scholarly journals Vasculitis damage index in Behçet’s disease

2021 ◽  
Vol 61 (1) ◽  
Author(s):  
Fatema T. Elgengehy ◽  
Sherif M. Gamal ◽  
Nesreen Sobhy ◽  
Ibrahem Siam ◽  
Ahmed M. Soliman ◽  
...  
Keyword(s):  
Behçet’S Disease ◽  
Behcet’S Disease ◽  
Behçet's Disease ◽  
Immunosuppressive Treatment ◽  
Damage Index ◽  
Clinical Manifestations ◽  
Behcet's Disease ◽  
Vasculitis Damage Index ◽  
Relationship Of ◽  
The Relationship

Abstract Background Vasculitis damage index (VDI) is a validated damage index for systemic vasculitis, and as Behçet’s disease is considered one of systemic vascular disease we aimed to study the relationship of the vasculitis damage index to clinical manifestations and comorbidity in patients with Behçet’s disease (BD) to determine if VDI could be used to assess damage in patients with BD. Methods A total of 109 patients with BD were recruited from the Rheumatology Department (outpatient and inpatient clinic), Cairo University Hospitals. All patients were subjected to full history taking, clinical examination, and routine laboratory investigations. Disease activity was assessed by the BD current activity form, and the VDI was calculated in all patients. The relationship of the VDI to the disease clinical manifestations was studied. Mann–Whitney and Kruskal Wallis tests were used to estimate differences in quantitative variables. Spearman correlation test was used to test for correlation between quantitative variables. Results In the current study, the VDI ranged from 1 to 10, with a mean of 3.5 ± 1.8. It was significantly associated with total thrombosis (P = 0.022); total neurological manifestations (P = 0.000), especially stroke and cranial nerve affection; uveitis (P = 0.005); avascular necrosis (AVN) (P = 0.015); osteoporosis (P = 0.01); impaired vision (P < 0.0001); cataract (P < 0.0001); and diabetes (P = 0.012). Generally, immunosuppressive treatment was significantly associated with VDI (P = 0.039), especially cyclophosphamide (P < 0.0001), biological agent (P = 0.008), chlorambucil (P = 0.003), and anticoagulant (P = 0.02). VDI was also significantly correlated with age (P = 0.033), disease duration (P = 0.029), and duration of eye involvement (P = 0.003). Conclusion VDI is significantly associated with most disease parameters of BD, except for parameters such as mucocutaneous manifestations and uncomplicated venous thrombosis; however, further studies may be needed to establish BD-specific damage index.

scholarly journals The relationship of HLA class I and II phenotypes to clinical features of Behcet's disease.

1990 ◽  
Vol 13 (2) ◽  
pp. 142-148 ◽  
Author(s):  
Kazuyuki Morita ◽  
Junko Moriuchi ◽  
Yukinobu Ichikawa ◽  
Kimiyoshi Tsuji ◽  
Shigeru Arimori
Keyword(s):  
Clinical Features ◽  
Behçet’S Disease ◽  
Behcet’S Disease ◽  
Behçet's Disease ◽  
Hla Class I ◽  
Class I ◽  
Behcet's Disease ◽  
Relationship Of ◽  
The Relationship

scholarly journals The relationship of pentraxin-3 levels with IL-17, fetuin-A, insulin in patients with Behçet's disease

2017 ◽  
Vol 35 (4) ◽  
pp. 195-200
Author(s):  
Sinem Sag ◽  
Ayhan Kamanlı ◽  
Mustafa Altındis ◽  
Mustafa Serdar Sag ◽  
Halil Harman ◽  
...  
Keyword(s):  
Behçet’S Disease ◽  
Behcet’S Disease ◽  
Behçet's Disease ◽  
Pentraxin 3 ◽  
Fetuin A ◽  
Behcet's Disease ◽  
Relationship Of ◽  
The Relationship

scholarly journals Behcet’s Disease: An In-depth Review About Pathogenesis, Gastrointestinal Manifestations And Management

