A retrospective analysis of patient-specific factors on voriconazole clearance

Introduction: Image-based robotic assistance appears to be a promising tool for individualizing alignment in total knee arthroplasty (TKA). The patient-specific model of the knee enables a preoperative 3D planning of component position. Adjustments to the individual soft-tissue situation can be done intraoperatively. Based on this, we have established a standardized workflow to implement the idea of kinematic alignment (KA) for robotic-assisted TKA. In addition, we have defined limits for its use. If these limits are reached, we switch to a restricted KA (rKA). The aim of the study was to evaluate (1) in what percentage of patients a true KA or an rKA is applicable, (2) whether there were differences regarding knee phenotypes, and (3) what the differences of philosophies in terms of component position, joint stability, and early patient outcome were. Methods: The study included a retrospective analysis of 111 robotic-assisted primary TKAs. Based on preoperative long leg standing radiographs, the patients were categorized into a varus, valgus, or neutral subgroup. Initially, all patients were planned for KA TKA. When the defined safe zone had been exceeded, adjustments to an rKA were made. Intraoperatively, the alignment of the components and joint gaps were recorded by robotic software. Results and conclusion: With our indication for TKA and the defined boundaries, “only” 44% of the patients were suitable for a true KA with no adjustments or soft tissue releases. In the varus group, it was about 70%, whereas it was 0% in the valgus group and 25% in the neutral alignment group. Thus, significant differences with regard to knee morphotypes were evident. In the KA group, a more physiological knee balance reconstructing the trapezoidal flexion gap (+2 mm on average laterally) was seen as well as a closer reconstruction of the surface anatomy and joint line in all dimensions compared to rKA. This resulted in a higher improvement in the collected outcome scores in favor of KA in the very early postoperative phase.

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Commentary: One size fits some—additional pulmonary blood flow at the Glenn operation and patient-specific factors

Journal of Thoracic and Cardiovascular Surgery ◽

10.1016/j.jtcvs.2021.01.082 ◽

2021 ◽

Author(s):

Neel K. Prabhu ◽

Nicholas D. Andersen ◽

Joseph W. Turek

Keyword(s):

Blood Flow ◽

Pulmonary Blood Flow ◽

Patient Specific ◽

Specific Factors

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Successful recanalization for acute ischemic stroke via the transbrachial approach

Journal of NeuroInterventional Surgery ◽

10.1136/neurintsurg-2014-011451 ◽

2014 ◽

Vol 8 (2) ◽

pp. 122-125 ◽

Cited By ~ 13

Author(s):

Masakazu Okawa ◽

Satoshi Tateshima ◽

David Liebeskind ◽

Latisha K Ali ◽

Michael L Thompson ◽

...

Keyword(s):

Ischemic Stroke ◽

Acute Ischemic Stroke ◽

Patient Specific ◽

Ischemic Stroke Patient ◽

Transfemoral Approach ◽

Acute Ischemic Stroke Patient ◽

Transbrachial Approach ◽

Stent Retrievers ◽

Endovascular Approach ◽

Specific Factors

The recent development of revascularization devices, including stent retrievers, has enabled increasingly higher revascularization rates for arterial occlusions in acute ischemic stroke. Patient-specific factors such as anatomy, however, may occasionally limit endovascular deployment of these new devices via the conventional transfemoral approach. We report three cases of acute ischemic stroke where a transbrachial endovascular approach to revascularization was used, resulting in successful recanalization. These examples suggest that a transbrachial approach may be considered as an alternative in the endovascular treatment of acute ischemic stroke.

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Measurement of B-domain-deleted ReFacto AF activity with a product-specific standard is affected by choice of reagent and patient-specific factors

Haemophilia ◽

10.1111/hae.13123 ◽

2017 ◽

Vol 24 (4) ◽

pp. 675-682 ◽

Cited By ~ 3

Author(s):

M. Jacquemin ◽

A. Vodolazkaia ◽

J. Toelen ◽

J. Schoeters ◽

I. Van Horenbeeck ◽

...

Keyword(s):

Patient Specific ◽

Specific Standard ◽

Specific Factors

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Retrospective analysis of 2D patient-specific IMRT verifications

Medical Physics ◽

10.1118/1.1879272 ◽

2005 ◽

Vol 32 (4) ◽

pp. 838-850 ◽

Cited By ~ 31

Author(s):

Nathan L. Childress ◽

R. Allen White ◽

Charles Bloch ◽

Mohammad Salehpour ◽

Lei Dong ◽

...

