scholarly journals Hypertriglyceridemia during infectious mononucleosis

2021 ◽  
Author(s):  
Emilio Manuel Páez-Guillán ◽  
Joaquín Campos-Franco ◽  
Mª del Rosario Alende-Sixto ◽  
Yago Garitaonaindía-Díaz ◽  
Arturo González-Quintela
Keyword(s):  
Acute Phase ◽  
Infectious Mononucleosis ◽  
Time Course ◽  
Control Sample ◽  
Serum Triglyceride ◽  
Total Serum ◽  
Total Serum Cholesterol ◽  
Serum Triglycerides ◽  
Cell Counts ◽  
Clinical Records

Abstract Background Hypertriglyceridemia can be observed in lymphoproliferative disorders. Epstein-Barr virus-induced infectious mononucleosis can be considered a self-limiting lymphoproliferative disorder. The aim of this study is to investigate serum triglyceride concentrations, associated factors, and time-course changes in patients with infectious mononucleosis. Methods We report on an adult patient with extreme hypertriglyceridemia (triglycerides > 1000 mg/dL) during infectious mononucleosis. We then reviewed the clinical records of 360 patients admitted to the hospital due to infectious mononucleosis (median age 19 years, range 15–87 years; 51.4% male). Serum triglyceride concentrations were compared with those of a control sample from the general population, aged 18–30 years (n = 75). A second measurement of serum triglyceride concentrations, obtained during convalescence (median of 30 days after the initial determination), was available for 160 patients. Results Triglyceride concentrations in the acute phase (median 156 mg/dL; range, 27–452 mg/dL) were significantly higher than those of controls (P < 0.001). A total of 194 patients (53.9%) showed hypertriglyceridemia (triglycerides > 150 mg/dL), which was more common in the older patients. A significant correlation was observed between serum triglycerides and white blood cell counts, total cholesterol levels, and markers of liver damage. Serum triglyceride concentrations tended to decrease during convalescence (P < 0.001) and were lower than the initial measurement in 83.7% of the cases. Conversely, total serum cholesterol concentrations during the acute phase were lower than those of the controls and increased during convalescence (P < 0.001). Conclusions Patients with severe (in-hospital) infectious mononucleosis frequently show mild, transient hypertriglyceridemia. Further studies are needed to elucidate the mechanisms underlying these findings.

scholarly journals Transient hypertriglyceridemia: a common finding during Epstein-Barr virus-induced infectious mononucleosis

2021 ◽  
Vol 20 (1) ◽  
Author(s):  
Emilio-Manuel Páez-Guillán ◽  
Joaquín Campos-Franco ◽  
Rosario Alende ◽  
Yago Garitaonaindía ◽  
Arturo González-Quintela
Keyword(s):  
Total Cholesterol ◽  
Acute Phase ◽  
Infectious Mononucleosis ◽  
Control Sample ◽  
Serum Triglyceride ◽  
Common Finding ◽  
Barr Virus ◽  
Cell Counts ◽  
Epstein Barr ◽  
White Blood Cell Counts

Abstract Background Hypertriglyceridemia can occur in lymphoproliferative disorders. Infectious mononucleosis is a self-limiting, benign lymphoproliferative disorder. This study aimed to investigate the serum triglyceride concentrations and their change over time in patients with infectious mononucleosis. Methods We evaluated an adult patient with severe hypertriglyceridemia (>1000 mg/dL) during infectious mononucleosis and reviewed the records of 360 patients admitted to our hospital because of infectious mononucleosis (median age, 19 years; range, 15-87 years; 51.4% male). We compared the serum triglyceride concentrations with those of a control sample from the general population (n=75). A second triglyceride measurement, obtained during convalescence (median of 30 days after the initial determination), was available for 160 patients. Results The triglyceride concentrations in the acute phase (median: 156 mg/dL) were significantly higher than those of the controls (median, 76 mg/dL; P<0.001). A total of 194 (53.9%) patients presented with hypertriglyceridemia (>150 mg/dL), which was more common in the patients older than 30 years than in the younger patients (78.6% vs. 50.6%; P<0.001). A significant correlation (P<0.005) was observed between the triglyceride levels and white blood cell counts, total cholesterol levels, and liver damage markers. The triglyceride concentrations decreased during convalescence (P<0.001) and were lower than the initial measurement in 83.7% of the cases. Conversely, the total cholesterol concentrations during the acute phase were lower than those of the controls and increased during convalescence (P<0.001). Conclusions Patients with severe infectious mononucleosis frequently show mild, transient hypertriglyceridemia. Further studies are needed to elucidate the mechanisms underlying this finding.

