scholarly journals Induction of remission in chronic urticaria by immunotherapy using immunoglobulin/histamine complex (Histobulin™): a case report

2021 ◽  
Vol 17 (1) ◽  
Author(s):  
Hyuk Soon Kim ◽  
Geunwoong Noh
Keyword(s):  
Chronic Urticaria ◽  
Symptom Control ◽  
Eosinophil Cationic Protein ◽  
Allergic Diseases ◽  
Early Response ◽  
Remission Induction ◽  
Blood Eosinophil ◽  
Late Response ◽  
Rapid Improvement ◽  
Cationic Protein

Abstract Background Symptom control is a major concern in chronic urticaria. Histobulin™ is a histamine/immunoglobulin complex that has been approved for allergic rhinitis, bronchial asthma and chronic urticaria in some countries. Not only has the immunoglobulin/histamine complex been reported to be effective in allergic diseases, including chronic urticaria, but recently, the possibility of remission induction in chronic urticaria by the immunoglobulin/histamine complex has been reported. Case presentation Histobulin™ was administered until remission was induced instead of fixing the number of administrations in four cases of chronic urticaria. Two patients showed an early response and finished treatment with 12 injections of Histobulin™, and the other two patients showed a late response and were injected 43 and 46 times. Remission was induced successfully in all four cases. Conclusions Histobulin™ is not only effective but also induces remission in CSU. The Histobulin™ therapy protocol in CSU may be better if the treatment is continued until remission is achieved. Based on the responses of the patients, early responders and late responders were present. The progression of the disease during treatment consisted of a slow improvement phase and a rapid improvement phase. Uniquely, the appropriate allergy laboratory results, including blood eosinophil fraction, total IgE and eosinophil cationic protein level, were normal in all 4 cases. Further studies concerning the mechanisms of Histobulin™ may be needed.

scholarly journals Induction of Remission in Chronic Urticaria by Immunotherapy Using Immunoglobulin/histamine Complex (HistobulinTM): A Case Report

2021 ◽  
Author(s):  
Hyuk Soon Kim ◽  
Geunwoong Noh
Keyword(s):  
Chronic Urticaria ◽  
Symptom Control ◽  
Eosinophil Cationic Protein ◽  
Early Response ◽  
Blood Eosinophil ◽  
Late Response ◽  
Rapid Improvement ◽  
Cationic Protein ◽  
Case Presentation ◽  
Therapy Protocol

Abstract Background: Symptom control is a major concern in chronic urticaria. HistobulinTM is a histamine/immunoglobulin complex and has been reported to be effective for chronic urticaria.Case Presentation: HistobulinTM was administered until remission was induced instead of fixing the number of administrations in four cases of chronic urticaria. Two patients showed an early response and finished treatment with 12 injections of Histobulin, and the other two patients showed a late response and were injected 43 times and 46 times. Remission was induced successfully in all four cases.Conclusions: HitobulinTM is not only effective but also induces remission in CSU. The HistobulinTM therapy protocol in CSU may be better if the treatment is continued until remission is achieved. Based on the responses of the patients, early responders and late responders were present. The progress of the disease during treatment consisted of a slow improvement phase and a rapid improvement phase. Uniquely, the appropriate allergy laboratory results, including blood eosinophil fraction, total IgE and eosinophil cationic protein level, were normal in all 4 cases. Further studies concerning the mechanisms of HistobulinTM may be needed.

scholarly journals Blood eosinophils and serum eosinophil cationic protein in patients with acute and chronic urticaria

1996 ◽  
Vol 5 (2) ◽  
pp. 113-115 ◽  
Author(s):  
G. Di Lorenzo ◽  
P. Mansueto ◽  
M. Melluso ◽  
G. Candore ◽  
D. Cigna ◽  
...  
Keyword(s):  
Chronic Urticaria ◽  
Eosinophil Cationic Protein ◽  
Chronic Idiopathic Urticaria ◽  
Blood Eosinophil ◽  
Cationic Protein ◽  
Acute Urticaria ◽  
Asymptomatic Patients ◽  
The Moment ◽  
Blood Eosinophils ◽  
Eosinophil Counts

