scholarly journals Genomic medicine in the Middle East

2021 ◽  
Vol 13 (1) ◽  
Author(s):  
Ahmad N. Abou Tayoun ◽  
Khalid A. Fakhro ◽  
Alawi Alsheikh-Ali ◽  
Fowzan S. Alkuraya
Keyword(s):  
Middle East ◽  
Genomic Medicine ◽  
Arab Countries ◽  
Counseling Services ◽  
Genomic Testing ◽  
Clinical Genetics ◽  
Mendelian Genetics ◽  
Current State ◽  
Training And Research ◽  
Genetic Counseling Services

AbstractWe discuss the current state of genomic medicine in Arab countries of the Middle East, a region with outsized contribution to Mendelian genetics due to inbreeding yet has poor representation in global variome datasets. We focus on genomic testing, clinical genetics, and genetic counseling services along with associated training and research programs. Finally, we highlight opportunities for improvement in genomic medicine services in this region.

scholarly journals Mainstreaming of genomic medicine in gastroenterology, present and future: a nationwide survey of UK gastroenterology trainees

BMJ Open ◽  
2019 ◽  
Vol 9 (10) ◽  
pp. e030505
Author(s):  
Ibrahim Al Bakir ◽  
Gregory Malcolm Sebepos-Rogers ◽  
Hilary Burton ◽  
Kevin J Monahan
Keyword(s):  
Personalised Medicine ◽  
Genomic Medicine ◽  
Nationwide Survey ◽  
Training Programme ◽  
Genomic Testing ◽  
Web Based ◽  
Current State ◽  
Future Clinical Practice ◽  
The Uk

ObjectiveGenomics and personalised medicine are increasingly relevant for patients with gastroenterological conditions. We aim to capture the current state of genomics training in gastroenterology to review current understanding, clinical experience and long-term educational needs of UK trainees.Design and settingA web-based nationwide survey of all UK gastroenterology specialty trainees was conducted in 2017.Results100 trainees (14% of UK gastroenterology trainees) completed this survey. Only 9% and 16% of respondents believe that their local training programme adequately prepares them for the future clinical practice using genomic medicine and personalised medicine, respectively. Barriers identified include the need for greater trainee education (95%), inadequate clinical guidance to base interventions on the results of genomic testing (53%), concerns over misinterpretation by patients (43%) and overuse/misuse of testing by clinicians (34%).Survey respondents felt prepared to perform HFE genotyping (98%), assess TPMT status (97%) and interpret HLA subtyping for suspected coeliac disease (85%). However, only a minority felt prepared to perform the following investigations: polyposis screening (34%), hereditary pancreatitis screening (30%), testing for Lynch yndrome (33%) and KRAS testing for colorectal cancer (20%).Most respondents would support holding dedicated training days on genomic medicine (83%), formal training provisions for the mainstreaming of genomic testing (64%), an update to the UK gastroenterology specialty training curriculum and examinations (57%) and better-defined referral pathways for local genomic services (91%).ConclusionMost gastroenterology trainees in this survey feel ill equipped to practise genomic and personalised medicine as consultants. We propose specific revisions to the UK gastroenterology specialty curriculum that addresses trainees needs.

scholarly journals Diverse perspectives on the current state of genomic medicine: has the revolution begun?

10.1186/gm241 ◽  
2011 ◽  
Vol 3 (5) ◽  
pp. 27 ◽  
Author(s):  
Dhara M MacDermed ◽  
Liliana Uribe-Bruce
Keyword(s):  
Genomic Medicine ◽  
Current State ◽  
The Revolution

scholarly journals Continuing the sequence? Towards an economic evaluation of whole genome sequencing for the diagnosis of rare diseases in Scotland

2021 ◽  
Author(s):  
Michael Abbott ◽  
Lynda McKenzie ◽  
Blanca Viridiana Guizar Moran ◽  
Sebastian Heidenreich ◽  
Rodolfo Hernández ◽  
...  
Keyword(s):  
Economic Evaluation ◽  
Genetic Testing ◽  
Whole Genome Sequencing ◽  
Genome Sequencing ◽  
Rare Diseases ◽  
Genomic Medicine ◽  
Future Research ◽  
Clinical Genetics ◽  
Whole Genome ◽  
Peace Of Mind

