scholarly journals The value of transbronchial lung biopsy in the diagnosis of lymphangioleiomyomatosis

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Wenshuai Xu ◽  
Han Cui ◽  
Hongrui Liu ◽  
Ruie Feng ◽  
Xinlun Tian ◽  
...  
Keyword(s):  
Lung Biopsy ◽  
Diagnostic Value ◽  
Transbronchial Lung Biopsy ◽  
Safe Procedure ◽  
Telephone Interviews ◽  
Positive Rate ◽  
Grade Ii ◽  
The Difference ◽  
Diffuse Lung ◽  
Probable Diagnosis

Abstract Background Transbronchial lung biopsy (TBLB) in the diagnosis of lymphangioleiomyomatosis (LAM) is not a common approach, although TBLB is often performed in diffuse lung diseases. We aimed to examine the diagnostic value and safety of TBLB in LAM patients based on the data collected in our center. Methods We reviewed LAM patients registered in our LAM Clinic from December 8, 2006, to December 31, 2019. All patients with definite or probable diagnosis of LAM who had been examined using TBLB were included. All available pathology slides were reviewed by an experienced LAM pathologist. All complications were reviewed by the medical records and confirmed using telephone interviews. Results The pathology results of 86 patients (including 74 definite LAM and 12 probable LAM) were available. The positive rate of TBLB in LAM patients was 49/86 (57.0%). The positive rates of SMA, HMB-45, ER, and PR in LAM patients were 97.6%, 93%, 84.6%, and 78.4% respectively. The positive rate of TBLB was 40%, 60% and 60.8% in patients with CT Grade I, Grade II, and Grade III respectively, and the difference was not significant. Patients who had 3–4 or 5–6 biopsied specimens had a higher rate of diagnosis than those with 1–2 biopsied specimens. Four patients (5.6%) reported pneumothorax. No major hemoptysis was reported. Conclusions TBLB is a feasible and safe procedure for obtaining a pathological diagnosis of LAM. Taking more than 2 samples during the biopsy procedure increased the rate of diagnosis.

The Value of Transbronchial Lung Biopsy in the Diagnosis of Lymphangioleiomyomatosis

2020 ◽  
Author(s):  
wenshuai xu ◽  
han cui ◽  
hongrui Liu ◽  
ruie feng ◽  
Xinlun Tian ◽  
...  
Keyword(s):  
Lung Biopsy ◽  
Diagnostic Value ◽  
Transbronchial Lung Biopsy ◽  
Safe Procedure ◽  
Telephone Interviews ◽  
Positive Rate ◽  
Diffuse Lung Diseases ◽  
The Difference ◽  
Diffuse Lung ◽  
Probable Diagnosis

Abstract BACKGROUND: Transbronchial lung biopsy (TBLB) in the diagnosis of lymphangioleiomyomatosis (LAM) is not a common approach, although TBLB is often performed in diffuse lung diseases. We aimed to examine the diagnostic value and safety of TBLB in LAM patients based on the data collected in our center.METHODS: We reviewed LAM patients registered with the LAM Clinic in our hospital from December 8, 2006, to December 30, 2019. All patients with definite or probable diagnosis of LAM who had been examined using TBLB were included. All available pathology slides were reviewed by an experienced LAM pathologist. All complications were reviewed by the medical record and confirmed using telephone interviews.RESULTS: The pathology results of 86 patients (including 74 definite LAM and 12 probable LAM) were available. The positive rate of TBLB in LAM patients was 49/86 (57.0%). The positive rates of SMA, HMB-45, ER, and PR in LAM patients were 97.6%, 93%, 84.6%, and 78.4%, respectively. The positive rate of TBLB was 40%, 60% and 60.8% in mild, moderate, or severe LAM patients, respectively, and the difference was not significant. Patients who had 3-4 or 5-6 biopsied specimens had a higher rate of diagnosis than those with 1-2 biopsied specimens. Four patients (5.6%) reported pneumothorax. No major hemoptysis was reported.CONCLUSIONS: TBLB is a feasible and safe procedure for obtaining a pathological diagnosis of LAM. Taking more than 2 samples during the biopsy procedure increased the rate of diagnosis.

scholarly journals Diagnostic Value of Transbronchial Lung Biopsy: Including Diagnostic Yield According to Tumor-bronchus Relationship

2000 ◽  
Vol 48 (4) ◽  
pp. 438
Author(s):  
Tae Kyong Kang ◽  
Seung Lck Cha ◽  
Jae Yong Park ◽  
Sang Chul Chae ◽  
Chang Ho Kim ◽  
...  
Keyword(s):  
Lung Biopsy ◽  
Diagnostic Yield ◽  
Diagnostic Value ◽  
Transbronchial Lung Biopsy