We have analysed the relationship of blood eosinophil count and serum eosinophil cationic protein (ECP) levels in patients with acute and chronic idiopathic urticaria. The ECP levels and eosinophil counts were measured in the peripheral blood of 15 patients with acute urticaria, 25 with chronic idiopathic urticaria and 10 normal healthy subjects. Blood eosinophil counts and serum ECP levels increased in all patients with acute urticaria. Concerning patients affected by chronic urticaria, taking into account the recrudescence of the disease at the moment of taking the blood sample, only symptomatic patients showed increased eosinophil blood values whereas serum ECP levels were increased both in symptomatic and asymptomatic patients. Furthermore, serum ECP levels in chronic urticaria did not correlate with the peripheral eosinophil counts, as they did in acute urticaria. The results of the present study indicate that eosinophils may play a role in the inflammatory mechanisms in patients with acute and chronic urticaria showing a positive correlation between serum ECP levels and disease activity.

scholarly journals Human toxocariasis and atopy

Parasite ◽  
2020 ◽  
Vol 27 ◽  
pp. 32 ◽  
Author(s):  
Jean-François Magnaval ◽  
Judith Fillaux ◽  
Sophie Cassaing ◽  
Alexis Valentin ◽  
Xavier Iriart ◽  
...  
Keyword(s):  
Eosinophil Cationic Protein ◽  
Multivariate Regression Analysis ◽  
Specific Ige ◽  
Outcome Variable ◽  
Bivariate Analysis ◽  
Blood Eosinophil ◽  
University Hospitals ◽  
Cationic Protein ◽  
Serum Total Ige ◽  
Inhalant Allergens

To assess the possible influence of atopy on the clinical picture of human toxocariasis, a retrospective study was carried out using file records for patients who attended the Outpatient Clinic of Parasitology in Toulouse University Hospitals. A total of 106 file records for patients who had been diagnosed with common/covert toxocariasis were extracted from the database. Forty-nine patients (20 females and 29 males) were considered atopic since they exhibited a long (≥ 1 year) history of various allergic issues along with a titer ≥ 0.7 kIU/L for specific IgE against at least two out of nine mixes of common inhalant allergens. Fifty-seven patients (42 females and 15 males) were designated nonatopic on the basis of a negative result (<0.35 kIU/L) of the test for specific IgE. Demographic (age and sex), clinical (20 signs or symptoms) and laboratory (blood eosinophil count, eosinophil cationic protein, serum total IgE, and specific anti-Toxocara IgE) variables were investigated by bivariate analysis followed by multivariate regression analysis using “atopy” as the outcome variable. On the basis of our results, the clinical or laboratory picture of toxocaral disease was not affected by the presence of an atopic status.

Diagnostic features of chronic urticaria

2016 ◽  
Vol 19 (5) ◽  
pp. 290-295
Author(s):  
N. G Kochergin ◽  
P. V Kolkhir ◽  
Olga A. Kosoukhova
Keyword(s):  
Chronic Urticaria ◽  
Eosinophil Cationic Protein ◽  
Autologous Serum ◽  
Diagnostic Features ◽  
Cationic Protein ◽  
Complement Components ◽  
Autologous Serum Skin Test ◽  
Acute Urticaria ◽  
Physical Urticaria ◽  
Working Age

Urticaria is etiologically heterogeneous disease, where the main clinical sign is a wheal. For the duration of the disease course secrete acute and chronic urticaria. If urticaria elements in the skin of the patient are observedfrom several hours to 6 weeks, it is classified as acute urticaria, cutaneous if the process continues for more than 6 weeks, it is a chronic urticaria. The aim of our work was the optimization of diagnosis of chronic urticaria on the basis of the study of clinical and allergological and immunological characteristics of the testing results. The study involved 60 patients between the ages of 18 to 73 years with confirmed clinical diagnosis of chronic urticaria. The study was conducted in the clinic of skin and venereal diseases ofI.M. Sechenov First Medical State Medical University. Conducted clinical and anamnestic examination: medical history, assessment of complaints, determining the severity of urticaria (UAS7), quality of life (CU-Q2oL, DLQI), control of the symptoms of urticaria (UCT); laboratory tests: clinical blood test, C-reactive protein, thyroid hormones and antibodies to thyroid structures, tests to exclude physical urticaria, autologous serum skin test, D-dimer, rheumatoid factor, eosinophil-cationic protein, the total of IgE, antinuclear antibodies , C3 / C4 complement components, protein fractions, coagulation, urinalysis, general analysis offeces, feces on eggs of worms and protozoa. The study was conducted within 1 month and included diagnostic consultation period and 5 consultations every 7 days. Identified specific clinical and laboratory features that can be assigned to the diagnostic criteria for autoimmune form of chronic urticaria, which will continue to pick up these patients rational treatment. The high prevalence of urticaria, a variety offorms of the disease, the presence ofpathology predominantly in patients of working age, often ineffective diagnostic actions cause the urgency of the problem and the need for further study of this disease.

