scholarly journals The basis and advances in clinical application of boron neutron capture therapy

2021 ◽  
Vol 16 (1) ◽  
Author(s):  
Huifang He ◽  
Jiyuan Li ◽  
Ping Jiang ◽  
Suqing Tian ◽  
Hao Wang ◽  
...  
Keyword(s):  
Boron Neutron Capture Therapy ◽  
Radiation Oncology ◽  
Neutron Capture ◽  
Normal Tissue ◽  
Neutron Capture Therapy ◽  
Thermal Neutrons ◽  
Neutron Sources ◽  
Boron Neutron Capture ◽  
High Linear Energy Transfer ◽  
Α Particles

AbstractBoron neutron capture therapy (BNCT) was first proposed as early as 1936, and research on BNCT has progressed relatively slowly but steadily. BNCT is a potentially useful tool for cancer treatment that selectively damages cancer cells while sparing normal tissue. BNCT is based on the nuclear reaction that occurs when 10B capture low-energy thermal neutrons to yield high-linear energy transfer (LET) α particles and recoiling 7Li nuclei. A large number of 10B atoms have to be localized within the tumor cells for BNCT to be effective, and an adequate number of thermal neutrons need to be absorbed by the 10B atoms to generate lethal 10B (n, α)7Li reactions. Effective boron neutron capture therapy cannot be achieved without appropriate boron carriers. Improvement in boron delivery and the development of the best dosing paradigms for both boronophenylalanine (BPA) and sodium borocaptate (BSH) are of major importance, yet these still have not been optimized. Here, we present a review of this treatment modality from the perspectives of radiation oncology, biology, and physics. This manuscript provides a brief introduction of the mechanism of cancer-cell-selective killing by BNCT, radiobiological factors, and progress in the development of boron carriers and neutron sources as well as the results of clinical study.

scholarly journals Boron Neutron Capture Therapy for Cancer: Future Prospects in Indonesia

2020 ◽  
Vol 35 (3) ◽  
pp. 199-201
Author(s):  
Bagaswoto Poedjomartono ◽  
Hanif Afkari ◽  
Edy Meiyanto ◽  
Alan Bangun ◽  
Yohanes Sardjono
Keyword(s):  
Boron Neutron Capture Therapy ◽  
Neutron Capture ◽  
Lethal Dose ◽  
Low Energy ◽  
Neutron Capture Therapy ◽  
Thermal Neutrons ◽  
Future Prospects ◽  
Alpha Radiation ◽  
Boron Neutron Capture ◽  
High Linear Energy Transfer

Boron neutron capture therapy (BNCT) is a form of cancer therapy based on the interaction of low-energy thermal neutrons and boron-10 (10-B) to produce alpha radiation from He-4 and Li-7 with a high linear energy transfer. A beam of neutrons irradiates a boron drug injected into the tumor, resulting in the boron-injected cancer cells receiving a lethal dose of radiation with the surrounding, healthy cells being minimally affected. Two boron drugs have been used clinically in BNCT, boron sodium captate (BSH) and borophenylalanine (BPA), while a third, pentagamaboronon-0 (PGB-0), is currently under development in the Faculty of Pharmacy of Universitas Gadjah Mada, Indonesia. In Indonesia, there has been a growing interest in the study and use of BNCT to treat cancer, as this method is expected to be safer and more effective than traditional cancer treatment methods.

Carboxyboranylamino ethanol: Unprecedented discovery of boron agent for neutron capture therapy in cancer treatment

2021 ◽  
Author(s):  
Yinghuai Zhu ◽  
Jianghong Cai ◽  
Narayan S Hosmane ◽  
Minoru Suzuki ◽  
Kazuko Uno ◽  
...  
Keyword(s):  
Pharmaceutical Industry ◽  
Cancer Treatment ◽  
Boron Neutron Capture Therapy ◽  
Neutron Capture ◽  
Neutron Capture Therapy ◽  
Neutron Sources ◽  
Boron Neutron Capture

Following the latest development and popularization of the neutron sources, boron neutron capture therapy (BNCT) has re-attracted great efforts and interest from both academia and pharmaceutical industry. The FDA approved...

