scholarly journals Ruptured arterial aneurysm in Wegener’s granulomatosis: a case report

2021 ◽  
Vol 15 (1) ◽  
Author(s):  
A. Gravos ◽  
K. Katsifa ◽  
P. Tselioti ◽  
V. Grammatikopoulou ◽  
K. Sakellaridis ◽  
...  
Keyword(s):  
Wegener’S Granulomatosis ◽  
Granulomatosis With Polyangiitis ◽  
Rare Complication ◽  
Supportive Therapy ◽  
Wegener's Granulomatosis ◽  
Multiple Organ ◽  
Ruptured Aneurysm ◽  
Arterial Aneurysm ◽  
Life Threatening ◽  
Old Greek

Abstract Background Aneurysm formation is a possible, but rare, complication of granulomatosis with polyangiitis, known as Wegener’s granulomatosis. Urgent diagnosis and therapy is very important because a ruptured aneurysm could be life threatening. Case presentation We, therefore, present the case of a 63-year-old Greek man who was diagnosed with granulomatosis with polyangiitis and retroperitoneal hematoma due to ruptured aneurysm in renal artery and upper pancreaticoduodenal artery. His clinical course was complicated by acute renal failure and acute respiratory failure due to alveolar hemorrhage. Emergency coil embolization was performed. Postembolization recovery was uneventful; no bleeding occurred. The patient underwent mechanical ventilation and continuous veno-venous hemofiltration and received combined immunosuppression and supportive therapy, but eventually died 30 days after admission to hospital from severe septic shock and multiple organ failure. Conclusion Endovascular treatment is the therapy of choice, especially for patients with ruptured aneurysms that are hemodynamically stable. Early diagnosis is very important, as urgent embolization and early initiation of immunosuppression therapy are the treatment of choice.

scholarly journals Wegener’s granulomatosis: surgical repair of severe subglottic stenosis

2020 ◽  
Vol 12 (4) ◽  
pp. 119-120
Author(s):  
Isabel Costa ◽  
António Lim ◽  
Cátia Azevedo ◽  
Fernando Mar ◽  
Berta Rodrigues ◽  
...  
Keyword(s):  
Surgical Procedures ◽  
Wegener’S Granulomatosis ◽  
Granulomatosis With Polyangiitis ◽  
Surgical Repair ◽  
Balloon Dilation ◽  
Wegener's Granulomatosis ◽  
Subglottic Stenosis ◽  
Transoral Laser Microsurgery ◽  
Atypical Form ◽  
Life Threatening

Laryngeal and subglottic stenosis are present in about 20% of patients with granulomatosis with polyangiitis. This atypical form of the disease can be severe and life-threatening. In what concerns to treatment, subglottic lesions are less responsive to conventional systemic therapy and interventional and surgical procedures should be considered. The authors present a case of a 30-year-old woman with diagnosis of Wegener’s granulomatosis who presented to our department with dyspnea and stridor due to a severe subglottic stenosis, requiring an emergent tracheostomy. The obstructive defect was electively and effectively repaired through a transoral laser microsurgery using local application prednisolone and mitomycin C followed by balloon dilation.

Morbidity and mortality associated with subglottic laryngotracheal stenosis in granulomatosis with polyangiitis (Wegener's granulomatosis): a single-centre experience in the United Kingdom

2014 ◽  
Vol 128 (9) ◽  
pp. 831-837 ◽  
Author(s):  
N P Jordan ◽  
H Verma ◽  
A Siddiqui ◽  
G A Morrison ◽  
D P D'Cruz
Keyword(s):  
United Kingdom ◽  
Wegener’S Granulomatosis ◽  
Granulomatosis With Polyangiitis ◽  
Systemic Vasculitis ◽  
Antineutrophil Cytoplasmic Antibody ◽  
Wegener's Granulomatosis ◽  
Laryngotracheal Stenosis ◽  
Surgical Interventions ◽  
The United Kingdom ◽  
Single Centre Experience

AbstractObjectives:We aimed to determine the prevalence of symptomatic subglottic laryngotracheal stenosis in patients with granulomatosis with polyangiitis (Wegener's granulomatosis); we also wanted to characterise the clinical outcomes and surgical interventions required, and the relapse rate in our cohort.Methods:We undertook a retrospective clinical review of all granulomatosis with polyangiitis patients with symptomatic subglottic laryngotracheal stenosis attending St Thomas' Hospital, London, United Kingdom.Results:Symptomatic subglottic laryngotracheal stenosis developed in 16 per cent of granulomatosis with polyangiitis patients attending our clinic. The median age of patients at diagnosis was 44 years (range: 34–81 years); 78 per cent of those presenting with subglottic laryngotracheal stenosis were women and 22 per cent were men. All patients were white; 67 per cent of patients were proteinase 3-antineutrophil cytoplasmic antibody-positive and 67 per cent developed relapsing disease requiring repeated surgical intervention. Subglottic laryngotracheal stenosis relapse was not associated with active systemic vasculitis elsewhere.Conclusion:Subglottic laryngotracheal stenosis is an uncommon but significant complication of granulomatosis with polyangiitis. Management of subglottic laryngotracheal stenosis requires a multi-disciplinary approach, with both rheumatological and otolaryngological expertise involved, given the relapsing nature of the disease.

