scholarly journals Pregnancy exposure of titanium dioxide nanoparticles causes intestinal dysbiosis and neurobehavioral impairments that are not significant postnatally but emerge in adulthood of offspring

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Junhao Su ◽  
Xinhao Duan ◽  
Yu Qiu ◽  
Lixiao Zhou ◽  
Hongyang Zhang ◽  
...  
Keyword(s):  
Risk Assessment ◽  
Titanium Dioxide ◽  
Microbial Community ◽  
Health Risk ◽  
Pregnant Women ◽  
Titanium Dioxide Nanoparticles ◽  
Neurodevelopmental Toxicity ◽  
Intestinal Dysbiosis ◽  
Pregnant Mice ◽  
Gut Microbial Community

Abstract Background Pregnancy exposure to titanium dioxide nanoparticles (TiO2NPs) is a vital consideration due to their inadvertent ingestion from environmental contamination. The potential health effects of TiO2NPs on the neurodevelopmental process should be seriously concerned in health risk assessment, especially for the pregnant women who are susceptible to the neurodevelopmental toxicity of nano-sized particles. However, the available evidence of neurodevelopmental toxicity of TiO2NPs remains very limited. Methods In the present study, the pregnant mice were intragastric administered with 150 mg/kg TiO2NPs from gestational day (GD) 8 to 21, the maternal behaviors and neurodevelopment-related indicators in offspring were all assessed at different time points after delivery. The gut microbial community in both dams and their offspring were detected by using 16S ribosomal RNA (rRNA) gene sequencing. The gut-brain axis related indicators were also determined in the offspring. Results The results clearly demonstrated that exposure to TiO2NPs did not affect the maternal behaviors of pregnant mice, or cause the deficits on the developmental milestones and perturbations in the early postnatal development of offspring. Intriguingly, our data revealed that pregnancy exposure of TiO2NPs did not affect locomotor function, learning and memory ability and anxiety-like behavior in offspring at postnatal day (PD) 21, but resulted in obvious impairments on these neurobehaviors at PD49. Similar phenomena were obtained in the composition of gut microbial community, intestinal and brain pathological damage in offspring in adulthood. Moreover, the intestinal dysbiosis induced by TiO2NPs might be highly associated with the delayed appearance of neurobehavioral impairments in offspring, possibly occurring through disruption of gut-brain axis. Conclusions This is the first report elucidated that pregnancy exposure to TiO2NPs caused delayed appearance of neurobehavioral impairments in offspring when they reached adulthood, although these perturbations did not happen at early life after delivery. These findings will provide valuable insights about neurodevelopmental toxicity of TiO2NPs, and call for comprehensive health risk assessment of TiO2NPs on the susceptible population, such as pregnant women. Graphical abstract

scholarly journals Potential health risk assessment of toxic metals contamination in clay eaten as pica (geophagia) among pregnant women of Ho in the Volta Region of Ghana.

2020 ◽  
Author(s):  
Nii Korley Kortei ◽  
Alice Koryo-Dabrah ◽  
Papa Toah Akonor ◽  
Nana Yaw Barima Manaphraim ◽  
Matilda Ayim-Akonor ◽  
...  
Keyword(s):  
Risk Assessment ◽  
Health Risk ◽  
Pregnant Women ◽  
Hazard Quotient ◽  
Health Problems ◽  
Target Hazard Quotient ◽  
Potential Health ◽  
Potential Health Risk ◽  
Adverse Health ◽  
Volta Region

Abstract Introduction: Geophagia although pleasurable and somewhat a necessity among pregnant women, also comes along with its own attendant problems such as exposure to potentially hazardous substances like bacteria, fungi, helminthes and ova, radioactive materials, and toxic elemental minerals in the soil depending on the geographical location.Methodology: This study evaluated the potential health risk involved during the exposure of pregnant women to toxic elemental minerals via the consumption of clay as pica (geophagia). Elemental mineral analysis was carried out using Buck Scientific 210VGP Flame Atomic Absorption Spectrophotometer (Buck Scientific, Inc. East Norwalk, USA). Risk assessment methods were also used to ascertain the various risks factors and the overall risk level.Results: Concentrations of the macro elements investigated were 1.38 ± 1.5, 2.40± 1.5, 7.74± 1.5, 4.01± 1.0, 13.24± 2.2 and 13.76± 2.1 mg/Kg for iron (Fe), copper (Cu), zinc (Zn), potassium (K), magnesium (Mg) and sodium (Na) respectively. While that for the micro elements were 1.63± 0.03 µg/Kg, 4.72±0.8, 0.53±0.02 and 1.85±0.3 mg/kg respectively for arsenic (As), manganese (Mn), lead (Pb) and nickel (Ni). Estimated Daily Intake (EDI), Hazard Quotient (HQ), Target Hazard Quotient (THQ) and Total Target Hazard Quotient (TTHQ) values ranged 0.611- 5.44 (mg/kg Bw/day), 6.26x10-4 – 106.5, 0.067-10.34 and 15 respectively.Conclusion: There is the likelihood of posing adverse health problems when clay samples obtained from Anfoega which is sited in the Volta region of Ghana is consumed due to the fact that the HQ’s of these elemental minerals were >1 which points to high content of Manganese (Mn) and Nickel (Ni). It is also likely to cause adverse health problems in an individual’s life time since THQ for Arsenic, Lead and Nickel were above 1. Ultimately, the cumulative effect of these toxicants were exceedingly great (≤ 15) which implied a high level of unsafety associated with this clay. Per the results from this study, it is not safe for pregnant women to consume clay as pica since these toxic elements may cause detrimental effects on the foetus of the unborn child.

