scholarly journals Spatial and seasonal distribution of Bulinus globosus and Biomphalaria pfeifferi in Ingwavuma, uMkhanyakude district, KwaZulu-Natal, South Africa: Implications for schistosomiasis transmission at micro-geographical scale

2021 ◽  
Vol 14 (1) ◽  
Author(s):  
Tawanda Manyangadze ◽  
Moses John Chimbari ◽  
Owen Rubaba ◽  
White Soko ◽  
Samson Mukaratirwa
Keyword(s):  
South Africa ◽  
Dissolved Oxygen ◽  
Intermediate Host ◽  
Negative Relationship ◽  
Sub Saharan Africa ◽  
Significant Negative Relationship ◽  
Generalised Linear Mixed Model ◽  
Kwazulu Natal ◽  
Geographical Scale ◽  
Bulinus Globosus

Abstract Background Schsistosomiasis is endemic in sub-Saharan Africa. It is transmitted by intermediate host snails such as Bulinus and Biomphalaria. An understanding of the abundance and distribution of snail vectors is important in designing control strategies. This study describes the spatial and seasonal variation of B. globosus and Bio. pfeifferi and their schistosome infection rates between May 2014 and May 2015 in Ingwavuma, uMkhanyakude district, KwaZulu-Natal province, South Africa. Methods Snail sampling was done on 16 sites once every month by two people for 30 min at each site using the scooping and handpicking methods. Snails collected from each site were screened for schistosome mammalian cercariae by the shedding method. The negative binomial generalised linear mixed model (glmm) was used to determine the relationship between abundances of the intermediate host snails and climatic factors [rainfall, land surface temperatures (LST), seasons, habitats, sampling sites and water physico-chemical parameters including pH and dissolved oxygen (DO)]. Results In total, 1846 schistosomiasis intermediate host snails were collected during the study period. Biompharia pfeifferi was more abundant (53.36%, n = 985) compared to B. globosus (46.64%, n = 861). Bulinus globosus was recorded at 12 sites (75%) and Bio. pfeifferi was present at 7 sites (43.8%). Biompharia pfeifferi cohabited with B. globosus at all the sites it was present. High numbers of Bio. pfeifferi (n = 872, 88.5%) and B. globosus (n = 705, 81.9%) were found between winter and mid-spring. Monthly rainfall showed a statistically significant negative relationship with the abundance of B. globosus (p < 0.05). Dissolved oxygen (DO) had a statistically significant positive relationship with the abundance of Bio. pfeifferi (p < 0.05) while (LST) had a statistically significant negative relationship (p < 0.05). More B. globosus (8.9%, n = 861) were shedding schistosome mammalian cercariae compared to Bio. pfeifferi (0.1%, n = 985) confirming the already documented high prevalence of S. haematobium in Ingwavuma compared to S. mansoni. Conclusion Results of this study provide updated information on the distribution of schistosomiasis intermediate host snails in the study area and contributes towards the understanding of the transmission dynamics of schistosomiasis at the micro-geographical scale in this area. Graphic Abstract

Molecular detection of natural infection ofLymnaea(Pseudosuccinea)columella(Gastropoda: Lymnaeidae) withFasciola gigantica(Digenea: Fasciolidae) from two provinces of South Africa

2019 ◽  
Vol 94 ◽  
Author(s):  
M.P. Malatji ◽  
S. Mukaratirwa
Keyword(s):  
South Africa ◽  
Intermediate Host ◽  
Molecular Detection ◽  
Natural Infection ◽  
Wide Distribution ◽  
Sub Saharan Africa ◽  
Snail Species ◽  
Eastern Cape ◽  
Kwazulu Natal ◽  
Sub Saharan

