scholarly journals Transient hypertriglyceridemia: a common finding during Epstein-Barr virus-induced infectious mononucleosis

2021 ◽  
Vol 20 (1) ◽  
Author(s):  
Emilio-Manuel Páez-Guillán ◽  
Joaquín Campos-Franco ◽  
Rosario Alende ◽  
Yago Garitaonaindía ◽  
Arturo González-Quintela
Keyword(s):  
Total Cholesterol ◽  
Acute Phase ◽  
Infectious Mononucleosis ◽  
Control Sample ◽  
Serum Triglyceride ◽  
Common Finding ◽  
Barr Virus ◽  
Cell Counts ◽  
Epstein Barr ◽  
White Blood Cell Counts

Abstract Background Hypertriglyceridemia can occur in lymphoproliferative disorders. Infectious mononucleosis is a self-limiting, benign lymphoproliferative disorder. This study aimed to investigate the serum triglyceride concentrations and their change over time in patients with infectious mononucleosis. Methods We evaluated an adult patient with severe hypertriglyceridemia (>1000 mg/dL) during infectious mononucleosis and reviewed the records of 360 patients admitted to our hospital because of infectious mononucleosis (median age, 19 years; range, 15-87 years; 51.4% male). We compared the serum triglyceride concentrations with those of a control sample from the general population (n=75). A second triglyceride measurement, obtained during convalescence (median of 30 days after the initial determination), was available for 160 patients. Results The triglyceride concentrations in the acute phase (median: 156 mg/dL) were significantly higher than those of the controls (median, 76 mg/dL; P<0.001). A total of 194 (53.9%) patients presented with hypertriglyceridemia (>150 mg/dL), which was more common in the patients older than 30 years than in the younger patients (78.6% vs. 50.6%; P<0.001). A significant correlation (P<0.005) was observed between the triglyceride levels and white blood cell counts, total cholesterol levels, and liver damage markers. The triglyceride concentrations decreased during convalescence (P<0.001) and were lower than the initial measurement in 83.7% of the cases. Conversely, the total cholesterol concentrations during the acute phase were lower than those of the controls and increased during convalescence (P<0.001). Conclusions Patients with severe infectious mononucleosis frequently show mild, transient hypertriglyceridemia. Further studies are needed to elucidate the mechanisms underlying this finding.

scholarly journals Hypertriglyceridemia during infectious mononucleosis

2021 ◽  
Author(s):  
Emilio Manuel Páez-Guillán ◽  
Joaquín Campos-Franco ◽  
Mª del Rosario Alende-Sixto ◽  
Yago Garitaonaindía-Díaz ◽  
Arturo González-Quintela
Keyword(s):  
Acute Phase ◽  
Infectious Mononucleosis ◽  
Time Course ◽  
Control Sample ◽  
Serum Triglyceride ◽  
Total Serum ◽  
Total Serum Cholesterol ◽  
Serum Triglycerides ◽  
Cell Counts ◽  
Clinical Records

Abstract Background Hypertriglyceridemia can be observed in lymphoproliferative disorders. Epstein-Barr virus-induced infectious mononucleosis can be considered a self-limiting lymphoproliferative disorder. The aim of this study is to investigate serum triglyceride concentrations, associated factors, and time-course changes in patients with infectious mononucleosis. Methods We report on an adult patient with extreme hypertriglyceridemia (triglycerides > 1000 mg/dL) during infectious mononucleosis. We then reviewed the clinical records of 360 patients admitted to the hospital due to infectious mononucleosis (median age 19 years, range 15–87 years; 51.4% male). Serum triglyceride concentrations were compared with those of a control sample from the general population, aged 18–30 years (n = 75). A second measurement of serum triglyceride concentrations, obtained during convalescence (median of 30 days after the initial determination), was available for 160 patients. Results Triglyceride concentrations in the acute phase (median 156 mg/dL; range, 27–452 mg/dL) were significantly higher than those of controls (P < 0.001). A total of 194 patients (53.9%) showed hypertriglyceridemia (triglycerides > 150 mg/dL), which was more common in the older patients. A significant correlation was observed between serum triglycerides and white blood cell counts, total cholesterol levels, and markers of liver damage. Serum triglyceride concentrations tended to decrease during convalescence (P < 0.001) and were lower than the initial measurement in 83.7% of the cases. Conversely, total serum cholesterol concentrations during the acute phase were lower than those of the controls and increased during convalescence (P < 0.001). Conclusions Patients with severe (in-hospital) infectious mononucleosis frequently show mild, transient hypertriglyceridemia. Further studies are needed to elucidate the mechanisms underlying these findings.

scholarly journals IMMUNOLOGIC INDEXES, ENZYME STATUS OF LYMPHOCYTES AND FUNCTIONAL ACTIVITY OF BLOOD NEUTROPHILS IN CHILDREN WITH INFECTIOUS MONONUCLEOSIS CAUSED BY EPSTEIN–BARR VIRUS

2013 ◽  
Vol 68 (7) ◽  
pp. 42-46
Author(s):  
L. M. Kurtasova ◽  
A. E. Tolstikova ◽  
A. A. Savchenko
Keyword(s):  
Acute Phase ◽  
Infectious Mononucleosis ◽  
Peripheral Blood ◽  
Epstein Barr Virus ◽  
Activity Levels ◽  
Immunological Parameters ◽  
Blood Lymphocytes ◽  
Barr Virus ◽  
Blood Neutrophils ◽  
Epstein Barr