scholarly journals Potential health risk assessment of toxic metals contamination in clay eaten as pica (geophagia) among pregnant women of Ho in the Volta Region of Ghana

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Nii Korley Kortei ◽  
Alice Koryo-Dabrah ◽  
Papa Toah Akonor ◽  
Nana Yaw Barimah Manaphraim ◽  
Matilda Ayim-Akonor ◽  
...  
Keyword(s):  
Risk Assessment ◽  
Health Risk ◽  
Pregnant Women ◽  
Health Risk Assessment ◽  
Toxic Metals ◽  
Potential Health ◽  
Potential Health Risk ◽  
Volta Region

Probabilistic risk assessment of emerging materials: case study of titanium dioxide nanoparticles

2017 ◽  
Vol 11 (4) ◽  
pp. 558-568 ◽  
Author(s):  
Michael P. Tsang ◽  
Danail Hristozov ◽  
Alex Zabeo ◽  
Antti Joonas Koivisto ◽  
Alexander Christian Østerskov Jensen ◽  
...  
Keyword(s):  
Risk Assessment ◽  
Titanium Dioxide ◽  
Titanium Dioxide Nanoparticles ◽  
Probabilistic Risk Assessment ◽  
Probabilistic Risk

Urinary Antibiotics of Pregnant Women in Eastern China and Cumulative Health Risk Assessment

2017 ◽  
Vol 51 (6) ◽  
pp. 3518-3525 ◽  
Author(s):  
Hexing Wang ◽  
Na Wang ◽  
Junhua Qian ◽  
Lingyun Hu ◽  
Peixin Huang ◽  
...  
Keyword(s):  
Risk Assessment ◽  
Health Risk ◽  
Pregnant Women ◽  
Health Risk Assessment ◽  
Eastern China

scholarly journals Potential health risk assessment of toxic metals contamination in clay eaten as pica (geophagia) among pregnant women of Ho in the Volta Region of Ghana.

2020 ◽  
Author(s):  
Nii Korley Kortei ◽  
Alice Koryo-Dabrah ◽  
Papa Toah Akonor ◽  
Nana Yaw Barima Manaphraim ◽  
Matilda Ayim-Akonor ◽  
...  
Keyword(s):  
Risk Assessment ◽  
Health Risk ◽  
Pregnant Women ◽  
Hazard Quotient ◽  
Health Problems ◽  
Target Hazard Quotient ◽  
Potential Health ◽  
Potential Health Risk ◽  
Adverse Health ◽  
Volta Region

Abstract Introduction: Geophagia although pleasurable and somewhat a necessity among pregnant women, also comes along with its own attendant problems such as exposure to potentially hazardous substances like bacteria, fungi, helminthes and ova, radioactive materials, and toxic elemental minerals in the soil depending on the geographical location. Methodology: This study evaluated the potential health risk involved during the exposure of pregnant women to toxic elemental minerals via the consumption of clay as pica (geophagia). Elemental mineral analysis was carried out using Buck Scientific 210VGP Flame Atomic Absorption Spectrophotometer (Buck Scientific, Inc. East Norwalk, USA). Risk assessment methods were also used to ascertain the various risks factors and the overall risk level. Results: Concentrations of the macro elements investigated were 1.38 ± 1.5, 2.40± 1.5, 7.74± 1.5, 4.01± 1.0, 13.24± 2.2 and 13.76± 2.1 mg/Kg for Fe, Cu, Zn, K, Mg and Na respectively. While that for the micro elements were 1.63± 0.03 µg/Kg, 4.72±0.8, 0.53±0.02 and 1.85±0.3 mg/kg respectively for Arsenic, Manganese, Lead and Nickel. Estimated Daily Intake (EDI), Hazard Quotient (HQ), Target Hazard Quotient (THQ) and Total Target Hazard Quotient (TTHQ) values ranged 0.611- 5.44 (mg/kg Bw/day), 6.26x10 -4 – 106.5, 0.067-10.34 and 15 respectively. Conclusion: There is the likelihood of posing adverse health problems when clay samples obtained from Anfoega which is sited in the Volta region of Ghana is consumed due to the fact that the calculated HQ’s of these elemental minerals were >1 which points to high content of Manganese (Mn) and Nickel (Ni). It is also likely to cause adverse health problems in an individual’s life time since THQ for Arsenic, Lead and Nickel were above 1. Ultimately, the cumulative effect of these toxicants were exceedingly great (≤ 15) which implied a high level of unsafety associated with this clay. Per the results from this study, it is not safe for pregnant women to consume clay as pica since these toxic elements may cause detrimental effects on the foetus of the unborn child.

