scholarly journals Prevalence and early-life determinants of mid-life multimorbidity: evidence from the 1970 British birth cohort

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Dawid Gondek ◽  
David Bann ◽  
Matt Brown ◽  
Mark Hamer ◽  
Alice Sullivan ◽  
...  
Keyword(s):  
Cohort Study ◽  
Confidence Interval ◽  
Birth Cohort ◽  
Risk Ratio ◽  
Early Life ◽  
Lower Risk ◽  
Alcohol Problems ◽  
Occupational Class ◽  
British Cohort Study ◽  
Prospective Longitudinal

Abstract Background We sought to: [1] estimate the prevalence of multimorbidity at age 46–48 in the 1970 British Cohort Study—a nationally representative sample in mid-life; and [2] examine the association between early-life characteristics and mid-life multimorbidity. Method A prospective longitudinal birth cohort of a community-based sample from the 1970 British Cohort Study (BCS70). Participants included all surviving children born in mainland Britain in a single week in April 1970; the analytical sample included those with valid data at age 46–48 (n = 7951; 2016–2018). The main outcome was multimorbidity, which was operationalised as a binary indicator of two or more long-term health conditions where at least one of these conditions was of physical health. It also included symptom complexes (e.g., chronic pain), sensory impairments, and alcohol problems. Results Prevalence of mid-life multimorbidity was 33.8% at age 46–48. Those with fathers from unskilled social occupational class (vs professional) at birth had 43% higher risk of mid-life multimorbidity (risk ratio = 1.43, 95% confidence interval 1.15 to 1.77). After accounting for potential child and family confounding, an additional kilogram of birthweight was associated with 10% reduced risk of multimorbidity (risk ratio = 0.90, 95% confidence interval 0.84 to 0.96); a decrease of one body mass index point at age 10 was associated with 3% lower risk (risk ratio = 1.03, 95% confidence interval 1.01 to 1.05); one standard deviation higher cognitive ability score at age 10 corresponded to 4% lower risk (risk ratio = 0.96, 95% confidence interval 0.91 to 1.00); an increase of one internalising problem at age 16 was equated with 4% higher risk (risk ratio = 1.04, 95% confidence interval 1.00 to 1.08) and of one externalising problem at age 16 with 6% higher risk (risk ratio = 1.06, 1.03 to 1.09). Conclusion Prevalence of multimorbidity was high in mid-life (33.8% at age 46–48) in Britain. Potentially modifiable early-life exposures, including early-life social circumstances, cognitive, physical and emotional development, were associated with elevated risk of mid-life multimorbidity.

scholarly journals Prevalence and early-life determinants of mid-life multimorbidity: evidence from the 1970 British birth cohort

2020 ◽  
Author(s):  
Dawid Gondek ◽  
David Bann ◽  
Matt Brown ◽  
Mark Hamer ◽  
Alice Sullivan ◽  
...  
Keyword(s):  
Cohort Study ◽  
Confidence Interval ◽  
Birth Cohort ◽  
Risk Ratio ◽  
Early Life ◽  
Lower Risk ◽  
Health Conditions ◽  
List Type ◽  
British Cohort Study ◽  
Nationally Representative

AbstractObjectivesWe sought to: (1) estimate the prevalence of multimorbidity at age 46-48 in the 1970 British Cohort Study—a nationally representative sample in mid-life; and (2) examine the association between early-life characteristics and mid-life multimorbidity in the 1970 British Cohort Study.DesignProspective longitudinal birth cohort.SettingA community based sample from the 1970 British Cohort Study (BCS70).ParticipantsAll surviving children born in mainland Britain in a single week in April 1970; the analytical sample was those with valid data at age 46-48 (n=7,951; 2016-2018).Main outcome measureMultimorbidity was operationalised as a binary indicator of two or more long-term health conditions where at least one of these conditions was of physical health. It also included symptom complexes (e.g. chronic pain), sensory impairments, and alcohol problems.ResultsPrevalence of mid-life multimorbidity was 33.8% at age 46-48. Those with fathers from unskilled social occupational class (vs. professional) at birth had 43% higher risk of mid-life multimorbidity (risk ratio=1.43, 95% confidence interval 1.15 to 1.70). After accounting for a range of potential child and family confounders, an additional kilogram of birthweight was associated with 10% reduced risk of multimorbidity (risk ratio=0.90, 95% confidence interval 0.84 to 0.96); a decrease of one body mass index point at age 10 was associated with 3% lower risk (risk ratio=1.03, 95% confidence interval 1.01 to 1.05); one standard deviation higher cognitive ability score at age 10 corresponded to 4% lower risk (risk ratio=0.96, 95% confidence interval 0.91 to 1.00); an increase of one internalising problem at age 16 was equated with 4% higher risk (risk ratio=1.04, 95% confidence interval 1.00 to 1.08) and of one externalising problem at age 16 with 6% higher risk (risk ratio=1.06, 1.03 to 1.09).ConclusionPrevalence of multimorbidity was high in mid-life (33.8% at age 46-48) in Britain, with those in a more disadvantaged social class a birth being disproportionally affected. Potentially modifiable early-life exposures including early-life social circumstances, cognitive, physical and emotional development were associated with mid-life multimorbidity.What is already known on this topic?Due to differences in outcome definition, estimates of multimorbidity prevalence in mid-life (age 40-60) have varied extensively in high-income countries—from 15 to 80% between 1961 and 2013.There is a lack of contemporary national data in Great Britain describing the burden and nature of multimorbidity according to an agreed definition.The association between early-life risk factors and individual health conditions have been widely studied, however it is unknown if they are associated with multimorbidity.What this study addsPrevalence of multimorbidity in mid-life (age 46-48) was 33.8% in a nationally representative birth cohort in 2016-2018.Disadvantaged early-life parental social class, lower birthweight, lower cognitive ability, higher childhood body-mass index, and a higher number of internalising and externalising problems were found to be associated with a higher mid-life multimorbidity.

