scholarly journals Primary malignant melanoma arising from ruptured ovarian mature cystic teratoma with elevated serum CA 19–9: a case report and review of literature

2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Won Ku Choi ◽  
Dong Hyun Lee ◽  
Dong Hyu Cho ◽  
Kyu Yun Jang ◽  
Kyoung Min Kim
Keyword(s):  
Malignant Melanoma ◽  
Malignant Tumors ◽  
Elevated Serum ◽  
Cystic Teratoma ◽  
Surgical Excision ◽  
Mature Cystic Teratoma ◽  
Primary Malignant Melanoma ◽  
Cystic Masses ◽  
Strong Immunoreactivity ◽  
Pleomorphic Cells

Abstract Background Ovarian mature cystic teratomas comprise tissues derived from all three germ layers. In rare incidences, malignant tumors may arise from ovarian mature cystic teratoma, which occurs in 0.2–1.8% of cases. A variety of tumors can arise within mature cystic teratoma, among which malignant melanoma is exceedingly rare. Case presentation A 42-year-old woman presented with abdominal pain. Transvaginal ultrasonography showed mixed echogenic cystic masses in both ovaries. Her serum cancer antigen (CA19–9) level was elevated at 29,770 U/ml. Surgical excision was performed. Histologic examination showed infiltrating nests of pleomorphic cells with prominent nucleoli and black pigments in the background of a mature cystic teratoma. These pleomorphic cells showed strong immunoreactivity for Melan-A and HMB-45. The patient was re-evaluated and the possibility of a melanoma at any other site was ruled out. Based on these findings, we concluded that the malignant melanoma originated from the ovarian mature cystic teratoma. Conclusion We report a rare case of primary malignant melanoma derived from an ovarian mature cystic teratoma.

scholarly journals Genetic Profiling of Malignant Melanoma Arising from an Ovarian Mature Cystic Teratoma: A Case Report

2021 ◽  
Vol 22 (5) ◽  
pp. 2436
Author(s):  
Kohei Nakamura ◽  
Eriko Aimono ◽  
Reika Takamatsu ◽  
Shigeki Tanishima ◽  
Tomonari Tohyama ◽  
...  
Keyword(s):  
Malignant Melanoma ◽  
Malignant Tumors ◽  
Cystic Teratoma ◽  
Homozygous Deletion ◽  
Mature Cystic Teratoma ◽  
Genetic Profiling ◽  
Improve Treatment ◽  
The Status ◽  
Genetic Mechanisms ◽  
Targeted Gene Sequencing

Ovarian mature cystic teratomas comprise tissues derived from all three germ layers. In rare cases, malignant tumors arise from ovarian mature cystic teratoma. A variety of tumors can arise from mature cystic teratoma, among which primary malignant melanoma (MM), for which no molecular analyses such as genomic sequencing have been reported to date, is exceedingly rare, thereby limiting possible therapeutic options using precision medicine. We used targeted gene sequencing to analyze the status of 160 cancer-related genes in a patient with MM arising from an ovarian mature cystic teratoma (MM-MCT). KRAS amplification and homozygous deletion in PTEN and RB1 were detected in tumor samples collected from the patient. No KRAS amplification has been previously reported in cutaneous MM, indicating that the carcinogenesis of MM-MCT differs from that of primary cutaneous melanomas. A better understanding of the underlying genetic mechanisms will help clarify the carcinogenesis of MM-MCT. In turn, this will enable treatment with novel targeting agents as well as the initial exploration of gene-based precision oncological therapies, which aim to improve treatment outcomes for patients with this disease.

Primary malignant melanoma arising from ovarian mature cystic teratoma: A case report and literature review

2010 ◽  
Vol 53 (9) ◽  
pp. 846 ◽  
Author(s):  
Jei-Won Moon ◽  
Ji Young Kim ◽  
You Jung Shin ◽  
Mi Young Lee ◽  
Hyuck Jae Choi ◽  
...  
Keyword(s):  
Case Report ◽  
Malignant Melanoma ◽  
Literature Review ◽  
Cystic Teratoma ◽  
Mature Cystic Teratoma ◽  
Primary Malignant Melanoma

scholarly journals Elevated serum CA 19-9 levels in dermoid cyst: a predictor of ovarian torsion and tissue necrosis?