scholarly journals A critical analysis of vulnerable populations in the Durham-York energy-from-waste incinerator human health risk assessment

2021 ◽  
Author(s):  
Nazira Panchbhaya
Keyword(s):  
Risk Assessment ◽  
Best Practices ◽  
Health Risk ◽  
Pregnant Women ◽  
Human Health ◽  
Health Risk Assessment ◽  
Vulnerable Populations ◽  
Human Health Risk ◽  
Human Health Risk Assessment ◽  
Waste Incinerator

A health risk assessment is an essential tool to assess effects of polluting facilities on vulnerable populations. The Durham-York Energy Centre is the first incinerator built in Ontario in over 20 years and it has caused public controversy due to the health effects of such facilities. The proponents conducted a human health risk assessment (HHRA) according to best practices to effectively protect the public. The objective of this thesis is to establish a HHRA best practice framework for vulnerable populations, particularly pregnant women and fetuses, to confirm if best practices were achieved and determine whether this group was adequately considered in the HHRA. Analysis ultimately showed that the Durham-York HHRA complied with most best practices but the failure to identify pregnant women and fetuses as a vulnerable population lead to some important deficiencies and omissions in the assessment.

scholarly journals Potential health risk assessment of toxic metals contamination in clay eaten as pica (geophagia) among pregnant women of Ho in the Volta Region of Ghana.

2020 ◽  
Author(s):  
Nii Korley Kortei ◽  
Alice Koryo-Dabrah ◽  
Papa Toah Akonor ◽  
Nana Yaw Barima Manaphraim ◽  
Matilda Ayim-Akonor ◽  
...  
Keyword(s):  
Risk Assessment ◽  
Health Risk ◽  
Pregnant Women ◽  
Hazard Quotient ◽  
Health Problems ◽  
Target Hazard Quotient ◽  
Potential Health ◽  
Potential Health Risk ◽  
Adverse Health ◽  
Volta Region

Abstract Introduction: Geophagia although pleasurable and somewhat a necessity among pregnant women, also comes along with its own attendant problems such as exposure to potentially hazardous substances like bacteria, fungi, helminthes and ova, radioactive materials, and toxic elemental minerals in the soil depending on the geographical location.Methodology: This study evaluated the potential health risk involved during the exposure of pregnant women to toxic elemental minerals via the consumption of clay as pica (geophagia). Elemental mineral analysis was carried out using Buck Scientific 210VGP Flame Atomic Absorption Spectrophotometer (Buck Scientific, Inc. East Norwalk, USA). Risk assessment methods were also used to ascertain the various risks factors and the overall risk level.Results: Concentrations of the macro elements investigated were 1.38 ± 1.5, 2.40± 1.5, 7.74± 1.5, 4.01± 1.0, 13.24± 2.2 and 13.76± 2.1 mg/Kg for Fe, Cu, Zn, K, Mg and Na respectively. While that for the micro elements were 1.63± 0.03 µg/Kg, 4.72±0.8, 0.53±0.02 and 1.85±0.3 mg/kg respectively for Arsenic, Manganese, Lead and Nickel. Estimated Daily Intake (EDI), Hazard Quotient (HQ), Target Hazard Quotient (THQ) and Total Target Hazard Quotient (TTHQ) values ranged 0.611- 5.44 (mg/kg Bw/day), 6.26x10-4 – 106.5, 0.067-10.34 and 15 respectively.Conclusion: There is the likelihood of posing adverse health problems when clay samples obtained from Anfoega which is sited in the Volta region of Ghana is consumed due to the fact that the HQ’s of these elemental minerals were >1 which points to high content of Manganese (Mn) and Nickel (Ni). It is also likely to cause adverse health problems in an individual’s life time since THQ for Arsenic, Lead and Nickel were above 1. Ultimately, the cumulative effect of these toxicants were exceedingly great (≤ 15) which implied a high level of unsafety associated with this clay. Per the results from this study, it is not safe for pregnant women to consume clay as pica since these toxic elements may cause detrimental effects on the foetus of the unborn child.

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