scholarly journals Unexpected tumor response to palliative pelvic radiotherapy in mismatch repair-deficient advanced prostate cancer: a case report

2020 ◽  
Vol 14 (1) ◽  
Author(s):  
Giovanni Aluisio ◽  
Ercole Mazzeo ◽  
Frank Lohr ◽  
Federica Fiocchi ◽  
Stefania Bettelli ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Computed Tomography ◽  
Mismatch Repair ◽  
Checkpoint Inhibitors ◽  
Locally Advanced ◽  
Computed Tomography Scan ◽  
Altered Expression ◽  
First Case ◽  
Repair Deficiency ◽  
Tomography Scan

Abstract Background Mismatch-repair-deficiency resulting in microsatellite instability (MSI) may confer increased radiosensitivity in locally advanced/metastatic tumors and thus radiotherapy (RT) potentially might have a changing role in treating this subset of patients, alone or in combination with checkpoint inhibitors. Case presentation We report a 76 year-old Italian male patient presenting with locally advanced undifferentiated prostate cancer (LAPC), infiltrating bladder and rectum. Molecular analysis revealed high-MSI with an altered expression of MSH2 and MSH6 at immunohistochemistry. Two months after 6 chemotherapy cycles with Docetaxel associated to an LHRH analogue, a computed tomography scan showed stable disease. After palliative RT (30 Gy/10 fractions) directed to the tumor mass with a 3D-conformal setup, a follow-up computed tomography scan at 8 weeks revealed an impressive response that remained stable at computed tomography after 9 months, with sustained biochemical response. To our knowledge, this is the first case of such a sustained response to low dose RT alone in high-MSI LAPC. Conclusions Routine evaluation of MSI in patients with locally problematic advanced tumors might change treatment strategy and treatment aim in this setting, from a purely palliative approach to a quasi-curative paradigm.

scholarly journals (Not-so) Unexpected Tumor Response to Palliative Pelvic Radiotherapy in Mismatch Repair-Deficient Advanced Prostate Cancer

2020 ◽  
Author(s):  
Giovanni Aluisio ◽  
Ercole Mazzeo ◽  
Frank Lohr ◽  
Federica Fiocchi ◽  
Stefania Bettelli ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Ct Scan ◽  
Mismatch Repair ◽  
Checkpoint Inhibitors ◽  
Locally Advanced ◽  
Altered Expression ◽  
First Case ◽  
Repair Deficiency ◽  
Changing Role

Abstract Mismatch-repair-deficiency resulting in microsatellite instability (MSI) may confer increased radiosensitivity in locally advanced/metastatic tumors and thus radiotherapy (RT) potentially might have a changing role in treating this subset of patients, alone or in combination with checkpoint inhibitors. We report a 76year-old patient presenting with locally advanced undifferentiated prostate cancer (LAPC), infiltrating bladder and rectum. Molecular analysis revealed high-MSI with an altered expression of MSH2 and MSH6 at immunohistochemistry. Two months after 6 chemotherapy cycles with Docetaxel associated to an LHRH analogue, a CT scan showed stable disease. After palliative RT (30Gy/10 fractions) directed to the tumor mass with a 3D-conformal setup, a follow-up CT scan at 8 weeks revealed an impressive response, that remained stable at CT after 9 months, with sustained biochemical response. To our knowledge, this is the first case of such a sustained response to low dose RT alone in H-MSI LAPC.Routine evaluation of MSI in patients with locally problematic advanced tumors might change treatment strategy and treatment aim in this setting, from a purely palliative approach to a quasi-curative paradigm.

scholarly journals Successful treatment of pyopneumothorax secondary to Streptococcus constellatus infection with linezolid: a case report and review of the literature

2020 ◽  
Vol 14 (1) ◽  
Author(s):  
Zhaorui Zhang ◽  
Binbin Xiao ◽  
Zhixin Liang
Keyword(s):  
Computed Tomography ◽  
Rare Event ◽  
Good Choice ◽  
Penicillin G ◽  
Computed Tomography Scan ◽  
Streptococcus Constellatus ◽  
First Case ◽  
Drug Sensitivity Test ◽  
Lung Condition ◽  
Tomography Scan

Abstract Background Pyopneumothorax secondary to Streptococcus constellatus infection is a clinically rare event, and few cases have been reported. Case presentation We report the case of a 55-year-old Han Chinese man with underlying diabetes who presented with fever of 17 days duration. A pulmonary computed tomography scan revealed right-sided massive pyopneumothorax. A culture of the pleural effusion and blood grew S. constellatus. A drug sensitivity test showed that the isolate was sensitive to linezolid, penicillin G, cefotaxime, vancomycin, and cefuroxime. Our patient was treated with linezolid for a total of 6 weeks. Subsequently, his chest computed tomography scan showed improved lung condition. Conclusion To the best of our knowledge, this is the first case of pyopneumothorax secondary to S. constellatus to be treated with linezolid. Pyopneumothorax may be caused by streptococcal infection, and linezolid is another good choice for treatment.

