Association between increased blood interleukin-6 levels on emergency department arrival and prolonged length of intensive care unit stay for blunt trauma

Introduction: The BIG score is a new pediatric trauma score composed of the admission base deficit (BD), the international normalized ratio (INR) and the Glasgow Coma Scale (GCS). A score<16 identifies children with a high probability of survival following blunt trauma.The objective of this study was to measure the criterion validity of the BIG score to predict in-hospital mortality among children visiting an emergency department with blunt trauma requiring an admission to the intensive care unit. Methods: This was a retrospective cohort study performed in a single tertiary care pediatric hospital between 2008 and 2016. Participants were all children (<18 years) visiting the emergency department for a blunt trauma requiring intensive care unit admission or who died at the emergency department. All charts were reviewed by a member of the research team using a standardized report form. To insure quality of data abstraction, 10% of the charts were reviewed in duplicate by a second rater blinded to the first evaluation. The primary outcome was in-hospital mortality. Baseline demographics, initial components of the BIG score, Injury Severity Score (ISS) and disposition were extracted. The primary analysis was the association between a BIG score ≥16 and in-hospital mortality. It was calculated that the inclusion of at least 25 deaths would provide confidence intervals of +/- 0.20 for proportions in the worst-case scenario. Results: Twenty-eight children died among the 336 who met the inclusion criteria. The inter-rater agreement for data abstraction was excellent with kappa scores or intraclass correlation coefficients higher than 0.8 for all variables. Two hundred eighty-four children had information on the three components of the BIG score and they were included in the primary analysis. A BIG score ≥16 demonstrated a sensitivity of 0.93 (95%CI: 0.76-0.98) and specificity of 0.83 (95%CI 0.78-0.87) to identify mortality. Using ROC curves, the area under the curve was higher for the BIG score (0.97; 95%IC: 0.95-0.99) in comparison to the ISS (0.78; 95%IC: 0.71-0.85). Conclusion: The BIG score is an excellent predictor of survival for children visiting the emergency department following a blunt trauma.

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Retrospective evaluation of the BIG score to predict mortality in pediatric blunt trauma

CJEM ◽

10.1017/cem.2017.379 ◽

2017 ◽

Vol 20 (4) ◽

pp. 592-599 ◽

Cited By ~ 5

Author(s):

Charlotte Grandjean-Blanchet ◽

Guillaume Emeriaud ◽

Marianne Beaudin ◽

Jocelyn Gravel

Keyword(s):

Intensive Care Unit ◽

Emergency Department ◽

Intensive Care ◽

Hospital Mortality ◽

Blunt Trauma ◽

Retrospective Cohort ◽

Injury Severity ◽

Tertiary Care ◽

Pediatric Trauma ◽

Primary Analysis

AbstractObjectivesThis study’s objective was to measure the criterion validity of the BIG score (a new pediatric trauma score composed of the initial base deficit [BD], international normalized ratio [INR], and Glasgow Coma Scale [GCS]) to predict in-hospital mortality among children admitted to the emergency department with blunt trauma requiring an admission to the intensive care unit, knowing that a score <16 identifies children with a high probability of survival.MethodsThis was a retrospective cohort study performed in a single tertiary care pediatric hospital between 2008 and 2016. Participants were all children admitted to the emergency department for a blunt trauma requiring intensive care unit admission or who died in the emergency department. The primary analysis was the association between a BIG score ≥16 and in-hospital mortality.ResultsTwenty-eight children died among the 336 who met the inclusion criteria. Two hundred eighty-four children had information on the three components of the BIG score, and they were included in the primary analysis. A BIG score ≥16 demonstrated a sensitivity of 0.93 (95% confidence interval [CI]: 0.76-0.98) and specificity of 0.83 (95% CI: 0.78-0.87) to identify mortality. Using receiver operating characteristic curves, the area under the curve was higher for the BIG score (0.97; 95% IC: 0.95-0.99) in comparison to the Injury Severity Score (0.78; 95% IC: 0.71-0.85).ConclusionIn this retrospective cohort, the BIG score was an excellent predictor of survival for children admitted to the emergency department following a blunt trauma.

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