scholarly journals Lipolytic Postbiotic from Lactobacillus paracasei Manages Metabolic Syndrome in Albino Wistar Rats

Molecules ◽  
2021 ◽  
Vol 26 (2) ◽  
pp. 472
Author(s):  
Ali Osman ◽  
Nashwa El-Gazzar ◽  
Taghreed N. Almanaa ◽  
Abdalla El-Hadary ◽  
Mahmoud Sitohy
Keyword(s):  
Metabolic Syndrome ◽  
Lipid Metabolism ◽  
Lipolytic Activity ◽  
Control Level ◽  
Serum Triglyceride ◽  
Positive Control ◽  
Lactobacillus Paracasei ◽  
Total Serum ◽  
Albino Rats ◽  
Total Serum Cholesterol

The current study investigates the capacity of a lipolytic Lactobacillus paracasei postbiotic as a possible regulator for lipid metabolism by targeting metabolic syndrome as a possibly safer anti-obesity and Anti-dyslipidemia agent replacing atorvastatin (ATOR) and other drugs with proven or suspected health hazards. The high DPPH (1,1-diphenyl-2-picrylhydrazyl) and ABTS [2,2′-azino-bis (3-ethyl benzothiazoline-6-sulphonic acid)] scavenging activity and high activities of antioxidant enzyme such as superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-px) of the Lactobacillus paracasei postbiotic (cell-free extract), coupled with considerable lipolytic activity, may support its action against metabolic syndrome. Lactobacillus paracasei isolate was obtained from an Egyptian cheese sample, identified and used for preparing the postbiotic. The postbiotic was characterized and administered to high-fat diet (HFD) albino rats (100 and 200 mg kg−1) for nine weeks, as compared to atorvastatin (ATOR; 10 mg kg−1). The postbiotic could correct the disruption in lipid metabolism and antioxidant enzymes in HFD rats more effectively than ATOR. The two levels of the postbiotic (100 and 200 mg kg−1) reduced total serum lipids by 29% and 34% and serum triglyceride by 32–45% of the positive control level, compared to only 25% and 35% in ATOR’s case, respectively. Both ATOR and the postbiotic (200 mg kg−1) equally decreased total serum cholesterol by about 40% and 39%, while equally raising HDL levels by 28% and 30% of the positive control. The postbiotic counteracted HFD-induced body weight increases more effectively than ATOR without affecting liver and kidney functions or liver histopathology, at the optimal dose of each. The postbiotic is a safer substitute for ATOR in treating metabolic syndrome.

Enzyme Induction and Serum and Lipoprotein Lipids: A Study of Glutethimide in Normal Subjects

1980 ◽  
Vol 58 (5) ◽  
pp. 419-421 ◽  
Author(s):  
C. H. Bolton ◽  
LYN Jackson ◽  
C. J. C. Roberts ◽  
M. Hartog
Keyword(s):  
Enzyme Induction ◽  
Time Course ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Lipoprotein Cholesterol ◽  
Total Serum ◽  
Total Serum Cholesterol ◽  
Low Density ◽  
Acid Excretion ◽  
Glucaric Acid

1. Serum and lipoprotein cholesterol and triglycerides were measured before, during and after the administration of glutethimide (500 mg daily) for 21 days to six healthy volunteer subjects. 2. Evidence of enzyme induction was provided by significant rises in d-glucaric acid excretion and antipyrine clearance. 3. Concentrations of total serum cholesterol, very-low-density-lipoprotein-, low-density-lipoprotein-and high-density-lipoprotein-cholesterol rose significantly during treatment. 4. The time course of these changes was delayed in comparison with the rise and fall in d-glucaric acid excretion. 5. There was no change in the triglyceride content of either whole serum or lipoprotein fractions at any time during the trial. 6. The study provides further evidence that enzyme-inducing agents cause a rise in certain lipid concentrations.

scholarly journals Evaluation of some biochemical changes in the serum of phensedyl addicts of Gaibandha District, Bangladesh

2014 ◽  
Vol 20 ◽  
pp. 57-65
Author(s):  
Md Rashidul Hasan ◽  
Parvez Hassan ◽  
Md Abdul Jalil Miah
Keyword(s):  
Serum Cholesterol ◽  
Biochemical Parameters ◽  
Ldl Cholesterol ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Serum Triglyceride ◽  
Hdl Cholesterol ◽  
Total Serum ◽  
Total Serum Cholesterol ◽  
P Value

