scholarly journals Left atrial strain - an early marker of left ventricular diastolic dysfunction in patients with hypertension and paroxysmal atrial fibrillation

2018 ◽  
Vol 16 (1) ◽  
Author(s):  
Jonas Jarasunas ◽  
Audrius Aidietis ◽  
Sigita Aidietiene
Keyword(s):  
Atrial Fibrillation ◽  
Diastolic Dysfunction ◽  
Paroxysmal Atrial Fibrillation ◽  
Left Atrial ◽  
Left Ventricular Diastolic Dysfunction ◽  
Left Ventricular ◽  
Left Atrial Strain ◽  
Early Marker ◽  
Ventricular Diastolic Dysfunction ◽  
Atrial Strain

scholarly journals Left atrial strain as sensitive marker of left ventricular diastolic dysfunction in heart failure

2020 ◽  
Vol 7 (4) ◽  
pp. 1956-1965 ◽  
Author(s):  
Athanasios Frydas ◽  
Daniel A. Morris ◽  
Evgeny Belyavskiy ◽  
Aravind‐Kumar Radhakrishnan ◽  
Martin Kropf ◽  
...  
Keyword(s):  
Heart Failure ◽  
Diastolic Dysfunction ◽  
Left Atrial ◽  
Left Ventricular Diastolic Dysfunction ◽  
Left Ventricular ◽  
Left Atrial Strain ◽  
Ventricular Diastolic Dysfunction ◽  
Atrial Strain ◽  
Sensitive Marker

Abstract 13979: Left Atrial Symmetry Changes in Atrial Fibrillation: Relation With Diastolic Dysfunction and Symptom Severity

Circulation ◽  
2014 ◽  
Vol 130 (suppl_2) ◽  
Author(s):  
Sotirios Nedios ◽  
Ole-A. Breithardt ◽  
Emmanuel Koutalas ◽  
Jedrzej Kosiuk ◽  
Philipp Sommer ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Linear Regression ◽  
Mitral Regurgitation ◽  
Diastolic Dysfunction ◽  
Symptom Severity ◽  
Left Atrial ◽  
Pulmonary Veins ◽  
Left Ventricular Diastolic Dysfunction ◽  
Left Ventricular ◽  
Ventricular Diastolic Dysfunction

Introduction: Atrial fibrillation (AF) progression has been associated with asymmetric left atrial (LA) dilatation and left ventricular diastolic dysfunction (LVDD). LVDD has been also correlated with symptom severity. Hypothesis: Aim of this study was to test the hypothesis that the pattern of LA asymmetry is associated to LVDD and symptom severity. Methods: In 104 patients (58±10 years old, 69% male) referred for AF ablation, CT data were used to determine the LA volume (LAV) after exclusion of the appendage and the pulmonary veins (PVs). A cutting plane, between the PV ostia and the appendage and parallel to the posterior wall, divided LAV into anterior- (LA-A) and posterior-LA (LA-P) parts. The ratio LA-A/LAV was defined as asymmetry index (ASI). LVDD was evaluated according to current guidelines and symptom severity was quantified using the European Heart Rhythm Association score. Results: Univariate linear regression revealed that ASI is associated with LVDD, LAV and mitral regurgitation. ASI was higher in patients with LVDD (n=35, 62±5% vs. 59±6%, p=0.013) and in patients with mitral regurgitation (n=67, 61±6% vs. 58±5%, p=0.025) than those without. LAV increase was associated with an ASI increase (r=0.26, p=0.008). Multiple linear regression analysis revealed that LAV (β=0.211, 95% CI: 0.003-0.071, p=0.033) and LVDD (β=0.207, 95% CI: 0.167-5.011, p=0.036) were the only independent predictors of ASI increase (adjusted r2=0.92, F=6.2, p=0.003). Patients with moderate-severe AF symptoms (n=61) had higher ASI (61±6% vs. 58±5%, p=0.012) and higher prevalence of LVDD (43% vs. 21%, p=0.034) than those with mild symptoms. Conclusions: LA symmetry changes are associated with dilatation and left ventricular diastolic dysfunction and correlate with symptom severity in AF.

scholarly journals Diabetes induces remodeling of the left atrial appendage independently of atrial fibrillation in a rodent model of type-2 diabetes

2021 ◽  
Vol 20 (1) ◽  
Author(s):  
Or Yosefy ◽  
Barucha Sharon ◽  
Chana Yagil ◽  
Mark Shlapoberski ◽  
Alejandro Livoff ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Sinus Rhythm ◽  
Diastolic Dysfunction ◽  
Left Atrial ◽  
Left Atrial Appendage ◽  
Left Ventricular Diastolic Dysfunction ◽  
Left Ventricular ◽  
Diabetic Patients ◽  
Thromboembolic Events ◽  
Ventricular Diastolic Dysfunction

Abstract Background Diabetic patients have an increased predisposition to thromboembolic events, in most cases originating from thrombi in the left atrial appendage (LAA). Remodeling of the LAA, which predisposes to thrombi formation, has been previously described in diabetic patients with atrial fibrillation, but whether remodeling of the LAA occurs in diabetics also in the absence of atrial fibrillation is unknown. To investigate the contribution of diabetes, as opposed to atrial fibrillation, to remodeling of the LAA, we went from humans to the animal model. Methods We studied by echocardiography the structure and function of the heart over multiple time points during the evolution of diabetes in the Cohen diabetic sensitive rat (CDs/y) provided diabetogenic diet over a period of 4 months; CDs/y provided regular diet and the Cohen diabetic resistant (CDr/y), which do not develop diabetes, served as controls. All animals were in sinus rhythm throughout the study period. Results Compared to controls, CDs/y developed during the evolution of diabetes a greater heart mass, larger left atrial diameter, wider LAA orifice, increased LAA depth, greater end-diastolic and end-systolic diameter, and lower E/A ratio—all indicative of remodeling of the LAA and left atrium (LA), as well as the development of left ventricular diastolic dysfunction. To investigate the pathophysiology involved, we studied the histology of the hearts at the end of the study. We found in diabetic CDs/y, but not in any of the other groups, abundance of glycogen granules in the atrial appendages , atria  and ventricles, which may be of significance as glycogen granules have previously been associated with cell and organ dysfunction in the diabetic heart. Conclusions We conclude that our rodent model of diabetes, which was in sinus rhythm, reproduced structural and functional alterations previously observed in hearts of human diabetics with atrial fibrillation. Remodeling of the LAA and of the LA in our model was unrelated to atrial fibrillation and associated with accumulation of glycogen granules. We suggest that myocardial accumulation of glycogen granules is related to the development of diabetes and may play a pathophysiological role in remodeling of the LAA and LA, which predisposes to atrial fibrillation, thromboembolic events and left ventricular diastolic dysfunction in the diabetic heart.

scholarly journals Transient manifestation of left ventricular diastolic dysfunction following ablation in patients with paroxysmal atrial fibrillation

2018 ◽  
Vol 41 (7) ◽  
pp. 978-984 ◽  
Author(s):  
Tomoko Minamisaka ◽  
Tetsuya Watanabe ◽  
Yukinori Shinoda ◽  
Kuniyasu Ikeoka ◽  
Hidetada Fukuoka ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Diastolic Dysfunction ◽  
Paroxysmal Atrial Fibrillation ◽  
Left Ventricular Diastolic Dysfunction ◽  
Left Ventricular ◽  
Ventricular Diastolic Dysfunction
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