Predictive Value of Serum Carbohydrate Antigen 19-9 in Malignant Intraductal Papillary Mucinous Neoplasms

2011 ◽  
Vol 35 (5) ◽  
pp. 1103-1109 ◽  
Author(s):  
Bin Xu ◽  
Wen-Yan Zheng ◽  
Da-Yong Jin ◽  
Wei-xing Ding ◽  
Wen-Hui Lou ◽  
...  
Keyword(s):  
Predictive Value ◽  
Carbohydrate Antigen ◽  
Intraductal Papillary Mucinous Neoplasms ◽  
Mucinous Neoplasms ◽  
Serum Carbohydrate Antigen

Predictive Value of Serum Carbohydrate Antigen 19-9 (CA19-9) for Early Mortality in Advanced Pancreatic Cancer

2017 ◽  
Vol 49 (4) ◽  
pp. 481-486 ◽  
Author(s):  
Pedro L. S. Usón Junior ◽  
Donato Callegaro-Filho ◽  
Diogo D. G. Bugano ◽  
Fernando Moura ◽  
Fernando C. Maluf
Keyword(s):  
Pancreatic Cancer ◽  
Predictive Value ◽  
Advanced Pancreatic Cancer ◽  
Carbohydrate Antigen ◽  
Early Mortality ◽  
Serum Carbohydrate Antigen

scholarly journals The association between serum ferritin levels and malignant intraductal papillary mucinous neoplasms

BMC Cancer ◽  
2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Xiaoling Zhuge ◽  
Hao Zhou ◽  
Liming Chen ◽  
Hui Chen ◽  
Xiao Chen ◽  
...  
Keyword(s):  
Serum Ferritin ◽  
Invasive Carcinoma ◽  
Elevated Serum ◽  
Area Under The Curve ◽  
Carbohydrate Antigen ◽  
High Serum ◽  
Tumor Biomarker ◽  
Intraductal Papillary Mucinous Neoplasms ◽  
Lesion Location ◽  
Mucinous Neoplasms

Abstract Background Serum ferritin levels are elevated in many malignancies. In this study, we showed the performance of serum ferritin in identifying malignant intraductal papillary mucinous neoplasms (IPMNs). Methods A total of 151 patients with pathologically confirmed IPMNs were enrolled. Serum tumor biomarker (carbohydrate antigen 19–9 (CA19–9) and carcinoembryonic antigen (CEA)) levels and serum ferritin levels were recorded. Lesion location, tumor size, diameter of the main pancreatic duct (MPD), mural nodule, and IPMN type, were collected from imaging examinations. IPMNs with high grade dysplasia and associated invasive carcinoma were considered malignant IPMNs. Results Serum ferritin levels in patients with malignant IPMNs were higher than those in patients with nonmalignant IPMNs (p <  0.05). Serum ferritin was an independent factor for the occurrence of malignant IPMNs (odds ratio (OR) = 1.18, 95% confidence interval (CI):1.01–1.39). A similar trend was found between high serum ferritin (> 149 ng/ml) and malignant IPMNs (OR = 5.64, 95% CI:1.78–17.92). The area under the curve (AUC) of serum ferritin was higher than that of CEA and CA19–9 in identifying malignant IPMNs (AUC = 0.67 vs. AUC = 0.58, 0.65). The combination of serum ferritin with IPMN type showed a similar performance to MPD diameter and the combination of serum CA19–9 with IPMN types in identifying malignant IPMNs (AUC = 0.78 vs. AUC = 0.79, 0.77) and invasive carcinoma (AUC = 0.77 vs. AUC = 0.79, 0.79). Conclusions Elevated serum ferritin is a factor associated with malignant IPMNs. Serum ferritin may be a useful marker for identifying malignancy in IPMNs.

scholarly journals The CT fish mouth ampulla sign: a highly specific finding in main duct and mixed intraductal papillary mucinous neoplasms

2019 ◽  
Vol 92 (1103) ◽  
pp. 20190461
Author(s):  
Ting Ting Zhang ◽  
Timothy J Sadler ◽  
Siobhan Whitley ◽  
Rebecca Brais ◽  
Edmund Godfrey
Keyword(s):  
Pancreatic Duct ◽  
Predictive Value ◽  
High Grade Dysplasia ◽  
High Grade ◽  
Main Duct ◽  
Intraductal Papillary Mucinous Neoplasms ◽  
Control Series ◽  
Duct Dilatation ◽  
Mucinous Neoplasms ◽  
Pancreatic Duct Dilatation

