scholarly journals The maintained attention assessment in patients affected by Myalgic encephalomyelitis/chronic fatigue syndrome: a reliable biomarker?

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Iñigo Murga ◽  
Larraitz Aranburu ◽  
Pascual A. Gargiulo ◽  
Juan-Carlos Gómez-Esteban ◽  
José-Vicente Lafuente
Keyword(s):  
Cognitive Function ◽  
Functional Limitations ◽  
Chronic Fatigue ◽  
Cognitive Effort ◽  
Control Group ◽  
Fatigue Syndrome ◽  
Final Sample ◽  
Normal Cognitive Function ◽  
Attention And Perception ◽  
Rule Out

AbstractThe maintained attention is the cause of great functional limitations in CFS/ME, a disease that mainly affects women in the central period of life. Cognitive function is explored using the Montreal Cognitive Assessment, the maintained attention using the Toulouse-Piéron test with which the Global Index of Attention and Perception (GIAP) is obtained, the fatigue using the visual analog scale and the perception of effort using the modified Borg scale. The final sample were 84 patients (66 women/18 men) who met diagnostic criteria (Fukuda-1994, Carruthers-2011) and 22 healthy controls (14 women/8 men). Most of patients maintain normal cognitive function, showing low or very low attention score in the 70% of patients with a marked cognitive fatigue compared to the control group (p < 0.05). There were no significant differences between genders in GIAP or fatigue for CFS/ME; however, sick women perceive cognitive effort higher than men. Deficits in sustained attention and the perception of fatigue, so effort after performing the proposed test are a sensitive and reliable indicator that allows us to substantiate a clinical suspicion and refer patients for further studies in order to confirm or rule out CFS/ME.

scholarly journals Complement Component C1q as a Potential Diagnostic Tool for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Subtyping

2021 ◽  
Vol 10 (18) ◽  
pp. 4171
Author(s):  
Jesús Castro-Marrero ◽  
Mario Zacares ◽  
Eloy Almenar-Pérez ◽  
José Alegre-Martín ◽  
Elisa Oltra
Keyword(s):  
Chronic Fatigue Syndrome ◽  
Clinical Symptoms ◽  
Hierarchical Cluster ◽  
Chronic Fatigue ◽  
Blood Parameters ◽  
Myalgic Encephalomyelitis ◽  
Complement Factor ◽  
Fatigue Syndrome ◽  
Pain Symptoms ◽  
Rule Out

Background: Routine blood analytics are systematically used in the clinic to diagnose disease or confirm individuals’ healthy status. For myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), a disease relying exclusively on clinical symptoms for its diagnosis, blood analytics only serve to rule out underlying conditions leading to exerting fatigue. However, studies evaluating complete and large blood datasets by combinatorial approaches to evidence ME/CFS condition or detect/identify case subgroups are still scarce. Methods: This study used unbiased hierarchical cluster analysis of a large cohort of 250 carefully phenotyped female ME/CFS cases toward exploring this possibility. Results: The results show three symptom-based clusters, classified as severe, moderate, and mild, presenting significant differences (p < 0.05) in five blood parameters. Unexpectedly the study also revealed high levels of circulating complement factor C1q in 107/250 (43%) of the participants, placing C1q as a key molecule to identify an ME/CFS subtype/subgroup with more apparent pain symptoms. Conclusions: The results obtained have important implications for the research of ME/CFS etiology and, most likely, for the implementation of future diagnosis methods and treatments of ME/CFS in the clinic.

scholarly journals Life events, difficulties and dilemmas in the onset of chronic fatigue syndrome: a case–control study

2003 ◽  
Vol 33 (7) ◽  
pp. 1185-1192 ◽  
Author(s):  
SIMON HATCHER ◽  
ALLAN HOUSE
Keyword(s):  
Chronic Fatigue Syndrome ◽  
Life Events ◽  
Stressful Life Events ◽  
Chronic Fatigue ◽  
Case Control ◽  
Stressful Events ◽  
Control Group ◽  
Liaison Psychiatry ◽  
Fatigue Syndrome

Background. The role of stress in the onset of chronic fatigue syndrome is unclear. Our objectives in this study were first, to determine the relation between the onset of chronic fatigue syndrome and stressful life events and difficulties. Secondly, we examined the role of a particular type of problem, dilemmas, in the onset of chronic fatigue syndrome.Method. We used a case–control design with 64 consecutive referrals from an Infectious Diseases/Liaison Psychiatry Fatigue clinic and 64 age- and sex-matched controls from a general practice population control group in Leeds. We had two main outcome measures; the odds ratios of the risk of developing chronic fatigue syndrome after experiencing a severe life event, severe difficulties or both in the year and 3 months preceding onset; and the proportion of subjects in each group who experienced a dilemma prior to onset.Results. Patients with chronic fatigue syndrome were more likely to experience severe events and difficulties in the 3 months (OR=9, 95% CI 3·2 to 25·1) and year (OR=4·3, 95% CI 1·8 to 10·2) prior to onset of their illness than population controls. In the 3 months prior to onset 19 of the 64 patients (30%) experienced a dilemma compared to none of the controls.Conclusions. Chronic fatigue syndrome is associated with stressful events and difficulties prior to onset. Those events and difficulties characterized as being dilemmas seem to be particularly important.

