scholarly journals Novel biomarker genes which distinguish between smokers and chronic obstructive pulmonary disease patients with machine learning approach

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Kazushi Matsumura ◽  
Shigeaki Ito
PLoS ONE ◽  
2017 ◽  
Vol 12 (11) ◽  
pp. e0188532 ◽  
Author(s):  
Sumanth Swaminathan ◽  
Klajdi Qirko ◽  
Ted Smith ◽  
Ethan Corcoran ◽  
Nicholas G. Wysham ◽  
...  

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Junfeng Peng ◽  
Chuan Chen ◽  
Mi Zhou ◽  
Xiaohua Xie ◽  
Yuqi Zhou ◽  
...  

An amendment to this paper has been published and can be accessed via a link at the top of the paper.


2022 ◽  
Vol 14 (1) ◽  
pp. 0-0

Identifying chronic obstructive pulmonary disease (COPD) severity stages is of great importance to control the related mortality rates and reduce the associated costs. This study aims to build prediction models for COPD stages and, to compare the relative performance of five machine learning algorithms to determine the optimal prediction algorithm. This research is based on data collected from a private hospital in Egypt for the two calendar years 2018 and 2019. Five machine learning algorithms were used for the comparison. The F1 score, specificity, sensitivity, accuracy, positive predictive value and negative predictive value were the performance measures used for algorithms comparison. Analysis included 211 patients’ records. Our results show that the best performing algorithm in most of the disease stages is the PNN with the optimal prediction accuracy and hence it can be considered as a powerful prediction tool used by decision makers in predicting severity stages of COPD.


2017 ◽  
Vol 25 (3) ◽  
pp. 811-827 ◽  
Author(s):  
Dimitris Spathis ◽  
Panayiotis Vlamos

This study examines the clinical decision support systems in healthcare, in particular about the prevention, diagnosis and treatment of respiratory diseases, such as Asthma and chronic obstructive pulmonary disease. The empirical pulmonology study of a representative sample (n = 132) attempts to identify the major factors that contribute to the diagnosis of these diseases. Machine learning results show that in chronic obstructive pulmonary disease’s case, Random Forest classifier outperforms other techniques with 97.7 per cent precision, while the most prominent attributes for diagnosis are smoking, forced expiratory volume 1, age and forced vital capacity. In asthma’s case, the best precision, 80.3 per cent, is achieved again with the Random Forest classifier, while the most prominent attribute is MEF2575.


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