scholarly journals Proton MR spectroscopy in characterization of focal bone lesions of peripheral skeleton

2019 ◽  
Vol 50 (1) ◽  
Author(s):  
Meenu Amar ◽  
Rohini Gupta Ghasi ◽  
L. G. Krishna ◽  
Geetika Khanna
Keyword(s):  
Mr Spectroscopy ◽  
Bone Lesions ◽  
Water Suppression ◽  
Low Grade ◽  
Benign Lesions ◽  
Giant Cell Tumors ◽  
Proton Mr Spectroscopy ◽  
Malignant Lesions ◽  
Peripheral Skeleton ◽  
Choline Peak

Abstract Background The aim of our study was to determine the value of single-voxel proton MR spectroscopy (1HMRS) in distinguishing benign from malignant focal bone lesions in the peripheral skeleton. MRI and 1HMRS was performed in 50 focal lesions (> 1 cm size) detected on radiographs of peripheral skeleton.1HMRS was performed at 1.5 T with TE of 144 ms with automatic shimming and water suppression. Qualitative analysis for a discrete choline peak at 3.2 ppm was done. Significance of the presence of choline peak on 1HMRS in distinguishing benign from malignant lesions was calculated using histopathology as a gold standard. Chi-square test was used and p value < 0.05 was considered significant. Results Forty-one benign and 9 malignant lesions were confirmed by histopathological results. Amongst malignant lesions, choline peak was positive in all but 1 case of low-grade lymphoma. MR spectra of 11 benign lesions showed the presence of choline peak. All 7 benign giant cell tumors (GCT) were positive for choline peak. The sensitivity, specificity, PPV, NPV of proton MR spectroscopy in differentiating benign from malignant lesions were 87.5%,71%,38.8%, and 96.4% respectively. p value was significant (< 0.05). Conclusion 1HMRS in focal bone lesions can help in the differentiation of malignant from benign musculoskeletal tumors. Although some benign lesions may show false-positive result, absence of choline peak is a reliable reassurance against malignancy. GCT is an exception amongst benign bone tumors as it consistently shows the presence of choline peak on 1HMRS.

First intraoperative, shared-resource, ultrahigh-field 3-Tesla magnetic resonance imaging system and its application in low-grade glioma resection

2010 ◽  
Vol 112 (1) ◽  
pp. 57-69 ◽  
Author(s):  
M. Necmettin Pamir ◽  
Koray Özduman ◽  
Alp Dinçer ◽  
Erdem Yildiz ◽  
Selçuk Peker ◽  
...  
Keyword(s):  
Mr Imaging ◽  
Mr Spectroscopy ◽  
Imaging System ◽  
Low Grade Glioma ◽  
Low Grade ◽  
Imaging Protocol ◽  
Proton Mr Spectroscopy ◽  
Shared Resource ◽  
Ultrahigh Field ◽  
And Diffusion

Object The authors describe the first shared-resource, 3-T intraoperative MR (ioMR) imaging system and analyze its impact on low-grade glioma (LGG) resection with an emphasis on the use of intraoperative proton MR spectroscopy. Methods The Acibadem University ioMR imaging facility houses a 3-T Siemens Trio system and consists of interconnected but independent MR imaging and surgical suites. Neurosurgery is performed using regular ferromagnetic equipment, and a patient can be transferred to the ioMR imaging system within 1.5 minutes by using a floating table. The ioMR imaging protocol takes < 10 minutes including the transfer, and the authors obtain very high–resolution T2-weighted MR images without the use of intravenous contrast. Functional sequences are performed when needed. A new 5-pin headrest–head coil combination and floating transfer table were specifically designed for this system. Results Since the facility became operational in June 2004, 56 LGG resections have been performed using ioMR imaging, and > 19,000 outpatient MR imaging procedures have been conducted. First-look MR imaging studies led to further resection attempts in 37.5% of cases as well as a 32.3% increase in the number of gross-total resections. Intraoperative ultrasonography detected 16% of the tumor remnants. Intraoperative proton MR spectroscopy and diffusion weighted MR imaging were used to differentiate residual tumor tissue from peritumoral parenchymal changes. Functional and diffusion tensor MR imaging sequences were used both pre- and postoperatively but not intraoperatively. No infections or other procedure-related complications were encountered. Conclusions This novel, shared-resource, ultrahigh-field, 3-T ioMR imaging system is a cost-effective means of affording a highly capable ioMR imaging system and increases the efficiency of LGG resections.