Aim. Explore the immunological parameters, levels of activity of NAD(P)-dependent dehydrogenases lymphocytes, interferon status parameters, phagocytic activity and chemiluminescence response of neutrophils in the blood of children in the acute phase of infectious mononucleosis caused by the Epstein-Barr virus. Patients and methods. 65 children at the age of 4–6 years old with infectious mononucleosis caused by EBV in acute phase were observed. Such indexes as cell-mediated, humoral and interferon immunity, NAD(P)-depended dehydrogenases activity in blood lymphocyte, phagocytes activity, levels of spontaneous and induced chemiluminescence of peripheral blood neutrophils were studied. Results. Children with EVB-infection have immunophenotype spectrum changes and changes of enzymes status of blood lymphocytes against the increasing in leucocytes and the useful increasing in lymphocytes. The useful increasing in IgA, IgM, IgG contenting in serum blood were found. The decreasing of spontaneous production of IFN α and the decreasing of induced production of IFN α, IFN γ were determined. The breach of phagocytes activity and chemiluminescent response of blood neutrophils were found. Conclusions. The children in the acute phase of infectious mononucleosis caused by the Epstein-Barr virus, there are changes in the immune status, changes the activity of NAD(P)-dependent dehydrogenases in blood lymphocytes, marked changes in functional and metabolic state of peripheral blood neutrophils. 

Diagnosis of infectious mononucleosis caused by Epstein-Barr virus in infants

2010 ◽  
Vol 52 (4) ◽  
pp. 536-540 ◽  
Author(s):  
Sumitaka Dohno ◽  
Akihiko Maeda ◽  
Yoshihito Ishiura ◽  
Tetsuya Sato ◽  
Mikiya Fujieda ◽  
...  
Keyword(s):  
Infectious Mononucleosis ◽  
Epstein Barr Virus ◽  
Barr Virus ◽  
Epstein Barr

scholarly journals Acute Acalculous Cholecystitis Due to a Primary Epstein Barr Virus Infection in a Pediatric Patient

2021 ◽  
Vol 13 (1) ◽  
pp. 86-90
Author(s):  
Carlos Leganés Villanueva ◽  
Ilaria Goruppi ◽  
Nuria Brun Lozano ◽  
Federica Bianchi ◽  
María Quinteiro González ◽  
...  
Keyword(s):  
Infectious Mononucleosis ◽  
Epstein Barr Virus ◽  
Acalculous Cholecystitis ◽  
Acute Acalculous Cholecystitis ◽  
Epstein Barr Virus Infection ◽  
Barr Virus ◽  
Acute Complications ◽  
Epstein Barr ◽  
Barr Virus Infection ◽  
Human Viruses

Epstein–Barr virus (EBV) is estimated to infect more than 98% of adults worldwide and is one of the most common human viruses. Acute acalculous cholecystitis (AAC) of the gallbladder is an atypical complication of infectious mononucleosis caused by EBV. Conservative management has been described in the context of AAC caused by EBV. A surgical approach must be considered in the case of acute complications such as perforation or gallbladder gangrene. We present the case of a 10-year-old female patient with AAC due to infectious mononucleosis syndrome caused by primary EBV infection.

scholarly journals Establishment and Maintenance of Gammaherpesvirus Latency Are Independent of Infective Dose and Route of Infection

2003 ◽  
Vol 77 (13) ◽  
pp. 7696-7701 ◽  
Author(s):  
Scott A. Tibbetts ◽  
Joy Loh ◽  
Victor van Berkel ◽  
James S. McClellan ◽  
Meagan A. Jacoby ◽  
...  
Keyword(s):  
Acute Phase ◽  
Latent Infection ◽  
Ex Vivo ◽  
Latent Infections ◽  
Human Pathogens ◽  
Infectious Dose ◽  
Murine Gammaherpesvirus ◽  
Barr Virus ◽  
Route Of Infection ◽  
Epstein Barr

ABSTRACT Gammaherpesviruses such as Epstein-Barr virus and Kaposi's sarcoma-associated herpesvirus are important human pathogens that establish long-term latent infections. Understanding of the initiation and maintenance of latent infections has important implications for the prevention and treatment of gammaherpesvirus-related diseases. Although much is known about gammaherpesvirus pathogenesis, it is unclear how the infectious dose of a virus influences its ability to establish latent infection. To examine the relationship between the infectious dose and gammaherpesvirus latency, we inoculated wild-type mice with 0.01 to 106 PFU of murine gammaherpesvirus 68 (γHV68) and quantitatively measured latency and acute-phase replication. Surprisingly, during latency, the frequencies of ex vivo reactivation were similar over a 107-fold range of doses for i.p. infection and over a 104-fold range of doses for intranasal infection. Further, the frequencies of cells harboring viral genome during latency did not differ substantially over similar dose ranges. Although the kinetics of acute-phase replication were delayed at small doses of virus, the peak titer did not differ significantly between mice infected with a large dose of virus and those infected with a small dose of virus. The results presented here indicate that any initiation of infection leads to substantial acute-phase replication and subsequent establishment of a maximal level of latency. Thus, infections with doses as small as 0.1 PFU of γHV68 result in stable levels of acute-phase replication and latent infection. These results demonstrate that the equilibrium level of establishment of gammaherpesvirus latency is independent of the infectious dose and route of infection.

Sign in / Sign up

Export Citation Format

Share Document