Concomitant histone deacetylase and phosphodiesterase 5 inhibition synergistically prevents the disruption in synaptic plasticity and it reverses cognitive impairment in a mouse model of Alzheimer’s disease

Phosphodiesterase 5

Dysregulation of the mTOR Pathway Mediates Impairment of Synaptic Plasticity in a Mouse Model of Alzheimer's Disease

PLoS ONE ◽

10.1371/journal.pone.0012845 ◽

2010 ◽

Vol 5 (9) ◽

pp. e12845 ◽

Cited By ~ 127

Author(s):

Tao Ma ◽

Charles A. Hoeffer ◽

Estibaliz Capetillo-Zarate ◽

Fangmin Yu ◽

Helen Wong ◽

...

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Synaptic Plasticity ◽

Mouse Model ◽

Mtor Pathway ◽

Isorhynchophylline ameliorates cognitive impairment via modulating amyloid pathology, tau hyperphosphorylation and neuroinflammation: Studies in a transgenic mouse model of Alzheimer’s disease

Brain Behavior and Immunity ◽

10.1016/j.bbi.2019.08.194 ◽

2019 ◽

Vol 82 ◽

pp. 264-278 ◽

Cited By ~ 6

Author(s):

Hui-Qin Li ◽

Siu-Po Ip ◽

Qiu-Ju Yuan ◽

Guo-Qing Zheng ◽

Karl K.W. Tsim ◽

...

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Cognitive Impairment ◽

Mouse Model ◽

Transgenic Mouse ◽

Transgenic Mouse Model ◽

Tau Hyperphosphorylation ◽

Amyloid Pathology ◽

β-Lapachone attenuates cognitive impairment and neuroinflammation in beta-amyloid induced mouse model of Alzheimer's disease

International Immunopharmacology ◽

10.1016/j.intimp.2020.106300 ◽

2020 ◽

Vol 81 ◽

pp. 106300 ◽

Cited By ~ 5

Author(s):

Narmin Mokarizadeh ◽

Pouran Karimi ◽

Marjan Erfani ◽

Saeed Sadigh-Eteghad ◽

Nazila Fathi Maroufi ◽

...

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Cognitive Impairment ◽

Mouse Model ◽

Beta Amyloid ◽

Intramuscular delivery of a single chain antibody gene prevents brain Aβ deposition and cognitive impairment in a mouse model of Alzheimer’s disease

Brain Behavior and Immunity ◽

10.1016/j.bbi.2010.05.010 ◽

2010 ◽

Vol 24 (8) ◽

pp. 1281-1293 ◽

Cited By ~ 25

Author(s):

Yan-Jiang Wang ◽

Chang-Yue Gao ◽

Miao Yang ◽

Xiao-Hong Liu ◽

Yin Sun ◽

...

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Cognitive Impairment ◽

Mouse Model ◽

Single Chain ◽

Single Chain Antibody ◽

Intramuscular Delivery ◽

Antibody Gene

Nobiletin, a citrus flavonoid, improves cognitive impairment and reduces soluble Aβ levels in a triple transgenic mouse model of Alzheimer's disease (3XTg-AD)

Behavioural Brain Research ◽

10.1016/j.bbr.2015.04.028 ◽

2015 ◽

Vol 289 ◽

pp. 69-77 ◽

Cited By ~ 53

Author(s):

Akira Nakajima ◽

Yuki Aoyama ◽

Eun-Joo Shin ◽

Yunsung Nam ◽

Hyoung-Chun Kim ◽

...

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Cognitive Impairment ◽

Mouse Model ◽

Transgenic Mouse ◽

Transgenic Mouse Model ◽

Triple Transgenic Mouse

Nootkatone, a neuroprotective agent from Alpiniae Oxyphyllae Fructus, improves cognitive impairment in lipopolysaccharide-induced mouse model of Alzheimer's disease

International Immunopharmacology ◽

10.1016/j.intimp.2018.06.042 ◽

2018 ◽

Vol 62 ◽

pp. 77-85 ◽

Cited By ~ 21

Author(s):

Yunlong Wang ◽

Mengshi Wang ◽

Mengjie Xu ◽

Tongde Li ◽

Kaiyue Fan ◽

...

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Cognitive Impairment ◽

Mouse Model ◽

Neuroprotective Agent ◽

Electroacupuncture Ameliorates Cognitive Impairment by Inhibiting the JNK Signaling Pathway in a Mouse Model of Alzheimer’s Disease

Frontiers in Aging Neuroscience ◽

10.3389/fnagi.2020.00023 ◽

2020 ◽

Vol 12 ◽

Cited By ~ 8

Author(s):

Yinshan Tang ◽

Anping Xu ◽

Shujun Shao ◽

You Zhou ◽

Bing Xiong ◽

...

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Cognitive Impairment ◽

Mouse Model ◽

Signaling Pathway ◽

Jnk Signaling ◽

Jnk Signaling Pathway

Disrupted-in-schizophrenia-1 protects synaptic plasticity in a transgenic mouse model of Alzheimer’s disease as a mitophagy receptor

Aging Cell ◽

10.1111/acel.12860 ◽

2018 ◽

Vol 18 (1) ◽

pp. e12860 ◽

Cited By ~ 18

Author(s):

Zhao-Tao Wang ◽

Mei-Hong Lu ◽

Yan Zhang ◽

Wen-Li Ji ◽

Lei Lei ◽

...

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Synaptic Plasticity ◽

Mouse Model ◽

Transgenic Mouse ◽

Transgenic Mouse Model ◽

AVP(4-8) Improves Cognitive Behaviors and Hippocampal Synaptic Plasticity in the APP/PS1 Mouse Model of Alzheimer’s Disease

Neuroscience Bulletin ◽

10.1007/s12264-019-00434-0 ◽

2019 ◽

Vol 36 (3) ◽

pp. 254-262 ◽

Cited By ~ 2

Author(s):

Xiumin Zhang ◽

Fang Zhao ◽

Chenfang Wang ◽

Jun Zhang ◽

Yu Bai ◽

...

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Synaptic Plasticity ◽

Mouse Model ◽

Cognitive Behaviors ◽

Hippocampal Synaptic Plasticity ◽

WBQ5187, a Multitarget Directed Agent, Ameliorates Cognitive Impairment in a Transgenic Mouse Model of Alzheimer’s Disease and Modulates Cerebral β-Amyloid, Gliosis, cAMP Levels, and Neurodegeneration

ACS Chemical Neuroscience ◽

10.1021/acschemneuro.9b00409 ◽

2019 ◽

Vol 10 (12) ◽

pp. 4787-4799

Author(s):

Zhiren Wang ◽

Mengru Cao ◽

Hongling Xiang ◽

Wei Wang ◽

Xing Feng ◽

...

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Cognitive Impairment ◽

Mouse Model ◽

Transgenic Mouse ◽

Transgenic Mouse Model ◽

Β Amyloid ◽

Camp Levels