Comparison of ocular biometric measurements in patients with cataract using three swept-source optical coherence tomography devices

Abstract Background Precise measurement of ocular biometry is critical for determining intraocular lens power. Newly developed swept-source optical coherence tomography (SS-OCT) - based ocular biometric devices, ANTERION and CASIA2 provide ocular biometric measurements as IOLMaster 700. This study aimed to assess agreement between three devices. Methods This retrospective comparative study includes patients with cataract who underwent ocular biometric measurements with three devices, ANTERION, CASIA2, and IOLMaster 700, at Seoul National University Hospital, in April 2020. Anterior keratometry, total keratometry, central corneal thickness (CCT), anterior chamber depth (ACD), lens thickness (LT), and axial length (AL) were the main parameters for the comparison. To assess the agreement between the devices, intraclass coefficient (ICC) and Bland-Altman analysis with 95% limits of agreement (LoA) were used. Results A total of 47 eyes of 29 patients were measured with three devices. Average anterior keratometry showed excellent agreement (ICC ≥ 0.989), and the mean difference was less than 0.1 D. However, the ICC of the total average keratometry ranged from 0.808 to 0.952, and the difference was more than 0.43 D. The AL measured by ANTERION and IOLMaster 700 showed excellent agreement (ICC = 0.999), and the mean difference was 0.005 mm. The ANTERION and IOLMaster 700 did not obtain AL in six (12.8%) and three (6.4%) cases, respectively (P = 0.001 by Fisher’s exact test). The CCT, ACD, and LT also showed excellent agreement (ICC > 0.9). Conclusions The new SS-OCT-based devices, ANTERION, and CASIA2 showed a good agreement with IOLMaster 700 in measuring ocular biometry except for the total keratometry. The AL of ANTERION and IOLMaster 700 showed excellent agreement.

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Comparison of Central Corneal Thickness Measurements between Angiovue Optical Coherence Tomography, Ultrasound Pachymetry and Ocular Biometry

Ophthalmology Research An International Journal ◽

10.9734/or/2020/v13i430172 ◽

2020 ◽

pp. 1-9

Author(s):

E. Pateras ◽

A. I. Kouroupaki

Keyword(s):

Optical Coherence Tomography ◽

Central Corneal Thickness ◽

Corneal Thickness ◽

Repeated Measurements ◽

Optical Coherence ◽

Swept Source ◽

Ocular Biometry ◽

Significant Linear Correlation ◽

Ultrasound Pachymetry ◽

The Mean

Purpose: To compare central corneal thickness (CCT) measurements and their reproducibility when taken by Ultrasound Pachymetry, Ocular Biometry and Angiovue Optical Coherence Tomography (OCT). Methods: Twenty-five healthy volunteers were recruited creating a sample size of 50 eyes. All subjects had pachymetric measurements by Ultrasound pachymetry (PachPen Handheld Pachymeter, Keeler Instruments Inc), Ocular biometry (IOL Master 700 Swept Source Biometry, Zeiss) and Angiovue Optical Coherence Tomography (Optovue Avanti RTVue XR Angiovue). The measurements of central corneal thickness for the three devices were taken by the same examiner twice for more accuracy. Results: The average measurements of central corneal thickness by Ultrasound pachymetry (PachPen Handheld Pachymeter, Keeler Instruments Inc), Ocular biometry (IOL Master 700 Swept Source Biometry, Zeiss) and Angiovue Optical Coherence Tomography (Optovue Avanti RTVue XR Angiovue) were 547.26 μm, 551.36 μm, and 536.42 μm, respectively. The mean standard deviation (SD) of repeated measurements by Ocular biometry was 48.87 μm, which was greater than the mean SD of 44.24 μm and 40.35 μm (P < 0.001) by ultrasound pachymetry and Angiovue optical coherence tomography, respectively. There were statistically significant differences in the measurement results among the 3 methods (Ultrasound pachymetry vs. Ocular biometry P = 0.019; Ultrasound pachymetry vs. Angiovue Optical Coherence Tomography; P < 0.001; Ocular biometry vs. Angiovue Optical Coherence Tomography P < 0.001). There was a significant linear correlation between the Ultrasound pachymetry and Ocular biometry (r = 0.945, P<0.001), Ultrasound pachymetry and Angiovue Optical Coherence Tomography (r = 0.895, P<0.001), and Ocular biometry and Angiovue Optical Coherence Tomography (r = 0.902, P<0.001). Conclusion: Central corneal thickness readings were comparable between PachPen Handheld Pachymeter, IOL Master 700 Biometry and Angiovue Optical Coherence Tomography; Angiovue optical coherence tomography gave significantly smaller values. The measurements of the 3 methods showed significant linear correlations with one another. All methods provided acceptable repeatability of measurements.