Low-Grade Gliomas and Focal Cortical Developmental Malformations: Differentiation with Proton MR Spectroscopy

Radiology ◽  
2004 ◽  
Vol 230 (3) ◽  
pp. 703-708 ◽  
Author(s):  
Kim Vuori ◽  
Leena Kankaanranta ◽  
Anna-Maija Häkkinen ◽  
Eija Gaily ◽  
Leena Valanne ◽  
...  
Keyword(s):  
Mr Spectroscopy ◽  
Low Grade ◽  
Proton Mr Spectroscopy ◽  
Low Grade Gliomas ◽  
Developmental Malformations

scholarly journals Current Status and Future Prospects of Proton MR Spectroscopy of the Breast with a 1.5T MR Unit

2010 ◽  
Vol 2010 ◽  
pp. 1-10 ◽  
Author(s):  
Mitsuhiro Tozaki ◽  
Katsuya Maruyama
Keyword(s):  
Mammary Gland ◽  
Clinical Practice ◽  
Clinical Data ◽  
Mr Spectroscopy ◽  
Basic Research ◽  
Clinical Applications ◽  
Current Status ◽  
Future Prospects ◽  
Proton Mr Spectroscopy ◽  
Malignant Lesions

Proton MR spectroscopy of the mammary gland area is used to be considered in the realm of basic research, but as a result of the advances in MR techniques, it is now being performed in ordinary clinical practice. It is particularly noteworthy that useful clinical data are now being accumulated with 1.5T MR units, which are the standard units. We think that, at this point, it is very important to systematically review the techniques, clinical applications, and future prospects of proton MR spectroscopy. We have performed proton MR spectroscopy with a 1.5T MR unit in over 3000 cases at our hospital. In this paper, we will comment on the current status of proton MR spectroscopy of the breast, primarily in regard to differentiation between benign and malignant lesions and prediction of the efficacy of chemotherapy while describing the data obtained at our hospital.

In Reply: Radionuclide Brain Scans in Convulsive Disorders?

PEDIATRICS ◽  
1972 ◽  
Vol 49 (5) ◽  
pp. 788-788
Author(s):  
Melvin Tefft
Keyword(s):  
Medical Center ◽  
Low Grade ◽  
Benign Lesions ◽  
Brain Scans ◽  
Low Grade Gliomas ◽  
Children's Hospital ◽  
Hospital Medical ◽  
Convulsive Disorders ◽  
Malignant Lesions ◽  
Epileptiform Seizures

I have noted the review of the experience of the Children's Hospital Medical Center, by Page, et al., in which gliomas related to epilepsy had an incidence of only 0.3%. However, as noted in the original article as published in Pediatrics of November 1971, lesions other than low grade gliomas may cause epileptiform seizures, including various benign lesions, and thus the overall incidence of abnormality might well be raised above the 0.3% level for malignant lesions.

Toward quantitative short-echo-time in vivo proton MR spectroscopy without water suppression

2006 ◽  
Vol 55 (6) ◽  
pp. 1441-1446 ◽  
Author(s):  
Zhengchao Dong ◽  
Wolfgang Dreher ◽  
Dieter Leibfritz
Keyword(s):  
Mr Spectroscopy ◽  
Water Suppression ◽  
Proton Mr Spectroscopy ◽  
Echo Time ◽  
Short Echo Time

The key role of correlation between MR spectroscopy choline peak and calcium sensing receptor for breast cancer: Diagnosis by a 3T MR scanner.

2013 ◽  
Vol 31 (15_suppl) ◽  
pp. e22132-e22132
Author(s):  
Gabriella Baio ◽  
Francesca Valdora ◽  
Daniele Pace ◽  
Sandra Salvi ◽  
Nicolo Villosio ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Mr Spectroscopy ◽  
Breast Lesions ◽  
Breast Cancers ◽  
Calcium Sensing Receptor ◽  
Calcium Sensing ◽  
Malignant Lesions ◽  
High Level ◽  
3T Mr ◽  
Choline Peak