AbstractThe main intermediate host ofFasciola giganticain sub-Saharan Africa isLymnaea(Radix)natalensis.Lymnaea(Pseudosuccinea)columellais capable of transmitting bothF. giganticaandF. hepaticaand has been reported to be present in South Africa. To date, no natural infection withF. giganticahas been reported despite the wide distribution of the snail. The aim of this study was to confirm whetherL.(P.)columellawas transmittingF. giganticaand/orF. hepaticain selected locations of KwaZulu-Natal and Eastern Cape provinces of South Africa.Lymnaea(Pseudosuccinea)columellasnails were collected from two locations in two provinces of South Africa and screened for cercariae shedding. This was followed by humanely sacrificing the screened snails, and whole tissue of each individual snail was homogenized and amplified using primers designed to amplify the ITS-1 region ofFasciolaspp. No cercariae were shed from the screened snails and molecular analysis showed that snails from the two locations were infected withF. gigantica. This study confirms natural infection ofL.(P.)columellawithF. giganticain South Africa, whereF. giganticaandF. hepaticahave already been reported to coexist. AlthoughL.(P.)columellais able to transmit the two species, surprisingly no infection withF. hepaticawas detected from the screened snails. The natural intermediate host ofF. giganticain southern Africa, including South Africa, isLymnaea(Radix)natalensisand comparative studies are needed to determine the competence of the two snail species in the transmission ofF. gigantica.

Paragonimiasis in KwaZulu-Natal province, South Africa

2012 ◽  
Vol 88 (1) ◽  
pp. 123-128 ◽  
Author(s):  
C.C. Appleton
Keyword(s):  
South Africa ◽  
Intermediate Host ◽  
Snail Species ◽  
Sufficient Information ◽  
Suspected Case ◽  
Melanoides Tuberculata ◽  
Kwazulu Natal ◽  
Second Intermediate Host ◽  
Adult Female Patient ◽  
Prosobranch Snail

AbstractNine cases of paragonimiasis have been reported from cats (4), dogs (2) and children (3) in South Africa, with an additional suspected case in an adult female patient. Details of these cases are reviewed. All nine cases, and perhaps the adult case as well, were from the province of KwaZulu-Natal but locality data are only available for six of them. These six cases represent four localities which all lie below 100 m above sea level in the province's lowlands, suggesting that there may be a focus of transmission here. The molluscan first intermediate host must be one of the two prosobranch snail species present in the area,Melanoides tuberculataorTomichia natalensis, and the decapod second intermediate host the common river crabPotamonautes sidneyi. All infected cats and dogs had pulmonary infections, while two human cases for which there is sufficient information had extrapulmonary infections. Transmission appears to be ongoing but the invasive snailTarebia graniferamay be competing with bothM. tuberculataandT. natalensis.If so, this may bring transmission to an end.

scholarly journals Factors influencing uptake of schistosomiasis research findings in ingwavuma area, uMkhanyakude District, Kwazulu-Natal, South Africa

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Tafadzwa Mindu ◽  
Moses J. Chimbari
Keyword(s):  
South Africa ◽  
Rural Areas ◽  
Health Workers ◽  
Sub Saharan Africa ◽  
Primary School Children ◽  
Factors Influencing ◽  
Kwazulu Natal ◽  
Research Uptake ◽  
Research Findings ◽  
Sub Saharan

Background: Research uptake is concerned with spreading ideas across multiple levels of the community. Barriers such as poverty, lack of infrastructure, illiteracy and culture prevent information sharing in arid rural areas of sub-Saharan Africa. Objective: This study explores the factors influencing schistosomiasis research uptake and the available channels for the uptake of research findings from a transdisciplinary and eco-health research project on schistosomiasis in Ingwavuma area, uMkhanyakude district, KwaZulu-Natal province in South Africa. Methods: This case study conducted in 2017 involved 78 primary school children and 73 heads of household recruited through convenience and purposive sampling. Data were collected through focus group discussions, then transcribed and analysed by the researcher using thematic analysis. Results: Factors such as poor knowledge, water and sanitation problems, and lack of sufficient health workers hindered the uptake of schistosomiasis research findings. Participants recommended several platforms to share schistosomiasis research findings with the community, including: door to door visits; social gatherings such as sports events, talent shows, and religious gatherings; mass media platforms such as radio and television; social media platforms such as WhatsApp, Facebook and Twitter; and printed media such as posters, booklets and pamphlets. Conclusions: There is a need to train health workers and peer educators in this area of South Africa to educate people about schistosomiasis infection, screening and treatment through home visits or social events. Schistosomiasis research findings must be synthesised and packaged in different forms for dissemination via multimedia media-based communication channels.

scholarly journals Occurrence of Theileria parva and other haemoprotozoa in cattle at the edge of Hluhluwe-iMfolozi Park, KwaZulu-Natal, South Africa