Association between early-life factors and risk of child-onset Crohnʼs disease among victorian children born 1983–1998: A birth cohort study

2009 ◽  
Vol 15 (6) ◽  
pp. 858-866 ◽  
Author(s):  
Anne-Louise Ponsonby ◽  
Anthony G. Catto-Smith ◽  
Angela Pezic ◽  
Sandy Dupuis ◽  
Jane Halliday ◽  
...  
Keyword(s):  
Cohort Study ◽  
Birth Cohort ◽  
Early Life ◽  
Birth Cohort Study ◽  
Early Life Factors

Early-life patterns of sugar consumption and dental caries in the permanent teeth: a birth cohort study

2021 ◽  
Author(s):  
Carlos Alberto Feldens ◽  
Igor Fonseca dos Santos ◽  
Paulo Floriani Kramer ◽  
Márcia Regina Vítolo ◽  
Vanessa Simas Braga ◽  
...  
Keyword(s):  
Cohort Study ◽  
Dental Caries ◽  
Birth Cohort ◽  
Early Life ◽  
Permanent Teeth ◽  
Birth Cohort Study ◽  
Sugar Consumption ◽  
Life Patterns

The Study of Asian Women and their Offspring’s Development and Environmental Exposures (SAWASDEE): A northern Thailand birth cohort study (Preprint)

2021 ◽  
Author(s):  
Dana Barr ◽  
Nancy Fiedler ◽  
Tippawan Prapamontol ◽  
Panrapee Suttiwan ◽  
Warangkana Naksen ◽  
...  
Keyword(s):  
Cohort Study ◽  
Birth Cohort ◽  
Prenatal Exposure ◽  
Environmental Exposures ◽  
World Health ◽  
Birth Cohort Study ◽  
Asian Women ◽  
Northern Thailand ◽  
Prospective Longitudinal ◽  
The Impact

BACKGROUND Prenatal exposure to pesticides have been linked to adverse neurodevelopmental outcomes. Gaps exist in the current literature about the timing and magnitude of exposures that result in these adverse outcomes. OBJECTIVE The Study of Asian Women and their Offspring’s Development and Environmental Exposures (SAWASDEE) Cohort was established to investigate the impact of prenatal exposure to pesticides on neurodevelopment during infancy and early childhood in northern Thailand. METHODS Recruitment of this prospective, longitudinal birth cohort began in July 2017 and was completed in June 2019 in Chom Thong and Fang, two farming districts in Chiang Mai Province in northern Thailand. Follow up of the study participants is on-going. During pregnancy, seven questionnaires were administered. Time-resolved biospecimen samples were collected monthly (for urine) and during each trimester (for blood) at antenatal care visits. Medical records were abstracted. Infants were administered the NICU Network Neurobehavioral Scale (NNNS) test at one month of age. We will complete a number of additional exposure related analyses. RESULTS A total of 1298 women were screened and of those 394 women were enrolled. The mean gestational age at enrollment was 9.9 weeks (STD = 2.6). Differences in literacy were observed between Chom Thong and Fang participants. In Fang about 51% reported being able to read in Thai compared to about 95% in Chom Thong. The percentages were comparable for reporting to be able to write in Thai. A total of 322 mother-child pairs completed the NNNS. CONCLUSIONS This longitudinal birth cohort study will inform risk assessment standards for pregnant women in Thailand and other countries. Building awareness of how insecticide exposure during specific windows of pregnancy affects the neurodevelopmental trajectories of children in developing countries is a specific need recognized by the World Health Organization.

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