Context: Abuse of the drug, Phensedyl like any other drug might exert adverse effects on vital organs of th e h u m an body like liver, kidney and heart. Objectives: To determine the effects of Phensedyl intake on the serum biochemical parameters of the addicts in order to access for damages of vital human organs like liver, kidney and heart. Materials and Methods: Study population consisted of 127 male Phensedyl addicts within the ages of 18–55 years of defined criteria from Gaibandha district, a Northern part of Bangladesh, during July 2009 to December 2011. Fifty (50) non-drug dependent healthy men of matched age, height, and socioeconomic status were included as controls from the same community. Biochemical parameters analyzed were – Serum creatinine, SGOT, SGPT and Lipid profiles (total serum cholesterol (TC), Serum triglyceride (TG), serum high-density lipoprotein (HDL) and low-density lipoprotein (LDL) cholesterol determined by semiautomatic biochemistry analyzer using commercially available kits Results: Abuse of Phensedyl appears not to hamper the normal renal and liver function in most of the addicts even after 8 years of Phensedyl intake irrespective of age except in case of 4 abusers. Serum total cholesterol (TC) remained almost unchanged among the addicts abusing Phensedyl for less than 8 years. But very strikingly, addicts taking Phensedyl for more than 8 years had higher trends in serum cholesterol i.e. more than 200 ml/dl. Of the addict’s, 44.36% abusing Phensedyl for less than 8 years had normal triglyceride (TG) values whereas, in 45.66% addicts abusing the drug for more than 8 years had clinically very significantly elevated triglyceride levels, which was also found to be statistically very significant (p value =0.0001), indicating the risk of developing cardiac diseases. Of the total addicts 53.53% had low levels of HDL cholesterol, which is clinically and statistically found to be very significant (p value =0.002). Of the addict’s 43% taking the drug for less than 8 years had normal LDL levels but significantly elevated values were recorded in 34% of the abusers who had been taking the drug for more than 8 years. Conclusion: Long time (> 8 years) Phensedyl abusers are at the high risk of developing Brain stroke, Coronary Heart Disease (CHD), Ischemic stroke or transient ischemic attack (TIA) as there is the triad of: Elevated LDL cholesterol, Low HDL cholesterol and elevated Triglyceride. DOI: http://dx.doi.org/10.3329/jbs.v20i0.17656 J. bio-sci. 20: 57-65, 2012

scholarly journals Genetic risk prediction in a small cohort of healthy adults in Atlanta

2013 ◽  
Vol 95 (1) ◽  
pp. 30-37 ◽  
Author(s):  
JING ZHAO ◽  
DALIA ARAFAT ◽  
KENNETH L. BRIGHAM ◽  
GREG GIBSON
Keyword(s):  
Genetic Risk ◽  
Well Being ◽  
Risk Scores ◽  
Total Serum ◽  
Total Serum Cholesterol ◽  
Unexpected Finding ◽  
Nucleotide Polymorphisms ◽  
Multiple Trait ◽  
Serum Triglycerides ◽  
Polygenic Scores

SummaryCompared with single markers, polygenic scores that evaluate the joint effects of multiple trait-associated variants are more effective in explaining the variance of traits and risk of diseases. In total, 182 CHDWB (Emory-Georgia Tech Center for Health Discovery and Well Being study) adults were genotyped to investigate the common variant contributions to three traits (height, BMI, serum triglycerides) and three diseases (coronary artery disease (CAD), type 2 diabetes (T2D) and asthma). Association was contrasted between weighted and simple allelic sum polygenic scores with quantitative traits, and with the Framingham risk scores for CAD and T2D. Although the cohort size is two or three orders of magnitude smaller than typical discovery cohorts, we were able to detect significant associations and to explain up to 5% of the traits by the genetic risk scores, despite a strong influence of outliers. An unexpected finding was that CAD-associated single nucleotide polymorphisms (SNPs) explain a significant amount of the variation for total serum cholesterol. Forward step-wise sequential addition of SNPs into the regression model showed that the top-ranked SNPs explain a large proportion of variance, whereas inclusion of gender and ethnicity also affect the performance of polygenic scores.

Enzymic serum cholesterol measurement with a basic autoanalyzer and Du Pont aca method.

