Correction to: Hepatoprotective effect of silymarin on fructose induced nonalcoholic fatty liver disease in male albino wistar rats

In parallel with the prevalence metabolic syndrome, nonalcoholic fatty liver disease (NAFLD) has become the most common chronic liver disease in most countries. It features a constellation of simple steatosis, nonalcoholic steatohepatitis (NASH), fibrosis, cirrhosis, and even hepatocellular carcinoma. There are no approved drugs for effective management of NAFLD and NASH. Jianpi Huoxue formula (JPHX) mainly consists of Atractylodes macrocephal(Baizhu), Salvia miltiorrhiza (Danshen), Rasux Paeonia Alba (Baishao), Rhizoma Alismatis (Zexie), and Fructus Schisandrae Chinensis (Wuweizi), which may have beneficial effects on NAFLD. The aim of the study was to identify the effect of JPHX on NAFLD.A NAFLD model was induced by methionine-choline-deficient food (MCD) in Wistar rats and orally administered with simultaneous JPHX, once a day for 8 weeks. Hepatocellular injury, lipid profile, inflammation, fibrosis, and apoptosis were evaluated. The results showed that JPHX significantly decreased the abnormal serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels compared with the MCD model (P<0.05). Furthermore, JPHX protected MCD diet-fed rats from accumulation of hepatic triglycerides (TG) and total cholesterol (TC). Histological examination demonstrated that JPHX noticeably normalized the NAFLD activity score (NAS). Moreover, JPHX ameliorated liver inflammation by decreasing TNF-αlevels and reduced collagen and matrix metalloproteinases in MCD diet-fed rats. In addition, JPHX prevented rats from MCD-induced cellular apoptosis, as suggested by TUNEL staining, and suppressed the activation of caspase 3 and 7 proteins. JPHX also inhibited the phosphorylation of JNK. In conclusion, JPHX exhibited a hepatoprotective effect against NAFLD in an MCD experimental model.

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Identification and differential expression of microRNAs associated with fat deposition in the liver of Wistar rats with nonalcoholic fatty liver disease

Gene ◽

10.1016/j.gene.2016.03.011 ◽

2016 ◽

Vol 585 (1) ◽

pp. 1-8 ◽

Cited By ~ 6

Author(s):

Deqing Zhang ◽

Yuqian Wang ◽

Zhibin Ji ◽

Zhonghua Wang

Keyword(s):

Liver Disease ◽

Fatty Liver ◽

Nonalcoholic Fatty Liver Disease ◽

Differential Expression ◽

Fatty Liver Disease ◽

Wistar Rats ◽

Fat Deposition ◽

Nonalcoholic Fatty Liver

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The Effects of a Fat- and Sugar-Enriched Diet and Chronic Stress on Nonalcoholic Fatty Liver Disease in Male Wistar Rats

Digestive Diseases and Sciences ◽

10.1007/s10620-009-1019-6 ◽

2009 ◽

Vol 55 (8) ◽

pp. 2227-2236 ◽

Cited By ~ 25

Author(s):

J.-h. Fu ◽

H.-s. Sun ◽

Y. Wang ◽

W.-q. Zheng ◽

Z.-y. Shi ◽

...

Keyword(s):

Liver Disease ◽

Fatty Liver ◽

Nonalcoholic Fatty Liver Disease ◽

Chronic Stress ◽

Fatty Liver Disease ◽

Wistar Rats ◽

Nonalcoholic Fatty Liver ◽

Male Wistar Rats

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β-ionone inhibits nonalcoholic fatty liver disease and its association with hepatocarcinogenesis in male Wistar rats

Chemico-Biological Interactions ◽

10.1016/j.cbi.2019.05.046 ◽

2019 ◽

Vol 308 ◽

pp. 377-384 ◽

Cited By ~ 1

Author(s):

Mayara Lilian Paulino Miranda ◽

Kelly Silva Furtado ◽

Fábia de Oliveira Andrade ◽

Renato Heidor ◽

Raquel Santana da Cruz ◽

...

Keyword(s):

Liver Disease ◽

Fatty Liver ◽

Nonalcoholic Fatty Liver Disease ◽

Fatty Liver Disease ◽

Wistar Rats ◽

Nonalcoholic Fatty Liver ◽

Male Wistar Rats

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Anti-inflammatory Mechanism of Ruzu Bitters on Diet-Induced Nonalcoholic Fatty Liver Disease in Male Wistar Rats

Evidence-based Complementary and Alternative Medicine ◽

10.1155/2020/5246725 ◽

2020 ◽

Vol 2020 ◽

pp. 1-8

Author(s):

Olubanke O. Ogunlana ◽

Oluseyi E. Ogunlana ◽

Tobi S. Adekunbi ◽

Babatunde O. Adetuyi ◽

Bose E. Adegboye ◽

...

Keyword(s):

Oxidative Stress ◽

Body Weight ◽

Liver Disease ◽

Fatty Liver ◽

Nonalcoholic Fatty Liver Disease ◽

Normal Saline ◽

Fatty Liver Disease ◽

Wistar Rats ◽

Nonalcoholic Fatty Liver ◽

Anti Inflammatory

Nonalcoholic fatty liver disease (NAFLD) has become notorious globally. Increasingly emerging evidence shows that NAFLD is strongly associated with inflammation, with proinflammatory cytokines such as interleukin-2 (IL-2), interleukin-6 (IL-6), and tumour necrosis factor-α (TNF-α) playing a vital role in its progression. In this work, an attempt was made to verify the anti-inflammatory activity of Ruzu herbal bitters (RHB), an antiobesity medicinal concoction, on NAFLD induced by a high-fat diet (HFD) in albino Wistar rats. Twenty-five (25) rats were divided into five groups as follows: Group 1, the normal control, was maintained on standard rat chow and received normal saline (1 ml/kg body weight (BW)/day) for twelve weeks. The other groups were maintained on HFD for twelve weeks. Thereafter, groups 2–5 were treated with pioglitazone (4 mg/kg BW/day), RHB (0.6 ml/kg BW/day), normal saline (1 ml/kg BW/day), and fenofibrate (10 mg/kg BW/day), respectively. The animals were sacrificed after the experimental period. Biochemical indicators of oxidative stress and inflammation were assayed in the liver according to standard methods. The histological features of the liver were also compared to assess liver damage. RHB significantly (p<0.05) reduced body weight and liver index, inhibited oxidative stress, boosted antioxidant enzymes by increasing the activity and level of SOD and GSH, reduced proinflammatory markers (IL-2, IL-6, TNF-α), and reversed histological alterations induced by NAFLD in rat liver. In conclusion, the anti-inflammatory activity of RHB in the prevention of NAFLD in rats has been confirmed.

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