Gas-stabilizing nanoparticles for ultrasound imaging and therapy of cancer

AbstractThe use of ultrasound in the clinic has been long established for cancer detection and image-guided tissue biopsies. In addition, ultrasound-based methods have been widely explored to develop more effective cancer therapies such as localized drug delivery, sonodynamic therapy, and focused ultrasound surgery. Stabilized fluorocarbon microbubbles have been in use as contrast agents for ultrasound imaging in the clinic for several decades. It is also known that microbubble cavitation could generate thermal, mechanical, and chemical effects in the tissue to improve ultrasound-based therapies. However, the large size, poor stability, and short-term cavitation activity of microbubbles limit their applications in cancer imaging and therapy. This review will focus on an alternative type of ultrasound responsive material; gas-stabilizing nanoparticles, which can address the limitations of microbubbles with their nanoscale size, robustness, and high cavitation activity. This review will be of interest to researchers who wish to explore new agents to develop improved methods for molecular ultrasound imaging and therapy of cancer.

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Multicenter, Randomized Phase III Study of Magnetic-Resonance-Guided Focused Ultrasound Surgery (MRgFUS) for the Treatment of Uterine Fibroids (MRgFUS TUF) Compared to Myomectomy in Symptomatic Medication and Not Sufficiently Treatable Uterine Fibroids

Case Medical Research ◽

10.31525/ct1-nct03948789 ◽

2019 ◽

Author(s):

Keyword(s):

Magnetic Resonance ◽

Focused Ultrasound ◽

Uterine Fibroids ◽

Phase Iii ◽

Ultrasound Surgery ◽

Focused Ultrasound Surgery ◽

Symptomatic Medication ◽

Phase Iii Study

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High-intensity focused ultrasound for treatment of uterine leiomyoma: efficacy of MR-guided focused ultrasound surgery and potential for improvements

Choonpa Igaku ◽

10.3179/jjmu.jjmu.r.16 ◽

2014 ◽

Vol 41 (5) ◽

pp. 687-698

Author(s):

Hidenobu FUKUNISHI ◽

Tomoko TAKAYAMA ◽

Takeshi MARUO ◽

Shinichi MATSUMOTO

Keyword(s):

High Intensity ◽

Uterine Leiomyoma ◽

Focused Ultrasound ◽

High Intensity Focused Ultrasound ◽

Ultrasound Surgery ◽

Focused Ultrasound Surgery

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Focused Ultrasound Surgery in Gynecology

10.1007/978-981-16-0939-8 ◽

2021 ◽

Author(s):

Felix Wong ◽

Lian Zhang ◽

Zhibiao Wang

Keyword(s):

Focused Ultrasound ◽

Ultrasound Surgery ◽

Focused Ultrasound Surgery

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Breaking the acoustic diffraction limit with an arbitrary shape acoustic magnifying lens

Scientific Reports ◽

10.1038/s41598-021-92297-7 ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

Ali Abdolali ◽

Hooman Barati Sedeh ◽

Mohammad Hosein Fakheri ◽

Chen Shen ◽

Fei Sun

Keyword(s):

Arbitrary Shape ◽

Design Principle ◽

Focused Ultrasound ◽

Effective Medium Theory ◽

Wide Spectrum ◽

Diffraction Limit ◽

Far Field ◽

Biomedical Sensors ◽

Focused Ultrasound Surgery ◽

Unit Cells

AbstractBased on the transformation acoustics methodology, the design principle for achieving an arbitrary shape magnifying lens (ASML) is proposed. Contrary to the previous works, the presented ASML is competent of realizing far-field high resolution images and breaking the diffraction limit, regardless of the position of the utilized sources. Therefore, objects locating within the designed ASML can be properly resolved in the far-field region. It is shown that the obtained material through the theoretical investigations becomes an acoustic null medium (ANM), which has recently gained a significant attention. Besides the homogeneity of ANM, which makes it an implementable material, it is also independent of the perturbation in the geometry of the lens, in such a way that the same ANM can be used for different structural topologies. The obtained ANM has been implemented via acoustics unit cells formed by membranes and side branches with open ends and then was utilized to realize an ASML with the aid of effective medium theory. It is shown that the far-field results of an ideal ASML abide well with the results of the implemented sample, validating the proposed design principle. The presented acoustic magnifying lens has a wide spectrum of possible applications ranging from medical imaging, and biomedical sensors to focused ultrasound surgery.

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