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Reliability of a New Swept-Source Optical Coherence Tomography Biometer in Healthy Children, Adults, and Cataract Patients

Journal of Ophthalmology ◽

10.1155/2020/8946364 ◽

2020 ◽

Vol 2020 ◽

pp. 1-9 ◽

Cited By ~ 1

Author(s):

Jinhai Huang ◽

Yuyu Zhao ◽

Giacomo Savini ◽

Guanshun Yu ◽

Jinjin Yu ◽

...

Keyword(s):

Optical Coherence Tomography ◽

Corneal Thickness ◽

Anterior Chamber Depth ◽

Healthy Children ◽

Optical Coherence ◽

Swept Source ◽

Repeatability And Reproducibility ◽

Optical Biometer ◽

Cataract Patients ◽

Iolmaster 700

Purpose. To comprehensively assess the reliability of a new optical biometer (IOLMaster 700), based on swept-source optical coherence tomography (SS-OCT) and comparison with a standard biometer (IOLMaster 500), in healthy children, adults, and cataract patients. Methods. A total of 301 eyes from 301 consecutive subjects were enrolled prospectively. Two experienced operators measured each eye three times consecutively with the IOLMaster 700. The axial length (AL), keratometry (K), anterior chamber depth (ACD), lens thickness (LT), central corneal thickness (CCT), and white-to-white (WTW) distance were recorded. Intraoperator repeatability and interoperator reproducibility of the IOLMaster 700 were analyzed using the test-retest (TRT), coefficients of variation (CoV), and intraclass correlation coefficients (ICCs). The agreement between the two devices was evaluated using the Bland–Altman method. Results. The repeatability and reproducibility of the SS-OCT optical biometer were high for all ocular biometry parameters in all groups, except for the WTW in cataract patients (TRT, 0.27–0.44 mm; ICC, 0.86–0.95). The reproducibility of averaged measurements from three consecutive readings (TRT : AL = 0.02 mm, CCT = 5.41 μm, ACD = 0.03 mm, LT = 0.03 mm, Km = 0.17 D, and WTW = 0.22 mm) was higher than the reproducibility of single measurements (TRT : AL = 0.04 mm, CCT = 7.43 μm, ACD = 0.06 mm, LT = 0.05 mm, Km = 0.26 D, and WTW = 0.35 mm) in the three groups. The consistency in the data between the two biometers was high, with narrow 95% LoAs in the three groups. Conclusion. Repeatability and reproducibility of the new SS-OCT optical biometer were excellent and consistent with that of the standard biometer with respect to healthy children, healthy adults, and cataract patients.