Eosinophil cationic protein, specific IgE and IgG4 in human toxocariasis

2006 ◽  
Vol 80 (4) ◽  
pp. 417-423 ◽  
Author(s):  
J.-F. Magnaval ◽  
J.-H. Faufingue ◽  
B. Morassin ◽  
R. Fabre
Keyword(s):  
Eosinophil Cationic Protein ◽  
Specific Ige ◽  
Blood Eosinophil ◽  
Regression Analyses ◽  
Cationic Protein ◽  
Blood Eosinophil Count ◽  
Atopic Status ◽  
Serum Total Ige ◽  
Inhalant Allergens ◽  
High Level

AbstractAmong 67 French patients presenting a toxocaral infection, various demographic, environmental, clinical and laboratory parameters (blood eosinophil count, eosinophil cationic protein (ECP), serum total IgE, specific IgE against common inhalant allergens, specific IgE and IgG4 againstToxocaraexcretory-secretory antigens) were investigated. Correlation studies and logistic regression analyses were conducted, testing elevated levels of ECP, specific anti-ToxocaraIgE or IgG4 as outcome variables An elevated ECP level was significantly associated with both cough and rhinitis, a high level of specific anti-ToxocaraIgE with itchy rashes and possible atopic status, and an increase of specific anti-ToxocaraIgG4 with rural residence.

scholarly journals Traditional Chinese MedicineZHENGIdentification Provides a Novel Stratification Approach in Patients with Allergic Rhinitis

2012 ◽  
Vol 2012 ◽  
pp. 1-9 ◽  
Author(s):  
Kai-Li Liang ◽  
Rong-San Jiang ◽  
Chia-Lin Lee ◽  
Pei-Jung Chiang ◽  
Jui-Shan Lin ◽  
...  
Keyword(s):  
Allergic Rhinitis ◽  
Immunoglobulin E ◽  
Linear Regression Analysis ◽  
Eosinophil Cationic Protein ◽  
Multiple Linear Regression Analysis ◽  
Total Serum ◽  
Blood Eosinophil ◽  
Cationic Protein ◽  
Explanatory Factors ◽  
Severity Scores

Background. We aimed to apply theZHENGidentification to provide an easy and useful tool to stratify the patients with allergic rhinitis (AR) through exploring the correlation between the quantified scores of AR symptoms and the TCMZHENGs.Methods. A total of 114 AR patients were enrolled in this observational study. All participants received the examinations of anterior rhinoscopy and acoustic rhinometry. Their blood samples were collected for measurement of total serum immunoglobulin E (IgE), blood eosinophil count (Eos), and serum eosinophil cationic protein (ECP). They also received two questionnaire to assess the severity scores of AR symptoms and quantified TCMZHENGscores. Multiple linear regression analysis was used to determine explanatory factors for the score of AR manifestations.Results. IgE and ECP level, duration of AR, the 2 derived TCMZHENGscores of “Yin-Xu − Yang-Xu”, and “Qi-Xu+Blood-Xu” were 5 explanatory variables to predict the severity scores of AR symptoms. The patients who had higher scores of “Yin-Xu − Yang-Xu” or “Qi-Xu+Blood-Xu” tended to manifest as “sneezer and runner” or “blockers,” respectively.Conclusions.The TCMZHENGscores correlated with the severity scores of AR symptoms and provided an easy and useful tool to stratify the AR patients.

scholarly journals Eosinophil Activity in Schistosoma mansoni Infections In Vivo and In Vitro in Relation to Plasma Cytokine Profile Pre- and Posttreatment with Praziquantel