Keyword(s):

Retrospective Analysis ◽

Patient Specific

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Complexity In The Context of Palliative Care: A Scoping Review

10.21203/rs.3.rs-969011/v1 ◽

2021 ◽

Author(s):

Hironori Ohinata ◽

Maho Aoyama ◽

Mitsunori Miyashita

Keyword(s):

Palliative Care ◽

Scoping Review ◽

Healthcare Providers ◽

The United States ◽

Patient Specific ◽

Future Research ◽

Care Needs ◽

Living Situation ◽

Research Activities ◽

Specific Factors

Abstract Background: Understanding the factors of complexity of patients in palliative care is very important for healthcare providers in addressing the care needs of their patients. However, the healthcare providers’ perception of the factors of complexity in palliative care lacks a common understanding. This study aimed to determine the scope of research activities and specific factors of complexity in the context of palliative care.Methods: A scoping literature review was performed, following the methods described by the Joanna Briggs Institute. We conducted an electronic literature search in MEDLINE (Ovid), PsycINFO, Web of Science Core Collection, and CINAHL, examining literature from May 1972 to 2020.Results: We identified 32 peer-reviewed articles published in English before 2020. The target literature mainly originated in Europe and the United States. The research methods included quantitative studies (n=13), qualitative studies (n=12), case studies (n=3), and reviews (n=4). We reviewed 32 studies and summarized the factors of complexity into three levels: the patient’s level, the healthcare setting level, and the socio-cultural landscape level. We identified factors affecting patient-specific complexity, including sex, race, age, living situation, family burden, resources, treatment, decision-making, communication, prognosis, disease, and comorbidity/complexity. Other factors identified as contributing to patient complexity were the interaction of physical, psychological, social, and spiritual categories, as well as the healthcare providers’ confidence and skills, and the socio-cultural components.Conclusions: This scoping review shows specific factors of complexity and future challenges in the context of palliative care. Future research should include the factors of complexity identified in this review and conduct longitudinal studies on the interactions among them. In addition, it is necessary to examine specific complexity factors in patients from various social and ethnic backgrounds.

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Comparison of patient-specific factors and outcomes for one- and two-stage basilic vein transposition fistulas

Journal of Vascular Surgery ◽

10.1016/j.jvs.2018.02.026 ◽

2018 ◽

Vol 68 (5) ◽

pp. 1482-1490 ◽

Cited By ~ 1

Author(s):

Andrew J. Shevitz ◽

Ann H. Kim ◽

Katherine L. Morrow ◽

David J. Johnson ◽

Patricia R. Campos ◽

...

Keyword(s):

Patient Specific ◽

Basilic Vein ◽

Two Stage ◽

Specific Factors

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Clinical Outcomes of 3D Printed Titanium Cage Implantation for Foot and Ankle Surgery

Foot & Ankle Orthopaedics ◽

10.1177/2473011420s00088 ◽

2020 ◽

Vol 5 (4) ◽

pp. 2473011420S0008

Author(s):

Bijan Abar ◽

Nicholas B. Allen ◽

Ken Gall ◽

Samuel B. Adams

Keyword(s):

Surgical Outcomes ◽

Patient Specific ◽

Salvage Procedure ◽

Foot And Ankle ◽

Device Failure ◽

Titanium Cage ◽

Ankle Surgery ◽

3D Printed ◽

Specific Factors ◽

Titanium Cages

Category Ankle; Trauma Introduction/Purpose: Critical Sized Defects (CSD) defined as bone loss greater than 1-2 cm in length or greater than 50% loss in circumference of bone remains a significant challenge in orthopaedic surgery. Patients can acquire these defects through trauma, nonunion post fracture, tumor removal, avascular necrosis, and congenital abnormalities. Custom 3D printed porous Titanium scaffolds are increasingly being used to treat CSD in Foot and Ankle Surgery. Implantation of 3D printed cages is considered a salvage procedure offered after the patient has failed other procedures. Implants fill the space of the defect, provide mechanical strength and provide opportunity for osseous integration. As implementation of this surgical technique is relatively new, further research is needed to assess surgical outcomes and inform future surgical decision making. Methods: This is a retrospective chart review study which examines surgical outcomes after using 3D printed Titanium cages. Patients who received a 3D printed Titanium cage between 1/1/2013 and 11/01/2018 with at least 1 year follow-up were included in this study. Primary outcome is device failure defined as removal of implant for any reason. If applicable, mechanism of failure was recorded for each case. Patient specific factors such as age, gender, race, BMI, diabetes status, Charlson Comorbidity Index, tobacco use, number of foot and ankle surgeries, prior limb infections and laterality of defect were recorded in addition to surgical variables including geometry of implant, duration of surgery, and perioperative antibiotics Results: 18 patients who received custom 3D printed Titanium cages were included in this study. Of the 18 patients, 5 patients (27.8%) had device failure, defined as removal of implant. Of the 5 failures, 2 were removed due to infection while the other 3 were removed due to hardware failure including fractured cage, broken screw and loose fixation. Conclusion: Custom 3D printed Titanium was successfully implemented in 72.2% of patients. Implants were only removed due to infection (2 patients) or mechanical failure of device (3 patients). Future studies need to be powered to determine if certain patient specific factors are associated with device failure. Data from this study and subsequent studies can be used to design better implants, decide who is a good surgical candidate, and create preoperative therapies to improve modifiable risk factors

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