2010 ◽  
Vol 81 (1) ◽  
Author(s):  
S. B.A.S. Yusufmia ◽  
N. E. Collins ◽  
R. Nkuna ◽  
M. Troskie ◽  
P. Van Den Bossche ◽  
...  
Keyword(s):  
South Africa ◽  
Buffy Coat ◽  
Babesia Bovis ◽  
Sub Saharan Africa ◽  
Significant Finding ◽  
Theileria Parva ◽  
Mortality And Morbidity ◽  
Kwazulu Natal ◽  
Pcr Rflp ◽  
Sub Saharan

Theileria parva, the most important bovine theilerial species in sub-Saharan Africa, causes widespread mortality and morbidity in endemic areas. A survey was conducted using buffy-coat specimens from 60 apparently healthy adult communally herded Nguni-type cattle at the northeastern edge of the Hluhluwe-iMfolozi Park to determine, by means of PCR and Reverse Line Blot (RLB) hybridisation, the occurrence of Theileria and Babesia species. The presence of Trypanosoma species was determined using PCR-RFLP. Results showed that 6.7 % of the specimens were positive for Theileria parva. This significant finding suggests that cattle in South Africa, and not only African buffaloes (Syncerus caffer), may be subclinical carriers of T. parva. Other species identified were T. mutans (83.3 %), T. velifera (70.0 %), Theileria sp. (sable) (46.8 %) and T. taurotragi (1.7 %). Two specimens (3.3 %) were positive for Babesia bovis and single specimens (1.7 %) positive for B. bigemina and B. rossi, respectively. Mixed infections, of up to 4 species, were common (65.0 %). Only 1 specimen was found to be positive for Trypanosoma vivax, and 2 for T. theileri, of which only the first species is pathogenic.

scholarly journals Establishing and Evaluating Cancer Surveillance System in KwaZulu-Natal, South Africa

2021 ◽  
Vol 20 ◽  
pp. 117693512110299
Author(s):  
Noluthando P Mbeje ◽  
Themba G Ginindza ◽  
Nkosana Jafta
Keyword(s):  
Public Health ◽  
South Africa ◽  
Urban Areas ◽  
Surveillance System ◽  
Cancer Registries ◽  
Health Systems Strengthening ◽  
Cancer Surveillance ◽  
Sub Saharan Africa ◽  
Cancer Burden ◽  
Kwazulu Natal

Background: The increasing cancer burden remains a public health challenge. Quality and accurate population data is important to improve cancer control, screening, and treatment programmes for the sub-Saharan Africa region. Aim: The aim of this study was to establish hospital-based cancer surveillance system, thereby reporting the burden that cancer diagnosis and treatment place on 3 hospitals – an approach of health systems strengthening. Methods: A hospital-based cancer surveillance was established in 3 public health facilities that provide oncology services in KwaZulu-Natal. An active method was used for finding cancer cases. The cancer surveillance database was evaluated according to the criteria recommended for cancer registries. Analyses of data included descriptive and crude incidence rates. Results: A total of 2307 newly diagnosed cancer cases were reported in 2018, with a majority from Inkosi Albert Luthuli Central hospital (65.3%), followed by Greys hospital (30.8%) and then Addington hospital (3.94%). Most of the cancer cases were from the 2 major urban areas of the province (eThekwini and uMgungundlovu district). The most commonly diagnosed cancers from all combined 3 facilities for both sexes were breast, cervix, colorectal, Kaposi Sarcoma, and lung. Approximately half of the cancer cases had no staging, and 12.8% of the cases were diagnosed at stage 4. The mostly prescribed treatments for the patients were radiotherapy and chemotherapy. Conclusions: Based on our hospital-based surveillance, cancer burden is high in the 3 facilities. Strengthening cancer screening and diagnostic policies and procedures that will allow expansion of accurate cancer surveillance system is essential in KwaZulu-Natal and South Africa as a whole.

