scholarly journals The progression of intracerebral hemorrhage (ICH) is related to the expression of integrin Β1 (ITGB1)

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Hai-Yang Ma ◽  
Yan Xu ◽  
Chun-You Qiao ◽  
Yi Peng ◽  
Qi Ding ◽  
...  

Abstract Background Intracerebral hemorrhage (ICH) is fatal and detrimental to quality of life. Clinically, options for monitoring are often limited, potentially missing subtle neurological changes. Integrin β 1 (ITGB1) and β 3 (ITGB3) are the main components of integrin family receptors, which regulate the formation and stability of blood vessels. This study explored the relationship between the expression of ITGB1 and ITGB3 in intracerebral hemorrhage (ICH) to analyze their functional and clinical relevance. Methods The expression of ITGB1 and ITGB3 in ICH was accomplished by immunohistochemical (IHC) staining and western blotting (WB) analysis, respectively. Results Furthermore, the results demonstrated that ITGB1 was expressed in ICH tissues, but ITGB3 was not expressed in ICH tissues. Conclusions In summary, the clinical progression of ICH was related to the expression of ITGB1. ITGB1 may be a potential biomarker and contribute to the treatment of ICH.

2020 ◽  
Author(s):  
Hai-Yang Ma ◽  
Yan Xu ◽  
Chun-You Qiao ◽  
Yi Peng ◽  
Qi Ding ◽  
...  

Abstract Background: Intracerebral hemorrhage (ICH) is fatal and detrimental to quality of life. Clinically, options for monitoring are often limited, potentially missing subtle neurological changes. Integrin β 1 (ITGB1) and β 3 (ITGB3) are the main components of integrin family receptors, which regulate the formation and stability of blood vessels. This study explored the relationship between expression of ITGB1, ITGB3 in intracerebral hemorrhage (ICH) to analyze their functional and clinical relevance.Methods: The expression of ITGB1 and ITGB3 in ICH was accomplished by immunohistochemical (IHC) staining and western blotting (WB) analysis, respectively. Results: Furthermore, the results demonstrated that ITGB1 was expressed in ICH tissues, but ITGB3 was not expressed in ICH tissues. Conclusions: In summary, the clinical progression of ICH was related to the expression of ITGB1. ITGB1 may be a potential biomarker and contribute to the treatment of ICH.


2021 ◽  
Author(s):  
Hai-Yang Ma ◽  
Yan Xu ◽  
Chun-You Qiao ◽  
Yi Peng ◽  
Qi Ding ◽  
...  

Abstract Background: Intracerebral hemorrhage (ICH) is fatal and detrimental to quality of life. Clinically, options for monitoring are often limited, potentially missing subtle neurological changes. Integrin β 1 (ITGB1) and β 3 (ITGB3) are the main components of integrin family receptors, which regulate the formation and stability of blood vessels. This study explored the relationship between expression of ITGB1, ITGB3 in intracerebral hemorrhage (ICH) to analyze their functional and clinical relevance. Methods: The expression of ITGB1 and ITGB3 in ICH was accomplished by immunohistochemical (IHC) staining and western blotting (WB) analysis, respectively. Results: Furthermore, the results demonstrated that ITGB1 was expressed in ICH tissues, but ITGB3 was not expressed in ICH tissues. Conclusions: In summary, the clinical progression of ICH was related to the expression of ITGB1. ITGB1 may be a potential biomarker and contribute to the treatment of ICH.


2020 ◽  
Author(s):  
Hai-Yang Ma ◽  
Yan Xu ◽  
Chun-You Qiao ◽  
Yi Peng ◽  
Qi Ding ◽  
...  

Abstract Background: Intracerebral hemorrhage (ICH) is fatal and detrimental to quality of life. Clinically, options for monitoring are often limited, potentially missing subtle neurological changes especially in low-grade patients. This study explored the relationship between expression of integrin β1 (ITGB1), β3 (ITGB3) in intracerebral hemorrhage (ICH) to analyze their functional and clinical relevance. Methods: The expression of ITGB1 and ITGB3 in ICH was accomplished by immunohistochemical (IHC) staining and western blotting (WB) analysis, respectively. Results: Furthermore, the results demonstrated that TGB1 was expressed in ICH tissues, but ITGB3 was not expressed in ICH tissues.Conclusions: In summary, the clinical progression of ICH was related to the expression of ITGB1. ITGB1 may be a potential biomarker and contribute to the treatment of ICH.


2018 ◽  
Vol 21 (5) ◽  
pp. 616-627 ◽  
Author(s):  
Luana Karoline Ferreira ◽  
Juliana Fernandes Filgueiras Meireles ◽  
Maria Elisa Caputo Ferreira

Abstract Objective: to analyze Brazilian and non-Brazilian scientific production that considers the relationship between the lifestyle and quality of life of the elderly. Method: an integrative review of literature was performed in the Scopus, PubMed, Virtual Health Library and PsycINFO databases. Four cross-searches were adopted: the English synonyms of the word "elderly" ("Aged", "Aging", "Old age" and "Elderly") with the terms "Quality of life" and "Lifestyle". Results: after the adoption of the inclusion and exclusion criteria, 21 articles were analyzed. Physical activity, diet, body composition, alcohol intake, smoking and social relations were the main components of lifestyle investigated. The studies show that these factors influence the perception of the quality of life of the elderly. In addition to these factors, sociodemographic characteristics, functional capacity, sleep quality and comorbidities are also factors that influence the quality of life of the elderly. Conclusion: interest in the relationship between the lifestyle and quality of life of the elderly has increased in recent years. It was observed that the lifestyle of the elderly has been investigated in several ways, however no qualitative studies were found using the search criteria adopted in this review. As future perspectives, it is hoped that tools for evaluating the lifestyle of the elderly will be developed and qualitative investigations will be carried out in order to obtain a deeper understanding of the specificities that exist in the relationship between the lifestyle and levels of quality of life in old age.


2002 ◽  
Author(s):  
R. Arnold ◽  
A. V. Ranchor ◽  
N. H. T. ten Hacken ◽  
G. H. Koeter ◽  
V. Otten ◽  
...  

2020 ◽  
Vol 17 (6) ◽  
pp. 76-91
Author(s):  
E. D. Solozhentsev

The scientific problem of economics “Managing the quality of human life” is formulated on the basis of artificial intelligence, algebra of logic and logical-probabilistic calculus. Managing the quality of human life is represented by managing the processes of his treatment, training and decision making. Events in these processes and the corresponding logical variables relate to the behavior of a person, other persons and infrastructure. The processes of the quality of human life are modeled, analyzed and managed with the participation of the person himself. Scenarios and structural, logical and probabilistic models of managing the quality of human life are given. Special software for quality management is described. The relationship of human quality of life and the digital economy is examined. We consider the role of public opinion in the management of the “bottom” based on the synthesis of many studies on the management of the economics and the state. The bottom management is also feedback from the top management.


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