AbstractNovel developments in genomic medicine may reduce the length of the diagnostic odyssey for patients with rare diseases. Health providers must thus decide whether to offer genome sequencing for the diagnosis of rare conditions in a routine clinical setting. We estimated the costs of singleton standard genetic testing and trio-based whole genome sequencing (WGS), in the context of the Scottish Genomes Partnership (SGP) study. We also explored what users value about genomic sequencing. Insights from the costing and value assessments will inform a subsequent economic evaluation of genomic medicine in Scotland. An average cost of £1,841 per singleton was estimated for the standard genetic testing pathway, with significant variability between phenotypes. WGS cost £6625 per family trio, but this estimate reflects the use of WGS during the SGP project and large cost savings may be realised if sequencing was scaled up. Patients and families valued (i) the chance of receiving a diagnosis (and the peace of mind and closure that brings); (ii) the information provided by WGS (including implications for family planning and secondary findings); and (iii) contributions to future research. Our costings will be updated to address limitations of the current study for incorporation in budget impact modelling and cost-effectiveness analysis (cost per diagnostic yield). Our insights into the benefits of WGS will guide the development of a discrete choice experiment valuation study. This will inform a user-perspective cost–benefit analysis of genome-wide sequencing, accounting for the broader non-health outcomes. Taken together, our research will inform the long-term strategic development of NHS Scotland clinical genetics testing services, and will be of benefit to others seeking to undertake similar evaluations in different contexts.

Middle East–Yemen Arab Republic–Asian Sub-Continent–East Africa–West Africa–Haiti–Colombia–Northern Ireland–Visits to political detainees

1973 ◽  
Vol 13 (142) ◽  
pp. 22-25
Keyword(s):  
Middle East ◽  
Northern Ireland ◽  
West Africa ◽  
East Africa ◽  
Prisoners Of War ◽  
Arab Countries ◽  
Yemen Arab Republic

ICRC delegates in Israel and the Arab countries have, in recent weeks, made several visits to prisoners of war. As usual, they talked with them without witnesses. In accordance with the established practice, reports are sent to the detaining authorities and to the prisoners' own governments.

Events in Northern Africa and Middle East: Causes and Consequences

2011 ◽  
pp. 11-25
Author(s):  
I. Labinskaya
Keyword(s):  
Middle East ◽  
North Africa ◽  
Large Scale ◽  
Arab Countries ◽  
Northern Africa ◽  
External Factors ◽  
Wide Range ◽  
The Usa ◽  
Oriental Studies

Political developments in North Africa and the Middle East that have begun in January 2011 are gaining strength and involve an increasing number of Arab countries. The participants of the Roundtable – experts from IMEMO, Institute of Oriental Studies (RAS), Institute of the USA and Canada (RAS) and Mrs. E. Suponina from “Moscow News” newspaper analyzed a wide range of issues associated with these events. Among them are: 1) the reasons for such a large-scale explosion, 2) the nature of the discussed developments (revolutions, riots?) and who are the subjects of the current “Arab drama”, 3) the role of Islam and political Islamism, 4) the role of external factors.

Pax Americana: Palestine and the Middle East in the Trump Era

2021 ◽  
Vol 4 (2) ◽  
pp. 193-208
Author(s):  
Mitri Raheb
Keyword(s):  
Middle East ◽  
Arab World ◽  
Arab Countries ◽  
The Other ◽  
Other Hand ◽  
Pax Romana ◽  
Full Speed ◽  
Biblical Language

Abstract Peace between Israel and the Arab world appears to be progressing like never before. It started with the UAE, followed by Bahrain and Morocco, and then with Sudan. A “new” Middle East is finally becoming a reality. Yet, on the other hand, the colonization of Palestinian land is progressing at full speed ever since President Trump recognized Jerusalem as the capital of Israel and moved the American Embassy there. During both the Embassy move and the so-called Abraham Accords with Arab countries and throughout the Trump era, biblical language has been employed. This paper will examine these political developments and biblical connotations. At the heart of the issue lies the question of what constitutes real peace. This paper argues that ‘the deal of the century’ was a form of Pax Romana rather than Pax Christi.

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