Diagnostic Value of Follow-up Transbronchial Lung Biopsy after Lung Rejection

2001 ◽  
Vol 164 (3) ◽  
pp. 460-463 ◽  
Author(s):  
CHRISTINA L. ABOYOUN ◽  
MICHAEL TAMM ◽  
PRASHANT N. CHHAJED ◽  
PETER HOPKINS ◽  
MONIQUE A. MALOUF ◽  
...  
Keyword(s):  
Lung Biopsy ◽  
Diagnostic Value ◽  
Transbronchial Lung Biopsy

Transbronchial Lung Biopsy through the Fiberoptic Bronchoscope in Diffuse Lung Disease

1975 ◽  
Vol 84 (5) ◽  
pp. 596-601 ◽  
Author(s):  
Lee R. Joyner ◽  
David J. Scheinhorn
Keyword(s):  
Lung Disease ◽  
Lung Biopsy ◽  
Patient Management ◽  
Clinical Course ◽  
Diagnostic Value ◽  
Fiberoptic Bronchoscope ◽  
Diffuse Lung Disease ◽  
Forceps Biopsy ◽  
Parenchymal Disease ◽  
Diffuse Lung

Transbronchial forceps biopsy (TBB) of the lung through the fiberoptic bronchoscope was performed in 74 patients. A histological diagnosis compatible with the clinical course, and roentgenographic appearance was obtained in 47 (64%) patients. There were six cases with inadequate tissue and ten cases where TBB was both nondiagnostic and of no other benefit in the subsequent management of the patient. This procedure was of particular value in evaluation of acutely ill patients with diffuse parenchymal disease. TBB either gave a specific diagnosis or correctly influenced patient management in 14 (89%) of 16 acutely ill patients with diffuse parenchymal disease. There was no uncontrollable hemorrhage; in one patient (15%) pneumothorax occurred. The safety and diagnostic value of this technique in the diagnosis of diffuse lung disease is proven.

scholarly journals Diagnostic value of Breast Specific Gamma Imaging with semiquantitative index (T/N) in Breast Cancer Diagnosis

2018 ◽  
Vol 2 (1) ◽  
pp. 32-37
Author(s):  
Dipendra Kumar Mallik ◽  
Wei Zhang Hong ◽  
Wei Zhu ◽  
Ge Yang Wei ◽  
Lei Shen ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Visual Analysis ◽  
Ductal Carcinoma ◽  
Statistical Significance ◽  
Diagnostic Value ◽  
N Value ◽  
Gamma Imaging ◽  
Grade Ii ◽  
The Difference ◽  
Grade Iii

Objective: The study in this part was to evaluate the diagnostic value of Breast Specific Gamma Imaging (BSGI) by semi-quantitative method for detection of breast cancer. Methods: 400 patients with indeterminate breast tumors that underwent BSGI were enrolled in this study. All included lesions were confirmed by postoperative pathology. BSGI evaluation was based on the visual interpretation and semi-quantitative parameters of the higher tumor to non-lesion (T/N) value of CC and MLO. Compared with pathological results, the optimal visual analysis and the value of T/N were calculated through ROC curve analysis. Independent t-test and Pearson linear correlation were applied for statistical analysis. Results: Tumor to non-lesion (T/N) ratio was available for 279 out of 400 patients. This population comprised 203 patients with malignant and 74 patients with benign lesion. ROC analysis showed critical value of T/N= 1.91, AUC is 0.83 (standard error=0.014, 95% confidence interval); BSGI sensitivity is 83.71% and specificity is 76%. T/N ratio for invasive and non-invasive cancers are 2.70± 0.88, and 2.09±0.44 respectively; the difference between two have statistical significance (t=3.32, P=0.001). Infiltrating ductal carcinoma (IDC) grade I, grade II, and grade III have T/N ratio of 2.33±0.94, 2.38±0.80, 2.89±0.89 respectively. The T/N differences between grade I and grade II have no statistical significance (t=0.12, P=0.89). The T/N differences between grade I and grade III have no statistical significance (t=1.56, P=0.12). The T/N differences between grade II and grade III have statistical significance (t=3.69, P<0.001). T/N value for tumor size <1cm and >1cm were 1.97±0.79 and 2.46±0.88 respectively; the difference between two have statistical significance (t=3.27, P=0.001). Conclusion: The semi-quantitative index of T/N correlates with clinico-pathological characteristics of tumor like: size, grade, and invasiveness of breast cancer, and at certain level can be helpful to determine patient’s prognosis.

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