scholarly journals Current obesity was associated with hypertension in children born very low birth weight

2021 ◽  
Vol 14 (1) ◽  
Author(s):  
Chompoonut Limratchapong ◽  
Pracha Nuntnarumit ◽  
Wischuri Paksi ◽  
Kwanchai Pirojsakul

Abstract Objectives Previous studies from the developed countries showed that children born very low birth weight have a higher risk of hypertension compared with that of the normal birth weight controls. However, studies regarding the prevalence of hypertension in such children from the developing countries are scarce. This study aimed to identify the perinatal and postnatal factors associated with hypertension in children born very low birth weight. Results Forty-six children aged ≥ 6 years from the VLBW cohort of Ramathibodi Hospital, Bangkok, Thailand underwent the ambulatory blood pressure monitoring. The prevalence of hypertension was 15.2% (7/46). The hypertension group had a significant higher BMI z-score at 3 years of age (0.90 ± 1.44 vs − 0.45 ± 1.47, p = 0.045) and a greater proportion of current obesity (42% vs 2.5%, p < 0.01) compared to those in the normotensive group. Multivariate analysis revealed that current obesity was associated with hypertension (OR 34.77, 95%CI 1.814–666.5). Among 36 children with normal office blood pressure, four children (11.1%) had high blood pressure uncovered by ABPM, called “masked hypertension”. Office systolic blood pressure at the 85th percentile was the greatest predictor for masked hypertension with a sensitivity of 75% and a specificity of 81.2%.

2021 ◽  
Author(s):  
Chompoonut Limratchapong ◽  
Pracha Nuntnarumit ◽  
Wischuri Paksi ◽  
Kwanchai Pirojsakul

Abstract Objectives: Previous studies from the developed countries showed that children born very low birth weight have a higher risk of hypertension compared with that of the normal birth weight controls. However, studies regarding the prevalence of hypertension in such children from the developing countries are scarce. This study aimed to identify the perinatal and postnatal factors associated with hypertension in children born very low birth weight.Results: Forty-six children aged ≥ 6 years from the VLBW cohort of Ramathibodi Hospital, Bangkok, Thailand underwent the ambulatory blood pressure monitoring. The prevalence of hypertension was 15.2% (7/46). The hypertension group had a significant higher BMI z-score at 3 years of age (0.90 ± 1.44 vs -0.45 ± 1.47, P = 0.045) and a greater proportion of current obesity (42% vs 2.5%, P < 0.01) compared to those in the normotensive group. Multivariate analysis revealed that current obesity was associated with hypertension (OR 20.5, 95%CI 1.07-391.5). Among 36 children with normal office blood pressure, four children (11.1%) had high blood pressure uncovered by ABPM, so-called “masked hypertension”. Office systolic blood pressure at the 85th percentile was the greatest predictor for masked hypertension with a sensitivity of 75% and a specificity of 81.2%.


2016 ◽  
Vol 35 (2) ◽  
pp. 141-147
Author(s):  
Garima Chawla ◽  
Baljeet Maini ◽  
Anand Kumar Bhardwaj

Introduction: India faces lot of neonatal morbidity. Non-invasive blood pressure (NIBP) monitoring is being used for monitoring sick new borns as a safe and cost effective method of blood pressure monitoring. But there is no available information on normal values of NIBP for neonates in India. With more stress of government (and advancement) in new born care, establishing normative data of NIBP in Indian newborns should be high priority. Material and Methods: This was an observational cohort study done in a level III neonatal intensive care unit. 164 clinically stable babies on day 1 of life were included. Blood pressure was measured by the Oscillometric method.Results: Progressive increase of blood pressure was seen with increasing birth weight. 10th, 50th, 75th, 95th Centile curves were drawn from available data. For very low birth weight babies (< 1500grams), the values of systolic, diastolic and mean BP (±2standard deviations (S.D.)) were found to be 53.7 ± 1.7, 29.1 ± 1.7 and 41 ± 1.1 mm Hg respectively. For low birth weight babies, i.e. with birth weight 1500-2499 grams, the values for systolic, diastolic and mean BP(±2 S.D.) were 62.2 ± 2.5, 34.8 ± 2.4 and 46.6 ± 2.4 mm Hg respectively. For normal weight babies (more than 2499 grams), the systolic, diastolic and mean BP (±2 S.D.) were 72.8 ± 4.2, 43 ± 4 and 55.3± 4 mm Hg respectively. The rise in systolic blood pressure with rising birth weight was highly significant (p <0.001). Similar were the results for diastolic and mean BPs, (p<0.001 for both),Conclusion: Blood pressure on day 1 of life appears to be directly related to birth weight. The effect is seen in all (i.e. systolic, diastolic and mean) blood pressure values.J Nepal Paediatr Soc 2015;35(2):141-146