2006 ◽  
Vol 13 (5) ◽  
pp. 584-593 ◽  
Author(s):  
Claus M. Reimert ◽  
Colin M. Fitzsimmons ◽  
Sarah Joseph ◽  
Joseph K. Mwatha ◽  
Frances M. Jones ◽  
...  
Keyword(s):  
Schistosoma Mansoni ◽  
Eosinophil Cationic Protein ◽  
Infection Intensity ◽  
Blood Eosinophil ◽  
Cationic Protein ◽  
Similar Reduction ◽  
Plasma Cytokine ◽  
Tnf Α

ABSTRACT Eosinophil activity in vivo and in vitro was studied in relation to infection intensities and plasma cytokine profiles of 51 Schistosoma mansoni-infected Ugandan fishermen before treatment and 24 h and 3 weeks posttreatment. Blood eosinophil numbers significantly declined 24 h posttreatment, but significant eosinophilia had developed by 3 weeks posttreatment. Cellular eosinophil cationic protein (ECP) content increased significantly during the transient eosinopenia but was significantly reduced 3 weeks later. No similar reduction in cellular eosinophil protein X (EPX) content was seen. Before treatment, S. mansoni infection intensity was positively correlated with 24-h boosts in plasma interleukin-5 (IL-5) and IL-6 levels, which were in turn negatively correlated with the posttreatment fall in eosinophil numbers. Significant correlations were observed between pretreatment infection intensities and plasma IL-10 and eotaxin levels. Treatment induced significant fluctuations in plasma IL-5, IL-6, IL-10, tumor necrosis factor alpha (TNF-α), and eotaxin levels. Optimal relative release of ECP and EPX in vitro was detected in S. mansoni soluble egg antigen-stimulated cultures during transient eosinopenia. Our data suggest that blood eosinophils are activated during S. mansoni infection and that treatment induces a burst in released antigens, causing increased production of IL-5, IL-6, IL-10, and eotaxin; a drop in TNF-α levels; and a transient sequestration of eosinophils, which leaves fewer degranulated eosinophils in the circulation 24 h posttreatment, followed by the development of eosinophilia 3 weeks later. During these events, it appears that preferential release of ECP occurs in vivo. Moreover, it is possible that infection intensity-dependent levels of plasma IL-10 may be involved in the prevention of treatment-induced anaphylactic reactions.

Serum levels of eosinophil cationic protein in allergic diseases and natural allergen exposure

1996 ◽  
Vol 97 (6) ◽  
pp. 1350-1355 ◽  
Author(s):  
Margherita Tomassini ◽  
Laura Magrini ◽  
Guido De Petrillo ◽  
Emilio Adriani ◽  
Stefano Bonini ◽  
...  
Keyword(s):  
Eosinophil Cationic Protein ◽  
Allergic Diseases ◽  
Serum Levels ◽  
Allergen Exposure ◽  
Cationic Protein

The Effect of Cetirizine on Nasal Allergic Response

1995 ◽  
Vol 9 (6) ◽  
pp. 361-366 ◽  
Author(s):  
P. Small ◽  
Doreen Barrett
Keyword(s):  
Late Phase ◽  
Eosinophil Cationic Protein ◽  
Allergen Challenge ◽  
Early Response ◽  
Significant Rise ◽  
Phase Changes ◽  
Allergic Response ◽  
Response Threshold ◽  
Cationic Protein ◽  
Nasal Allergen Challenge

The effect of cetirizine on both early and late nasal allergic response was assessed in 15 ragweed sensitive patients. All patients were challenged before treatment and after 7 days of cetirizine 10 mg qd. Clinical assessments and measurements of mediators were performed at baseline, after positive challenge, 1 and 2 hours later, and repeated 7 and 8 hours later. There was a significant change (P < 0.0001) in the early response threshold to ragweed challenges after cetirizine. There were early phase elevations of prostaglandin D2, leukotriene C4, and eosinophil cationic protein both pre and post-treatment. Late phase changes were difficult to detect, but a statistically significant rise of both prostaglandin D2 and histamine was diminished after cetirizine treatment. Cetirizine clinically inhibited the early response to nasal allergen challenge, but early mediators were not affected. An effect on the late phase could not be clearly demonstrated.

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