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Displacement between anterior chamber width obtained by swept-source anterior segment optical coherence tomography and white-to-white distance

PLoS ONE ◽

10.1371/journal.pone.0251990 ◽

2021 ◽

Vol 16 (5) ◽

pp. e0251990

Author(s):

Teerajet Taechameekietichai ◽

Anwell Nguyen ◽

Sunee Chansangpetch ◽

Shan C. Lin

Keyword(s):

Optical Coherence Tomography ◽

Anterior Chamber ◽

Intraclass Correlation ◽

Anterior Segment ◽

Mean Difference ◽

Optical Coherence ◽

Limits Of Agreement ◽

Swept Source ◽

The Mean ◽

The Relationship

Purpose To determine the relationship between the external limbal location, represented by white-to-white (WTW) distance, and the actual angle location, represented by spur-to-spur (STS) and angle-to-angle (ATA) distances. Methods 166 eyes from 166 participants were imaged using CASIA2 anterior chamber optical coherence tomography (AS-OCT) and LenStar LS 900 optical biometer. The horizontal ATA and STS were measured using the swept-source Fourier-domain AS-OCT (CASIA2). The horizontal WTW was automatically measured using LenStar. The displacement lengths (DL) between WTW-STS and WTW-ATA were calculated. Bland-Altman plots and intraclass correlation were performed. Results The study showed that WTW has a positive correlation with STS (ICC = 0.82, p<0.001) and ATA (ICC = 0.82, p<0.001). The Bland-Altman analysis demonstrated that the mean difference of WTW-STS is 0.10 mm (95% CI 0.06 to 0.14 mm) with limits of agreement of -0.42 to 0.63 mm between WTW and STS, and the mean difference of WTW-ATA is 0.10 mm (95% CI 0.06 to 0.15 mm) with limits of agreement of -0.48 to 0.64 mm between WTW and ATA. Linear regression with adjustment showed that a WTW value greater than 12.07 mm is associated with a greater DL (WTW-STS DL ß 0.18, p = 0.003; WTW-ATA DL ß 0.14, p = 0.03). Conclusions Greater WTW was significantly associated with higher displacement of WTW from the two distances representing anterior chamber width. External limbal location may not accurately represent the actual angle location in eyes with larger WTW.

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Correlation between Central Corneal Thickness and Degree of Myopia among Malaysian Patients Undergoing Laser Keratorefractive Surgery

Journal of Advances in Medicine and Medical Research ◽

10.9734/jammr/2020/v32i2230705 ◽

2020 ◽

pp. 52-58

Author(s):

Sagili Chandrasekhara Reddy ◽

Mohd Mansor Shariff ◽

Aina Malindri Dasrilsyah

Keyword(s):

Optical Coherence Tomography ◽

Refractive Surgery ◽

Central Corneal Thickness ◽

Corneal Thickness ◽

Anterior Segment ◽

Military Hospital ◽

Moderate Degree ◽

Optical Coherence ◽

Corneal Refractive Surgery ◽

The Mean

Purpose: To determine the central corneal thickness in myopic adult patients scheduled for laser corneal refractive surgery and to explore its correlation with degree of refractive error. Materials and Methods: The case records of 130 myopic patients who underwent laser corneal refractive surgery in a military hospital over a period of two years were reviewed to determine the central corneal thickness. All patients had 6/6 vision with best correction, and did not have any other anterior segment or fundus diseases in both eyes. The central corneal thickness was measured with Visante Carl Zeiss anterior segment optical coherence tomography instrument. Results: Out of 130 patients, males were more (73, 56.2%); mean age of patients was 33.8 years (range 18-60 years) and majority were Malays (110, 84.6%). The spherical power of myopia ranged from – 0.5 to – 10.00 D, and the cylindrical power ranged from – 0.25 to – 3.25 D. The mean central corneal thickness of both eyes was 528.2 µm (range 331- 615 µm); in the mild degree of myopia (- 0.50 to - 2.00 D) 527.9 µm, moderate degree (- 2.25 to -5.00 D) 529.4 µm, and high degree (-5.25 to -11.00 D) 523.9 µm. Conclusion: The anterior segment optical coherence tomography provides noncontact, rapid, pachymetry mapping of the corneal thickness. In Malaysian patients, the mean central corneal thickness of both eyes in myopia was 528.1 µm (range 331- 615 µm). There was no correlation between the mean central corneal thickness and degree of myopia, different genders, age groups, ethnic groups and two eyes.

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