scholarly journals Ruptured arterial aneurysm of the kidney in a patient with Wegener's granulomatosis

2003 ◽  
Vol 18 (12) ◽  
pp. 2671-2673 ◽  
Author(s):  
R. Senf ◽  
J. S. Jurgensen ◽  
U. Teichgraber ◽  
D. Kampf ◽  
R. Schindler
Keyword(s):  
Wegener’S Granulomatosis ◽  
Wegener's Granulomatosis ◽  
Arterial Aneurysm

scholarly journals Rheumatoid Arthritis and Granulomatosis With Polyangiitis (Wegener’s Granulomatosis): A Rare Association

2020 ◽  
Vol 31 (2) ◽  
pp. 114-119
Author(s):  
Wafia Najifa ◽  
Mohiuddin Sharif ◽  
Rajib Roy ◽  
Mahfuzul Haque ◽  
Md Robed Amin
Keyword(s):  
Rheumatoid Arthritis ◽  
Clinical Practice ◽  
Wegener’S Granulomatosis ◽  
Granulomatosis With Polyangiitis ◽  
Wegener's Granulomatosis ◽  
Overlap Syndrome ◽  
Wegener Granulomatosis ◽  
Overlap Syndromes ◽  
Rare Association

The presentation of Rheumatoid arthritis (RA) combined with a second rheumatological disorder thatis, different RA overlap syndromes are frequently encountered in clinical practice. But RA-vasculitisoverlaps are relatively rare. This paper presents a case of Rheumatoid arthritis and Granulomatosiswith polyangiitis (Wegener granulomatosis) overlap syndrome which is first of its kind reported from Bangladesh. Bangladesh J Medicine July 2020; 31(2) : 114-119

scholarly journals Granulomatosis (Wegener's granulomatosis) with polyangiitis presented as pulmonary manifestation: a case report

2020 ◽  
Vol 8 (8) ◽  
Author(s):  
Qusay Jummaa Lazim ◽  
Sinan Shakir Gheni Atrah ◽  
Khalid Jawad Mutlag ◽  
Haider Saadoon Qasim Alhilfi ◽  
Ahmed Muhi Fahad ◽  
...  
Keyword(s):  
Case Report ◽  
Wegener’S Granulomatosis ◽  
Granulomatosis With Polyangiitis ◽  
Wegener's Granulomatosis ◽  
Pulmonary Manifestation

‘Prostate Abscess' as the Initial Manifestation of Granulomatosis with Polyangiitis (Wegener's Granulomatosis)

2014 ◽  
Vol 96 (2) ◽  
pp. 244-246 ◽  
Author(s):  
Sotirios Tsiodras ◽  
Garyfalia Poulakou ◽  
Konstantinos Leventakos ◽  
Helen Panopoulou ◽  
Antonia Elezoglou ◽  
...  
Keyword(s):  
Wegener’S Granulomatosis ◽  
Granulomatosis With Polyangiitis ◽  
Systemic Disease ◽  
Wegener's Granulomatosis ◽  
Initial Manifestation ◽  
Postoperative Fever ◽  
Systemic Involvement ◽  
Left Pleural Effusion ◽  
Antibody Levels

Prostatic involvement in granulomatosis with polyangiitis (GWP), formerly known as Wegener's granulomatosis, is rare, mostly arising in the context of systemic involvement. Prostatic involvement as the first manifestation of this systemic disease is exceptionally rare. We hereby present the case of a 41-year-old male patient who underwent transurethral prostate resection for what was initially diagnosed as suppurative, focally necrotizing prostatitis. Prolonged postoperative fever that did not respond to various treatments, as well as the subsequent appearance of a left pleural effusion, a left upper pulmonary lobe lesion and cutaneous nodules, led to a reevaluation of histological slides which, along with the determination of serum c-ANCA/anti-PR3 antibody levels, established the diagnosis of GWP. Physicians, and especially urologists and infectious diseases specialists, should be aware of this rare association and consider GWP in the event of nonresolving prostatitis, especially when characteristic symptoms from other systems appear.

Ear, Nose and Throat Manifestations of Wegener's Granulomatosis (Granulomatosis With Polyangiitis)

2012 ◽  
Vol 63 (3) ◽  
pp. 206-211 ◽  
Author(s):  
Carmelo Morales-Angulo ◽  
Roberto García-Zornoza ◽  
Sergio Obeso-Agüera ◽  
Jaime Calvo-Alén ◽  
Miguel A. González-Gay
Keyword(s):  
Wegener’S Granulomatosis ◽  
Granulomatosis With Polyangiitis ◽  
Wegener's Granulomatosis ◽  
Nose And Throat
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