The role of PET/computed tomography scan in the management of prostate cancer

2011 ◽  
Vol 21 (3) ◽  
pp. 230-236 ◽  
Author(s):  
Maria Picchio ◽  
Elisabetta Giovannini ◽  
Cristina Messa
Keyword(s):  
Prostate Cancer ◽  
Computed Tomography ◽  
Computed Tomography Scan ◽  
Tomography Scan

scholarly journals Radiologic Findings of Splenic Abscess: A Report of Two Cases

2021 ◽  
Vol 5 (5) ◽  
pp. 01-03
Author(s):  
Sule M.B ◽  
Umar A.U ◽  
Gele I.H ◽  
Ribah M.M ◽  
Aliyu A.Z
Keyword(s):  
Computed Tomography ◽  
Mortality Rate ◽  
Antimicrobial Agents ◽  
Splenic Abscess ◽  
Rare Entity ◽  
Computed Tomography Scan ◽  
Radiologic Findings ◽  
First Case ◽  
Post Traumatic ◽  
Tomography Scan

Splenic abscess is a very rare entity with an incidence of about 0.14-0.7% in autopsy studies. Splenic abscess has been reported to have a mortality rate of about47%, it has various causes but usually associated with trauma and infections of the spleen. We report two cases of splenic abscess; a child with post traumatic cause and a middle aged lady with an unknown cause. Both cases were diagnosed of having the abscess following imaging; the first case had abdominopelvic ultrasound that showed an abscess cavity with a volume of about 11mls and subsequently resolved following medical treatment with intravenous antimicrobial agents. The second case however had an abdominopelvic computed tomography scan that showed a huge splenic abscess with a volume of about 1400mls; she had a successful splenectomy. We report the radiologic findings of these cases due to the rare nature of splenic abscess as reported in the literature.

scholarly journals Clinical Predictors and Recommendations for Staging Computed Tomography Scan Among Men With Prostate Cancer

Urology ◽  
2014 ◽  
Vol 84 (6) ◽  
pp. 1329-1334 ◽  
Author(s):  
Rachel Risko ◽  
Selin Merdan ◽  
Paul R. Womble ◽  
Christine Barnett ◽  
Zaojun Ye ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Computed Tomography ◽  
Computed Tomography Scan ◽  
Clinical Predictors ◽  
Tomography Scan

Which patients with newly diagnosed prostate cancer need a computed tomography scan of the abdomen and pelvis? An analysis based on 588 patients

Urology ◽  
1999 ◽  
Vol 54 (3) ◽  
pp. 490-494 ◽  
Author(s):  
Nancy Lee ◽  
Jeffrey H Newhouse ◽  
Carl A Olsson ◽  
Mitchell C Benson ◽  
Daniel P Petrylak ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Computed Tomography ◽  
Newly Diagnosed ◽  
Computed Tomography Scan ◽  
Tomography Scan

scholarly journals Gallbladder volvulus and hernia through the foramen of Winslow: a case report

2020 ◽  
Vol 2020 (10) ◽  
Author(s):  
Toan Huy Nguyen ◽  
Kinh Huy Tran ◽  
Xuan Anh Le ◽  
Huong Van Nguyen ◽  
Quyet Van Ha
Keyword(s):  
Computed Tomography ◽  
Case Report ◽  
Clinical Signs ◽  
Computed Tomography Scan ◽  
Foramen Of Winslow ◽  
First Case ◽  
Hypochondriac Region ◽  
Uncommon Condition ◽  
The Right ◽  
Tomography Scan

Abstract Gallbladder hernia through the foramen of Winslow is an uncommon condition and gallbladder hernia combined with volvulus is even rarer. A 70-year-old patient was hospitalized with the clinical signs of pain in the right hypochondriac region associated with fever. The computed tomography scan images showed some signs of gallbladder herniation through the foramen of Winslow. We decided to remove the gallbladder and found the gallbladder infundibulum twisted and necrotic. This was the first case of a male patient who suffered from gallbladder herniation with volvulus after three cases of female patients reported in the literature.

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