Author(s):  
Annibal Sabino ◽  
Eduardo de Souza ◽  
Ana Goulart ◽  
Adriana Lima ◽  
Nelson Sass

Objective To evaluate whether the presence of maternal blood pressure reduces the risks of morbidity, perinatal mortality and morbidity at 24 months of age in very low birth weight infants (VLBWIs) compared with a control group. Methods A retrospective, observational, case-control study. Total 49 VLBWIs were allocated to the study group, called the maternal arterial hypertension group (AHG), and matched with 44 in the control group (CG). The infants were assessed during hospitalization and at 12 and 24 months corrected age at a specialized clinic. For the assessment of growth, the World Health Organization (WHO) Anthro software (Geneva, 2006) was used, and for the psychomotor assessment, the Denver II test was used. Results In relation to the antenatal variables, the infants of the AHG had more centralized circulation assessed by Doppler, received more corticosteroids and magnesium sulfate, and were born by cesarean section more frequently. In terms of the postnatal and in-hospital outcomes, the AHG had a higher gestational age at birth (30.7 versus 29.6 weeks) and a lower frequency of 5-minute Apgar scores of less than 7 (26.5% versus 52.3%). The CG had a higher rate of pulmonary dysplasia (30.2% versus 8.3%). There were no differences in terms of hospital mortality, complications, somatic growth and functional problems at 24 months of corrected age. Conclusion The presence of maternal hypertension, especially preeclampsia, was not a protective factor against morbidity, mortality and evolution in VLBWIs aged up to 24 months. Therefore, the clinical practice should be focused on prolonging the pregnancy for as long as possible in these conditions as well.


2011 ◽  
Vol 26 (7) ◽  
pp. 1115-1121 ◽  
Author(s):  
Andrea F. Duncan ◽  
Roy J. Heyne ◽  
Janet S. Morgan ◽  
Naveed Ahmad ◽  
Charles R. Rosenfeld

BJPsych Open ◽  
2016 ◽  
Vol 2 (1) ◽  
pp. 38-44 ◽  
Author(s):  
Donald M. Lyall ◽  
Hazel M. Inskip ◽  
Daniel Mackay ◽  
Ian J. Deary ◽  
Andrew M. McIntosh ◽  
...  

BackgroundLow birth weight has been inconsistently associated with risk of developing affective disorders, including major depressive disorder (MDD). To date, studies investigating possible associations between birth weight and bipolar disorder (BD), or personality traits known to predispose to affective disorders such as neuroticism, have not been conducted in large cohorts.AimsTo assess whether very low birth weight (<1500 g) and low birth weight (1500–2490 g) were associated with higher neuroticism scores assessed in middle age, and lifetime history of either MDD or BD. We controlled for possible confounding factors.MethodRetrospective cohort study using baseline data on the 83 545 UK Biobank participants with detailed mental health and birth weight data. Main outcomes were prevalent MDD and BD, and neuroticism assessed using the Eysenck Personality Inventory Neuroticism scale - Revised (EPIN-R)ResultsReferent to normal birth weight, very low/low birth weight were associated with higher neuroticism scores, increased MDD and BD. The associations between birth weight category and MDD were partially mediated by higher neuroticism.ConclusionsThese findings suggest that intrauterine programming may play a role in lifetime vulnerability to affective disorders.


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