Bahan Sasaran Sebagai Sumber Neutron yang Optimal untuk Boron Neutron Capture Therapy (BNCT)

2017 ◽  
Vol 1 ◽  
pp. 104
Author(s):  
Yan Surono ◽  
C Cari ◽  
Yohannes Sarjono
Keyword(s):  
Cancer Cells ◽  
Boron Neutron Capture Therapy ◽  
Neutron Capture ◽  
Neutron Capture Therapy ◽  
Radioactive Elements ◽  
Therapeutic Technique ◽  
The Core ◽  
Boron Neutron Capture ◽  
Deadly Disease ◽  
Α Particles

<p><strong>Abstract</strong> Cancer is a deadly disease that exist on planet earth. Efforts were made to be able to kill cancer cells either by manual operation or by radiotherapy. One way to use energy radiation radioactive elements as killers of cancer cells is Boron Neutron Capture Therapy (BNCT). BNCT is a therapeutic technique that utilizes the interaction of neutron capture by the core 10B will produce α-particles and nuclei 7Li results by reaction 10B (n, α) 7Li. It therefore requires a material that will produce neutrons used in BNCT. Materials  target that will be searched in order to obtain optimal materials according to the requirements provided by the International Atomic Agency (IAEA).<em></em></p><p><em> </em></p><p><strong>Keywords </strong>: Kanker, Material, Neutron, BNCT</p><p align="center"><strong><em> </em></strong></p><p><strong>Abstrak</strong> Kanker adalah salah satu penyakit yang mematikan yang ada di planet bumi. Upaya upaya dilakukan untuk dapat membunuh sel kanker baik itu  secara operasi manual maupun dengan cara radioterapi. Salah satu cara yang memanfaatkan energi radiasi unsur unsur radioaktif sebagai pembunuh sel kanker adalah Boron Neutron Capture Therapy (BNCT). BNCT merupakan teknik terapi yang memanfaatkan interaksi tangkapan neutron oleh inti 10B yang akan menghasilkan partikel-α dan inti hasil 7Li melalui reaksi 10B(n,α) 7Li. Oleh sebab itu diperlukan material yang akan menghasilkan neutron digunakan dalam BNCT. Bahan - bahan sasaran yang akan ditelusur dalam upaya mendapatkan bahan yang optimal sesuai persyaratan yang diberikan oleh International Atomic Agency (IAEA).</p><p><em> </em></p><p><strong>Kata Kunci </strong>: Kanker, Material, Neutron, BNCT</p>

scholarly journals Dosimetry of In Vivo Experiment for Lung Cancer Based on Boron Neutron Capture Therapy on Radial Piercing Beam Port Kartini Nuclear Reactor by MCNPX Simulation Method

2018 ◽  
Vol 35 (3) ◽  
pp. 213-216
Author(s):  
Atika Maysaroh ◽  
Kusminarto Kusminarto ◽  
Dwi Satya Palupi ◽  
Yohannes Sardjono
Keyword(s):  
Lung Cancer ◽  
Boron Neutron Capture Therapy ◽  
Neutron Capture ◽  
Boron Concentration ◽  
Gamma Ray ◽  
Neutron Capture Therapy ◽  
Thermal Neutrons ◽  
Boron Neutron Capture ◽  
Beam Port

Cancer is one of the leading causes of death globally, with lung cancer being among the most prevalent. Boron Neutron Capture Therapy (BNCT) is a cancer therapy method that uses the interaction between thermal neutrons and boron-10 which produces a decaying boron-11 particle and emits alpha, lithium 7 and gamma particles. A study was carried out to model an in vivo experiment of rat organisms that have lung cancer. Dimensions of a rat’s body were used in Konijnenberg research. Modeling lung cancer type, non-small cell lung cancer, was used in Monte Carlo N Particle-X. Lung cancer was modeled with a spherical geometry consisting of 3 dimensions: PTV, GTV, and CTV. In this case, the neutron source was from the radial piercing beam port of Kartini Reactor, Yogyakarta. The variation of boron concentration was 20, 25, 30, 35, 40, and 40 µg/g cancer. The output of the MCNP calculation was neutron scattering dose, gamma-ray dose and neutron flux from the reactor. A neutron flux was used to calculate the alpha proton and gamma-ray dose from the interaction of tissue material and thermal neutrons. The total dose was calculated from a four-dose component in BNCT. The results showed that the dose rate will increase when the boron concentration is higher, whereas irradiating time will decrease.

scholarly journals RT-06 PLANNING OF BORON NEUTRON CAPTURE THERAPY (BNCT) USING POSITRON EMISSION TOMOGRAPHY (PET)

2019 ◽  
Vol 1 (Supplement_2) ◽  
pp. ii22-ii22
Author(s):  
Shinji Kawabata ◽  
Koji Takeuchi ◽  
Ryo Hiramatsu ◽  
Yoko Matsushita ◽  
Motomasa Furuse ◽  
...  
Keyword(s):  
Boron Neutron Capture Therapy ◽  
Neutron Capture ◽  
Normal Tissue ◽  
Treatment Plan ◽  
Individual Treatment ◽  
Neutron Capture Therapy ◽  
High Accumulation ◽  
Boron Neutron Capture ◽  
Positron Emission ◽  
Particle Irradiation