1978 ◽  
Vol 24 (9) ◽  
pp. 1624-1627 ◽  
Author(s):  
B Fingerhut
Keyword(s):  
Serum Cholesterol ◽  
Continuous Flow ◽  
Flow System ◽  
Serum Triglyceride ◽  
Total Serum ◽  
Total Serum Cholesterol ◽  
Serum Triglyceride Concentration ◽  
Clinically Significant ◽  
Significant Interference ◽  
Cholesterol Measurement

Abstract I compared enzymic methods for total serum cholesterol as used with discrete (Du Pont aca and reagent packs) and continuous-flow (Boehringer Mannheim reagents and the Technicon AuotAnalyzer I) analysis of normal, icteric, and lipemic sera. The regression equation for 24 clear, non-icteric sera was: y (continuous flow) = 0.944x (aca) + 10.69; r = 0.971, Syx +/- 53.7 mg of cholesterol per liter. The continuous-flow system indicated no significant interference when as much as 350 mg of bilirubin was added per liter. Results with the aca method indicated a decrease in apparent cholesterol of about 5 mg/liter per milligram of added bilirubin. Serial diluting of lipemic sera resulted in falsely higher values with the aca method but no clinically significant effect on results with the AutoAnalyzer procedure. Apparent cholesterol as measured with the aca became proportionately greater than AutoAnalyzer values with increasing serum triglyceride concentration.

Results of a Phase IV Study Carried Out with Acipimox in Type II Diabetic Patients with Concomitant Hyperlipoproteinaemia

1989 ◽  
Vol 17 (4) ◽  
pp. 373-380 ◽  
Author(s):  
M. Lavezzari ◽  
G. Milanesi ◽  
E. Oggioni ◽  
F. Pamparana
Keyword(s):  
Adverse Events ◽  
Fasting Blood Glucose ◽  
Lipid Lowering ◽  
Total Serum ◽  
Total Serum Cholesterol ◽  
Diabetic Patients ◽  
Slight Reduction ◽  
Type Ii ◽  
Serum Triglycerides ◽  
Phase Iv

The aim of this phase IV study was to assess the tolerability and efficacy of acipimox, a lipid-lowering drug, in 3009 type II diabetic out-patients with types II and IV hyperlipoproteinaemia. The study was carried out by 150 Italian diabetes centres. Acipimox was given at the dosage of one capsule (250 mg), two or three times daily for at least 2 months. Acipimox produced a mean fall of 43% in serum triglycerides and of 18% in total serum cholesterol levels compared with baseline. The lipid-lowering effect was present throughout treatment, but was most pronounced at the end of treatment. An increase in the serum concentration of high density lipoprotein cholesterol (15%) was also observed at the end of the trial. Fasting blood glucose and glycosylated haemoglobin levels showed a slight reduction during the study. Adverse events were reported in 263 (8.8%) cases and 165 (5.4%) patients discontinued the treatment. The female trial population showed a nearly two-fold greater incidence of adverse events than the males. In the majority of cases the adverse events experienced by patients were transient episodes of flushing and mild gastro-intestinal disturbances (e.g. gastric pain and pyrexia).

Growth, Fecundity, and Energy Stores of White Sucker (Catostomus commersoni) from Lakes Containing Elevated Levels of Copper and Zinc

1988 ◽  
Vol 45 (8) ◽  
pp. 1355-1365 ◽  
Author(s):  
K. R. Munkittrick ◽  
D. G. Dixon
Keyword(s):  
Liver Glycogen ◽  
Nutritional Deficiencies ◽  
Total Serum ◽  
Total Serum Cholesterol ◽  
White Sucker ◽  
Food Groups ◽  
Catostomus Commersoni ◽  
Serum Triglycerides ◽  
Sediment Metals ◽  
Lipid Stores

White sucker (Catostomus commersoni) were collected from lakes with elevated levels of both copper (13–15 μg∙L−1) and zinc (209–253 μg∙L−1) and from control lakes. In all cases the fish reached maturity between 4 and 6 yr of age, and until 6 yr of age there were no differences in length or weight of fish collected from control and contaminated lakes. After this age, fish from contaminated sites were significantly smaller and shorter than those from control sites. In addition, female sucker from contaminated lakes failed to exhibit significant increases in either length or weight after the age of maturity. The fish from contaminated lakes also exhibited decreases in egg size and fecundity, no significant increases in fecundity with age, and an increased incidence of spawning failure. The failure of female fish to grow significantly after maturity, and the decreased energetic commitment to reproduction, suggests that the food base in the contaminated lakes was limiting the performance of the female sucker. These fish exhibited decreased muscle lipid stores, decreased serum lipid levels during the postspawning period, and an apparent decrease in visceral lipid stores during the autumn. There was no effect of collection site on body stores of liver glycogen, liver lipids, serum triglycerides, or total serum cholesterol. It is known that several major food groups were missing from the sediments of contaminated lakes and that sediments under water deeper than 5 m may be incapable of supporting macroinvertebrates. Most of the alterations in sucker growth and reproduction appear to be related to nutritional deficiencies as a result of the chronic effects of elevated sediment metals on the food base of the sucker.