Objective: Main duct and mixed intraductal papillary mucinous neoplasms (IPMN) are pre-malignant cystic pancreatic neoplasms associated with pancreatic duct dilatation. Distinguishing these from benign causes of pancreatic duct dilatation is important in order to allow appropriate surveillance or surgery. A patulous duodenal papilla with extrusion of mucus at endoscopic evaluation, the endoscopic fish mouth ampulla (E-FMA) sign, is reported in main duct and mixed IPMN. We aimed to establish whether a CT correlate (CT-FMA) of this sign exists and whether this was associated with the presence of invasion or high-grade dysplasia. We defined the CT-FMA sign as an uninterrupted column of water attenuation material running from the pancreatic duct to the duodenal lumen. Methods: A retrospective, blinded review of 44 patients with histologically confirmed IPMN and 87 age-matched controls with pancreatic duct dilatation on CT was undertaken. A case–control series matched for the degree of pancreatic duct dilatation was used to compare the rates of invasion or high-grade dysplasia between main duct and mixed IPMN patients, with and without a CT-FMA sign. Results: The CT-FMA sign could be identified in 18.5% patients with main duct/mixed IPMN with specificity 100%, positive predictive value 100% and negative predictive value 79.8%. A significant association was found between CT-FMA in main duct/mixed IPMN compared to controls, but not with the presence of high-grade dysplasia or invasion. Conclusions: The CT-FMA sign is a newly reported, highly specific sign of MD and mixed IPMN. Advances in knowledge: If a fish mouth ampulla is identified at CT, a diagnosis of main duct or mixed IPMN is highly likely.

scholarly journals Cytological analysis of small branch-duct intraductal papillary mucinous neoplasms provides a more accurate risk assessment of malignancy than symptoms

CytoJournal ◽  
2011 ◽  
Vol 8 ◽  
pp. 21 ◽  
Author(s):  
Jill Ono ◽  
Kurt A. Yaeger ◽  
Muriel Genevay ◽  
Mari Mino-Kenudson ◽  
William R. Brugge ◽  
...  
Keyword(s):  
Predictive Value ◽  
High Threshold ◽  
Imaging Features ◽  
High Grade ◽  
Positive Cytology ◽  
Intraductal Papillary Mucinous Neoplasms ◽  
Branch Duct ◽  
Small Branch ◽  
Mucinous Neoplasms ◽  
Sensitivity Specificity

Objectives: The Sendai guidelines for management of patients with clinically suspected intraductal papillary mucinous neoplasms (IPMN) recommend resection of cysts > 30 mm, a dilated main pancreatic duct (MPD) > 6 mm, a mural nodule (MN), symptoms or positive cytology. Although sensitive, asymptomatic cysts, nonspecific symptoms, and a high threshold for positive cytology limit the specificity of the guidelines. We have assessed the value of cytology relative to symptom for predicting malignancy in IPMNs without high-risk imaging features. Materials and Methods: We retrospectively reviewed the clinical, radiological, and cytological data of 31 small branch-duct IPMNs without a MN. The cytological presence of high-grade atypical epithelial cells (HGA) was considered true positive, with a corresponding histology of high-grade dysplasia or invasive carcinoma. The performance of cytology versus symptoms was evaluated by calculating the sensitivity, specificity, negative predictive value (NPV), positive predictive value (PPV), and accuracy. Results: The sensitivity (0.80), specificity (0.85), and accuracy (0.84) of HGA were higher than the corresponding performance characteristics of symptoms (0.60, 0.45, and 0.48, respectively). The NPV of no HGA on cytology was > 95%. Conclusions: Cytology is a better predictor of malignancy than symptoms, for the conservative management of small branch-duct IPMNs. Cytology contributes to a highly accurate triple negative test for malignancy in small IPMN: No dilated MPD, MN or HGA.

Predictive value of low serum pancreatic enzymes in invasive intraductal papillary mucinous neoplasms

Pancreatology ◽  
2016 ◽  
Vol 16 (5) ◽  
pp. 893-899 ◽  
Author(s):  
Yosuke Yagi ◽  
Atsuhiro Masuda ◽  
Yoh Zen ◽  
Mamoru Takenaka ◽  
Hirochika Toyama ◽  
...  
Keyword(s):  
Predictive Value ◽  
Pancreatic Enzymes ◽  
Intraductal Papillary Mucinous Neoplasms ◽  
Mucinous Neoplasms ◽  
Low Serum

Intestinal Heterotopic Pancreas Involved by Simultaneous PanIN-2 Lesion and Endocrine Microadenoma: a Unique Case

2017 ◽  
Vol 26 (2) ◽  
pp. 199-202
Author(s):  
Remus Cornea ◽  
Sorina Taban ◽  
Cristian Suciu ◽  
Codruta Lazureanu ◽  
Alis Dema
Keyword(s):  
Histopathological Examination ◽  
Intraepithelial Neoplasia ◽  
Heterotopic Pancreas ◽  
Pancreatic Intraepithelial Neoplasia ◽  
Unique Case ◽  
Intraductal Papillary Mucinous Neoplasms ◽  
Pancreatic Endocrine Neoplasm ◽  
First Case ◽  
Mucinous Neoplasms

We hereby present the case of a 58-year-old male who underwent a total gastrectomy for gastric neoplasm. During the surgery, a tumor mass in the jejunum was identified, considered as metastasis, and resected. The histopathological examination of the jejunal lesion showed ectopic pancreas. In this area, two pathological distinct lesions were identified, one histologically compatible with pancreatic intraepithelial neoplasia (PanIN) type 2 lesion and the other with morphologic criteria for endocrine microadenoma. To our knowledge, this is the first case that evidences the presence of a concomitant premalignant exocrine lesion and benign endocrine lesion in a heterotopic pancreas (HP).Abbreviations: HP: heterotopic pancreas; IPMN: Intraductal Papillary Mucinous Neoplasms; PanIN: Pancreatic Intraepithelial Neoplasia; PEN: pancreatic endocrine neoplasm.

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