e22132 Background: The Ca2+-sensing receptor (CaSR) regulates the Ca2+ signaling and its expression is present in both normal and malignant breast tissues. Recently, we demonstrated in a pre-clinical setting the CaSR expression in breast cancer mouse model by manganese enhanced MRI (Baio G et al. Eur Rad 2011). Alteration in choline phospholipid metabolism as detected by MRI, is a common feature of breast and many other cancer cells or tumors. Since CaSR-ChoK signaling plays an important role in breast cancer, we compared the MRS (MR spectroscopy) choline peak by a 3T MR scanner between calcium sensing receptor positive and negative breast cancers. Methods: Breast MRI of 16 consecutive patients with breast lesions were performed by a 3T MR and MRS findings were defined as positive by the visual inspection for the presence or the absence of choline peak. MRS imaging were compared with histologic findings and the pattern of CaSR by immunohistochemistry. The immunohistochemical results were qualitatively classified according to intensity and pattern of the staining, using a 6-point scale to score the intensity of the CaSR expression (0, absent; 5, intense, widespread expression). Results: A choline peak was present in 10 of 15 malignant lesions and the CaSR expression was between 3 to 5 score at immunohistochemestry analysis (p<.0006). In 4 of 15 malignant lesions the choline peak was absent or not consistent at the visual analysis with a CaSR patterns of 1-2. In one benign lesion (papillary hyperplasia), the choline peak was consistent and the CaSR pattern was with score 3. Conclusions: In this study we evaluated if MRS presence or absence of choline peak well correlated with CaSR positive and negative breast cancers. We observed a choline peak with an high level expression of CaSR (score 3-5) in 67% of the breast lesions, while in 27% of the lesions the choline peak was absent with a low CaSR expression (score 1-2). These preliminary results support the hypothesis that CaSR represents an important role in the production of choline in breast cancer, determining an increase of his production when CaSR is expressed at high level and implicating and absence of choline peak when CaSR is not expressed.

In Vivo Proton MR Spectroscopy of the Breast Using the Total Choline Peak Integral as a Marker of Malignancy

2009 ◽  
Vol 192 (6) ◽  
pp. 1608-1617 ◽  
Author(s):  
Francesco Sardanelli ◽  
Alfonso Fausto ◽  
Giovanni Di Leo ◽  
Robin de Nijs ◽  
Marianne Vorbuchner ◽  
...  
Keyword(s):  
Mr Spectroscopy ◽  
Proton Mr Spectroscopy ◽  
Choline Peak

Effects of Contrast Agent on Water Suppression and Shimming of Kidney Single-Volume Proton MR Spectroscopy at 3.0T

2010 ◽  
Vol 17 (12) ◽  
pp. 1462-1467 ◽  
Author(s):  
Li Xu ◽  
Chang-Hong Liang ◽  
Biao Huang ◽  
Shao-Heng Tan ◽  
Dongzhi Cen ◽  
...  
Keyword(s):  
Contrast Agent ◽  
Mr Spectroscopy ◽  
Water Suppression ◽  
Proton Mr Spectroscopy

scholarly journals Increased uptake of 68Ga-DOTA-FAPI-04 in bones and joints: metastases and beyond

2021 ◽  
Author(s):  
Chunxia Qin ◽  
Yangmeihui Song ◽  
Xi Liu ◽  
Yongkang Gai ◽  
Qingyao Liu ◽  
...  
Keyword(s):  
Bone Metastases ◽  
Bone Diseases ◽  
Bone Lesions ◽  
Benign Lesions ◽  
Osteofibrous Dysplasia ◽  
Benign Diseases ◽  
Pet Ct ◽  
Malignant Lesions ◽  
The Mean

Abstract Purpose: To describe the uptake of 68Gallium-labelled fibroblast activation protein inhibitor (68Ga-FAPI) in bones and joints for better understanding of the role of 68Ga-FAPI PET in benign and malignant bone lesions and joint diseases. Methods: All 129 68Ga-FAPI PET/MR or PET/CT scans from June 1, 2020 to February 20, 2021 performed at our PET centre were retrospectively reviewed. Foci of elevated 68Ga-FAPI uptake in bones and joints were identified. All lesions were divided into malignant and benign disease. Benign lesions included osteofibrous dysplasia, periodontitis, degenerative bone diseases, arthritis, and other inflammatory or trauma-related abnormalities. The number, locations and SUVmax of all lesions were recorded and analysed. Results: Elevated uptake of 68Ga-FAPI in/around bones and joints were found in 82 cases (63.57%). A total of 295 lesions were identified, including 94 (31.9%) malignant lesions (all were metastases) and 201 (68.1%) benign lesions. The benign lesions consisted of 13 osteofibrous dysplasia, 48 degenerative bone disease, 33 periodontitis, 56 arthritis, and 51 other inflammatory or trauma-related abnormalities. Spine, shoulder joint, alveolar ridge, and pelvis were the most commonly involved locations. Bone metastases were mainly distributed in the spine, pelvis and ribs. Among benign diseases, periodontitis and arthritis are site-specific. The mean SUVmax of bone metastases was significantly higher than that of benign diseases (7.14 ± 4.33 vs. 3.57 ± 1.60, p < 0.0001), but overlap existed. The differences in SUVmax among subgroups of benign diseases were statistically significant (p < 0.0001), with much higher uptake in periodontitis (4.45 ± 1.17). Conclusion: 68Ga-FAPI accumulated in both bone metastases and some benign diseases of bones and joints. Although the uptake of 68Ga-FAPI was often higher in bone metastases, this finding cannot be used to distinguish between benign and malignant lesions.

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