Hearing loss after radiosurgery-blame it on Cochlear dose or the radiation tool!

The therapeutic approach in sensorineural hearing loss (ISSNHL) is far from a consensual protocol among ENT (ear, nose and throat) doctors. The present paper describes our experience with Hyperbaric Oxygen Therapy (HBOT) as salvage treatment for selected patients with the sudden sensorineural hearing loss. The HBOT method has shown an efficacy of 50% in our study, as salvage treatment in ISSNHL after initially corticoids therapy. Thus, we can assert without doubt that HBOT represents a viable option for those patients who want to continue the effort to regain hearing. Under the auspices of the national ENT society, through a collective effort, can be achieved a therapeutic consensus in the sensorineural hearing loss. In this consensual document, HBOT can be found both as initial and salvage therapy, alone or in the multimodal therapeutical variant. Further, the National Health Insurance House should introduce the reimbursement of HBOT sessions in the methodological norms, in order to offer this new therapeutic solution to all patients.

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An evaluation on the role of MPV on idiopathic sudden hearing loss etiology

European Archives of Oto-Rhino-Laryngology ◽

10.1007/s00405-014-3201-5 ◽

2014 ◽

Vol 272 (9) ◽

pp. 2571-2572

Author(s):

Murat Sereflican ◽

Veysel Yurttas ◽

Fatma Erdem

Keyword(s):

Hearing Loss ◽

Sudden Hearing Loss

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MicroRNAs in acquired sensorineural hearing loss

The Journal of Laryngology & Otology ◽

10.1017/s0022215119001439 ◽

2019 ◽

Vol 133 (8) ◽

pp. 650-657

Author(s):

H H R Chen ◽

P Wijesinghe ◽

D A Nunez

Keyword(s):

Hearing Loss ◽

Sensorineural Hearing Loss ◽

English Language ◽

Assessment Tool ◽

Sudden Hearing Loss ◽

Sudden Sensorineural Hearing Loss ◽

Sensorineural Hearing ◽

Language Studies ◽

Age Related

AbstractObjectiveThis review summarises the current literature on the role of microRNAs in presbyacusis (age-related hearing loss) and sudden sensorineural hearing loss.MethodsMedline, PubMed, Web of Science and Embase databases were searched for primary English-language studies, published between 2000 and 2017, which investigated the role of microRNAs in the pathogenesis of presbyacusis or sudden sensorineural hearing loss. Quality of evidence was assessed using the National Institutes of Health quality assessment tool.ResultsNine of 207 identified articles, 6 of good quality, satisfied the review's inclusion criteria. In presbyacusis, microRNAs in pro-apoptotic and autophagy pathways are upregulated, while microRNAs in proliferative and differentiation pathways are downregulated. Evidence for microRNAs having an aetiological role in sudden hearing loss is limited.ConclusionA shift in microRNA expression, leading to reduced cellular activity and impaired inner-ear homeostasis, may contribute to the pathogenesis of presbyacusis.

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Role of Perilymphatic Fistula in Sudden Hearing Loss: An Animal Model

Annals of Otology Rhinology & Laryngology ◽

10.1177/000348948909800701 ◽

1989 ◽

Vol 98 (7) ◽

pp. 491-495 ◽

Cited By ~ 19

Author(s):

Eric M. Oshiro ◽

Clough Shelton ◽

Hugh S. Lusted

Keyword(s):

Hearing Loss ◽

Round Window ◽

Sudden Hearing Loss ◽

Complete Loss ◽

Perilymphatic Fistula ◽

Correct Placement ◽

Before And After ◽

Cochlear Partition ◽

Fluid Leak

The electrophysiologic response of the guinea pig cochlea was monitored after sequential lesions to Reissner's membrane and the round window (RW). Action potential (AP) responses to click stimuli were recorded from the RW before and after discrete puncture-type lesions were created in the cochlear partition of the second turn. Observed decrements were typically minor, comparable to no greater than 10 dB attenuation of stimulus intensity. The RW membranes then were perforated to create perilymphatic fistulas. Further monitoring demonstrated a rapid (within 5 to 10 minutes), severe decrement in AP amplitude and latency, with complete loss of the AP within 1 hour. Control animals with RW perforations alone did not show these decrements. Correct placement of the second turn lesions was documented by histology. We conclude that discrete lesions in the cochlear duct are not reflected in the AP input-output functions unless there is a fluid leak from the RW, and thus present a possible model for idiopathic sudden hearing loss.

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