2021 ◽  
Author(s):  
Anthony Nguyen ◽  
Shubhra Upadhyay ◽  
Muhammad Ali Javaid ◽  
Abdul Moiz Qureshi ◽  
Shahan Haseeb ◽  
...  
Keyword(s):  
Behçet’S Disease ◽  
Behcet’S Disease ◽  
Behçet's Disease ◽  
Age Groups ◽  
Clinical Manifestations ◽  
Signs And Symptoms ◽  
Vascular Disorder ◽  
Robust Algorithms ◽  
Behcet's Disease ◽  
Relapsing Remitting

Background: Behcet’s Disease (BD) is a complex inflammatory vascular disorder that follows a relapsing-remitting course with diverse clinical manifestations. The prevalence of the disease varies throughout the globe and targets different age groups. There are many variations of BD, however, intestinal BD is not only more common but has many signs and symptoms. Summary: BD is a relapsing-remitting inflammatory vascular disorder with multiple system involvement, affecting vessels of all types and sizes that targets young adults. The etiology of BD is unknown but many factors including genetic mechanisms, vascular changes, hypercoagulability and dysregulation of immune function are believed to be responsible. BD usually presents with signs and symptoms of ulcerative disease of the small intestine; endoscopy being consistent with the clinical manifestations. The mainstay of treatment depends upon the severity of the disease. Corticosteroids are recommended for severe forms of the disease and aminosalicylic acids are used in maintaining remission in mild to moderate forms of the disease. Key messages: In this review, we have tried to summarize in the present review the clinical manifestations, differential diagnoses and management of intestinal BD. Hopefully, this review will enable health policymakers to ponder over establishing clear endpoints for treatment, surveillance investigations and creating robust algorithms.

scholarly journals Acute Agitation as an Initial Manifestation of Neuro-Behçet’s Disease

2018 ◽  
Vol 2018 ◽  
pp. 1-3
Author(s):  
Yuki Otsuka ◽  
Tetsuya Yumoto ◽  
Hiromi Ihoriya ◽  
Namiko Matsumoto ◽  
Kota Sato ◽  
...  
Keyword(s):  
Behçet’S Disease ◽  
Behcet’S Disease ◽  
Parietal Lobe ◽  
Psychiatric Symptoms ◽  
Behçet's Disease ◽  
Physical Restraint ◽  
Clinical Manifestations ◽  
Initial Manifestation ◽  
Behcet's Disease ◽  
Acute Agitation

Managing acutely agitated or violent patients in the emergency department (ED) represents a significant challenge. Acute agitation as an initial manifestation of neuro-Behcet’s disease (NBD) is an extremely rare clinical entity. A 44-year-old male, who had been complaining about a severe headache and fever for several days, was admitted to our ED due to acutely presented incontinence and agitation. On admission, physical restraint and sedation with sevoflurane and propofol were required for his combative and violent behavior. Cerebrospinal fluid examination revealed increased cell count. Fluid attenuated inversion recovery magnetic resonance imaging showed a high intensity signal in the left parietal lobe and bilateral occipital lobe. As infectious meningoencephalitis was suspected, empirical therapy was immediately started. He recovered uneventfully without neurological defect in seven days. Based on positive human leukocyte antigen B-51 and clinical manifestations, the diagnosis of NBD was made and remitted by steroid therapy. Although acute NBD commonly presents with focal neurological symptoms, psychiatric symptoms could be considered the first manifestation. A focused and thorough examination coupled with appropriate management strategies can assist emergency clinicians safely and effectively manage these patients.

scholarly journals The effect of vitamin D on clinical manifestations and activity of Behçet’s disease

2017 ◽  
Vol 1 ◽  
pp. 15-20 ◽  
Author(s):  
Nurşad Aslan ◽  
Kamile Demirci ◽  
Tuba Güler ◽  
Fulya Dörtbaş ◽  
Ebru Kale
Keyword(s):  
Vitamin D ◽  
Behçet’S Disease ◽  
Behcet’S Disease ◽  
Behçet's Disease ◽  
Clinical Manifestations ◽  
Behcet's Disease
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