Evaluation of onion (Allium cepa) germplasm entries for resistance to onion thrips, Thrips tabaci (Lindeman) in Tanzania

2017 ◽  
Vol 37 (02) ◽  
pp. 98-113 ◽  
Author(s):  
Gabriel Michael Njau ◽  
Agnes M. S. Nyomora ◽  
Fekadu Fufa Dinssa ◽  
Jian-Cheng Chang ◽  
P. Malini ◽  
...  
Keyword(s):  
Negative Relationship ◽  
Thrips Tabaci ◽  
Sub Saharan Africa ◽  
Leaf Damage ◽  
Leaf Angle ◽  
Total Phenol Content ◽  
Onion Thrips ◽  
Leaf Toughness ◽  
Biochemical Basis ◽  
Significant Negative Relationship

AbstractOnion thrips,Thrips tabaci(Lindeman), is a prominent species infesting onion and tomato in the northern highlands of Tanzania. It causes considerable leaf damage by direct feeding and also transmits theIris yellow spot virus(IYSV). Hence, one of the objectives of this study was to identify the most resistant onion entries againstT. tabaci.One highly resistant (VI038552) and two resistant onion entries (VI038512 and AVON 1067) were identified againstT. tabaci. Besides thrips resistance, the bulb size of VI038512 was also equivalent to one of the commercial varieties, Texas. The highly resistant VI038552 recorded the highest yield, followed by the resistant entry, VI038512. However, the yield of AVON 1067 was significantly lower. Elucidation of the biophysical bases of resistance revealed that there was a significant negative correlation between leaf angle as well as leaf toughness and thrips damage. The total epicuticular wax content in the leaves had a weak and non-significant negative relationship with thrips damage. The scanning electron microscopic study confirmed that the wax crystals occurred as filaments, rods, platelets, tubes and complex dendritic structures, and that they were densely arranged in resistant or moderately resistant entries. Studies on the biochemical basis of resistance confirmed that there was a significant negative relationship between total phenol content and thrips damage. Similarly, the relationship between total foliar amino acids or total sugars and thrips damage was inversely correlated and non-significant. Hence, entries VI038552 and VI038512 could be promising candidates for breeding programmes aimed at developing onion varieties that are resistant to thrips and that are high yielding, which will help to enhance the productivity of onions in sub-Saharan Africa.

scholarly journals Zwakala Ndoda: a cluster and individually randomized trial aimed at improving testing, linkage, and adherence to treatment for hard-to reach men in KwaZulu-Natal, South Africa

Trials ◽  
2019 ◽  
Vol 20 (1) ◽  
Author(s):  
Heidi van Rooyen ◽  
Tawanda Makusha ◽  
Phillip Joseph ◽  
Thulani Ngubane ◽  
Michal Kulich ◽  
...  
Keyword(s):  
South Africa ◽  
Viral Load ◽  
Randomized Trial ◽  
Hiv Testing ◽  
Hiv Treatment ◽  
Sub Saharan Africa ◽  
Structural Barriers ◽  
Combination Prevention ◽  
Care Services ◽  
Kwazulu Natal

Abstract Background Men in sub-Saharan Africa are less likely than women to get tested for HIV, less likely to present for treatment, less likely to be maintained in treatment, more likely to have detectable viral load, more likely to transmit HIV with unprotected intercourse, and more likely to progress to AIDS and die sooner from HIV. The ultimate objective of this research is to provide evidence-based strategies to improve HIV testing and treatment of HIV-infected men. Methods This study is being conducted in the Greater Edendale Area and Vulindlela region in KwaZulu-Natal, South Africa. It is a two-stage design of a cluster-randomized trial and an individual randomized trial to test how structural and individual-level interventions address the demand-side factors that affect HIV testing and treatment for hard-to reach, high-risk men. It combines male-focused mobilization, community-based mobile HIV testing services, and a small incentive to determine if the strategies singly and in combination can result in more men diagnosed with HIV, and more men linked to and maintained in care with undetectable viral load. Discussion A priority for sub-Sahara Africa is developing and evaluating novel and cost-effective strategies for identifying hard-to-reach groups such as men, linking them to HIV testing and care services, and maintaining them in care to the point of viral suppression. We propose a combination prevention intervention that addresses men’s individual, interpersonal, and structural barriers to testing and care. This includes male-led mobilization to encourage uptake of testing and treatment, male-focused testing venues, male-only counselors, developing counseling models that are flexible and responsive to men, and strategies for adhering to clinic visits without missing work and navigating the healthcare system. By thoughtfully combining male-focused mobilization, and testing and addressing some of the barriers to male engagement with health facilities, this study hopes to add to the growing evidence base about how to reach, test, link, and maintain a hard-to-reach group such as men in HIV treatment and care services. Trial registration ClinicalTrials.gov, NCT03794245. Registered on 4 January 2019.

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