scholarly journals Chronic fatigue syndrome: a clinical and laboratory study with a well matched control group

1995 ◽  
Vol 237 (5) ◽  
pp. 499-506 ◽  
Author(s):  
CAROLINE M. A. SWANINK ◽  
JAN H. M. M. VERCOULEN ◽  
GIJS BLEIJENBERG ◽  
JAN F. M. FENNIS ◽  
JOEP M. D. GALAMA ◽  
...  
Keyword(s):  
Chronic Fatigue Syndrome ◽  
Laboratory Study ◽  
Matched Control ◽  
Chronic Fatigue ◽  
Control Group ◽  
Matched Control Group ◽  
Fatigue Syndrome

Ubiquinol-10 supplementation improves autonomic nervous function and cognitive function in chronic fatigue syndrome

BioFactors ◽  
2016 ◽  
Vol 42 (4) ◽  
pp. 431-440 ◽  
Author(s):  
Sanae Fukuda ◽  
Junzo Nojima ◽  
Osami Kajimoto ◽  
Kouzi Yamaguti ◽  
Yasuhito Nakatomi ◽  
...  
Keyword(s):  
Cognitive Function ◽  
Chronic Fatigue Syndrome ◽  
Chronic Fatigue ◽  
Autonomic Nervous Function ◽  
Autonomic Nervous ◽  
Fatigue Syndrome ◽  
Nervous Function

scholarly journals RESPONSE TO ADAMSON ET AL. (2020): “COGNITIVE BEHAVIOURAL THERAPY FOR CHRONIC FATIGUE AND CHRONIC FATIGUE SYNDROME: OUTCOMES FROM A SPECIALIST CLINIC IN THE UK”

2021 ◽  
Author(s):  
Brian Hughes ◽  
David Tuller
Keyword(s):  
Chronic Fatigue Syndrome ◽  
Cognitive Behavioural Therapy ◽  
Chronic Fatigue ◽  
Scientific Publication ◽  
Behavioural Therapy ◽  
Control Group ◽  
Fatigue Syndrome ◽  
Sample Attrition ◽  
Cognitive Behavioural ◽  
The Uk

In this review, we consider the paper by Adamson et al., published in the October 2020 issue of the Journal of the Royal Society of Medicine. The authors interpret their data as revealing significant improvements following cognitive behavioural therapy in a large sample of patients with chronic fatigue syndrome and chronic fatigue. Overall, the research is hampered by several fundamental methodological limitations that are not acknowledged sufficiently, or at all, by the authors. These include: (a) sampling ambiguity; (b) weak measurement; (c) survivor bias; (d) missing data; and (e) lack of a control group. In particular, the study is critically hampered by sample attrition, rendering the presentation of statements in the Abstract misleading with regard to points of fact, and, in our view, urgently requiring a formal published correction. In light of the fact that the paper was approved by multiple peer-reviewers and editors, we reflect on what its publication can teach us about the nature of contemporary scientific publication practices.

scholarly journals Examining Types of Fatigue Among Individuals with ME/CFS

2009 ◽  
Vol 29 (3) ◽  
Author(s):  
Leonard Jason ◽  
Tricia Jessen ◽  
Nicole Porter ◽  
Aaron Boulton ◽  
Mary Gloria-Njoku
Keyword(s):  
Chronic Fatigue Syndrome ◽  
Chronic Fatigue ◽  
Control Group ◽  
Factor Analyses ◽  
Factor Solution ◽  
Fatigue Syndrome ◽  
Scale Reliability ◽  
Prominent Symptom ◽  
Different Types ◽  
General Populations

Severe, persisting fatigue is a prominent symptom of Myalgic Encephalomyelitis/chronic fatigue syndrome (ME/CFS), but individuals with this illness frequently report the occurrence of unique fatigue states that might be different from conventional symptoms of fatigue. The present study attempted to assess a comprehensive set of fatigue symptoms that have been commonly reported among patients with ME/CFS. A 22-item fatigue questionnaire was developed and administered to 130 persons diagnosed with ME/CFS and 251 controls. Adequate scale reliability was found. Factor analyses revealed a five-factor structure for participants with ME/CFS but only a one factor solution for the control group. The new scale was also contrasted with other more traditional scales developed to measure fatigue. Findings suggest that individuals with ME/CFS experience different types of fatigue than what are reported in the general populations.

scholarly journals Moxibustion for Chronic Fatigue Syndrome: A Systematic Review and Meta-Analysis

2021 ◽  
Vol 2021 ◽  
pp. 1-11
Author(s):  
Jianyu You ◽  
Jing Ye ◽  
Haiyan Li ◽  
Wenguo Ye ◽  
Ensi Hong
Keyword(s):  
Chronic Fatigue Syndrome ◽  
Data Extraction ◽  
Meta Analysis ◽  
Complementary Therapy ◽  
Chronic Fatigue ◽  
Assessment Instrument ◽  
Favorable Effect ◽  
Control Group ◽  
Level Of Evidence ◽  
Fatigue Syndrome

