odds ratios of the two cutoffs for predicting malignancy were calculated. A review of 1493 articles yielded 20 retrospective studies with 3982 resected cases. A cutoff of ≥5 mm is more sensitive than the ≥10 mm cutoff and has pooled sensitivity of 72.20% and 75.60% for classification of HGD and IC, respectively. Both MPD cutoffs of ≥5 mm and ≥10 mm were associated with malignancy (OR = 4.36 (95% CI: 2.82, 6.75) vs. OR = 3.18 (95% CI: 2.25, 4.49), respectively). The odds of HGD and IC for patients with MPD ≥5 mm were 5.66 (95% CI: 3.02, 10.62) and 7.40 (95% CI: 4.95, 11.06), respectively. OR of HGD and IC for MPD ≥10 mm cutoff were 4.36 (95% CI: 3.20, 5.93) and 4.75 (95% CI: 2.39, 9.45), respectively. IPMN with MPD of >5 mm could very likely be malignant. In selected IPMN patients, pancreatectomy should be considered when MPD is >5 mm.

scholarly journals Nomogram for the Prediction of High-Grade Dysplasia and Invasive Carcinoma in Patients With Intraductal Papillary Mucinous Neoplasms of the Pancreas Based on Variables of Noninvasive Examination

2021 ◽  
Vol 11 ◽  
Author(s):  
Bo Li ◽  
Xiaohan Shi ◽  
Suizhi Gao ◽  
Shuo Shen ◽  
Yun Bian ◽  
...  
Keyword(s):  
Logistic Regression ◽  
Regression Analysis ◽  
Logistic Regression Analysis ◽  
Malignant Disease ◽  
Invasive Carcinoma ◽  
Multivariable Logistic Regression Analysis ◽  
High Grade ◽  
Intraductal Papillary Mucinous Neoplasms ◽  
Discrimination Power ◽  
Mucinous Neoplasms

Intraductal papillary mucinous neoplasms (IPMNs) are a heterogeneous group of neoplasms and represent the most common identifiable precursor lesions of pancreatic cancer. Clinical decision-making of the risk for malignant disease, including high-grade dysplasia and invasive carcinoma, is challenging. Moreover, discordance on the indication for resection exists between the contemporary guidelines. Furthermore, most of the current nomogram models for predicting malignant disease depend on endoscopic ultrasonography to evaluate the precise size of mural nodules. Thus, this study aimed to propose a model to predict malignant disease using variables from a noninvasive examination. We evaluated patients who underwent resection of pathologically confirmed IPMNs between November 2010 and December 2018 and had preoperative clinical data available for review. Based on binary multivariable logistic regression analysis, we devised a nomogram model to predict malignant IPMNs. The area under the receiver operating characteristics curve (AUC) was used to evaluate the discrimination power of the model. Of the 333 patients who underwent resection of IPMNs, 198 (59.5%) had benign and 135 (40.5%) had malignant IPMNs. Multivariable logistic regression analysis showed that cyst size, cyst location, cyst wall enhancement, multicystic lesion, diameter of main pancreatic duct, neutrophil-to-lymphocyte ratio, serum carbohydrate antigen 19-9, and carcinoembryonic antigen were significantly associated with malignancy. The nomogram, constructed based on these variables, showed excellent discrimination power with an AUC of 0.859 (95% CI: 0.818–0.900, P &lt; 0.001). In conclusion, we have developed a nomogram consisting of a combination of cross-sectional imaging features and blood markers, variables that can readily be obtained by noninvasive examinations during the surveillance period, which can distinguish benign from malignant IPMNs. Nevertheless, external validation is warranted.

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