Abstract Boron neutron capture therapy (BNCT) is the particle irradiation therapy that the selective radiation for tumor cells is available for theoretically. The role that the amino acid (phenylalanine) PET (18F-BPA-PET) that we used boronophenylalanine (BPA) which is a boron compound for neutron capture reaction as a tracer carries out is major in our BNCT especially for the recent non-craniotomy BNCT, and it covers by treatment, observation from indication. In this report, we introduce this PET as a principal axis about BNCT and a relation of the PET.In our BNCT, we calculated the drug accumulation to the tumor from BPA-PET before neutron irradiation and reflected it for individual treatment. We become able to decide indication of BNCT by using this PET study, and the indication expansion to other systemic cancers including head and neck cancer and lung, liver is now worked on actively. Also, in other irradiation modalities, they make a radiation plan based on PET study, and several reports to try the improvement of results had been present, however, high radiation doses will be “ exposed “ to the lesion showing high accumulation in BPA-PET in BNCT. We determine the neutron exposure time from the dosage for the normal tissue in the actual treatment, but the Lesion / Normal tissue ratio obtained from BPA-PET is reflected by the evaluation of the tumor dose and the following treatment plan. Also, after the treatment, diagnoses of the pathologic condition such as an increase in tumor volume, a recurrence or the radiation necrosis might be difficult, and we found that the PET study was useful in the follow-up stage for the patients with already treated malignant brain tumor.

scholarly journals CYTOPATHIC EFFECTS OF ACCELERATOR-BASED BORON NEUTRON CAPTURE THERAPY ON HUMAN GLIOBLASTOMA CELLS

2019 ◽  
Vol 18 (4) ◽  
pp. 34-42
Author(s):  
V. A. Byvaltsev ◽  
E. L. Zavjalov ◽  
V. V. Kanygin ◽  
A. I. Kasatova ◽  
A. I. Kichigin ◽  
...  
Keyword(s):  
Cell Line ◽  
Boron Neutron Capture Therapy ◽  
Neutron Capture ◽  
Boron Concentration ◽  
Neutron Capture Therapy ◽  
Neutron Sources ◽  
Cytopathic Effects ◽  
Boron Neutron Capture ◽  
Colony Forming Assay ◽  
U87 Cells

Boron neutron capture therapy (BNCT) is a targeted therapy based on a selective damage to cancer cells due to the interaction between boron-10 isotope and neutron. Reactor-based BNCT has been found to be effective in the treatment of high-grade gliomas. It is believed that compact accelerator-based neutron sources will ensure widespread adoption of the technique in clinical practice. New accelerator-based neutron sources are being actively developed all over the world. At the Institute of Nuclear Physics (Russia), the accelerator-based neutron source was developed for pre-clinical studies of BNCT.Purpose: to determine the cytopathic effects of accelerator-based BNCT on the human U87-glioblastoma cell line and to select a concentration of boron drugs that do not have a toxic effect on the cells before irradiation in vitro.Material and Methods. To assess the cytopathic effects (MTT test and colony-forming assay) of various concentrations of boron-containing drugs, U87 cells were incubated with boronophenylalanine (BPA) and sodium borocaptate (BSH) for 1, 2 and 10 days. The effect of BNCT on the U87 cell line was determined using colony-forming assay.Results. The MTT test showed a decrease in cell survival at a boron-10 isotope concentration of 160 μg/ml after 48 hours and 640 μg/ml after 24 hours of incubation for BPA. The cytopathic effects for sodium BSH appeared at a boron concentration of 80 µg / ml after 48 hours of incubation, and survival fraction of cells was reduced to 89 % compared to the control. According to the colonyforming assay, the cytotoxic effects of BSH and BPA at a boron concentration of 40 µg/ml in the medium were 79.6 and 84 %, respectively. The proportions of surviving cells were 18 ± 2 % and 13 ± 2 % after epithermal neutron irradiation in the presence of boronophenylalanine and in the presence of sodium borocaptate, respectively. Cell death without boron drugs occurred due to the neutron elastic scattering, nuclear reactions of thermal neutron capture by hydrogen and nitrogen, and accompanying gamma radiation.Conclusion. The study clearly showed a decrease in the proportion of surviving U87 cells after accelerator-based BNCT in the presence of 10B-enriched BSH and BPA. 

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