Objective. This review aimed at systematically evaluating the efficacy and safety of moxibustion for chronic fatigue syndrome (CFS). Methods. Relevant trials were searched in seven digital databases up to January 2021. After literature screening, data extraction, and literature quality evaluation, the included studies were meta-analyzed using RevMan 5.4 software. The evidence level was assessed using the Grading of Recommendations, Assessment, Development, and Evaluation (GRADE). Results. Fifteen studies involving 1030 CFS participants were included. Meta-analyses showed a favorable effect of moxibustion on the total effective rate compared with acupuncture (OR = 4.58, 95%CI = [2.85, 7.35], P < 0.00001 ) and drugs (OR = 6.36, 95%CI = [3.48, 11.59], P < 0.00001 ). Moxibustion also appeared to significantly reduce fatigue severity measured by fatigue scale-14 (FS-14) (WMD = −2.20, 95% CI = [−3.16, −1.24], P < 0.00001 ) and fatigue assessment instrument (FAI) (WMD = −16.36, 95% CI = [−26.58, −6.14], P = 0.002 ) compared with the control group. In addition, among the 15 included studies, only two studies reported adverse events related to moxibustion, and the symptoms were relatively mild. The quality of evidence based on the 15 included trials was assessed as moderate to very low. Conclusions. Based on limited evidence, moxibustion might be an effective and safe complementary therapy for CFS, which can be recommended to manage CFS. Because of the limited level of evidence in this review, further high-quality trials are still needed to confirm these findings.

scholarly journals Polio Vaccination and Chronic Fatigue Syndrome

2021 ◽  
pp. 43-49
Author(s):  
Andrew P. Smith ◽  
Marie Thomas
Keyword(s):  
Chronic Fatigue Syndrome ◽  
Booster Vaccination ◽  
Chronic Fatigue ◽  
Control Group ◽  
Healthy Controls ◽  
Enterovirus Infection ◽  
Negative Effects ◽  
Virus Shedding ◽  
Fatigue Syndrome ◽  
Polio Vaccination

Background: Previous research has suggested that enteroviruses may be implicated in the development and persistence of Chronic Fatigue Syndrome (CFS). One method of investigating this topic has been to use a polio vaccination challenge, and a previous study showed that CFS patients had more shedding than healthy controls. There was no effect of the vaccination on the clinical condition or wellbeing of the CFS patients. Methods: In the previous study, the control group were more likely to have had a recent booster vaccination. This was controlled in the present study, where 18 CFS patients were randomly assigned to vaccination or placebo conditions. Nine healthy volunteers were also given the polio vaccination. Results: The results confirmed that vaccination had no negative effects on the CFS group. Although there was more virus shedding in the CFS polio group than in the control polio group, this difference was not significant. Conclusion: This study confirms that polio vaccination is not contraindicated in CFS patients but could not confirm that they are more susceptible to enterovirus infection.

scholarly journals Effect of Mindfulness Sessions on Chronic Fatigue Syndrome and Job Satisfaction of Nurses: A Randomized Clinical Trial

2021 ◽  
Author(s):  
Nasrin Bonakdari ◽  
Nadereh Mohammadi ◽  
Mohammad Reza Taghvizadeh Yazdi ◽  
Reza Norouzadeh ◽  
Mohammad Abbasinia ◽  
...  
Keyword(s):  
Job Satisfaction ◽  
Clinical Trial ◽  
Chronic Fatigue Syndrome ◽  
Randomized Clinical Trial ◽  
Intervention Group ◽  
Clinical Trial Design ◽  
Well Being ◽  
Chronic Fatigue ◽  
Control Group ◽  
Fatigue Syndrome

Abstract Background: Nursing is considered a stressful profession, so nurses are at higher risk of physical and mental illness. Mindfulness is an important concept for nursing with practical implications for nurse well-being, development, and quality nursing care sustainability.Objectives: This study identified mindfulness sessions' effect on nurses' chronic fatigue syndrome(CFS) and job satisfaction )JS.(Methods: A randomized clinical trial design was conducted on 80 nurses to intervention and control groups. The intervention in the intervention group was eight mindfulness sessions training, and the control group had no intervention. Nurses' CFS and JS were assessed using the Minnesota Satisfaction Questionnaire and The Multidimensional Fatigue Inventory.Results: After implementing a mindfulness-based stress reduction program, the intervention group nurses reported lower CFS and higher JS than the control group(p<0.005). Conclusion: The findings of this study indicate the effectiveness of mindfulness programs on improving nurses' chronic fatigue and JS. Since CFS and job dissatisfaction are two disturbing elements for nurses' optimal performance in professional and personal life, this study can recommend the implementation of mindfulness exercises as a routine, operational and uncomplicated program in nurses.

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