scholarly journals Coconut milk gavage enhanced fecal bile excretion by modulating hepatic Fxr expression but failed to improve fasting serum cholesterol profile in C57BL/6 mice

OCL ◽  
2020 ◽  
Vol 27 ◽  
pp. 50
Author(s):  
Hong Kin Wong ◽  
Quok Cheong Choo ◽  
Choy Hoong Chew
Keyword(s):  
Fatty Acids ◽  
Serum Cholesterol ◽  
Fatty Acid Content ◽  
Health Effect ◽  
Serum Triglyceride ◽  
Coconut Milk ◽  
Farnesoid X Receptor ◽  
Total Serum ◽  
Total Serum Cholesterol ◽  
Potential Health

The consumption of coconut milk has long been regarded as detrimental to cardiovascular health due to its high saturated fatty acid content. Contradictorily, emerging evidences have highlighted that the fatty acids in coconut lipids, which comprise mostly of medium-chain fatty acids (MCFA), may be beneficial to the regulation of serum cholesterol. To identify the potential health effect of coconut milk on lipid metabolism, this current study employed an intragastric gavage method on C57BL/6 mice to investigate the physiological and molecular alteration in the mice subject after 8 weeks of gavage intervention. The supplementation of coconut milk did not affect the levels of serum triglyceride, but it induced the total serum cholesterol after 2 weeks of treatment. The serum cholesterol level subsequently plateaued, but an increase in bile acid excretion was observed, most likely through the modulation of bile regulating genes, i.e. farnesoid X receptor (Fxr) and Cyp7a1. Despite that, the total cholesterol to HDL cholesterol ratio of coconut milk group was comparable to that of the light cream group. In short, coconut milk supplementation promoted cholesterol excretion through the fecal bile route but did not significantly improve the serum cholesterol profile of C57BL/6 mice.

scholarly journals Dyslipidaemia in Cortical Versus Subcortical Infarction

1970 ◽  
Vol 24 (1) ◽  
pp. 24-33
Author(s):  
Tarun Kanti Sarker ◽  
Md Ruhul Kuddus ◽  
Md Rezaul Karim Khan ◽  
AKM Anwar Ullah ◽  
Md Rafiqul Islam ◽  
...  
Keyword(s):  
Ischaemic Stroke ◽  
Serum Triglyceride ◽  
Hdl Cholesterol ◽  
Lacunar Infarct ◽  
Total Serum ◽  
Total Serum Cholesterol ◽  
Case Group ◽  
Control Subjects ◽  
Cholesterol Levels ◽  
Subcortical Infarct

Objectives: The aim of the study was to predict risk of cerebral infarction either cortical or lacunar in population having dyslipidaemia and to create awareness regarding it as a risk factor for ischaemic stroke and to take preventive measures for the prevention of a first or recurrent ischaemic stroke. Method: This study was conducted in the Department of Nurology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka from March to October, 2006. This study included 30 acute ischaemic stroke patients diagnosed by history, clinical findings and confirmed by CT/MRI scan of head within 2 weeks of attack. Both man and woman age ranging from 40-90 years were eligible to enter into the study. The same number of age and sex matched nonstroke patients who gave blood for analysis were included as control. Result: In this study among other risk factors total serum cholesterol was raised in both cortical and lacunar infarct in 50% of cases in comparison to 33.3% controls (P<0.05). LDL-cholesterol levels were raised in both cortical and lacunar infarct in 50% of cases compared to 30% controls (P<0.05). HDL-cholesterol levels were significantly low in cases (70%) compared to control subjects (26.7%). It was significantly low in cases of cortical infarct (77.3%) compared to 50% cases of lacunar infarct (P<0.01). Serum triglyceride levels were raised in 60% of case group and 26.7% of control subjects (P<0.01). Serum triglyceride levels were raised in 54.5% cases of cortical infarcts compared to 75% cases of lacunar infarcts. Conclusion: The results indicate an association between dyslipidaemia and the risk of ischaemic stroke, specially cortical type. Dyslipidaemia more related to cortical infarct than subcortical infarct. Low level of HDL-cholesterol was related to cortical infarct but not with subcortical infarct. DOI: http://dx.doi.org/10.3329/bjn.v24i1.3037 Bangladesh Journal of Neuroscience 2008; Vol. 24 (1) : 24-33

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