2019 ◽  
Vol 8 (6) ◽  
pp. 2571
Author(s):  
Ruby Bhatia ◽  
Simmanjit Kaur ◽  
Sunita Mor ◽  
Naazbir Kaur ◽  
Ritika Gupta
Keyword(s):  
Dermoid Cyst ◽  
Ovarian Tissue ◽  
Elevated Serum ◽  
Cystic Teratoma ◽  
Exploratory Laparotomy ◽  
Carbohydrate Antigen ◽  
Mature Cystic Teratoma ◽  
Reproductive Age ◽  
Tissue Necrosis ◽  
Benign Condition

Dermoid cyst (mature cystic teratoma) with well differentiated derivatives of all the three-germ cell layer is a benign tumour with ovaries being the commonest site. Dermoid cyst accounts for more than half of ovarian tumours in girls below 20 years of age. 80% of dermoid cyst are seen in reproductive age group between 20-40 years. Size of dermoid cyst usually varies between 5-10 cm and it may be bilateral in 10% of cases. Malignant transformation is very rare occurrence only in 1-3% cases, however torsion may occur in 15% of dermoid cyst. Carbohydrate antigen or cancer antigen 19-9 is usually raised in gastrointestinal tumours, pancreatic malignancy, pseudocyst of pancreas. However, it may be raised in some other malignancies and benign condition like torsion of dermoid cyst. Authors report an unusual case of torsion large dermoid cyst with tissue necrosis along with significantly elevates levels of serum CA 19-9. A 30-year-old P1L1 female presented with chief complaint of heaviness and pain lower abdomen and loss of five kilogram weight for last three months. A provisional diagnosis of dermoid was made. Serum CA 19-9 level were 1126 IU significantly raised. An exploratory laparotomy done under regional anaesthesia. A large demoid cyst 12*10 cm with torsion and areas of gangrene in ovarian tissue was seen replacing left ovary. Large and small intestine, stomach, pancreas were explored to rule out any pathology. Histopathology confirmed diagnosis of mature cystic teratoma. There was significant fall in serum Ca 19-9 levels to 247 U/ml two weeks after surgery and levels returned to normal limit six weeks after surgery.

scholarly journals Primary retromolar malignant melanoma in a Latin American patient

2020 ◽  
Vol 48 (4) ◽  
pp. 030006052091924
Author(s):  
Carlos-Martín Ardila ◽  
Joan-Michael Arce-Jaramillo ◽  
Efraín Álvarez-Martínez
Keyword(s):  
Latin America ◽  
Malignant Melanoma ◽  
Latin American ◽  
Surgical Excision ◽  
Primary Malignant Melanoma ◽  
Ki 67 ◽  
Metastatic Lesions ◽  
Immunohistochemistry Staining ◽  
American Patient ◽  
Hmb 45

Primary malignant melanoma of the oral mucosa is rare and has scarcely been reported in patients from Latin America. The most frequently affected sites include the palate and gingiva of the maxilla. In this report, we describe primary malignant melanoma in a Latin American patient. A 3 × 3.5-cm black tumor was observed on the upper left retromolar area. The lesion exhibited a sessile base, irregular edges, soft consistency, and pain on palpation. Immunohistochemistry staining results were positive for S100 and HMB-45; the Ki-67 index was 20%. Contrast tomography of the skull, face, abdomen, and thorax, as well as ultrasound of the liver, did not reveal metastatic lesions. The patient underwent wide surgical excision of the lesion, followed by radiotherapy; he was subsequently rehabilitated with a somato prosthesis.

Elevated CA 19-9 Levels in Mature Cystic Teratoma of the Ovary

2009 ◽  
Vol 24 (1) ◽  
pp. 52-56 ◽  
Author(s):  
Min Sun Kyung ◽  
Joong Sub Choi ◽  
Seung Hwa Hong ◽  
Hak Soon Kim
Keyword(s):  
Tumor Markers ◽  
Elevated Serum ◽  
Cystic Teratoma ◽  
Ovarian Torsion ◽  
Mature Cystic Teratoma ◽  
Ca 125 ◽  
Clinical Value ◽  
Blood Samples ◽  
Serum Tumor Markers

The purpose of this study was to evaluate the clinical value of serum tumor markers in patients with ovarian mature cystic teratoma (MCT). We retrospectively evaluated 163 women who underwent surgery for MCT of the ovary between March 2003 and August 2007 and who provided preoperative blood samples for the measurement of CA 19-9 and CA 125. The rates of elevated serum CA 19-9 and CA 125 levels were 31.9% (52/163) and 13.5% (22/163), respectively. The rate of ovarian torsion was 12.9% (21/163). There were significant differences between the elevated CA 19-9 group and the normal CA 19-9 group in the diameters of the tumors and the rates of ovarian torsion. Elevated serum CA 19-9 levels correlated with larger tumor diameters and higher torsion rates. CA 19-9 may be a useful tool for the diagnosis of ovarian MCT. Elevated CA 19-9 levels appear to correlate with larger tumor diameters and higher rates of ovarian torsion.

31. A malignant melanoma arising in a mature cystic teratoma

Pathology ◽  
2014 ◽  
Vol 46 ◽  
pp. S116
Author(s):  
Kianoosh Noori Sarnie ◽  
Afaf Haddad ◽  
Denys Fortune
Keyword(s):  
Malignant Melanoma ◽  
Cystic Teratoma ◽  
Mature Cystic Teratoma
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