scholarly journals Characterization of bone metabolism in hungarian psoriatic arthritis patients: a case–control study

2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Zsófia Pethő ◽  
Edit Kalina ◽  
Zoltán Pap ◽  
Katalin Hodosi ◽  
Rebeka Falcsik ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Disease Activity ◽  
Bone Mineral ◽  
Osteoporotic Fracture ◽  
Case Control Study ◽  
Independent Predictor ◽  
Mineral Density ◽  
Major Osteoporotic Fracture ◽  
Volumetric Bmd ◽  
Control Study

Abstract Background Skeletal manifestations are predominant in psoriatic arthritis (PsA). The aim of this cross-sectional, case-control study is the complex assessment of areal and volumetric bone mineral density (BMD), fracture risk, vitamin D status and bone turnover markers, and its association with disease-related variables. Methods Lumbar spine (L1-L4) and femoral neck (FN) areal, and distal radius (DR) volumetric BMD, 10-year probability of major and hip osteoporotic fracture as assessed by the fracture risk assessment (FRAX) tool, markers of bone metabolism and disease activity were assessed. Results Upon comparison of the disease and age- and sex-matched control groups, there was a statistically significant difference in FN areal (0.952 (0.607–1.292) g/cm2 vs. 1.016 (0.760–1.550) g/cm2; p = 0.001) and DR total volumetric (284.3 (138.9–470.3) mg/cm3 vs. 367.0 (287.0–412.0) mg/cm3; p < 0.001) BMD, 10 year probability for major osteoporotic (3.7% (0.7–32%) vs. 2.6% (0–17.5%); p = 0.003) and hip (0.4% (0–16%) vs. 0.05% (0–6.1%); p = 0.002) fracture and 25-hydroxyvitamin D status (47.5 (10–120) nmol/L vs. 64 (10–137; p < 0.001) nmol/L). As compared to areal assessment, volumetric BMD measurements identified a significantly higher number of patients with low bone mineral density (T-Score ≤ − 1.00) (34% vs. 88%, p < 0.001). Upon multiple linear regression analysis, disease activity score, as determined by DAS28 assessment, was an independent predictor of 10-year probability for major osteoporotic fracture (B (95%CI) = 1.351 (0.379–2.323); p = 0.007). Conclusion In the studied PsA cohort, disease activity was an independent predictor of 10-year probability for a major osteoporotic fracture, and complemented assessment of volumetric and areal BMD assured better efficacy at identifying those with low bone mineral density.

Bone mineral density in Brazilian Midwest women recently diagnosed with breast cancer: A case-control study

2018 ◽  
Vol 92 ◽  
pp. S50
Author(s):  
R. De Freitas Junior ◽  
L.V. Gonçalves ◽  
R.M. Schingaglia ◽  
J. Godinho-Mota ◽  
K.A. Martins ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Bone Mineral Density ◽  
Bone Mineral ◽  
Case Control Study ◽  
Case Control ◽  
Mineral Density ◽  
Control Study

93 Does Spinal Bone Mineral Density Predict An Absolute 10 Year Probability of Sustaining A Major Osteoporotic Fracture

2021 ◽  
Vol 50 (Supplement_1) ◽  
pp. i12-i42
Author(s):  
A Nandi ◽  
N Obiechina ◽  
A Timperley ◽  
F Al-Khalidi
Keyword(s):  
Bone Mineral Density ◽  
Bone Mineral ◽  
Osteoporotic Fracture ◽  
Negative Correlation ◽  
Pearson Correlation ◽  
Fragility Fractures ◽  
Mineral Density ◽  
Major Osteoporotic Fracture ◽  
T Score ◽  
The Mean

Abstract Introduction Spine and hip bone mineral density (BMD) have previously been shown to predict the risk of sustaining future fractures. Although these have been shown in population studies, there is a paucity of trials looking at the relationship between BMD and 10 year probability of major osteoporotic fractures (Using FRAX UK without BMD) in patients with previous fragility fractures. Aims To evaluate the correlation between spinal T-score and an absolute 10 year probability of sustaining a major osteoporotic fracture (using FRAX without BMD) in patients with prior fragility fractures. Methods A retrospective cross-sectional analysis of 202 patients (29 males and 173 females) with prior fragility fractures attending a fracture prevention clinic between January and August 2019 was performed. Patients with pathological and high impact traumatic fractures were excluded. The BMD at the spine was determined using the lowest T-score of the vertebrae from L1 to L4. Using the FRAX (UK) without BMD, the absolute 10 year probability of sustaining a major osteoporotic fracture was calculated for each patient. Statistical analysis was performed using SPSS 26 software. Results The mean T-score at the spine was −1.15 (SD +/− 1.90) for all patients, −0.68 (SD +/− 0.45) for males and − 1.23 (SD +/− 0.14) for females. The mean FRAX score without BMD for major osteoporotic fracture was 18.5% (SD +/− 8.84) for all patients, 11.41% (SD +/−0.62) and 19.7% (SD +/−0.68) for males and females respectively. Pearson correlation coefficient showed a statistically significant, slightly negative correlation between spinal T- score and the FRAX (UK) without BMD (r = −0.157; p &lt; 0.05). Correlation was not statistically significant when males (r = 0.109; p = 0.59) and females (r = 0.148; p = 0.053) were considered independently. Conclusion In patients with prior fragility fracture spinal BMD has a statistically significant negative correlation with an absolute 10 year probability of sustaining a major osteoporotic fracture.

Vitamin D Status and Bone Mineral Density (BMD) and Its Relation With Severity of COPD: A Case Control Study

CHEST Journal ◽  
2013 ◽  
Vol 144 (4) ◽  
pp. 683A
Author(s):  
Gopi Khilnani ◽  
N Raj Kanna ◽  
Nandita Gupta ◽  
Vijay Hadda ◽  
Neetu Jain ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Vitamin D ◽  
Bone Mineral ◽  
Case Control Study ◽  
Case Control ◽  
Vitamin D Status ◽  
Mineral Density ◽  
Control Study

scholarly journals Evaluating Bone Health in Egyptian Children with Forearm Fractures: A Case Control Study

2016 ◽  
Vol 2016 ◽  
pp. 1-6 ◽  
Author(s):  
Abeer El-Sakka ◽  
Cristina Penon ◽  
Adham Hegazy ◽  
Salwa Elbatrawy ◽  
Amr Gobashy ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Vitamin D ◽  
Bone Mineral ◽  
Case Control Study ◽  
Case Control ◽  
Forearm Fractures ◽  
Mineral Density ◽  
Vitamin D Intake ◽  
Egyptian Children ◽  
Control Study

Objective. To determine the likelihood of vitamin D deficiency and low bone mineral density in Egyptian children with forearm fractures.Methods. A case control study of 46 children aged 3 to 10 years with or without forearm fractures. Validated questionnaires were used to assess calcium and vitamin D intake as well as sun exposure. Serum calcium, phosphorus, alkaline phosphatase, and 25-hydroxy-vitamin D were collected. Bone mineral density was evaluated using dual-energy X-ray absorptiometry.Results. Compared to the Control group, calcium and vitamin D intake was lower in the Cases group (p=0.03). Cases had higher Body Mass Index than Controls,p=0.01. Children in the Cases group had lower mean serum calcium values8.3±1.4compared to9.3±1.1in Controls (p=0.01). Alkaline phosphatase was higher in Cases265±65.8than Controls226±54.6(p=0.03). Vitamin D and bone mineral density scores were significantly lower in the Cases group (p<0.05).Conclusion. Our data shows an increased rate of vitamin D deficiency and decreased bone mineral density in Egyptian children with forearm fractures.

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